A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis

Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature...

Full description

Saved in:
Bibliographic Details
Published inBMC genomics Vol. 22; no. 1; pp. 497 - 20
Main Authors Disatham, Joshua, Brennan, Lisa, Chauss, Daniel, Kantorow, Jason, Afzali, Behdad, Kantorow, Marc
Format Journal Article
LanguageEnglish
Published London BioMed Central 03.07.2021
Springer Nature B.V
BMC
Subjects
Animal Genetics and Genomics
ATAC-seq
Binding sites
Biomedical and Life Sciences
Cell cycle
Cell Differentiation
Cellular structure
Chi-square test
Chromatin
Chromatin remodeling
CUT&RUN
Deoxyribonucleic acid
Differentiation (biology)
DNA
Embryogenesis
Epithelial cells
Epithelium
Eye lens
Gene expression
Gene regulation
Gene silencing
Genes
Genomes
Genomics
Glycolysis
HIF1α
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Lens, Crystalline
Lenses
Life Sciences
Microarrays
Microbial Genetics and Genomics
Mitochondria
Oxygen
Plant Genetics and Genomics
Proteins
Proteomics
RNA-seq
Statistical tests
Structure-function relationships
Transcription factors
Wnt protein
Chromatin
RNA-seq
Gene regulation
CUT&RUN
Hypoxia
Transcriptional regulation
HIF1α
ATAC-seq
DNA binding
Online AccessGet full text
ISSN1471-2164
1471-2164
DOI10.1186/s12864-021-07795-9

Cover

Abstract Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. Results CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ 2 test p  < 1 × 10 − 55 ) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
AbstractList During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes.BACKGROUNDDuring eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes.CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ2 test p < 1 × 10- 55) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency.RESULTSCUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ2 test p < 1 × 10- 55) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency.These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.CONCLUSIONSThese data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ test p < 1 × 10 ) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
Abstract Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. Results CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ2 test p < 1 × 10− 55) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. Results CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ2 test p < 1 × 10− 55) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. Results CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ 2 test p  < 1 × 10 − 55 ) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
ArticleNumber 497
Author Kantorow, Jason
Afzali, Behdad
Disatham, Joshua
Chauss, Daniel
Kantorow, Marc
Brennan, Lisa
Author_xml – sequence: 1
  givenname: Joshua
  surname: Disatham
  fullname: Disatham, Joshua
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University
– sequence: 2
  givenname: Lisa
  surname: Brennan
  fullname: Brennan, Lisa
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University
– sequence: 3
  givenname: Daniel
  surname: Chauss
