NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a bet...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 10; no. 1; pp. 2882 - 16
Main Authors Luan, Peipei, Jian, Weixia, Xu, Xu, Kou, Wenxin, Yu, Qing, Hu, Handan, Li, Dali, Wang, Wei, Feinberg, Mark W., Zhuang, Jianhui, Xu, Yawei, Peng, Wenhui
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.06.2019
Nature Publishing Group
Nature Portfolio
Subjects
13
13/1
13/31
13/51
13/89
13/95
14
14/34
49/109
631/443/592/75/593
631/80/86/388
64/60
Animals
Antigen presentation
Antigens
Aorta
Apoptosis
Blood Pressure
Bone Marrow Transplantation
Cell Proliferation
Cells, Cultured
Cytokines - genetics
Cytokines - metabolism
Heart Rate
Humanities and Social Sciences
Humans
Hyperplasia
Immunity
Innate immunity
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Mice
Mice, Knockout
multidisciplinary
Muscles
Myocytes, Smooth Muscle - metabolism
Pioglitazone
Plasmids
Rodents
Science
Science (multidisciplinary)
Smooth muscle
Transcriptome
Tunica Intima - metabolism
Vascular Remodeling
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-019-10784-y

Cover

Abstract NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout ( Nlrc5 −/− ) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5 −/− mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ. NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.
AbstractList NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5-/-) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5-/- mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5-/-) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5-/- mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.
NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.
NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout ( Nlrc5 −/− ) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5 −/− mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ. NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.
NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5−/−) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5−/− mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.
NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5 ) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5 mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.
NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout ( Nlrc5 −/− ) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5 −/− mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.
ArticleNumber 2882
Author Kou, Wenxin
Jian, Weixia
Xu, Xu
Yu, Qing
Xu, Yawei
Wang, Wei
Zhuang, Jianhui
Luan, Peipei
Peng, Wenhui
Feinberg, Mark W.
Li, Dali
Hu, Handan
Author_xml – sequence: 1
  givenname: Peipei
  surname: Luan
  fullname: Luan, Peipei
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine
– sequence: 2
  givenname: Weixia
  surname: Jian
  fullname: Jian, Weixia
  organization: Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine
– sequence: 3
  givenname: Xu
  surname: Xu
  fullname: Xu, Xu
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
– sequence: 4
  givenname: Wenxin
  surname: Kou
  fullname: Kou, Wenxin
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
– sequence: 5
  givenname: Qing
  surname: Yu
  fullname: Yu, Qing
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
– sequence: 6
  givenname: Handan
  surname: Hu
  fullname: Hu, Handan
  organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
– sequence: 7
  givenname: Dali
  orcidid: 0000-0002-0679-8477
  surname: Li
  fullname: Li, Dali
  organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
– sequence: 8
  givenname: Wei
  surname: Wang
  fullname: Wang, Wei
  organization: Columbia Center for Translational Immunology, Columbia University Medical Center
– sequence: 9
  givenname: Mark W.
  orcidid: 0000-0001-9523-3859
  surname: Feinberg
  fullname: Feinberg, Mark W.
  organization: Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
– sequence: 10
  givenname: Jianhui
  surname: Zhuang
  fullname: Zhuang, Jianhui
  email: jh_zhuang@tongji.edu.cn
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
– sequence: 11
  givenname: Yawei
  surname: Xu
  fullname: Xu, Yawei
  email: xuyawei@tongji.edu.cn
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
– sequence: 12
  givenname: Wenhui
  orcidid: 0000-0003-2937-0024
  surname: Peng
  fullname: Peng, Wenhui
  email: pwenhui@tongji.edu.cn
  organization: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31253783$$D View this record in MEDLINE/PubMed
BookMark eNp9kt1uFCEYhiemxtbaG_DATOKJJ6P8DnBi0mz8abLRptFjwgCzy4aFCkybuS7vw2uS7rba9qCcQOB9H174vpfNQYjBNs1rCN5DgPmHTCDpWQeg6CBgnHTzs-YIAQI7yBA-uLc-bE5y3oA6sICckBfNIYaIYsbxUSO_LS8WtHVh7QZXchtsdKG4rWrHmLaquBjqyvt47cKqvVJZT16lqt9MaW5VMK1xyeri57pXbFK6Qq5dWbfn56cXf36_ap6Pymd7cjsfNz8_f_qx-Notv385W5wuO00JKF1NA8YBCgiFYQM3jDE-cE0gUmYQ4yAQZpiPvSIccALV0AvFkNawh8AgQvFxc7bnmqg28jLVF6RZRuXkbiOmlVSpOO2t1EipUYtBU22IGg3XoNe2YjQ1lGFUWR_3rMtp2FqjbShJ-QfQhyfBreUqXsmeCgEQq4B3t4AUf002F7l1WVvvVf3eKUuEKOghQfTmrrePpJs4pVC_qqqIqOVlPa-qN_cT_YtyV8cq4HuBTjHnZEepXdlVrwZ0XkIgb7pG7rtGVqzcdY2cqxU9st7RnzThvSlXcVjZ9D_2E66_BCjWdg
