Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

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Published inBlood cancer journal (New York) Vol. 11; no. 6; pp. 108 - 6
Main Authors Blaeschke, Franziska, Stenger, Dana, Apfelbeck, Antonia, Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Mahdawi, Jasmin, Ortner, Eva, Lepenies, Mareike, Habjan, Nicola, Rataj, Felicitas, Willier, Semjon, Kaeuferle, Theresa, Majzner, Robbie G., Busch, Dirk H., Kobold, Sebastian, Feuchtinger, Tobias
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 04.06.2021
Springer Nature B.V
Nature Publishing Group
Subjects
13/31
13/44
631/250/251
631/67/1990/283/2125
692/699/1541/1990/283/2125
Antigens, CD19 - immunology
Biomedical and Life Sciences
Biomedicine
Cancer Research
CD28 Antigens - therapeutic use
Cell Line, Tumor
Correspondence
Hematology
Humans
Immunotherapy, Adoptive
Oncology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy
Programmed Cell Death 1 Receptor - therapeutic use
Receptors, IgE - immunology
Recombinant Fusion Proteins - pharmacology
Online AccessGet full text
ISSN2044-5385
2044-5385
DOI10.1038/s41408-021-00499-z

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ArticleNumber 108
Author Blaeschke, Franziska
Apfelbeck, Antonia
Feuchtinger, Tobias
Willier, Semjon
Kaeuferle, Theresa
Rataj, Felicitas
Kobold, Sebastian
Lepenies, Mareike
Majzner, Robbie G.
Stenger, Dana
Benmebarek, Mohamed-Reda
Ortner, Eva
Busch, Dirk H.
Cadilha, Bruno L.
Mahdawi, Jasmin
Habjan, Nicola
Author_xml – sequence: 1
  givenname: Franziska
  surname: Blaeschke
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  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich
– sequence: 2
  givenname: Dana
  surname: Stenger
  fullname: Stenger, Dana
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, German Cancer Consortium (DKTK), Partner Site Munich
– sequence: 3
  givenname: Antonia
  surname: Apfelbeck
  fullname: Apfelbeck, Antonia
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich
– sequence: 4
  givenname: Bruno L.
  surname: Cadilha
  fullname: Cadilha, Bruno L.
  organization: Center for Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich
– sequence: 5
  givenname: Mohamed-Reda
  surname: Benmebarek
  fullname: Benmebarek, Mohamed-Reda
  organization: Center for Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich
– sequence: 6
  givenname: Jasmin
  surname: Mahdawi
  fullname: Mahdawi, Jasmin
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich
– sequence: 7
  givenname: Eva
  surname: Ortner
  fullname: Ortner, Eva
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– sequence: 10
  givenname: Felicitas
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  fullname: Rataj, Felicitas
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– sequence: 11
  givenname: Semjon
  surname: Willier
  fullname: Willier, Semjon
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich
– sequence: 12
  givenname: Theresa
  surname: Kaeuferle
  fullname: Kaeuferle, Theresa
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, National Center for Infection Research (DZIF)
– sequence: 13
  givenname: Robbie G.
  surname: Majzner
  fullname: Majzner, Robbie G.
  organization: Department of Pediatrics, Stanford University School of Medicine, Stanford Cancer Institute, Stanford University School of Medicine
– sequence: 14
  givenname: Dirk H.
  orcidid: 0000-0001-8713-093X
  surname: Busch
  fullname: Busch, Dirk H.
  organization: National Center for Infection Research (DZIF), Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Focus Group “Clinical Cell Processing and Purification”, Institute for Advanced Study, TUM
– sequence: 15
  givenname: Sebastian
  surname: Kobold
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– sequence: 16
  givenname: Tobias
  orcidid: 0000-0002-8517-9681
  surname: Feuchtinger
  fullname: Feuchtinger, Tobias
  email: tobias.feuchtinger@med.uni-muenchen.de
  organization: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, German Cancer Consortium (DKTK), Partner Site Munich, National Center for Infection Research (DZIF)
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SubjectTerms 13/31
13/44
631/250/251
631/67/1990/283/2125
692/699/1541/1990/283/2125
Antigens, CD19 - immunology
Biomedical and Life Sciences
Biomedicine
Cancer Research
CD28 Antigens - therapeutic use
Cell Line, Tumor
Correspondence
Hematology
Humans
Immunotherapy, Adoptive
Oncology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy
Programmed Cell Death 1 Receptor - therapeutic use
Receptors, IgE - immunology
Recombinant Fusion Proteins - pharmacology
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Title Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins
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Volume 11
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