Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercros...

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Published inNature communications Vol. 10; no. 1; pp. 4097 - 15
Main Authors Vorobyev, Artem, Gupta, Yask, Sezin, Tanya, Koga, Hiroshi, Bartsch, Yannic C., Belheouane, Meriem, Künzel, Sven, Sina, Christian, Schilf, Paul, Körber-Ahrens, Heiko, Beltsiou, Foteini, Lara Ernst, Anna, Khil’chenko, Stanislav, Al-Aasam, Hassanin, Manz, Rudolf A., Diehl, Sandra, Steinhaus, Moritz, Jascholt, Joanna, Kouki, Phillip, Boehncke, Wolf-Henning, Mayadas, Tanya N., Zillikens, Detlef, Sadik, Christian D., Nishi, Hiroshi, Ehlers, Marc, Möller, Steffen, Bieber, Katja, Baines, John F., Ibrahim, Saleh M., Ludwig, Ralf J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 10.09.2019
Nature Publishing Group
Nature Portfolio
Subjects
38/23
38/91
45
631/208/205
631/208/729/743
631/250/38
64/60
692/308/2056
Animals
Animals, Outbred Strains
Antibodies, Antinuclear - genetics
Autoimmunity
Bacteria - growth & development
Biodiversity
Community composition
Crosses, Genetic
Diet
Environmental factors
Environmental impact
Female
Fungi - growth & development
Gene mapping
Gene sequencing
Genes
Genetic Association Studies
Genetic Predisposition to Disease
Genetics
Genomes
Genotype-environment interactions
Humanities and Social Sciences
Intestine
Lupus Nephritis - genetics
Lupus Nephritis - immunology
Male
Mice
Microbiota
multidisciplinary
Phenotypic variations
Physical Chromosome Mapping
Quantitative trait loci
Quantitative Trait Loci - genetics
Quantitative Trait, Heritable
Science
Science (multidisciplinary)
Spleen - metabolism
Transcriptome - genetics
Whole Genome Sequencing
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-019-11952-w

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Abstract Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies. Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.
AbstractList Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies. Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.
Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies.
Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies.Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies.
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.
ArticleNumber 4097
Author Möller, Steffen
Mayadas, Tanya N.
Sina, Christian
Ibrahim, Saleh M.
Bieber, Katja
Koga, Hiroshi
Jascholt, Joanna
Manz, Rudolf A.
Sadik, Christian D.
Vorobyev, Artem
Körber-Ahrens, Heiko
Khil’chenko, Stanislav
Boehncke, Wolf-Henning
Ehlers, Marc
Baines, John F.
Ludwig, Ralf J.
Steinhaus, Moritz
Sezin, Tanya
Künzel, Sven
Diehl, Sandra
Kouki, Phillip
Schilf, Paul
Gupta, Yask
Lara Ernst, Anna
Zillikens, Detlef
Beltsiou, Foteini
Bartsch, Yannic C.
Al-Aasam, Hassanin
Belheouane, Meriem
Nishi, Hiroshi
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31506438$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/ncomms15475
10.1016/j.jaad.2016.07.065
10.1038/nature10413
10.1002/art.20553
10.1093/database/baq020
10.1186/s13059-014-0550-8
10.1074/jbc.M701132200
10.2337/dc12-2211
10.1038/ismej.2014.64
10.1038/s41598-017-13356-6
10.1198/tas.2011.11077
10.3389/fphys.2017.00236
10.1093/nar/gkw1133
10.1038/ncomms7495
10.1038/nature12820
10.1111/j.1365-2249.2012.04568.x
10.1128/AEM.03006-05
10.1038/s41467-019-08535-0
10.1016/j.yexcr.2012.02.013
10.1038/nmicrobiol.2017.4
10.1534/genetics.114.167056
10.1038/nmeth.f.303
10.1186/s13059-015-0775-1
10.1093/bioinformatics/bts503
10.1186/s40168-017-0373-4
10.1093/nar/gku1179
10.7717/peerj.2584