CitedBy_id crossref_primary_10_1039_D3TB00344B
crossref_primary_10_1016_j_taap_2021_115733
crossref_primary_10_1016_j_isci_2023_106313
crossref_primary_10_3389_fimmu_2024_1426620
crossref_primary_10_1186_s12964_024_02012_y
crossref_primary_10_1021_acsnano_4c09419
crossref_primary_10_1016_j_biopha_2020_110287
crossref_primary_10_1016_j_cellsig_2024_111341
crossref_primary_10_1016_j_heliyon_2024_e31659
crossref_primary_10_1016_j_apsb_2023_09_013
crossref_primary_10_1016_j_phrs_2020_104916
crossref_primary_10_1089_ars_2023_0383
crossref_primary_10_1016_j_jacbts_2022_10_001
crossref_primary_10_3389_fimmu_2024_1355012
crossref_primary_10_1007_s00018_020_03659_9
crossref_primary_10_1186_s13046_020_01609_8
crossref_primary_10_1016_j_tranon_2023_101742
crossref_primary_10_1177_0300060520925352
crossref_primary_10_3390_cells10061523
crossref_primary_10_2147_CCID_S409621
crossref_primary_10_3390_ijms24108595
crossref_primary_10_1007_s11033_024_10153_z
crossref_primary_10_1016_j_mvr_2022_104405
crossref_primary_10_1016_j_bbadis_2024_167224
crossref_primary_10_1161_CIRCRESAHA_122_321080
crossref_primary_10_1186_s10020_024_00798_8
crossref_primary_10_1016_j_ejphar_2024_176947
crossref_primary_10_1186_s12951_021_01119_5
crossref_primary_10_3390_ijms23148049
crossref_primary_10_1016_j_bbrc_2020_05_151
Cites_doi 10.1038/ncomms10554
10.4049/jimmunol.1102671
10.1074/jbc.M703652200
10.1161/ATVBAHA.107.161224
10.1038/cr.2012.53
10.1161/ATVBAHA.116.307923
10.1161/CIRCULATIONAHA.114.011090
10.1016/j.cell.2010.03.040
10.1074/jbc.M112.364604
10.1096/fj.201700511RR
10.1161/CIRCULATIONAHA.116.026046
10.1016/j.immuni.2007.10.002
10.3389/fimmu.2013.00397
10.1161/CIRCRESAHA.116.301313
10.1038/cr.2012.56
10.1371/journal.pone.0098899
10.1161/CIRCRESAHA.107.164384
10.2174/1381612823666161118145850
10.1371/journal.pgen.1005088
10.1093/cvr/cvr238
10.1073/pnas.1018515108
10.1080/2162402X.2016.1151593
10.1016/j.bbrc.2016.09.101
10.1161/CIRCULATIONAHA.108.845461
10.1038/nm1102-1249
10.1016/S0140-6736(11)61662-0
10.1161/HYPERTENSIONAHA.115.05332
10.1161/CIRCRESAHA.116.301312
10.1371/journal.ppat.0030152
10.1016/j.imbio.2011.08.011
10.1002/cncr.27865
10.1074/jbc.M110.109736
10.1155/2015/816856
10.1124/pr.114.010090
10.1007/s10753-013-9804-y
10.3389/fimmu.2017.00150
10.1210/me.2013-1427
10.1093/cvr/cvs135
10.1016/j.cmet.2014.08.005
10.1083/jcb.201505091
10.1146/annurev.immunol.20.083001.084359
10.3389/fimmu.2013.00333
10.1073/pnas.1008684107
10.1016/j.atherosclerosis.2015.08.037
10.1161/CIR.0000000000000484
10.1016/j.bbrc.2012.01.104
10.1161/ATVBAHA.118.310223
10.1038/ni.1985
10.1007/s13238-012-2109-3
10.1038/ncomms6160
10.4049/jimmunol.1401065
10.1016/j.yjmcc.2014.02.012
10.1371/journal.pone.0175855
10.2174/1568026616666160617072521
10.1038/nri3339
10.1016/j.bbrc.2011.07.006
ContentType Journal Article
Copyright The Author(s) 2019
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2019
– notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-019-10784-y
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection (subscription)
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
ProQuest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
ProQuest SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
AAdvanced Technologies & Aerospace Database (subscription)
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest - Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


Publicly Available Content Database

MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 16
ExternalDocumentID oai_doaj_org_article_c2aafc9bc5cd4afd8c06ce0d2c5d5732
PMC6599027
31253783
10_1038_s41467_019_10784_y
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81670746; 81800424; 81370391; 81670230
  funderid: https://doi.org/10.13039/501100001809
– fundername: Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)
  grantid: HL134849; HL134849
  funderid: https://doi.org/10.13039/100000009
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81670746
– fundername: NIGMS NIH HHS
  grantid: R01 GM115605
– fundername: NHLBI NIH HHS
  grantid: R01 HL115141
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81800424
– fundername: Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)
  grantid: HL134849
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81370391
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81670230
– fundername: NHLBI NIH HHS
  grantid: R01 HL134849
– fundername: ;
  grantid: 81670746; 81800424; 81370391; 81670230
– fundername: ;
  grantid: HL134849; HL134849
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c540t-5370fb19119d7b8d7778b8c412adb9fb923738f6a480841ab69a72cc1610d2453
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:00:22 EDT 2025
Thu Aug 21 14:05:34 EDT 2025
Thu Sep 04 18:05:52 EDT 2025
Wed Aug 13 01:49:58 EDT 2025
Mon Jul 21 05:52:49 EDT 2025
Tue Jul 01 04:08:39 EDT 2025
Thu Apr 24 22:57:29 EDT 2025
Fri Feb 21 02:38:59 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-5370fb19119d7b8d7778b8c412adb9fb923738f6a480841ab69a72cc1610d2453
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-9523-3859
0000-0003-2937-0024
0000-0002-0679-8477
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-019-10784-y
