Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene seque...

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Published inScientific reports Vol. 10; no. 1; pp. 13706 - 11
Main Authors Romero-Hidalgo, Sandra, Flores-Rivera, José, Rivas-Alonso, Verónica, Barquera, Rodrigo, Villarreal-Molina, María Teresa, Antuna-Puente, Bárbara, Macias-Kauffer, Luis Rodrigo, Villalobos-Comparán, Marisela, Ortiz-Maldonado, Jair, Yu, Neng, Lebedeva, Tatiana V., Alosco, Sharon M., García-Rodríguez, Juan Daniel, González-Torres, Carolina, Rosas-Madrigal, Sandra, Ordoñez, Graciela, Guerrero-Camacho, Jorge Luis, Treviño-Frenk, Irene, Escamilla-Tilch, Monica, García-Lechuga, Maricela, Tovar-Méndez, Víctor Hugo, Pacheco-Ubaldo, Hanna, Acuña-Alonzo, Victor, Bortolini, Maria-Cátira, Gallo, Carla, Bedoya, Gabriel, Rothhammer, Francisco, González-Jose, Rolando, Ruiz-Linares, Andrés, Canizales-Quinteros, Samuel, Yunis, Edmond, Granados, Julio, Corona, Teresa
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.08.2020
Nature Publishing Group
Nature Portfolio
Subjects
631/208
631/250
692/308
692/499
Alleles
American Natives - genetics
Aquaporin 4
Aquaporin 4 - genetics
Autoimmune diseases
Case-Control Studies
Disease
DNA microarrays
Drb1 protein
Epidemiology
Female
Gene Frequency
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genetics
Genomes
Histocompatibility antigen HLA
HLA Antigens - genetics
Humanities and Social Sciences
Humans
Laboratories
Male
Mexico - epidemiology
Minority & ethnic groups
multidisciplinary
Multiple sclerosis
Neuromyelitis
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - genetics
Population
Science
Science (multidisciplinary)
Tissue typing
Mexico
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-69224-3

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Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10 –6 ). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P  = 8 × 10 –10 ). Class II HLA alleles HLA- DQB1 *03:01, - DRB1 *08:02, - DRB1 *16:02, - DRB1 *14:06 and - DQB1 *04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
AbstractList Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10 –6 ). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P  = 8 × 10 –10 ). Class II HLA alleles HLA- DQB1 *03:01, - DRB1 *08:02, - DRB1 *16:02, - DRB1 *14:06 and - DQB1 *04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10 ). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10 ). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10-6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10-10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10-6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10-10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
ArticleNumber 13706
Author Villarreal-Molina, María Teresa
Barquera, Rodrigo
Lebedeva, Tatiana V.
Canizales-Quinteros, Samuel
Bortolini, Maria-Cátira
Bedoya, Gabriel
Antuna-Puente, Bárbara
Granados, Julio
Alosco, Sharon M.
Rivas-Alonso, Verónica
Gallo, Carla
Pacheco-Ubaldo, Hanna
Ruiz-Linares, Andrés
Rosas-Madrigal, Sandra
Macias-Kauffer, Luis Rodrigo
Tovar-Méndez, Víctor Hugo
Treviño-Frenk, Irene
Yunis, Edmond
González-Torres, Carolina
Acuña-Alonzo, Victor
González-Jose, Rolando
Ortiz-Maldonado, Jair
Escamilla-Tilch, Monica
Romero-Hidalgo, Sandra
García-Lechuga, Maricela
Guerrero-Camacho, Jorge Luis
Villalobos-Comparán, Marisela
Ordoñez, Graciela
Rothhammer, Francisco
Corona, Teresa
García-Rodríguez, Juan Daniel
Flores-Rivera, José
Yu, Neng
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Snippet Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the...
Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from...
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SubjectTerms 631/208
631/250
692/308
692/499
Alleles
American Natives - genetics
Aquaporin 4
Aquaporin 4 - genetics
Autoimmune diseases
Case-Control Studies
Disease
DNA microarrays
Drb1 protein
Epidemiology
Female
Gene Frequency
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genetics
Genomes
Histocompatibility antigen HLA
HLA Antigens - genetics
Humanities and Social Sciences
Humans
Laboratories
Male
Mexico - epidemiology
Minority & ethnic groups
multidisciplinary
Multiple sclerosis
Neuromyelitis
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - genetics
Population
Science
Science (multidisciplinary)
Tissue typing
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Title Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
URI https://link.springer.com/article/10.1038/s41598-020-69224-3
https://www.ncbi.nlm.nih.gov/pubmed/32792643
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https://www.proquest.com/docview/2434477943
https://pubmed.ncbi.nlm.nih.gov/PMC7426416
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