10.1038/srep08310
10.1093/bioinformatics/btq461
10.1038/s41467-017-00453-3
10.1093/intimm/dxx033
10.1111/mec.12481
10.1534/genetics.116.188292
10.1371/journal.pgen.1003225
10.1038/ncomms15062
10.1534/g3.114.013748
10.1128/AEM.00062-07
10.1038/ng.3897
10.1038/nature08494
10.1186/s13059-016-0974-4
10.3892/mmr.2017.7052
10.4049/jimmunol.167.12.7141
10.1073/pnas.230304397
10.1111/exd.12192
10.1086/519795
10.1093/bioinformatics/btt656
10.1046/j.1365-2222.2001.01184.x
10.1016/j.immuni.2011.01.014
10.1186/s40168-017-0275-5
10.1016/j.cell.2018.04.037
10.1111/j.1365-2249.1992.tb06879.x
10.1016/j.cmet.2017.06.007
10.1038/s41467-018-03202-2
10.1111/2041-210X.12399
10.1194/jlr.M076513
10.1186/s13059-016-1024-y
10.1016/j.ajhg.2017.06.005
10.1093/bioinformatics/btr381
10.7717/peerj.4303
10.1186/gb-2011-12-6-r60
10.1007/s10038-007-0219-1
10.1093/nar/gkt338
10.1093/bioinformatics/btu170
10.1038/nprot.2012.016
10.3389/fimmu.2018.00427
10.1189/jlb.70.4.578
10.1128/mSphere.00351-17
10.1093/bioinformatics/bty734
10.1093/ajcn/86.4.899
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Copyright The Author(s) 2019
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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References Kanno, Nose, Itoh, Taniguchi, Kyogoku (CR22) 1992; 89
Belheouane, Gupta, Kunzel, Ibrahim, Baines (CR62) 2017; 5
Johnson (CR10) 2007; 86
Li (CR38) 2012; 168
Wuerzberger-Davis (CR20) 2011; 34
(CR60) 2015; 43
Kamatani (CR40) 2008; 53
Safran (CR55) 2010; 2010
Visscher (CR1) 2017; 101
Wunnenburger (CR41) 2017; 7
Geurts (CR17) 2015; 6
Parker (CR11) 2014; 198
Nash (CR33) 2017; 5
MacArthur (CR54) 2017; 45
Koljalg (CR71) 2013; 22
Iyer (CR7) 2018; 173
Shen (CR15) 2017; 8
Rojo (CR26) 2015; 5
Edgar (CR63) 2010; 26
Wurstle, Laussmann, Rehm (CR21) 2012; 318
Takeshita (CR8) 2017; 76
Rognes, Flouri, Nichols, Quince, Mahe (CR70) 2016; 4
Halfvarson (CR27) 2017; 2
Fu, Luo, Luo, Zhu, Garvey (CR18) 2007; 282
Acosta-Rodriguez, de Groot, Rijo-Ferreira, Green, Takahashi (CR37) 2017; 26
Brown, Price, Patsopoulos, Zaitlen (CR5) 2016; 203
David (CR24) 2014; 505
Gatti (CR47) 2014; 4
Robinson (CR51) 2017; 3
Segata (CR29) 2011; 12
Xie (CR39) 2001; 167
Jonsson (CR44) 2017; 49
Luzina (CR30) 2001; 70
Garcia-Alcalde (CR52) 2012; 28
Jackson (CR34) 2018; 6
Edgar, Haas, Clemente, Quince, Knight (CR64) 2011; 27
Chung (CR3) 2019; 10
Lauc (CR14) 2013; 9
Franks, Pearson, Florez (CR43) 2013; 36
DeSantis (CR66) 2006; 72
Xia (CR61) 2013; 41
Liao, Smyth, Shi (CR58) 2014; 30
Yamaguchi (CR42) 2017; 16
Gweon (CR69) 2015; 6
CR50
Fave (CR4) 2018; 9
Purcell (CR45) 2007; 81
Manolio (CR2) 2009; 461
Caporaso (CR67) 2010; 7
Wang, Garrity, Tiedje, Cole (CR65) 2007; 73
Padyukov, Silva, Stolt, Alfredsson, Klareskog (CR6) 2004; 50
Malkiel, Barlev, Atisha-Fregoso, Suurmond, Diamond (CR31) 2018; 9
Doran (CR13) 2016; 17
Trapnell (CR57) 2012; 7
Keane (CR12) 2011; 477
Love, Huber, Anders (CR59) 2014; 15
Leclercq (CR28) 2017; 8
Mita, Hasegawa, Saito, Akiyama (CR19) 2001; 31
Bolger, Lohse, Usadel (CR56) 2014; 30
Edwards (CR36) 2017; 29
Gupta (CR9) 2013; 22
CR25
West, Galecki (CR48) 2012; 65
CR68
Benson (CR49) 2015; 16
Karp (CR35) 2017; 8
Mott, Talbot, Turri, Collins, Flint (CR46) 2000; 97
Chen (CR16) 2017; 58
Aqel (CR23) 2017; 8
Tong (CR32) 2014; 8
McLaren (CR53) 2016; 17
LA David (11952_CR24) 2014; 505
BT West (11952_CR48) 2012; 65
AK Benson (11952_CR49) 2015; 16
Q Wang (11952_CR65) 2007; 73
CC Parker (11952_CR11) 2014; 198
TM Keane (11952_CR12) 2011; 477
AG Doran (11952_CR13) 2016; 17
IG Luzina (11952_CR30) 2001; 70
S Yamaguchi (11952_CR42) 2017; 16