  fullname: Chauss, Daniel
  organization: Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH
– sequence: 4
  givenname: Jason
  surname: Kantorow
  fullname: Kantorow, Jason
  organization: University of Florida
– sequence: 5
  givenname: Behdad
  surname: Afzali
  fullname: Afzali, Behdad
  organization: Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH
– sequence: 6
  givenname: Marc
  surname: Kantorow
  fullname: Kantorow, Marc
  email: mkantoro@health.fau.edu
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34215186$$D View this record in MEDLINE/PubMed
BookMark eNqNks1u1DAUhSNURH_gBVggS2zYBHw9jp1skEaF0pEq2MDacjzXMxk59mAnhXksXoRnwukMpe2iYmXLPufT8T0-LY588FgUL4G-BajFuwSsFrykDEoqZVOVzZPiBLiEkoHgR3f2x8VpShtKQdaselYczziDKiNOCpwTO3ozdMFrR3q9JcGSFfrQd4ZcLi7g96_yw-c5MaHfOvyJiXSeDGskuEPi0CcS8Rq1w2U-jWFcrUk_uozL_kR0hu5Sl54XT612CV8c1rPi28XHr-eX5dWXT4vz-VVpKk6HknEwLdgWmgpoA5pbQWkrazAUeFtzORMtRwO0BSYt4zU0oqKVbik2WkgzOysWe-4y6I3axq7XcaeC7tTNQYgrpePQGYfKIgNuRFvTasmptM0yz1BaCgBWAmsya7ZnjX6rdz-0c7dAoGoqQO0LULkAdVOAmlzv967t2Pa4NOiHqN29KPdvfLdWq3CtcjF8VokMeHMAxPB9xDSovksGndMew5hUltU5rxCT9PUD6SaMMY98UlWsriQTkFWv7ia6jfL3D2RBvReYGFKKaJXpBj39iBywc4-_lj2w_teIDoNNWexXGP_FfsT1B46R5Dc
CitedBy_id crossref_primary_10_3390_cells11213516
crossref_primary_10_3390_cells12222636
crossref_primary_10_1016_j_ydbio_2023_09_005
crossref_primary_10_1016_j_freeradbiomed_2024_12_031
crossref_primary_10_1186_s13072_023_00478_7
crossref_primary_10_3390_biom13040693
Cites_doi 10.1038/nmeth.3317
10.7554/eLife.21856
10.1093/nar/gkw377
10.1113/jphysiol.2004.068619
10.1016/j.preteyeres.2017.10.001
10.1091/mbc.e06-09-0809
10.1002/cpz1.90
10.1016/j.diff.2018.07.003
10.1167/iovs.08-2118
10.1080/15548627.2017.1332567
10.1016/j.biomaterials.2018.02.045
10.1038/embor.2009.256
10.1096/fj.15-278036
10.1242/jeb.00670
10.1016/j.semcdb.2016.02.011
10.1016/j.jhep.2018.05.021
10.1534/g3.114.012120
10.1080/15548627.2019.1591672
10.1182/blood-2002-11-3324
10.1113/EP085318
10.1038/s41598-017-03921-4
10.4049/jimmunol.177.3.1941
10.1016/j.bbabio.2010.02.011
10.1038/sj.emboj.7600196
10.1016/j.bbadis.2016.09.020
10.1002/humu.23696
10.1098/rsob.190220
10.1016/0304-4165(78)90229-5
10.1002/bies.201400036
10.1016/j.ydbio.2008.06.002
10.1128/MCB.00780-07
10.1042/BJ20081055
10.1016/S0891-5849(01)00634-7
10.1093/bioinformatics/btv145
10.1158/0008-5472.CAN-05-4564
10.1073/pnas.0708818104
10.1242/jcs.035022
10.1038/cddis.2017.478
10.1038/onc.2009.49
10.1038/nprot.2018.015
10.1016/j.exer.2004.04.005
10.1038/nprot.2012.101
10.1002/dvdy.10115
10.1007/s10384-014-0318-4
10.1096/fj.01-0944rev
10.1006/exer.2002.2057
10.1093/bioinformatics/btr260
10.4161/auto.5552
10.1038/nbt.3122
10.1242/bio.041095
10.1093/bioinformatics/btq033
10.1038/nmeth.1923
10.1093/nar/gki839
10.1101/gad.12.23.3764
10.1002/pro.3159
10.1016/j.exer.2020.108129
10.14806/ej.17.1.200
10.1093/nar/gkw257
10.1186/gb-2012-13-9-r50
10.1242/jcs.113.11.1913
10.1136/jcp.2003.015032
10.1167/iovs.16-21398
10.1016/0378-1119(91)90273-E
10.4161/auto.28768
10.1007/s11568-011-9150-9
10.1098/rstb.2010.0302
10.1007/s00232-012-9458-y
10.1073/pnas.0506580102