PMID 31253783
PQID 2249019768
PQPubID 546298
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_c2aafc9bc5cd4afd8c06ce0d2c5d5732
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6599027
proquest_miscellaneous_2250614252
proquest_journals_2249019768
pubmed_primary_31253783
crossref_citationtrail_10_1038_s41467_019_10784_y
crossref_primary_10_1038_s41467_019_10784_y
springer_journals_10_1038_s41467_019_10784_y
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-06-28
PublicationDateYYYYMMDD 2019-06-28
PublicationDate_xml – month: 06
  year: 2019
  text: 2019-06-28
  day: 28
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Cheung (CR35) 2013; 119
Lamkanfi, Kanneganti (CR31) 2012; 217
Zhang (CR38) 2011; 92
Meissner (CR18) 2010; 107
Soccio, Chen, Lazar (CR48) 2014; 20
Kufer, Sansonetti (CR11) 2011; 12
Neerincx, Castro, Guarda, Kufer (CR14) 2013; 4
Hasan (CR55) 2015; 66
McCrindle (CR23) 2017; 135
Dominguez, Alvarez, de Lera (CR46) 2017; 17
Dzau, Braun-Dullaeus, Sedding (CR1) 2002; 8
Meissner, Li, Liu, Gagnon, Kobayashi (CR19) 2012; 418
King (CR27) 2009; 120
Schlaweck (CR7) 2011; 411
Hillaire-Buys, Faillie, Montastruc (CR49) 2011; 378
Duan, Usher, Mortensen (CR36) 2008; 102
Tellides, Pober (CR3) 2015; 116
Libby, Hansson (CR44) 2015; 116
Neerincx (CR39) 2014; 193
Castano-Rodriguez, Kaakoush, Goh, Fock, Mitchell (CR13) 2014; 9
Zhang (CR47) 2014; 72
Wright, Bortolini, Tadayyon, Bopst (CR53) 2014; 28
Xu, Farmer, Smith (CR33) 2007; 282
Robbins (CR43) 2012; 287
Kanneganti, Lamkanfi, Nunez (CR10) 2007; 27
Schober (CR2) 2008; 28
Lim (CR52) 2015; 243
Majesky (CR29) 2018; 38
Benko, Kovacs, Hezel, Kufer (CR16) 2017; 8
Cheng (CR30) 2017; 136
Janeway, Medzhitov (CR8) 2002; 20
Rodriguez (CR41) 2016; 5
Meng (CR45) 2015; 211
Staehli (CR25) 2012; 188
Sage (CR4) 2014; 130
Kroker, Bruning (CR37) 2015; 2015
Goulopoulou, McCarthy, Webb (CR40) 2016; 68
Zhuang (CR54) 2017; 37
Sirard, Vignal, Dessein, Chamaillard (CR9) 2007; 3
Neerincx (CR56) 2010; 285
Zhong, Kinio, Saleh (CR12) 2013; 4
Cui (CR20) 2010; 141
Li, Xu, Huang, Peng, Li (CR21) 2014; 37
Ludigs (CR32) 2015; 11
Cole (CR6) 2011; 108
Lacolley, Regnault, Nicoletti, Li, Michel (CR28) 2012; 95
Zhang (CR5) 2014; 5
Kobayashi, van den Elsen (CR17) 2012; 12
Su (CR51) 2016; 479
Yao (CR24) 2012; 22
Luan (CR22) 2018; 32
Yao, Qian (CR15) 2013; 4
Ludigs (CR26) 2016; 7
Tung, Ahmed, Peshdary, Atlas (CR34) 2017; 12
Ivanova, Myasoedova, Melnichenko, Orekhov (CR50) 2017; 23
Tong (CR42) 2012; 22
KF Cheung (10784_CR35) 2013; 119
S Goulopoulou (10784_CR40) 2016; 68
TD Kanneganti (10784_CR10) 2007; 27
P Lacolley (10784_CR28) 2012; 95
KS Kobayashi (10784_CR17) 2012; 12
S Lim (10784_CR52) 2015; 243
RE Soccio (10784_CR48) 2014; 20
A Neerincx (10784_CR39) 2014; 193
P Luan (10784_CR22) 2018; 32
G Tellides (10784_CR3) 2015; 116
S Schlaweck (10784_CR7) 2011; 411
P Libby (10784_CR44) 2015; 116
VJ Dzau (10784_CR1) 2002; 8
CA Janeway Jr. (10784_CR8) 2002; 20
JE Cole (10784_CR6) 2011; 108
D Su (10784_CR51) 2016; 479
SM King (10784_CR27) 2009; 120
GM Rodriguez (10784_CR41) 2016; 5
AJ Kroker (10784_CR37) 2015; 2015
Y Yao (10784_CR15) 2013; 4
Y Zhong (10784_CR12) 2013; 4
SM Zhang (10784_CR5) 2014; 5
Y Zhang (10784_CR47) 2014; 72
LL Zhang (10784_CR38) 2011; 92
M Lamkanfi (10784_CR31) 2012; 217
N Castano-Rodriguez (10784_CR13) 2014; 9
EA Ivanova (10784_CR50) 2017; 23
MB Wright (10784_CR53) 2014; 28
A Schober (10784_CR2) 2008; 28
SZ Duan (10784_CR36) 2008; 102
F Staehli (10784_CR25) 2012; 188
DM Hasan (10784_CR55) 2015; 66
S Benko (10784_CR16) 2017; 8
L Li (10784_CR21) 2014; 37
J Zhuang (10784_CR54) 2017; 37
Y Xu (10784_CR33) 2007; 282
AP Sage (10784_CR4) 2014; 130
J Cui (10784_CR20) 2010; 141
K Ludigs (10784_CR32) 2015; 11
D Hillaire-Buys (10784_CR49) 2011; 378
MW Majesky (10784_CR29) 2018; 38
TB Meissner (10784_CR19) 2012; 418
TA Kufer (10784_CR11) 2011; 12
Q Meng (10784_CR45) 2015; 211
A Neerincx (10784_CR56) 2010; 285
Y Tong (10784_CR42) 2012; 22
JC Sirard (10784_CR9) 2007; 3
Y Yao (10784_CR24) 2012; 22
GR Robbins (10784_CR43) 2012; 287
WL Cheng (10784_CR30) 2017; 136
TB Meissner (10784_CR18) 2010; 107
A Neerincx (10784_CR14) 2013; 4
EWY Tung (10784_CR34) 2017; 12
BW McCrindle (10784_CR23) 2017; 135
K Ludigs (10784_CR26) 2016; 7
M Dominguez (10784_CR46) 2017; 17
References_xml – volume: 7
  year: 2016
  ident: CR26
  article-title: NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10554
– volume: 188
  start-page: 3820
  year: 2012
  end-page: 3828
  ident: CR25
  article-title: NLRC5 deficiency selectively impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1102671
– volume: 282
  start-page: 26046
  year: 2007
  end-page: 26056
  ident: CR33
  article-title: Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M703652200
– volume: 28
  start-page: 1950
  year: 2008
  end-page: 1959
  ident: CR2
  article-title: Chemokines in vascular dysfunction and remodeling
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.107.161224
– volume: 22
  start-page: 822
  year: 2012
  end-page: 835
  ident: CR42
  article-title: Enhanced TLR-induced NF-kappaB signaling and type I interferon responses in NLRC5 deficient mice
  publication-title: Cell Res.