Z Chen (11952_CR16) 2017; 58
AM Bolger (11952_CR56) 2014; 30
DM Gatti (11952_CR47) 2014; 4
Y Fu (11952_CR18) 2007; 282
X Shen (11952_CR15) 2017; 8
SS Iyer (11952_CR7) 2018; 173
L Li (11952_CR38) 2012; 168
W McLaren (11952_CR53) 2016; 17
AK Nash (11952_CR33) 2017; 5
HS Gweon (11952_CR69) 2015; 6
M Belheouane (11952_CR62) 2017; 5
RC Edgar (11952_CR64) 2011; 27
S Wunnenburger (11952_CR41) 2017; 7
SI Aqel (11952_CR23) 2017; 8
M Safran (11952_CR55) 2010; 2010
Gene Ontology Consortium. (11952_CR60) 2015; 43
MJ Fave (11952_CR4) 2018; 9
S Jonsson (11952_CR44) 2017; 49
T Rognes (11952_CR70) 2016; 4
MI Love (11952_CR59) 2014; 15
11952_CR25
M Tong (11952_CR32) 2014; 8
F Garcia-Alcalde (11952_CR52) 2012; 28
11952_CR68
KM Robinson (11952_CR51) 2017; 3
C Trapnell (11952_CR57) 2012; 7
G Lauc (11952_CR14) 2013; 9
MR Edwards (11952_CR36) 2017; 29
J Xia (11952_CR61) 2013; 41
W Chung (11952_CR3) 2019; 10
RJ Johnson (11952_CR10) 2007; 86
D Rojo (11952_CR26) 2015; 5
L Geurts (11952_CR17) 2015; 6
J Halfvarson (11952_CR27) 2017; 2
H Kanno (11952_CR22) 1992; 89
TA Manolio (11952_CR2) 2009; 461
N Segata (11952_CR29) 2011; 12
11952_CR50
Y Liao (11952_CR58) 2014; 30
S Leclercq (11952_CR28) 2017; 8
MA Jackson (11952_CR34) 2018; 6
J Takeshita (11952_CR8) 2017; 76
S Xie (11952_CR39) 2001; 167
R Mott (11952_CR46) 2000; 97
PW Franks (11952_CR43) 2013; 36
BC Brown (11952_CR5) 2016; 203
JG Caporaso (11952_CR67) 2010; 7
PM Visscher (11952_CR1) 2017; 101
S Malkiel (11952_CR31) 2018; 9
TZ DeSantis (11952_CR66) 2006; 72
S Purcell (11952_CR45) 2007; 81
RC Edgar (11952_CR63) 2010; 26
VA Acosta-Rodriguez (11952_CR37) 2017; 26
NA Karp (11952_CR35) 2017; 8
Y Gupta (11952_CR9) 2013; 22
SM Wuerzberger-Davis (11952_CR20) 2011; 34
H Mita (11952_CR19) 2001; 31
ML Wurstle (11952_CR21) 2012; 318
Y Kamatani (11952_CR40) 2008; 53
L Padyukov (11952_CR6) 2004; 50
J MacArthur (11952_CR54) 2017; 45
U Koljalg (11952_CR71) 2013; 22
References_xml – volume: 8
  year: 2017
  ident: CR35
  article-title: Prevalence of sexual dimorphism in mammalian phenotypic traits
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15475
– volume: 76
  start-page: 393
  year: 2017
  end-page: 403
  ident: CR8
  article-title: Psoriasis and comorbid diseases: implications for management
  publication-title: J. Am. Acad. Dermatol
  doi: 10.1016/j.jaad.2016.07.065
– volume: 477
  start-page: 289
  year: 2011
  end-page: 294
  ident: CR12
  article-title: Mouse genomic variation and its effect on phenotypes and gene regulation
  publication-title: Nature
  doi: 10.1038/nature10413
– volume: 50
  start-page: 3085
  year: 2004
  end-page: 3092
  ident: CR6
  article-title: A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.20553
– ident: CR68
– volume: 2010
  start-page: baq020
  year: 2010
  ident: CR55
  article-title: GeneCards Version 3: the human gene integrator
  publication-title: Database
  doi: 10.1093/database/baq020
– volume: 15
  year: 2014
  ident: CR59
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 282
  start-page: 31525
  year: 2007
  end-page: 31533
  ident: CR18
  article-title: NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M701132200
– volume: 36
  start-page: 1413
  year: 2013
  end-page: 1421
  ident: CR43
  article-title: Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects
  publication-title: Diabetes Care
  doi: 10.2337/dc12-2211
– volume: 8
  start-page: 2193
  year: 2014
  end-page: 2206
  ident: CR32
  article-title: Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism
  publication-title: ISME J.