10.1101/gr.229102
10.1096/fj.08-110221
10.1091/mbc.e10-04-0312
10.1093/bioinformatics/btp352
10.1016/S0168-9525(00)02093-X
10.1038/nature07006
10.1111/1440-1681.12717
10.1038/s41467-017-02683-x
10.1016/j.exer.2018.06.003
10.1111/cpr.12363
10.1093/nar/gkp335
10.1101/gr.4222606
10.1073/pnas.0610666104
10.1016/j.bbrc.2019.03.098
10.1093/bioinformatics/btr261
10.1182/blood-2007-11-126763
10.1093/database/bat074
10.1098/rstb.2010.0324
10.1111/j.1432-0436.2006.00068.x
10.1016/j.preteyeres.2017.04.001
10.1242/dev.123026
10.1038/nrm3941
10.1371/journal.pone.0003078
10.1093/bioinformatics/btp616
10.7554/eLife.46314
10.1016/j.exer.2016.02.013
10.1038/nm0603-677
10.1186/1471-2105-14-128
10.1091/mbc.e16-12-0865
10.12659/MSM.910601
10.1167/iovs.06-0401
10.1016/j.cell.2018.03.016
10.1186/gb-2008-9-9-r137
10.1242/dev.01060
10.1016/j.ydbio.2019.04.020
10.1242/jcs.217240
10.1016/j.exer.2019.02.024
10.20944/preprints201803.0004.v1
10.1083/jcb.107.6.2729
10.1002/0471142727.mb2129s109
10.1128/MCB.00166-09
10.2174/156652410793937741
10.1016/j.ydbio.2005.01.020
10.1007/s00424-005-1413-7
10.3390/cells8030214
10.1038/s41467-019-12107-7
10.1186/s12886-019-1229-4
10.1167/iovs.12-11357
10.1093/bioinformatics/btu170
10.1016/j.ydbio.2009.05.566
10.15252/embr.201846401
10.1371/journal.pone.0052948
10.1002/dvdy.22035
10.1038/nrg2522
10.1016/bs.pmbts.2015.04.007
10.1096/fj.02-0568fje
10.1038/cdd.2016.152
10.1007/s00439-011-1064-z
10.1182/blood-2010-10-314427
10.1038/nature05602
10.1016/j.exer.2008.07.017
10.3390/ijms19103093
10.1016/j.exer.2018.01.018
10.1016/j.tig.2017.08.001
ContentType Journal Article
Copyright The Author(s) 2021
2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QP
7QR
7SS
7TK
7U7
7X7
7XB
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.1186/s12864-021-07795-9
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Entomology Abstracts (Full archive)
Neurosciences Abstracts
Toxicology Abstracts
Health & Medical Collection (Proquest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials Local Electronic Collection Information
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection (UHCL Subscription)
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (Proquest)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database (Proquest)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Open Access Full Text
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
Toxicology Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 6
  dbid: BENPR
  name: ProQuest One Academic
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1471-2164
EndPage 20
ExternalDocumentID oai_doaj_org_article_fe214c6b805d407f9d0777f0111f7129
10.1186/s12864-021-07795-9
PMC8254356
34215186
10_1186_s12864_021_07795_9
Genre Journal Article
GrantInformation_xml – fundername: NEI NIH HHS
  grantid: R01 EY029708
GroupedDBID ---
0R~
23N
2WC
2XV
53G
5VS
6J9
7X7
88E
8AO
8FE
8FH
8FI
8FJ
AAFWJ
AAHBH
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADUKV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
IAO
IGS
IHR
INH
INR
ISR
ITC
KQ8
LK8
M1P
M48
M7P