  doi: 10.1038/cr.2012.53
– volume: 37
  start-page: 84
  year: 2017
  end-page: 97
  ident: CR54
  article-title: The Yin-Yang dynamics of DNA methylation is the key regulator for smooth muscle cell phenotype switch and vascular remodeling
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.307923
– volume: 130
  start-page: 1363
  year: 2014
  end-page: 1373
  ident: CR4
  article-title: MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.011090
– volume: 141
  start-page: 483
  year: 2010
  end-page: 496
  ident: CR20
  article-title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.040
– volume: 287
  start-page: 24294
  year: 2012
  end-page: 24303
  ident: CR43
  article-title: Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.364604
– volume: 32
  start-page: 1070
  year: 2018
  end-page: 1084
  ident: CR22
  article-title: NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation
  publication-title: FASEB J.
  doi: 10.1096/fj.201700511RR
– volume: 136
  start-page: 1412
  year: 2017
  end-page: 1433
  ident: CR30
  article-title: Interferon regulatory factor 4 inhibits neointima formation by engaging Kruppel-like factor 4 signaling
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.026046
– volume: 27
  start-page: 549
  year: 2007
  end-page: 559
  ident: CR10
  article-title: Intracellular NOD-like receptors in host defense and disease
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.10.002
– volume: 4
  start-page: 397
  year: 2013
  ident: CR14
  article-title: NLRC5, at the heart of antigen presentation
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00397
– volume: 116
  start-page: 307
  year: 2015
  end-page: 311
  ident: CR44
  article-title: Inflammation and immunity in diseases of the arterial tree: players and layers
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.301313
– volume: 22
  start-page: 836
  year: 2012
  end-page: 847
  ident: CR24
  article-title: NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
  publication-title: Cell Res.
  doi: 10.1038/cr.2012.56
– volume: 9
  start-page: e98899
  year: 2014
  ident: CR13
  article-title: The NOD-like receptor signalling pathway in infection and related gastric cancer: a case-control study and gene expression analyses
  publication-title: PloS One
  doi: 10.1371/journal.pone.0098899
– volume: 102
  start-page: 283
  year: 2008
  end-page: 294
  ident: CR36
  article-title: Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.107.164384
– volume: 23
  start-page: 1119
  year: 2017
  end-page: 1124
  ident: CR50
  article-title: Peroxisome proliferator-activated receptor (PPAR) gamma agonists as therapeutic agents for cardiovascular disorders: focus on atherosclerosis
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612823666161118145850
– volume: 11
  start-page: e1005088
  year: 2015
  ident: CR32
  article-title: NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005088
– volume: 92
  start-page: 484
  year: 2011
  end-page: 493
  ident: CR38
  article-title: PPARgamma attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvr238
– volume: 108
  start-page: 2372
  year: 2011
  end-page: 2377
  ident: CR6
  article-title: Unexpected protective role for Toll-like receptor 3 in the arterial wall
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1018515108
– volume: 5
  start-page: e1151593
  year: 2016
  ident: CR41
  article-title: NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1151593
– volume: 479
  start-page: 887
  year: 2016
  end-page: 892
  ident: CR51
  article-title: Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2016.09.101
– volume: 120
  start-page: 785
  year: 2009
  end-page: 791
  ident: CR27
  article-title: Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic mice
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.108.845461
– volume: 8
  start-page: 1249
  year: 2002
  end-page: 1256
  ident: CR1
  article-title: Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies
  publication-title: Nat. Med.
  doi: 10.1038/nm1102-1249
– volume: 378
  start-page: 1543
  year: 2011
  end-page: 1544
  ident: CR49
  article-title: Pioglitazone and bladder cancer
  publication-title: Lancet
  doi: 10.1016/S0140-6736(11)61662-0
– volume: 66
  start-page: 211
  year: 2015
  end-page: 220
  ident: CR55
  article-title: Smooth muscle peroxisome proliferator-activated receptor gamma plays a critical role in formation and rupture of cerebral aneurysms in mice in vivo
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.115.05332
– volume: 116
  start-page: 312
  year: 2015
  end-page: 322
  ident: CR3
  article-title: Inflammatory and immune responses in the arterial media
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.301312
– volume: 3
  start-page: e152
  year: 2007
  ident: CR9
  article-title: Nod-like receptors: cytosolic watchdogs for immunity against pathogens
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.0030152
– volume: 217
  start-page: 13
  year: 2012
  end-page: 16
  ident: CR31
  article-title: Regulation of immune pathways by the NOD-like receptor NLRC5
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2011.08.011
– volume: 119
  start-page: 1217
  year: 2013
  end-page: 1226
  ident: CR35
  article-title: CITED2 is a novel direct effector of peroxisome proliferator-activated receptor gamma in suppressing hepatocellular carcinoma cell growth
  publication-title: Cancer
  doi: 10.1002/cncr.27865
– volume: 285
  start-page: 26223
  year: 2010
  end-page: 26232
  ident: CR56
  article-title: A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.109736
– volume: 2015
  start-page: 816856
  year: 2015
  ident: CR37
  article-title: Review of the structural and dynamic mechanisms of PPARgamma partial agonism
  publication-title: PPAR Res.
