In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit
Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OC...
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| Published in | Scientific reports Vol. 11; no. 1; pp. 21052 - 12 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
26.10.2021
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-021-00637-4 |
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| Abstract | Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only
(
12
×
5
)
mm
2
. The system achieves 94 dB imaging sensitivity with 750
μ
W on the sample, 50 kHz imaging speed and 5.5
μ
m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. |
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| AbstractList | Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only
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(
12
×
5
)
mm
2
. The system achieves 94 dB imaging sensitivity with 750
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μ
W on the sample, 50 kHz imaging speed and 5.5
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μ
m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only (12×5)mm2. The system achieves 94 dB imaging sensitivity with 750 μW on the sample, 50 kHz imaging speed and 5.5 μm axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only ( 12 × 5 ) mm 2 . The system achieves 94 dB imaging sensitivity with 750 μ W on the sample, 50 kHz imaging speed and 5.5 μ m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Abstract Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only $$(12 \times 5)\;{\text {mm}}^2$$ ( 12 × 5 ) mm 2 . The system achieves 94 dB imaging sensitivity with 750 $$\upmu $$ μ W on the sample, 50 kHz imaging speed and 5.5 $$\upmu $$ μ m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach-Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only [Formula: see text]. The system achieves 94 dB imaging sensitivity with 750 [Formula: see text]W on the sample, 50 kHz imaging speed and 5.5 [Formula: see text]m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only $$(12 \times 5)\;{\text {mm}}^2$$ ( 12 × 5 ) mm 2 . The system achieves 94 dB imaging sensitivity with 750 $$\upmu $$ μ W on the sample, 50 kHz imaging speed and 5.5 $$\upmu $$ μ m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach-Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only [Formula: see text]. The system achieves 94 dB imaging sensitivity with 750 [Formula: see text]W on the sample, 50 kHz imaging speed and 5.5 [Formula: see text]m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC.Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach-Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only [Formula: see text]. The system achieves 94 dB imaging sensitivity with 750 [Formula: see text]W on the sample, 50 kHz imaging speed and 5.5 [Formula: see text]m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC. |
| ArticleNumber | 21052 |
| Author | Duelk, Marcus Drexler, Wolfgang Salas, Matthias Gloor, Stefan Hainberger, Rainer Sagmeister, Martin Kraft, Jochen Rank, Elisabet A. Leitgeb, Rainer A. Muellner, Paul Nevlacsil, Stefan |
| Author_xml | – sequence: 1 givenname: Elisabet A. surname: Rank fullname: Rank, Elisabet A. email: elisabet.rank@meduniwien.ac.at organization: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna – sequence: 2 givenname: Stefan surname: Nevlacsil fullname: Nevlacsil, Stefan organization: AIT Austrian Institute of Technology GmbH – sequence: 3 givenname: Paul surname: Muellner fullname: Muellner, Paul organization: AIT Austrian Institute of Technology GmbH – sequence: 4 givenname: Rainer surname: Hainberger fullname: Hainberger, Rainer organization: AIT Austrian Institute of Technology GmbH – sequence: 5 givenname: Matthias surname: Salas fullname: Salas, Matthias organization: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna – sequence: 6 givenname: Stefan surname: Gloor fullname: Gloor, Stefan organization: EXALOS AG – sequence: 7 givenname: Marcus surname: Duelk fullname: Duelk, Marcus organization: EXALOS AG – sequence: 8 givenname: Martin surname: Sagmeister fullname: Sagmeister, Martin organization: ams AG – sequence: 9 givenname: Jochen surname: Kraft fullname: Kraft, Jochen organization: ams AG – sequence: 10 givenname: Rainer A. surname: Leitgeb fullname: Leitgeb, Rainer A. organization: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna – sequence: 11 givenname: Wolfgang surname: Drexler fullname: Drexler, Wolfgang organization: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34702941$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0140-6736(19)33051-X 10.1117/12.841702 10.1364/BOE.8.001638 10.1038/s41377-020-00450-0 10.1007/978-3-319-06419-2 10.1364/OL.24.001484 10.1364/OE.404588 10.1364/OE.24.001573 10.1364/BOE.6.002562 10.1364/BOE.9.001871 10.1364/BOE.5.001050 10.1364/OPEX.12.002404 10.1038/s41586-020-2764-0 10.1364/CLEO_AT.2014.ATu2P.4 10.1186/s40942-020-00262-9 10.1117/12.889920 10.1038/lsa.2015.131 10.1515/aot-2017-0061 10.1364/OL.37.004820 |
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| Snippet | Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems.... Abstract Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT)... |
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| Title | In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit |
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