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
U2A
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QP
7QR
7SS
7TK
7U7
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
5PM
2VQ
4.4
ADRAZ
ADTOC
AHSBF
C1A
EJD
H13
HYE
IPNFZ
RIG
UNPAY
ID FETCH-LOGICAL-c540t-241cb1fb1951091a4f600b781c014b84736b4ec10b127f248196505ab0e9a67c3
IEDL.DBID DOA
ISSN 1471-2164
IngestDate Fri Oct 03 12:53:16 EDT 2025
Sun Oct 26 03:55:51 EDT 2025
Tue Sep 30 16:26:22 EDT 2025
Fri Sep 05 14:35:55 EDT 2025
Tue Oct 07 05:52:47 EDT 2025
Thu Apr 03 07:02:38 EDT 2025
Wed Oct 01 01:08:20 EDT 2025
Thu Apr 24 23:01:53 EDT 2025
Sat Sep 06 07:30:27 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Chromatin
RNA-seq
Gene regulation
CUT&RUN
Hypoxia
Transcriptional regulation
HIF1α
ATAC-seq
DNA binding
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-241cb1fb1951091a4f600b781c014b84736b4ec10b127f248196505ab0e9a67c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/fe214c6b805d407f9d0777f0111f7129
PMID 34215186
PQID 2552857261
PQPubID 44682
PageCount 20
ParticipantIDs doaj_primary_oai_doaj_org_article_fe214c6b805d407f9d0777f0111f7129
unpaywall_primary_10_1186_s12864_021_07795_9
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8254356
proquest_miscellaneous_2548407666
proquest_journals_2552857261
pubmed_primary_34215186
crossref_citationtrail_10_1186_s12864_021_07795_9
crossref_primary_10_1186_s12864_021_07795_9
springer_journals_10_1186_s12864_021_07795_9
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-07-03
PublicationDateYYYYMMDD 2021-07-03
PublicationDate_xml – month: 07
  year: 2021
  text: 2021-07-03
  day: 03
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle BMC genomics
PublicationTitleAbbrev BMC Genomics
PublicationTitleAlternate BMC Genomics
PublicationYear 2021
Publisher BioMed Central
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: Springer Nature B.V
– name: BMC
References CM Garcia (7795_CR99) 2009; 88
Y Zhang (7795_CR63) 2018; 24
7795_CR110
7795_CR111
D Chauss (7795_CR52) 2014; 4
N Liu (7795_CR118) 2018; 173
RL Schweers (7795_CR14) 2007; 104
7795_CR93
7795_CR12
7795_CR98
T Ma (7795_CR66) 2016; 146
W Zheng (7795_CR85) 2009; 23
7795_CR13
7795_CR19
TL Bailey (7795_CR135) 2011; 27
7795_CR18
F Dayan (7795_CR33) 2006; 66
A Maeda (7795_CR101) 2009; 238
7795_CR106
H Li (7795_CR121) 2009; 25
7795_CR100
FJ Lovicu (7795_CR76) 2005; 280
M Sano (7795_CR31) 2007; 446
GJ Wistow (7795_CR77) 1988; 107
7795_CR87
W Aerbajinai (7795_CR11) 2003; 102
Y-B Shui (7795_CR82) 2008; 49
X Chen (7795_CR105) 2017; 24
M Pertea (7795_CR128) 2015; 33
BA Boswell (7795_CR39) 2017; 28
G Bellot (7795_CR46) 2009; 29
MV Kuleshov (7795_CR136) 2016; 44
A Sue Menko (7795_CR53) 2002; 75
L Lyu (7795_CR103) 2016; 30
7795_CR30
J Lyu (7795_CR88) 2004; 131
JA Whitson (7795_CR62) 2017; 58
SK Nandi (7795_CR109) 2019; 182
KF Chen (7795_CR83) 2005; 33
Z Xie (7795_CR137) 2021; 1
7795_CR34
A Cvekl (7795_CR74) 2017; 33
JL Walker (7795_CR102) 2002; 224
G Wu (7795_CR80) 2007; 18
J Feng (7795_CR124) 2012; 7
A Diwan (7795_CR16) 2007; 104
Y Furuta (7795_CR81) 1998; 12
7795_CR36
S Bassnett (7795_CR44) 2003; 206