  doi: 10.1038/ismej.2014.64
– volume: 7
  year: 2017
  ident: CR41
  article-title: Associations between genetic risk variants for kidney diseases and kidney disease etiology
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-13356-6
– volume: 65
  start-page: 274
  year: 2012
  end-page: 282
  ident: CR48
  article-title: An overview of current software procedures for fitting linear mixed models
  publication-title: Am. Stat.
  doi: 10.1198/tas.2011.11077
– ident: CR25
– volume: 8
  start-page: 236
  year: 2017
  ident: CR23
  article-title: Daily moderate exercise is beneficial and social stress is detrimental to disease pathology in murine lupus nephritis
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2017.00236
– volume: 45
  start-page: D896
  year: 2017
  end-page: D901
  ident: CR54
  article-title: The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw1133
– volume: 6
  year: 2015
  ident: CR17
  article-title: Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7495
– volume: 505
  start-page: 559
  year: 2014
  end-page: 563
  ident: CR24
  article-title: Diet rapidly and reproducibly alters the human gut microbiome
  publication-title: Nature
  doi: 10.1038/nature12820
– volume: 168
  start-page: 178
  year: 2012
  end-page: 185
  ident: CR38
  article-title: Murine lupus strains differentially model unique facets of human lupus serology
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/j.1365-2249.2012.04568.x
– volume: 72
  start-page: 5069
  year: 2006
  end-page: 5072
  ident: CR66
  article-title: Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.03006-05
– volume: 10
  year: 2019
  ident: CR3
  article-title: Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08535-0
– ident: CR50
– volume: 3
  start-page: e000122
  year: 2017
  ident: CR51
  article-title: Aligner optimization increases accuracy and decreases compute times in multi-species sequence data
  publication-title: Micro. Genom.
– volume: 318
  start-page: 1213
  year: 2012
  end-page: 1220
  ident: CR21
  article-title: The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome
  publication-title: Exp. Cell Res
  doi: 10.1016/j.yexcr.2012.02.013
– volume: 2
  start-page: 17004
  year: 2017
  ident: CR27
  article-title: Dynamics of the human gut microbiome in inflammatory bowel disease
  publication-title: Nat. Microbiol
  doi: 10.1038/nmicrobiol.2017.4
– volume: 198
  start-page: 103
  year: 2014
  end-page: 116
  ident: CR11
  article-title: High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice
  publication-title: Genetics
  doi: 10.1534/genetics.114.167056
– volume: 7
  start-page: 335
  year: 2010
  end-page: 336
  ident: CR67
  article-title: QIIME allows analysis of high-throughput community sequencing data
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.f.303
– volume: 16
  year: 2015
  ident: CR49
  article-title: Host genetic architecture and the landscape of microbiome composition: humans weigh in
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0775-1
– volume: 28
  start-page: 2678
  year: 2012
  end-page: 2679
  ident: CR52
  article-title: Qualimap: evaluating next-generation sequencing alignment data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts503
– volume: 5
  year: 2017
  ident: CR33
  article-title: The gut mycobiome of the Human Microbiome Project healthy cohort
  publication-title: Microbiome
  doi: 10.1186/s40168-017-0373-4
– volume: 43
  start-page: D1049
  year: 2015
  end-page: D1056
  ident: CR60
  article-title: going forward
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1179
– volume: 4
  start-page: e2584
  year: 2016
  ident: CR70
  article-title: VSEARCH: a versatile open source tool for metagenomics
  publication-title: PeerJ
  doi: 10.7717/peerj.2584
– volume: 5
  year: 2015
  ident: CR26
  article-title: Ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases
  publication-title: Sci. Rep.