  doi: 10.1155/2015/816856
– volume: 68
  start-page: 142
  year: 2016
  end-page: 167
  ident: CR40
  article-title: Toll-like receptors in the vascular system: sensing the dangers within
  publication-title: Pharm. Rev.
  doi: 10.1124/pr.114.010090
– volume: 37
  start-page: 835
  year: 2014
  end-page: 847
  ident: CR21
  article-title: NLRC5 mediates cytokine secretion in RAW264.7 macrophages and modulated by the JAK2/STAT3 pathway
  publication-title: Inflammation
  doi: 10.1007/s10753-013-9804-y
– volume: 8
  start-page: 150
  year: 2017
  ident: CR16
  article-title: NLRC5 functions beyond MHC I regulation—what do we know so far?
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00150
– volume: 28
  start-page: 1756
  year: 2014
  end-page: 1768
  ident: CR53
  article-title: Minireview: Challenges and opportunities in development of PPAR agonists
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2013-1427
– volume: 95
  start-page: 194
  year: 2012
  end-page: 204
  ident: CR28
  article-title: The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvs135
– volume: 20
  start-page: 573
  year: 2014
  end-page: 591
  ident: CR48
  article-title: Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.08.005
– volume: 211
  start-page: 1025
  year: 2015
  end-page: 1040
  ident: CR45
  article-title: Reversible ubiquitination shapes NLRC5 function and modulates NF-kappaB activation switch
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201505091
– volume: 20
  start-page: 197
  year: 2002
  end-page: 216
  ident: CR8
  article-title: Innate immune recognition
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.20.083001.084359
– volume: 4
  start-page: 333
  year: 2013
  ident: CR12
  article-title: Functions of NOD-Like Receptors in Human Diseases
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00333
– volume: 107
  start-page: 13794
  year: 2010
  end-page: 13799
  ident: CR18
  article-title: NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008684107
– volume: 243
  start-page: 107
  year: 2015
  end-page: 119
  ident: CR52
  article-title: Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2015.08.037
– volume: 135
  start-page: e927
  year: 2017
  end-page: e999
  ident: CR23
  article-title: Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000484
– volume: 418
  start-page: 786
  year: 2012
  end-page: 791
  ident: CR19
  article-title: The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.01.104
– volume: 38
  start-page: e17
  year: 2018
  end-page: e24
  ident: CR29
  article-title: Vascular development
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.310223
– volume: 12
  start-page: 121
  year: 2011
  end-page: 128
  ident: CR11
  article-title: NLR functions beyond pathogen recognition
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1985
– volume: 4
  start-page: 168
  year: 2013
  end-page: 175
  ident: CR15
  article-title: Expression regulation and function of NLRC5
  publication-title: Protein Cell
  doi: 10.1007/s13238-012-2109-3
– volume: 5
  year: 2014
  ident: CR5
  article-title: Interferon regulatory factor 9 is critical for neointima formation following vascular injury
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6160
– volume: 193
  start-page: 3090
  year: 2014
  end-page: 3100
  ident: CR39
  article-title: The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1401065
– volume: 72
  start-page: 85
  year: 2014
  end-page: 94
  ident: CR47
  article-title: TNF-alpha promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-kappaB and PPAR-gamma
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2014.02.012
– volume: 12
  start-page: e0175855
  year: 2017
  ident: CR34
  article-title: Firemaster(R) 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter
  publication-title: PloS One
  doi: 10.1371/journal.pone.0175855
– volume: 17
  start-page: 631
  year: 2017
  end-page: 662
  ident: CR46
  article-title: Natural and structure-based RXR ligand scaffolds and their functions
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026616666160617072521
– volume: 12
  start-page: 813
  year: 2012
  end-page: 820
  ident: CR17
  article-title: NLRC5: a key regulator of MHC class I-dependent immune responses
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3339
– volume: 411
  start-page: 627
  year: 2011
  end-page: 631
  ident: CR7
  article-title: Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.07.006
– volume: 9
  start-page: e98899
  year: 2014
  ident: 10784_CR13
  publication-title: PloS One
  doi: 10.1371/journal.pone.0098899
– volume: 20
  start-page: 197
  year: 2002
  ident: 10784_CR8
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.20.083001.084359
– volume: 72
  start-page: 85
  year: 2014
  ident: 10784_CR47
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2014.02.012
– volume: 116
  start-page: 307
  year: 2015
  ident: 10784_CR44
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.301313
– volume: 136
  start-page: 1412
  year: 2017
  ident: 10784_CR30
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.026046
– volume: 107
  start-page: 13794
  year: 2010
  ident: 10784_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008684107
– volume: 135
  start-page: e927
  year: 2017
  ident: 10784_CR23
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000484
– volume: 5
  year: 2014
  ident: 10784_CR5
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6160
– volume: 95
  start-page: 194
  year: 2012
  ident: 10784_CR28
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvs135
– volume: 102
  start-page: 283
  year: 2008
  ident: 10784_CR36
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.107.164384
– volume: 418
  start-page: 786
  year: 2012
  ident: 10784_CR19
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.01.104
– volume: 12
  start-page: 121
  year: 2011
  ident: 10784_CR11
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1985
– volume: 12
  start-page: 813
  year: 2012
  ident: 10784_CR17
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3339
– volume: 22
  start-page: 822
  year: 2012
  ident: 10784_CR42
  publication-title: Cell Res.