C Chen (7795_CR116) 2017; 50
M Martin (7795_CR126) 2011; 17
VI Shestopalov (7795_CR6) 2000; 113
7795_CR129
AM Bolger (7795_CR119) 2014; 30
S Bassnett (7795_CR3) 2003; 206
LJ Dawes (7795_CR89) 2013; 54
DC Beebe (7795_CR4) 2014; 58
7795_CR122
S Bassnett (7795_CR1) 2011; 366
7795_CR120
J Jia (7795_CR71) 2007; 27
7795_CR22
GF Weber (7795_CR38) 2006; 47
KC Bhuyan (7795_CR107) 1978; 542
7795_CR23
M Sun (7795_CR79) 2019; 40
M Koshiji (7795_CR55) 2004; 23
Y-B Shui (7795_CR17) 2008; 49
7795_CR26
7795_CR27
7795_CR24
7795_CR25
S Rudnizky (7795_CR50) 2017; 26
7795_CR113
L Zhang (7795_CR68) 2010; 10
Y Baba (7795_CR92) 2019; 512
7795_CR117
K Tanimoto (7795_CR125) 2010; 4
M Azimi (7795_CR72) 2018; 102
RY Kim (7795_CR78) 1991; 103
C Jiang (7795_CR49) 2009; 10
EJ Dudek (7795_CR59) 2001; 31
SA Lachke (7795_CR91) 2012; 131
AR Quinlan (7795_CR131) 2010; 26
T Shao (7795_CR29) 2018; 69
7795_CR56
LS Musil (7795_CR41) 2012; 245
S Rowan (7795_CR70) 2008; 321
7795_CR54
7795_CR57
7795_CR58
RH Wenger (7795_CR20) 2002; 16
S Venkatesh (7795_CR51) 2015; 16
7795_CR140
D Chen (7795_CR94) 2012; 7
G Yu (7795_CR132) 2015; 31
DF Higgins (7795_CR32) 2007; 117
7795_CR40
LA Brennan (7795_CR7) 2018; 174
LM Hodgkinson (7795_CR90) 2010; 16
7795_CR45
7795_CR42
7795_CR43
SS Saravanamuthu (7795_CR104) 2009; 332
M Rothe (7795_CR73) 2017; 144
7795_CR47
Y Yu (7795_CR115) 2018; 165
MT Ju (7795_CR65) 2018; 169
ME Lindholm (7795_CR28) 2016; 101
PJ Skene (7795_CR35) 2018; 13
S Bassnett (7795_CR75) 2017; 60
7795_CR138
7795_CR139
D Kim (7795_CR127) 2015; 12
MA Wride (7795_CR67) 2011; 366
MC Brahimi-Horn (7795_CR21) 2009; 122
KV Ramana (7795_CR60) 2003; 17
WJ Kent (7795_CR130) 2002; 12
JC Morote-Garcia (7795_CR84) 2008; 111
7795_CR5
7795_CR2
I Mylonis (7795_CR95) 2019; 8
7795_CR8
J Zhang (7795_CR15) 2008; 4
7795_CR9
JA Smythies (7795_CR48) 2019; 20
S Basu (7795_CR37) 2014; 10
TW Whiteld (7795_CR97) 2012; 13
BL Baechler (7795_CR108) 2019; 15
F Ramírez (7795_CR133) 2016; 44
M Gao (7795_CR114) 2017; 8
Y Zhang (7795_CR123) 2008; 9
7795_CR61
IP Newton (7795_CR86) 2010; 21
MC Bosco (7795_CR112) 2006; 177
7795_CR64
7795_CR69
TL Bailey (7795_CR134) 2009; 37
SJ Cooper (7795_CR96) 2006; 16
A Diwan (7795_CR10) 2009; 119
References_xml – volume: 12
  start-page: 357
  year: 2015
  ident: 7795_CR127
  publication-title: Nat Methods
  doi: 10.1038/nmeth.3317
– ident: 7795_CR34
  doi: 10.7554/eLife.21856
– volume: 44
  start-page: W90
  issue: W1
  year: 2016
  ident: 7795_CR136
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw377
– ident: 7795_CR5
  doi: 10.1113/jphysiol.2004.068619
– ident: 7795_CR2
  doi: 10.1016/j.preteyeres.2017.10.001
– ident: 7795_CR45
– volume: 18
  start-page: 1018
  year: 2007
  ident: 7795_CR80
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e06-09-0809
– volume: 1
  start-page: e90
  year: 2021
  ident: 7795_CR137
  publication-title: Curr Protoc
  doi: 10.1002/cpz1.90
– volume: 102
  start-page: 40
  year: 2018
  ident: 7795_CR72
  publication-title: Differentiation
  doi: 10.1016/j.diff.2018.07.003
– volume: 49
  start-page: 4961
  year: 2008
  ident: 7795_CR17