  doi: 10.1038/srep08310
– volume: 26
  start-page: 2460
  year: 2010
  end-page: 2461
  ident: CR63
  article-title: Search and clustering orders of magnitude faster than BLAST
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq461
– volume: 8
  year: 2017
  ident: CR15
  article-title: Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00453-3
– volume: 29
  start-page: 263
  year: 2017
  end-page: 276
  ident: CR36
  article-title: Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice
  publication-title: Int. Immunol.
  doi: 10.1093/intimm/dxx033
– volume: 22
  start-page: 5271
  year: 2013
  end-page: 5277
  ident: CR71
  article-title: Towards a unified paradigm for sequence-based identification of fungi
  publication-title: Mol. Ecol.
  doi: 10.1111/mec.12481
– volume: 203
  start-page: 1105
  year: 2016
  end-page: 1116
  ident: CR5
  article-title: Local joint testing improves power and identifies hidden heritability in association studies
  publication-title: Genetics
  doi: 10.1534/genetics.116.188292
– volume: 9
  start-page: e1003225
  year: 2013
  ident: CR14
  article-title: Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1003225
– volume: 8
  year: 2017
  ident: CR28
  article-title: Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15062
– volume: 4
  start-page: 1623
  year: 2014
  end-page: 1633
  ident: CR47
  article-title: Quantitative trait locus mapping methods for diversity outbred mice
  publication-title: G3 (Bethesda)
  doi: 10.1534/g3.114.013748
– volume: 73
  start-page: 5261
  year: 2007
  end-page: 5267
  ident: CR65
  article-title: Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
  publication-title: Appl Environ. Microbiol
  doi: 10.1128/AEM.00062-07
– volume: 49
  start-page: 1182
  year: 2017
  end-page: 1191
  ident: CR44
  article-title: Identification of sequence variants influencing immunoglobulin levels
  publication-title: Nat. Genet
  doi: 10.1038/ng.3897
– volume: 461
  start-page: 747
  year: 2009
  end-page: 753
  ident: CR2
  article-title: Finding the missing heritability of complex diseases
  publication-title: Nature
  doi: 10.1038/nature08494
– volume: 17
  year: 2016
  ident: CR53
  article-title: The Ensembl variant effect predictor
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0974-4
– volume: 86
  start-page: 899
  year: 2007
  end-page: 906
  ident: CR10
  article-title: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
  publication-title: Am. J. Clin. Nutr.
– volume: 16
  start-page: 4061
  year: 2017
  end-page: 4067
  ident: CR42
  article-title: Suppression of hepatic dysfunction in tenascinXdeficient mice fed a highfat diet
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2017.7052
– volume: 167
  start-page: 7141
  year: 2001
  end-page: 7149
  ident: CR39
  article-title: Genetic contributions of nonautoimmune SWR mice toward lupus nephritis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.167.12.7141
– volume: 97
  start-page: 12649
  year: 2000
  end-page: 12654
  ident: CR46
  article-title: A method for fine mapping quantitative trait loci in outbred animal stocks
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.230304397
– volume: 22
  start-page: 552
  year: 2013
  end-page: 553
  ident: CR9
  article-title: Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease
  publication-title: Exp. Dermatol
  doi: 10.1111/exd.12192
– volume: 81
  start-page: 559
  year: 2007
  end-page: 575
  ident: CR45
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: CR58
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 31
  start-page: 1714
  year: 2001
  end-page: 1723
  ident: CR19
  article-title: Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils
  publication-title: Clin. Exp. Allergy
  doi: 10.1046/j.1365-2222.2001.01184.x
– volume: 34
  start-page: 188
  year: 2011
  end-page: 200
  ident: CR20
  article-title: Nuclear export of the NF-kappaB inhibitor IkappaBalpha is required for proper B cell and secondary lymphoid tissue formation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.01.014
– volume: 5
  year: 2017
  ident: CR62
  article-title: Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts
  publication-title: Microbiome
  doi: 10.1186/s40168-017-0275-5
– volume: 173
  start-page: 1123
  year: 2018
  end-page: 1134 e1111
  ident: CR7
  article-title: Dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses
  publication-title: Cell
  doi: 10.1016/j.cell.2018.04.037
– volume: 89
  start-page: 68
  year: 1992
  end-page: 73
  ident: CR22
  article-title: Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/j.1365-2249.1992.tb06879.x
– volume: 70
  start-page: 578
  year: 2001
  end-page: 584
  ident: CR30
  article-title: Spontaneous formation of germinal centers in autoimmune mice
  publication-title: J. Leukoc. Biol.