  doi: 10.1038/cr.2012.53
– volume: 28
  start-page: 1756
  year: 2014
  ident: 10784_CR53
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2013-1427
– volume: 411
  start-page: 627
  year: 2011
  ident: 10784_CR7
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.07.006
– volume: 20
  start-page: 573
  year: 2014
  ident: 10784_CR48
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.08.005
– volume: 28
  start-page: 1950
  year: 2008
  ident: 10784_CR2
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.107.161224
– volume: 11
  start-page: e1005088
  year: 2015
  ident: 10784_CR32
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005088
– volume: 17
  start-page: 631
  year: 2017
  ident: 10784_CR46
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026616666160617072521
– volume: 285
  start-page: 26223
  year: 2010
  ident: 10784_CR56
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.109736
– volume: 108
  start-page: 2372
  year: 2011
  ident: 10784_CR6
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1018515108
– volume: 68
  start-page: 142
  year: 2016
  ident: 10784_CR40
  publication-title: Pharm. Rev.
  doi: 10.1124/pr.114.010090
– volume: 4
  start-page: 333
  year: 2013
  ident: 10784_CR12
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00333
– volume: 287
  start-page: 24294
  year: 2012
  ident: 10784_CR43
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.364604
– volume: 119
  start-page: 1217
  year: 2013
  ident: 10784_CR35
  publication-title: Cancer
  doi: 10.1002/cncr.27865
– volume: 8
  start-page: 1249
  year: 2002
  ident: 10784_CR1
  publication-title: Nat. Med.
  doi: 10.1038/nm1102-1249
– volume: 188
  start-page: 3820
  year: 2012
  ident: 10784_CR25
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1102671
– volume: 7
  year: 2016
  ident: 10784_CR26
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10554
– volume: 4
  start-page: 168
  year: 2013
  ident: 10784_CR15
  publication-title: Protein Cell
  doi: 10.1007/s13238-012-2109-3
– volume: 38
  start-page: e17
  year: 2018
  ident: 10784_CR29
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.310223
– volume: 479
  start-page: 887
  year: 2016
  ident: 10784_CR51
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2016.09.101
– volume: 12
  start-page: e0175855
  year: 2017
  ident: 10784_CR34
  publication-title: PloS One
  doi: 10.1371/journal.pone.0175855
– volume: 22
  start-page: 836
  year: 2012
  ident: 10784_CR24
  publication-title: Cell Res.
  doi: 10.1038/cr.2012.56
– volume: 23
  start-page: 1119
  year: 2017
  ident: 10784_CR50
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612823666161118145850
– volume: 66
  start-page: 211
  year: 2015
  ident: 10784_CR55
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.115.05332
– volume: 243
  start-page: 107
  year: 2015
  ident: 10784_CR52
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2015.08.037
– volume: 116
  start-page: 312
  year: 2015
  ident: 10784_CR3
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.301312
– volume: 282
  start-page: 26046
  year: 2007
  ident: 10784_CR33
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M703652200
– volume: 130
  start-page: 1363
  year: 2014
  ident: 10784_CR4
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.011090
– volume: 37
  start-page: 84
  year: 2017
  ident: 10784_CR54
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.307923
– volume: 92
  start-page: 484
  year: 2011
  ident: 10784_CR38
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvr238
– volume: 378
  start-page: 1543
  year: 2011
  ident: 10784_CR49
  publication-title: Lancet
  doi: 10.1016/S0140-6736(11)61662-0
– volume: 4
  start-page: 397
  year: 2013
  ident: 10784_CR14
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00397
– volume: 217
  start-page: 13
  year: 2012
  ident: 10784_CR31
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2011.08.011
– volume: 5
  start-page: e1151593
  year: 2016
  ident: 10784_CR41
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1151593
– volume: 193
  start-page: 3090
  year: 2014
  ident: 10784_CR39
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1401065
– volume: 37
  start-page: 835
  year: 2014
  ident: 10784_CR21
  publication-title: Inflammation
  doi: 10.1007/s10753-013-9804-y
– volume: 211
  start-page: 1025
  year: 2015
  ident: 10784_CR45
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201505091
– volume: 32
  start-page: 1070
  year: 2018
  ident: 10784_CR22
  publication-title: FASEB J.
  doi: 10.1096/fj.201700511RR
– volume: 2015
  start-page: 816856
  year: 2015
  ident: 10784_CR37
  publication-title: PPAR Res.
  doi: 10.1155/2015/816856
– volume: 141
  start-page: 483
  year: 2010
  ident: 10784_CR20
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.040
– volume: 120
  start-page: 785
  year: 2009
  ident: 10784_CR27
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.108.845461
– volume: 27
  start-page: 549
  year: 2007
  ident: 10784_CR10
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.10.002
– volume: 3
  start-page: e152
  year: 2007
  ident: 10784_CR9
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.0030152
– volume: 8
  start-page: 150
  year: 2017
  ident: 10784_CR16
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00150
SSID ssj0000391844
Score 2.448824
Snippet NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation....
NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2882
SubjectTerms 13
13/1
13/31
13/51
13/89
13/95
14
14/34
49/109
631/443/592/75/593
631/80/86/388
64/60
Animals
Antigen presentation
Antigens
Aorta
Apoptosis
Blood Pressure
Bone Marrow Transplantation
Cell Proliferation
Cells, Cultured
Cytokines - genetics
Cytokines - metabolism
Heart Rate
Humanities and Social Sciences
Humans
Hyperplasia
Immunity
Innate immunity
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Mice
Mice, Knockout
multidisciplinary
Muscles
Myocytes, Smooth Muscle - metabolism
Pioglitazone
Plasmids
Rodents
Science
Science (multidisciplinary)
Smooth muscle
Transcriptome
Tunica Intima - metabolism
Vascular Remodeling
SummonAdditionalLinks – databaseName: DOAJ
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9UwEB5kQfBFvFtdJYJvWjbNpUke18VlEV2WxYV9C0nasJVjj3i6yPld_g9_k5O0p-7x-uJbaadhmFu-yWUG4LkSplGRm5JjclKKmqJLsViVRlWOeR0Md2lB_91xfXQm3pzL8yutvtKZsLE88Ci4vcCci8H4IEMjXGx0oHVoacOCbKTiOfpSQ68kUzkGc4Opi5huyVCu91YixwRENBh5lBblemsmygX7f4cyfz0s-dOOaZ6IDm_BzQlBkv2R89twre3vwPWxp-T6Ltjjt6cHknT9Ree7YUX6dtn1Q_fRkfmeIj4tFssvODrZHERF-g8oXeL6hoyz3GJNUimJdIlqRdJqLTk52T_99vUenB2-fn9wVE5dFMqAaGwoJVc0ekzLKtSK141SSqMSRMVc4030iPAU17F2QlMtKudr4xQLAaEgSllIfh92-mXfPgRCRZQtddRo0WLaEk1sVRC1Fzy4IH0soNpI1IapxHjqdLGweaubaztqwaIWbNaCXRfwYv7n01hg46_Ur5KiZspUHDu_QJOxk8nYf5lMAbsbNdvJY1cWoQxCIwRnuoBn82f0tbSB4lBXl4lGpgSaSRziwWgVMycckSJXmhegtuxli9XtL313ket51xIhAVMFvNxY1g-2_iyKR_9DFI_hBksuQeuS6V3YGT5ftk8QZQ3-aXao7zkyJho
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3ZatwwUKQbCn0Jves2LSr0rTWRdVjyQylJSAilXZalgbwJHVbjsrWT7Iay39X_6Dd15Ctsj7wZeywkza3RzCD0RvLCy8CKlIFzkvKcAEvRkKWFzAy1yhXMxAP9z9P85JR_PBNnW2g65MLEa5WDTGwFtW9cPCPfA1UDqguUp_pwcZnGrlExujq00DB9awX_vi0xdgdtg0gWZIK2D46ms_l46hLroSvO--wZwtTekreyAoYGiSQVT9cbGqot5P8v6_PvS5R_RFJbBXV8H-30liXe70jhAdoq64fobtdrcv0I6emn-aHAVX1e2Wq1xHXZVLCU7waP-YvwtFg0P2B0PFxQBfhvsOvY1B532m-xxrHEREyuWuJ4iotns_35r5-P0enx0ZfDk7TvrpA6sNJWqWCSBAvuWgbYsspLKRUgh2fUeFsEC5afZCrkhiuieGZsXhhJnQMTkXjKBXuCJnVTl88QJjyIkhhSKF6COxOKUErHc8uZM07YkKBs2FHt-tLjsQPGQrchcKZ0hwUNWNAtFvQ6QW_Hfy66whu3Qh9ERI2QsWh2-6K5-qp7HtSOGhNcYZ1wnpvglSO5K2ExTnghGU3Q7oBm3XPyUt_QXYJej5-BB2NgxQCuriOMiI41FTDE044qxpkwoEMmFUuQ3KCXjalufqmr87bOdy7AVKAyQe8GyrqZ1v-34vntq3iB7tFI7CRPqdpFk9XVdfkS7KqVfdUzy29EECH1
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VrZC4IN4ECjISN4hI_Iid41JRVSuoqkKl3izbiWmqJYu6qdD-Lv4Hv4mx80ALBYlblIytiWfG_saeGQO8lLyspGdlytA5SXmRoUlRn6elzA21ypXMhA39D0fF4SlfnImzHaBjLkwM2o8lLeM0PUaHvVnzaNIISHDikIqnmxuwqyROvzPYnc8XHxfTzkqoea44HzJkMqauaby1CsVi_dchzD8DJX87LY2L0MEduD2gRzLv-b0LO3V7D27290lu7oM-en-yL0jTnje26dakrVdN2zVfDJlyFPFpuVx9w97JGISK9Bc4ssS0FelXuOWGhDISIYFqTcJOLTk-np_8-P4ATg_efdo_TIcbFFKHSKxLBZOZt-iS5SgRqyoppUIB8JyaypbeIrqTTPnCcJUpnhtblEZS5xAGZhXlgj2EWbtq68dAMu5FnZmsVLxGl8WXvpaOF5YzZ5ywPoF8HFHthvLi4ZaLpY7H3EzpXgoapaCjFPQmgVdTm699cY1_Ur8NgpooQ2Hs-GJ1-VkPiqIdNca70jrhKm58pVxWuBp_xolKSEYT2BvFrAdrXWuEMQiLEJipBF5Mn9HOwuGJQVldBRoRnGcqsItHvVZMnDBEiUwqloDc0pctVre_tM15rOVdCIQDVCbwetSsX2z9fSie_B_5U7hFg_JnRUrVHsy6y6v6GWKpzj4fjOcneeMbFQ
  priority: 102
  providerName: Springer Nature
Title NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ
URI https://link.springer.com/article/10.1038/s41467-019-10784-y