  publication-title: Investig Opthalmology Vis Sci
  doi: 10.1167/iovs.08-2118
– ident: 7795_CR27
  doi: 10.1080/15548627.2017.1332567
– volume: 165
  start-page: 48
  year: 2018
  ident: 7795_CR115
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.02.045
– ident: 7795_CR12
  doi: 10.1038/embor.2009.256
– volume: 30
  start-page: 1087
  year: 2016
  ident: 7795_CR103
  publication-title: FASEB J
  doi: 10.1096/fj.15-278036
– volume: 206
  start-page: 4353
  issue: 23
  year: 2003
  ident: 7795_CR3
  publication-title: J Exp Biol
  doi: 10.1242/jeb.00670
– ident: 7795_CR110
  doi: 10.1016/j.semcdb.2016.02.011
– volume: 69
  start-page: 886
  year: 2018
  ident: 7795_CR29
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2018.05.021
– ident: 7795_CR23
  doi: 10.1534/g3.114.012120
– volume: 15
  start-page: 1606
  year: 2019
  ident: 7795_CR108
  publication-title: Autophagy
  doi: 10.1080/15548627.2019.1591672
– volume: 102
  start-page: 712
  year: 2003
  ident: 7795_CR11
  publication-title: Blood
  doi: 10.1182/blood-2002-11-3324
– volume: 101
  start-page: 28
  year: 2016
  ident: 7795_CR28
  publication-title: Exp Physiol
  doi: 10.1113/EP085318
– ident: 7795_CR56
  doi: 10.1038/s41598-017-03921-4
– volume: 177
  start-page: 1941
  year: 2006
  ident: 7795_CR112
  publication-title: J Immunol
  doi: 10.4049/jimmunol.177.3.1941
– ident: 7795_CR22
  doi: 10.1016/j.bbabio.2010.02.011
– volume: 23
  start-page: 1949
  year: 2004
  ident: 7795_CR55
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7600196
– ident: 7795_CR36
  doi: 10.1016/j.bbadis.2016.09.020
– volume: 40
  start-page: 380
  year: 2019
  ident: 7795_CR79
  publication-title: Hum Mutat
  doi: 10.1002/humu.23696
– ident: 7795_CR100
  doi: 10.1098/rsob.190220
– volume: 542
  start-page: 28
  year: 1978
  ident: 7795_CR107
  publication-title: BBA - Gen Subj
  doi: 10.1016/0304-4165(78)90229-5
– ident: 7795_CR113
  doi: 10.1002/bies.201400036
– volume: 321
  start-page: 111
  year: 2008
  ident: 7795_CR70
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2008.06.002
– volume: 27
  start-page: 7236
  year: 2007
  ident: 7795_CR71
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00780-07
– volume: 206
  start-page: 4353
  issue: 23
  year: 2003
  ident: 7795_CR44
  publication-title: J Exp Biol
  doi: 10.1242/jeb.00670
– volume: 16
  start-page: 2765
  year: 2010
  ident: 7795_CR90
  publication-title: Mol Vis
– ident: 7795_CR19
  doi: 10.1042/BJ20081055
– volume: 31
  start-page: 651
  year: 2001
  ident: 7795_CR59
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(01)00634-7
– volume: 31
  start-page: 2382
  year: 2015
  ident: 7795_CR132
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 66
  start-page: 3688
  issue: 7
  year: 2006
  ident: 7795_CR33
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-4564
– volume: 104
  start-page: 19500
  year: 2007
  ident: 7795_CR14
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0708818104
– volume: 122
  start-page: 1055
  issue: 8
  year: 2009
  ident: 7795_CR21
  publication-title: J Cell Sci
  doi: 10.1242/jcs.035022
