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Keywords: Azetidines - adverse effects; Azetidines - therapeutic use; Cardiovascular; Clinical trials; Double-Blind Method; Ezetimibe - adverse effects; Ezetimibe - therapeutic use; Female; Human health and pathology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypercholesterolemia - drug therapy; Life Sciences; Lipid-lowering drugs; Lipoproteins; Male; Middle Aged; Monoclonal antibodies; PCSK9; Safety; Santé publique et épidémiologie; Lipid-lowering drugs; Clinical trials; Monoclonal antibodies; PCSK9; Lipoproteins