The blood-brain barrier in aging and neurodegeneration

The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age...

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Published inMolecular psychiatry Vol. 27; no. 6; pp. 2659 - 2673
Main Authors Knox, Emily G., Aburto, Maria R., Clarke, Gerard, Cryan, John F., O’Driscoll, Caitriona M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2022
Nature Publishing Group
Subjects
631/154
631/378
Aging
Behavioral Sciences
Biological Psychology
Blood-brain barrier
Homeostasis
Intestinal microflora
Medicine
Medicine & Public Health
Metabolites
Microbiota
Neurodegeneration
Neurosciences
Parenchyma
Pharmacotherapy
Physiology
Psychiatry
Recovery of function
Review
Review Article
Online AccessGet full text
ISSN1359-4184
1476-5578
1476-5578
DOI10.1038/s41380-022-01511-z

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Abstract The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.
AbstractList The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.
Author Knox, Emily G.
Aburto, Maria R.
Clarke, Gerard
O’Driscoll, Caitriona M.
Cryan, John F.
Author_xml – sequence: 1
  givenname: Emily G.
  orcidid: 0000-0003-3741-7339
  surname: Knox
  fullname: Knox, Emily G.
  organization: Pharmacodelivery Group, School of Pharmacy, University College Cork, APC Microbiome Ireland, University College Cork
– sequence: 2
  givenname: Maria R.
  surname: Aburto
  fullname: Aburto, Maria R.
  organization: APC Microbiome Ireland, University College Cork, Department of Anatomy and Neuroscience, University College Cork
– sequence: 3
  givenname: Gerard
  orcidid: 0000-0001-9771-3979
  surname: Clarke
  fullname: Clarke, Gerard
  organization: APC Microbiome Ireland, University College Cork, Department of Psychiatry and Neurobehavioural Science, University College Cork
– sequence: 4
  givenname: John F.
  orcidid: 0000-0001-5887-2723
  surname: Cryan
  fullname: Cryan, John F.
  organization: APC Microbiome Ireland, University College Cork, Department of Anatomy and Neuroscience, University College Cork
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  givenname: Caitriona M.
  orcidid: 0000-0002-6915-6201
  surname: O’Driscoll
  fullname: O’Driscoll, Caitriona M.
  email: caitriona.odriscoll@ucc.ie
  organization: Pharmacodelivery Group, School of Pharmacy, University College Cork
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35361905$$D View this record in MEDLINE/PubMed
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Aging
Behavioral Sciences
Biological Psychology
Blood-brain barrier
Homeostasis
Intestinal microflora
Medicine
Medicine & Public Health
Metabolites
Microbiota
Neurodegeneration
Neurosciences
Parenchyma
Pharmacotherapy
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Title The blood-brain barrier in aging and neurodegeneration
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