– volume: 8
  start-page: e3082
  year: 2017
  ident: 7795_CR114
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2017.478
– ident: 7795_CR9
  doi: 10.1038/onc.2009.49
– volume: 13
  start-page: 1006
  issue: 5
  year: 2018
  ident: 7795_CR35
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2018.015
– ident: 7795_CR106
  doi: 10.1016/j.exer.2004.04.005
– volume: 7
  start-page: 1728
  year: 2012
  ident: 7795_CR124
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2012.101
– volume: 224
  start-page: 361
  year: 2002
  ident: 7795_CR102
  publication-title: Dev Dyn
  doi: 10.1002/dvdy.10115
– volume: 58
  start-page: 225
  issue: 3
  year: 2014
  ident: 7795_CR4
  publication-title: Jpn J Ophthalmol
  doi: 10.1007/s10384-014-0318-4
– volume: 16
  start-page: 1151
  issue: 10
  year: 2002
  ident: 7795_CR20
  publication-title: FASEB J
  doi: 10.1096/fj.01-0944rev
– volume: 75
  start-page: 485
  year: 2002
  ident: 7795_CR53
  publication-title: Exp Eye Res
  doi: 10.1006/exer.2002.2057
– ident: 7795_CR139
  doi: 10.1093/bioinformatics/btr260
– volume: 4
  start-page: 354
  year: 2008
  ident: 7795_CR15
  publication-title: Autophagy
  doi: 10.4161/auto.5552
– volume: 117
  start-page: 3810
  year: 2007
  ident: 7795_CR32
  publication-title: J Clin Invest
– volume: 33
  start-page: 290
  year: 2015
  ident: 7795_CR128
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3122
– ident: 7795_CR98
  doi: 10.1242/bio.041095
– volume: 26
  start-page: 841
  year: 2010
  ident: 7795_CR131
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq033
– ident: 7795_CR120
  doi: 10.1038/nmeth.1923
– volume: 33
  start-page: 5190
  year: 2005
  ident: 7795_CR83
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki839
– volume: 12
  start-page: 3764
  year: 1998
  ident: 7795_CR81
  publication-title: Genes Dev
  doi: 10.1101/gad.12.23.3764
– volume: 26
  start-page: 1266
  year: 2017
  ident: 7795_CR50
  publication-title: Protein Sci
  doi: 10.1002/pro.3159
– ident: 7795_CR8
  doi: 10.1016/j.exer.2020.108129
– volume: 17
  start-page: 10
  year: 2011
  ident: 7795_CR126
  publication-title: EMBnet.journal
  doi: 10.14806/ej.17.1.200
– volume: 44
  start-page: W160
  year: 2016
  ident: 7795_CR133
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw257
– volume: 13
  start-page: R50
  year: 2012
  ident: 7795_CR97
  publication-title: Genome Biol
  doi: 10.1186/gb-2012-13-9-r50
– volume: 119
  start-page: 203
  year: 2009
  ident: 7795_CR10
  publication-title: J Clin Invest
– volume: 113
  start-page: 1913
  issue: 11
  year: 2000
  ident: 7795_CR6
  publication-title: J Cell Sci
  doi: 10.1242/jcs.113.11.1913
– ident: 7795_CR54
  doi: 10.1136/jcp.2003.015032
– volume: 58
  start-page: 2666
  year: 2017
  ident: 7795_CR62
  publication-title: Investig Ophthalmol Vis Sci
  doi: 10.1167/iovs.16-21398
– volume: 103
  start-page: 193
  year: 1991
  ident: 7795_CR78
  publication-title: Gene
  doi: 10.1016/0378-1119(91)90273-E
– volume: 10
  start-page: 1193
  issue: 7
  year: 2014
  ident: 7795_CR37
  publication-title: Autophagy.