– volume: 26
  start-page: 267
  year: 2017
  end-page: 277 e262
  ident: CR37
  article-title: Mice under Caloric Restriction Self-impose A Temporal Restriction of Food Intake as Revealed by an Automated Feeder System
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.06.007
– volume: 9
  year: 2018
  ident: CR4
  article-title: Gene-by-environment interactions in urban populations modulate risk phenotypes
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03202-2
– volume: 6
  start-page: 973
  year: 2015
  end-page: 980
  ident: CR69
  article-title: PIPITS: an automated pipeline for analyses of fungal internal transcribed spacer sequences from the Illumina sequencing platform
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/2041-210X.12399
– volume: 58
  start-page: 1624
  year: 2017
  end-page: 1635
  ident: CR16
  article-title: Leptogenic effects of NAPE require activity of NAPE-hydrolyzing phospholipase D
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M076513
– volume: 17
  year: 2016
  ident: CR13
  article-title: Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1024-y
– volume: 101
  start-page: 5
  year: 2017
  end-page: 22
  ident: CR1
  article-title: 10 Years of GWAS discovery: biology, function, and translation
  publication-title: Am. J. Hum. Genet
  doi: 10.1016/j.ajhg.2017.06.005
– volume: 27
  start-page: 2194
  year: 2011
  end-page: 2200
  ident: CR64
  article-title: UCHIME improves sensitivity and speed of chimera detection
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr381
– volume: 6
  start-page: e4303
  year: 2018
  ident: CR34
  article-title: Detection of stable community structures within gut microbiota co-occurrence networks from different human populations
  publication-title: PeerJ
  doi: 10.7717/peerj.4303
– volume: 12
  year: 2011
  ident: CR29
  article-title: Metagenomic biomarker discovery and explanation
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-6-r60
– volume: 53
  start-page: 64
  year: 2008
  end-page: 73
  ident: CR40
  article-title: Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population
  publication-title: J. Hum. Genet.
  doi: 10.1007/s10038-007-0219-1
– volume: 41
  start-page: W63
  year: 2013
  end-page: W70
  ident: CR61
  article-title: INMEX–a web-based tool for integrative meta-analysis of expression data
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt338
– volume: 30
  start-page: 2114
  year: 2014
  end-page: 2120
  ident: CR56
  article-title: Trimmomatic: a flexible trimmer for Illumina sequence data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 7
  start-page: 562
  year: 2012
  end-page: 578
  ident: CR57
  article-title: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2012.016
– volume: 9
  start-page: 427
  year: 2018
  ident: CR31
  article-title: Plasma cell differentiation pathways in systemic lupus erythematosus
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00427
– volume: 101
  start-page: 5
  year: 2017
  ident: 11952_CR1
  publication-title: Am. J. Hum. Genet
  doi: 10.1016/j.ajhg.2017.06.005
– volume: 70
  start-page: 578
  year: 2001
  ident: 11952_CR30
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.70.4.578
– volume: 7
  year: 2017
  ident: 11952_CR41
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-13356-6
– volume: 6
  start-page: 973
  year: 2015
  ident: 11952_CR69
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/2041-210X.12399
– volume: 4
  start-page: e2584
  year: 2016
  ident: 11952_CR70
  publication-title: PeerJ
  doi: 10.7717/peerj.2584
– volume: 3
  start-page: e000122
  year: 2017
  ident: 11952_CR51
  publication-title: Micro. Genom.