https://www.ncbi.nlm.nih.gov/pubmed/31253783
https://www.proquest.com/docview/2249019768
https://www.proquest.com/docview/2250614252
https://pubmed.ncbi.nlm.nih.gov/PMC6599027
https://doaj.org/article/c2aafc9bc5cd4afd8c06ce0d2c5d5732
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELb2ISQuiDeBpTISNwgkfsTOAaFutWVVQVUVKvUW2U68GxRSaLuC_i7-B7-JsZMUFQoSlySyHcuZR_yNx55B6KlgaS4sTUMKxknIkghUitg4TEWsiJYmpcot6L8bJ-czNprz-QHq0h21BFztNe1cPqnZsnrx7cvmNSj8q-bIuHy5Yl7dAazAT0VIFm4O0bH3F7mtfC3c939mmoJB4xzNJGJxCHM3bc_R7O9mZ67yIf334dA_t1P-5lP1U9XwJrrRYkzcb4TiFjoo6tvoWpN1cnMHZeO30wHHZX1Z6nK9wnWxKOt1-Unh7UlGeKqqxVfoHXdbVaH9R6A_VnWOm3mw2mAXbMIds1pht56LJ5P-9Mf3u2g2PPswOA_bPAuhAby2DjkVkdVguMXANy1zIYQENrGYqFynVgMGFFTaRDEZSRYrnaRKEGMALEY5YZzeQ0f1oi4eIBwxy4tIRalkBRg2NrWFMCzRjBpluLYBijuKZqYNQu5yYVSZd4ZTmTVcyIALmedCtgnQs-07n5sQHP9sfeoYtW3pwmf7gsXyImu1MTNEKWtSbbjJmbK5NFFiCvgYw3MuKAnQScfmrBPJDMAOgCeAbzJAT7bVoI3OxaKAV1euDXcmNuHQxf1GKrYjoYAlqZA0QGJHXnaGultTl5c-4nfCATQQEaDnnWT9GtbfSfHwvwj3CF0nTvajJCTyBB2tl1fFYwBca91Dh2Iu4CqHb3rouN8fvR_B_fRsPJlC6SAZ9PxSRs9r209B2St6
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0Kq2QnBBvEkpYCQ4QdTEj9g5VKgtrbZ0u1qtWqk3YzsxDdpmS3erar-LO5_ANzHOq1oevfUWJY419rzHnhmE3gqWZsLRNKTgnIQsiYCliIvDVMSaGGlTqn1A_3CY9I_Z5xN-soJ-trkw_lplKxMrQZ1NrY-Rb4CqAdUFylN-PP8e-q5R_nS1baGhm9YK2WZVYqxJ7DjIF1fgws029z8Bvt8Rsrd7tNMPmy4DoQVrZR5yKiJnwG2JAWojMyGEBCBZTHRmUmfAAhJUukQzGUkWa5OkWhBrwVSKMsJ81whQAavMB1B6aHV7dzgad1EeX39dMtZk60RUbsxYJZtgKSABhWThYkkjVo0D_mXt_n1p84-T20oh7j1A9xtLFm_VpPcQreTlI3Sn7m25eIzUcDDe4bgoTwtTzGe4zKcFbN2Zxl2-JDxNJtMrmB23F2Jh_DfAMtZlhmttO1lgX9LCJ3PNsI8a49Foa_zrxxN0fCv7_BT1ymmZP0c4Yo7nkY5SyXJwn1zqcmFZYhi12nLjAhS3O6psU-rcd9yYqOrInUpVY0EBFlSFBbUI0Pvun_O60MeNo7c9orqRvkh39WJ68VU1PK8s0drZ1FhuM6ZdJm2U2BwWY3nGBSUBWm_RrBrJMVPXdB6gN91n4Hl_kKMBV5d-DPeOPOEwxbOaKjpIKFisVEgaILFEL0ugLn8pi9OqrnjCwTQhIkAfWsq6Buv_W7F28ypeo7v9o8OBGuwPD16ge8QTfpSERK6j3vziMn8JNt3cvGoYB6Mvt82rvwF_h10u
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3JbtQw1Kpagbgg9gYKGAlOEE3iJXYOFeo2amkZjUZU6s3YTkwHDZnSTFXlu_gLDnwTz9mqYemttyhxLNtv99sQei1YmglH05CCcRKyJAKSIi4OUxFrYqRNqfYX-h9Hyf4x-3DCT1bQzy4XxodVdjyxZtTZ3Po78gGIGhBdIDzlwLVhEePd4fuz76HvIOU9rV07Dd22Wcg263JjbZLHYV5dgjlXbh7sAuzfEDLc-7SzH7YdB0ILmssi5FREzoAJE8MOjMyEEBIWzGKiM5M6A9qQoNIlmslIslibJNWCWAtqU5QR5jtIgDhYEyD1wRBc294bjSf9jY-vxS4ZazN3IioHJav5FGwLuKGQLKyWpGPdROBfmu_fAZx_eHFr4Ti8h-62Wi3eatDwPlrJiwfoVtPnsnqI1OhossPxtDidmumixEU-n8LRfdO4z52Ep9lsfgmz4y44FsZ_BYhjXWS4kbyzCvvyFj6xq8T-BhmPx1uTXz8eoeMbOefHaLWYF_k6whFzPI90lEqWgynlUpcLyxLDqNWWGxeguDtRZduy5777xkzV7ncqVQMFBVBQNRRUFaC3_T9nTdGPa0dve0D1I33B7vrF_PyLaulfWaK1s6mx3GZMu0zaKLE5bMbyjAtKArTRgVm1XKRUVzgfoFf9Z6B_79TRAKsLP4Z7o55wmOJJgxX9Sihor1RIGiCxhC9LS13-UkxP6xrjCQc1hYgAvesw62pZ_z-Kp9fv4iW6DTSrjg5Gh8_QHeLxPkpCIjfQ6uL8In8O6t3CvGjpBqPPN02qvwELWWFy
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=NLRC5+inhibits+neointima+formation+following+vascular+injury+and+directly+interacts+with+PPAR%CE%B3&rft.jtitle=Nature+communications&rft.au=Luan%2C+Peipei&rft.au=Jian%2C+Weixia&rft.au=Xu%2C+Xu&rft.au=Kou%2C+Wenxin&rft.date=2019-06-28&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-019-10784-y&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_019_10784_y
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon