Effects of inhaled nitric oxide on outcome after prolonged cardiac arrest in mild therapeutic hypothermia treated rats
Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO migh...
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| Published in | Scientific reports Vol. 8; no. 1; pp. 6743 - 9 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
30.04.2018
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-018-25213-1 |
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| Abstract | Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in brain protection. iNO augmented mild therapeutic hypothermia (MTH) may improve outcome after CA exceeding the effect of MTH alone. Following ten minutes of CA and three minutes of cardiopulmonary resuscitation, 20 male Sprague-Dawley rats were randomized to receive MTH at 33 °C for 6hrs or MTH + 20ppm iNO for 5hrs; one group served as normothermic control. During the experiment blood was taken for biochemical evaluation. A neurological deficit score was calculated daily for seven days post CA. On day seven, brains and hearts were harvested for histological evaluation. Treatment groups showed a significant decrease in lactate levels six hours post resuscitation in comparison to controls. TNF-α release was significantly lower in MTH + iNO treated animals only at four hours post ROSC. While only the combination of MTH and iNO improved neurological function in a statistically significant manner in comparison to controls on days 4–7 after CA, there was no significant difference between groups treated with MTH and MTH + iNO. |
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| AbstractList | Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in brain protection. iNO augmented mild therapeutic hypothermia (MTH) may improve outcome after CA exceeding the effect of MTH alone. Following ten minutes of CA and three minutes of cardiopulmonary resuscitation, 20 male Sprague-Dawley rats were randomized to receive MTH at 33 °C for 6hrs or MTH + 20ppm iNO for 5hrs; one group served as normothermic control. During the experiment blood was taken for biochemical evaluation. A neurological deficit score was calculated daily for seven days post CA. On day seven, brains and hearts were harvested for histological evaluation. Treatment groups showed a significant decrease in lactate levels six hours post resuscitation in comparison to controls. TNF-α release was significantly lower in MTH + iNO treated animals only at four hours post ROSC. While only the combination of MTH and iNO improved neurological function in a statistically significant manner in comparison to controls on days 4-7 after CA, there was no significant difference between groups treated with MTH and MTH + iNO.Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in brain protection. iNO augmented mild therapeutic hypothermia (MTH) may improve outcome after CA exceeding the effect of MTH alone. Following ten minutes of CA and three minutes of cardiopulmonary resuscitation, 20 male Sprague-Dawley rats were randomized to receive MTH at 33 °C for 6hrs or MTH + 20ppm iNO for 5hrs; one group served as normothermic control. During the experiment blood was taken for biochemical evaluation. A neurological deficit score was calculated daily for seven days post CA. On day seven, brains and hearts were harvested for histological evaluation. Treatment groups showed a significant decrease in lactate levels six hours post resuscitation in comparison to controls. TNF-α release was significantly lower in MTH + iNO treated animals only at four hours post ROSC. While only the combination of MTH and iNO improved neurological function in a statistically significant manner in comparison to controls on days 4-7 after CA, there was no significant difference between groups treated with MTH and MTH + iNO. Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in brain protection. iNO augmented mild therapeutic hypothermia (MTH) may improve outcome after CA exceeding the effect of MTH alone. Following ten minutes of CA and three minutes of cardiopulmonary resuscitation, 20 male Sprague-Dawley rats were randomized to receive MTH at 33 °C for 6hrs or MTH + 20ppm iNO for 5hrs; one group served as normothermic control. During the experiment blood was taken for biochemical evaluation. A neurological deficit score was calculated daily for seven days post CA. On day seven, brains and hearts were harvested for histological evaluation. Treatment groups showed a significant decrease in lactate levels six hours post resuscitation in comparison to controls. TNF-α release was significantly lower in MTH + iNO treated animals only at four hours post ROSC. While only the combination of MTH and iNO improved neurological function in a statistically significant manner in comparison to controls on days 4–7 after CA, there was no significant difference between groups treated with MTH and MTH + iNO. Abstract Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in brain protection. iNO augmented mild therapeutic hypothermia (MTH) may improve outcome after CA exceeding the effect of MTH alone. Following ten minutes of CA and three minutes of cardiopulmonary resuscitation, 20 male Sprague-Dawley rats were randomized to receive MTH at 33 °C for 6hrs or MTH + 20ppm iNO for 5hrs; one group served as normothermic control. During the experiment blood was taken for biochemical evaluation. A neurological deficit score was calculated daily for seven days post CA. On day seven, brains and hearts were harvested for histological evaluation. Treatment groups showed a significant decrease in lactate levels six hours post resuscitation in comparison to controls. TNF-α release was significantly lower in MTH + iNO treated animals only at four hours post ROSC. While only the combination of MTH and iNO improved neurological function in a statistically significant manner in comparison to controls on days 4–7 after CA, there was no significant difference between groups treated with MTH and MTH + iNO. |
| ArticleNumber | 6743 |
| Author | Nolte, Kay Derwall, Matthias Fries, Michael Berger, Philipp Gaisa, Nadine T. Brücken, Anne Rossaint, Rolf Marx, Gernot Bleilevens, Christian |
| Author_xml | – sequence: 1 givenname: Anne surname: Brücken fullname: Brücken, Anne email: abruecken@ukaachen.de organization: Department of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 2 givenname: Christian surname: Bleilevens fullname: Bleilevens, Christian organization: Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 3 givenname: Philipp surname: Berger fullname: Berger, Philipp organization: Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 4 givenname: Kay surname: Nolte fullname: Nolte, Kay organization: Institute of Neuropathology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 5 givenname: Nadine T. surname: Gaisa fullname: Gaisa, Nadine T. organization: Institute of Pathology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 6 givenname: Rolf surname: Rossaint fullname: Rossaint, Rolf organization: Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 7 givenname: Gernot surname: Marx fullname: Marx, Gernot organization: Department of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 8 givenname: Matthias surname: Derwall fullname: Derwall, Matthias organization: Department of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30 – sequence: 9 givenname: Michael surname: Fries fullname: Fries, Michael organization: Department of Anaesthesiology, St. Vincenz Hospital Limburg, Auf dem Schafsberg |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29713000$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_niox_2022_06_005 crossref_primary_10_3389_fnins_2022_1087725 crossref_primary_10_1016_j_niox_2021_07_001 crossref_primary_10_1016_j_ajem_2020_06_066 crossref_primary_10_1016_j_brainresbull_2021_05_014 crossref_primary_10_3389_fped_2019_00558 crossref_primary_10_1016_j_jneumeth_2022_109554 crossref_primary_10_1097_PCC_0000000000002187 crossref_primary_10_1097_MCC_0000000000000820 crossref_primary_10_1007_s10047_021_01284_2 |
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| Snippet | Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches... Abstract Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
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| SubjectTerms | 692/308/409 692/700/1750 Cardiac arrest Cerebral blood flow Heart Heart diseases Humanities and Social Sciences Hypothermia Ischemia Lactic acid multidisciplinary Neurological complications Nitric oxide Reperfusion Rodents Science Science (multidisciplinary) Statistical analysis Tumor necrosis factor-α |
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| Title | Effects of inhaled nitric oxide on outcome after prolonged cardiac arrest in mild therapeutic hypothermia treated rats |
| URI | https://link.springer.com/article/10.1038/s41598-018-25213-1 https://www.ncbi.nlm.nih.gov/pubmed/29713000 https://www.proquest.com/docview/2032765240 https://www.proquest.com/docview/2033381891 https://pubmed.ncbi.nlm.nih.gov/PMC5928159 https://doaj.org/article/133d2956de0f4dc6af449015ff033bd7 |
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