– volume: 22
  start-page: 5271
  year: 2013
  ident: 11952_CR71
  publication-title: Mol. Ecol.
  doi: 10.1111/mec.12481
– volume: 26
  start-page: 2460
  year: 2010
  ident: 11952_CR63
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq461
– volume: 17
  year: 2016
  ident: 11952_CR53
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0974-4
– volume: 50
  start-page: 3085
  year: 2004
  ident: 11952_CR6
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.20553
– volume: 8
  start-page: 236
  year: 2017
  ident: 11952_CR23
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2017.00236
– volume: 43
  start-page: D1049
  year: 2015
  ident: 11952_CR60
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1179
– volume: 16
  start-page: 4061
  year: 2017
  ident: 11952_CR42
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2017.7052
– volume: 7
  start-page: 562
  year: 2012
  ident: 11952_CR57
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2012.016
– volume: 198
  start-page: 103
  year: 2014
  ident: 11952_CR11
  publication-title: Genetics
  doi: 10.1534/genetics.114.167056
– volume: 31
  start-page: 1714
  year: 2001
  ident: 11952_CR19
  publication-title: Clin. Exp. Allergy
  doi: 10.1046/j.1365-2222.2001.01184.x
– volume: 167
  start-page: 7141
  year: 2001
  ident: 11952_CR39
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.167.12.7141
– volume: 7
  start-page: 335
  year: 2010
  ident: 11952_CR67
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.f.303
– volume: 5
  year: 2017
  ident: 11952_CR33
  publication-title: Microbiome
  doi: 10.1186/s40168-017-0373-4
– volume: 27
  start-page: 2194
  year: 2011
  ident: 11952_CR64
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr381
– volume: 16
  year: 2015
  ident: 11952_CR49
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0775-1
– volume: 8
  start-page: 2193
  year: 2014
  ident: 11952_CR32
  publication-title: ISME J.
  doi: 10.1038/ismej.2014.64
– volume: 461
  start-page: 747
  year: 2009
  ident: 11952_CR2
  publication-title: Nature
  doi: 10.1038/nature08494
– ident: 11952_CR25
  doi: 10.1128/mSphere.00351-17
– ident: 11952_CR50
– volume: 8
  year: 2017
  ident: 11952_CR28
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15062
– volume: 12
  year: 2011
  ident: 11952_CR29
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-6-r60
– volume: 49
  start-page: 1182
  year: 2017
  ident: 11952_CR44
  publication-title: Nat. Genet
  doi: 10.1038/ng.3897
– volume: 10
  year: 2019
  ident: 11952_CR3
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08535-0
– volume: 9
  start-page: 427
  year: 2018
  ident: 11952_CR31
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00427
– volume: 29
  start-page: 263
  year: 2017
  ident: 11952_CR36
  publication-title: Int. Immunol.
  doi: 10.1093/intimm/dxx033
– volume: 81
  start-page: 559
  year: 2007
  ident: 11952_CR45
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 22
  start-page: 552
  year: 2013
  ident: 11952_CR9
  publication-title: Exp. Dermatol
  doi: 10.1111/exd.12192
– ident: 11952_CR68
  doi: 10.1093/bioinformatics/bty734
– volume: 15
  year: 2014
  ident: 11952_CR59
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 2010
  start-page: baq020
  year: 2010
  ident: 11952_CR55
  publication-title: Database
  doi: 10.1093/database/baq020
– volume: 203
  start-page: 1105
  year: 2016
  ident: 11952_CR5
  publication-title: Genetics
  doi: 10.1534/genetics.116.188292
– volume: 26
  start-page: 267
  year: 2017
  ident: 11952_CR37
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.06.007
– volume: 76
  start-page: 393
  year: 2017
  ident: 11952_CR8
  publication-title: J. Am. Acad. Dermatol
  doi: 10.1016/j.jaad.2016.07.065
– volume: 28
  start-page: 2678
  year: 2012
  ident: 11952_CR52
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts503
– volume: 5
  year: 2015
  ident: 11952_CR26
  publication-title: Sci. Rep.
  doi: 10.1038/srep08310
– volume: 477
  start-page: 289
  year: 2011
  ident: 11952_CR12
  publication-title: Nature
  doi: 10.1038/nature10413
– volume: 9
  start-page: e1003225
  year: 2013
  ident: 11952_CR14
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1003225
– volume: 282
  start-page: 31525
  year: 2007
  ident: 11952_CR18
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M701132200
– volume: 318
  start-page: 1213
  year: 2012
  ident: 11952_CR21
  publication-title: Exp. Cell Res
  doi: 10.1016/j.yexcr.2012.02.013
– volume: 173
  start-page: 1123
  year: 2018
  ident: 11952_CR7
  publication-title: Cell
  doi: 10.1016/j.cell.2018.04.037
– volume: 30
  start-page: 2114
  year: 2014
  ident: 11952_CR56
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 86
  start-page: 899
  year: 2007
  ident: 11952_CR10
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/86.4.899
– volume: 8
  year: 2017
  ident: 11952_CR15
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00453-3
– volume: 53
  start-page: 64
  year: 2008
  ident: 11952_CR40
  publication-title: J. Hum. Genet.
