From purines to purinergic signalling: molecular functions and human diseases

Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligan...

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Published inSignal transduction and targeted therapy Vol. 6; no. 1; pp. 162 - 20
Main Authors Huang, Zhao, Xie, Na, Illes, Peter, Di Virgilio, Francesco, Ulrich, Henning, Semyanov, Alexey, Verkhratsky, Alexei, Sperlagh, Beata, Yu, Shu-Guang, Huang, Canhua, Tang, Yong
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.04.2021
Nature Publishing Group
Subjects
631/154/555
692/4017
Apoptosis
Cancer Research
Cell Biology
Cell Communication
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases - genetics
Metabolic Diseases - metabolism
Metabolism
Oncology
Pathology
Purines - metabolism
Receptors, Purinergic - genetics
Receptors, Purinergic - metabolism
Review
Review Article
Signal Transduction
Online AccessGet full text
ISSN2059-3635
2095-9907
2059-3635
DOI10.1038/s41392-021-00553-z

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Abstract Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as “purinergic signalling”. Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.
AbstractList Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as "purinergic signalling". Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as "purinergic signalling". Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.
Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as "purinergic signalling". Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.
Abstract Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors, which mediate extracellular communication referred to as “purinergic signalling”. Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation, differentiation, migration, apoptosis and other physiological processes critical for the proper function of organisms. Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration, rheumatic immune diseases, inflammation, and cancer. Particularly, gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia. Compelling evidence indicates that purinoceptors are potential therapeutic targets, with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential. Furthermore, dietary and herbal interventions help to restore and balance purine metabolism, thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders. Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.
ArticleNumber 162
Author Semyanov, Alexey
Di Virgilio, Francesco
Ulrich, Henning
Verkhratsky, Alexei
Tang, Yong
Huang, Canhua
Yu, Shu-Guang
Huang, Zhao
Illes, Peter
Sperlagh, Beata
Xie, Na
Author_xml – sequence: 1
  givenname: Zhao
  surname: Huang
  fullname: Huang, Zhao
  organization: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy
– sequence: 2
  givenname: Na
  surname: Xie
  fullname: Xie, Na
  organization: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy
– sequence: 3
  givenname: Peter
  surname: Illes
  fullname: Illes, Peter
  organization: International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, Universitaet Leipzig
– sequence: 4
  givenname: Francesco
  surname: Di Virgilio
  fullname: Di Virgilio, Francesco
  organization: Department of Medical Sciences, University of Ferrara
– sequence: 5
  givenname: Henning
  surname: Ulrich
  fullname: Ulrich, Henning
  organization: International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Department of Biochemistry, Institute of Chemistry, University of São Paulo
– sequence: 6
  givenname: Alexey
  orcidid: 0000-0002-6800-0942
  surname: Semyanov
  fullname: Semyanov, Alexey
  organization: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Sechenov First Moscow State Medical University
– sequence: 7
  givenname: Alexei
  orcidid: 0000-0003-2592-9898
  surname: Verkhratsky
  fullname: Verkhratsky, Alexei
  organization: International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Sechenov First Moscow State Medical University, Faculty of Biology, Medicine and Health, The University of Manchester
– sequence: 8
  givenname: Beata
  surname: Sperlagh
  fullname: Sperlagh, Beata
  organization: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences
– sequence: 9
  givenname: Shu-Guang
  surname: Yu
  fullname: Yu, Shu-Guang
  organization: International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Acupuncture and Chronobiology Key Laboratory of Sichuan Province
– sequence: 10
  givenname: Canhua
  orcidid: 0000-0003-2247-7750
  surname: Huang
  fullname: Huang, Canhua
  email: hcanhua@scu.edu.cn
  organization: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine
– sequence: 11
  givenname: Yong
  orcidid: 0000-0002-2543-066X
  surname: Tang
  fullname: Tang, Yong
  email: tangyong@cdutcm.edu.cn
  organization: International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Acupuncture and Chronobiology Key Laboratory of Sichuan Province
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33907179$$D View this record in MEDLINE/PubMed
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Snippet Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis....
Abstract Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide...
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692/4017
Apoptosis
Cancer Research
Cell Biology
Cell Communication
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases - genetics
Metabolic Diseases - metabolism
Metabolism
Oncology
Pathology
Purines - metabolism
Receptors, Purinergic - genetics
Receptors, Purinergic - metabolism
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Review Article
Signal Transduction
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Title From purines to purinergic signalling: molecular functions and human diseases
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