  doi: 10.1007/s10038-007-0219-1
– volume: 9
  year: 2018
  ident: 11952_CR4
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03202-2
– volume: 505
  start-page: 559
  year: 2014
  ident: 11952_CR24
  publication-title: Nature
  doi: 10.1038/nature12820
– volume: 6
  year: 2015
  ident: 11952_CR17
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7495
– volume: 5
  year: 2017
  ident: 11952_CR62
  publication-title: Microbiome
  doi: 10.1186/s40168-017-0275-5
– volume: 6
  start-page: e4303
  year: 2018
  ident: 11952_CR34
  publication-title: PeerJ
  doi: 10.7717/peerj.4303
– volume: 36
  start-page: 1413
  year: 2013
  ident: 11952_CR43
  publication-title: Diabetes Care
  doi: 10.2337/dc12-2211
– volume: 17
  year: 2016
  ident: 11952_CR13
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1024-y
– volume: 89
  start-page: 68
  year: 1992
  ident: 11952_CR22
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/j.1365-2249.1992.tb06879.x
– volume: 168
  start-page: 178
  year: 2012
  ident: 11952_CR38
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/j.1365-2249.2012.04568.x
– volume: 72
  start-page: 5069
  year: 2006
  ident: 11952_CR66
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.03006-05
– volume: 34
  start-page: 188
  year: 2011
  ident: 11952_CR20
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.01.014
– volume: 30
  start-page: 923
  year: 2014
  ident: 11952_CR58
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 73
  start-page: 5261
  year: 2007
  ident: 11952_CR65
  publication-title: Appl Environ. Microbiol
  doi: 10.1128/AEM.00062-07
– volume: 97
  start-page: 12649
  year: 2000
  ident: 11952_CR46
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.230304397
– volume: 65
  start-page: 274
  year: 2012
  ident: 11952_CR48
  publication-title: Am. Stat.
  doi: 10.1198/tas.2011.11077
– volume: 8
  year: 2017
  ident: 11952_CR35
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15475
– volume: 45
  start-page: D896
  year: 2017
  ident: 11952_CR54
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw1133
– volume: 58
  start-page: 1624
  year: 2017
  ident: 11952_CR16
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M076513
– volume: 4
  start-page: 1623
  year: 2014
  ident: 11952_CR47
  publication-title: G3 (Bethesda)
  doi: 10.1534/g3.114.013748
– volume: 2
  start-page: 17004
  year: 2017
  ident: 11952_CR27
  publication-title: Nat. Microbiol
  doi: 10.1038/nmicrobiol.2017.4
– volume: 41
  start-page: W63
  year: 2013
  ident: 11952_CR61
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt338
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Snippet Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of...
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait...
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proquest
pubmed
crossref
springer
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Publisher
StartPage 4097
SubjectTerms 38/23
38/91
45
631/208/205
631/208/729/743
631/250/38
64/60
692/308/2056
Animals
Animals, Outbred Strains
Antibodies, Antinuclear - genetics
Autoimmunity
Bacteria - growth & development
Biodiversity
Community composition
Crosses, Genetic
Diet
Environmental factors
Environmental impact
Female
Fungi - growth & development
Gene mapping
Gene sequencing
Genes
Genetic Association Studies
Genetic Predisposition to Disease
Genetics
Genomes
Genotype-environment interactions
Humanities and Social Sciences
Intestine
Lupus Nephritis - genetics
Lupus Nephritis - immunology
Male
Mice
Microbiota
multidisciplinary
Phenotypic variations
Physical Chromosome Mapping
Quantitative trait loci
Quantitative Trait Loci - genetics
Quantitative Trait, Heritable
Science
Science (multidisciplinary)
Spleen - metabolism
Transcriptome - genetics
Whole Genome Sequencing
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Title Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line
URI https://link.springer.com/article/10.1038/s41467-019-11952-w
https://www.ncbi.nlm.nih.gov/pubmed/31506438
https://www.proquest.com/docview/2287989724
https://www.proquest.com/docview/2288734405
https://pubmed.ncbi.nlm.nih.gov/PMC6736984
https://doaj.org/article/33aa09018c92411598dc61043de133d0
Volume 10
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