  doi: 10.4161/auto.28768
– volume: 4
  start-page: 35
  year: 2010
  ident: 7795_CR125
  publication-title: HUGO J
  doi: 10.1007/s11568-011-9150-9
– volume: 366
  start-page: 1250
  year: 2011
  ident: 7795_CR1
  publication-title: Philos Trans R Soc Lond Ser B Biol Sci
  doi: 10.1098/rstb.2010.0302
– volume: 245
  start-page: 357
  year: 2012
  ident: 7795_CR41
  publication-title: J Membr Biol
  doi: 10.1007/s00232-012-9458-y
– ident: 7795_CR140
  doi: 10.1073/pnas.0506580102
– volume: 12
  start-page: 996
  year: 2002
  ident: 7795_CR130
  publication-title: Genome Res
  doi: 10.1101/gr.229102
– volume: 23
  start-page: 204
  year: 2009
  ident: 7795_CR85
  publication-title: FASEB J
  doi: 10.1096/fj.08-110221
– volume: 21
  start-page: 3630
  year: 2010
  ident: 7795_CR86
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e10-04-0312
– volume: 25
  start-page: 2078
  issue: 16
  year: 2009
  ident: 7795_CR121
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– ident: 7795_CR122
  doi: 10.1016/S0168-9525(00)02093-X
– ident: 7795_CR13
  doi: 10.1038/nature07006
– ident: 7795_CR30
  doi: 10.1111/1440-1681.12717
– ident: 7795_CR26
  doi: 10.1038/s41467-017-02683-x
– volume: 174
  start-page: 173
  year: 2018
  ident: 7795_CR7
  publication-title: Exp Eye Res
  doi: 10.1016/j.exer.2018.06.003
– volume: 50
  start-page: e12363
  issue: 5
  year: 2017
  ident: 7795_CR116
  publication-title: Cell Prolif
  doi: 10.1111/cpr.12363
– volume: 37
  start-page: W202
  year: 2009
  ident: 7795_CR134
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkp335
– volume: 16
  start-page: 1
  year: 2006
  ident: 7795_CR96
  publication-title: Genome Res
  doi: 10.1101/gr.4222606
– volume: 104
  start-page: 6794
  year: 2007
  ident: 7795_CR16
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0610666104
– volume: 512
  start-page: 927
  year: 2019
  ident: 7795_CR92
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2019.03.098
– volume: 27
  start-page: 1653
  year: 2011
  ident: 7795_CR135
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr261
– volume: 111
  start-page: 5571
  year: 2008
  ident: 7795_CR84
  publication-title: Blood
  doi: 10.1182/blood-2007-11-126763
– ident: 7795_CR57
  doi: 10.1093/database/bat074
– volume: 366
  start-page: 1219
  issue: 1568
  year: 2011
  ident: 7795_CR67
  publication-title: Philos Trans R Soc B Biol Sci
  doi: 10.1098/rstb.2010.0324
– ident: 7795_CR69
  doi: 10.1111/j.1432-0436.2006.00068.x
– volume: 60
  start-page: 181
  year: 2017
  ident: 7795_CR75
  publication-title: Prog Retin Eye Res
  doi: 10.1016/j.preteyeres.2017.04.001
– ident: 7795_CR93
  doi: 10.1242/dev.123026
– volume: 16
  start-page: 178
  year: 2015
  ident: 7795_CR51
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3941
– ident: 7795_CR111
  doi: 10.1371/journal.pone.0003078
– ident: 7795_CR129
  doi: 10.1093/bioinformatics/btp616
– ident: 7795_CR117
  doi: 10.7554/eLife.46314
– volume: 146
  start-page: 318
  year: 2016
  ident: 7795_CR66
  publication-title: Exp Eye Res
  doi: 10.1016/j.exer.2016.02.013
– ident: 7795_CR24
  doi: 10.1038/nm0603-677
– ident: 7795_CR138
  doi: 10.1186/1471-2105-14-128
– volume: 28
  start-page: 907
  year: 2017
  ident: 7795_CR39
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e16-12-0865
– volume: 24
  start-page: 7424
  year: 2018
  ident: 7795_CR63
  publication-title: Med Sci Monit
  doi: 10.12659/MSM.910601
– volume: 47
  start-page: 4490
  year: 2006
  ident: 7795_CR38
  publication-title: Investig Ophthalmol Vis Sci
  doi: 10.1167/iovs.06-0401
– volume: 173
  start-page: 430
  year: 2018
  ident: 7795_CR118
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.016
– volume: 9
  start-page: R137
  issue: 9
  year: 2008
  ident: 7795_CR123
  publication-title: Genome Biol
  doi: 10.1186/gb-2008-9-9-r137
– volume: 131
  start-page: 1813
  year: 2004
  ident: 7795_CR88
  publication-title: Development
  doi: 10.1242/dev.01060
– ident: 7795_CR43
  doi: 10.1016/j.ydbio.2019.04.020
– ident: 7795_CR40
  doi: 10.1242/jcs.217240
– volume: 182
  start-page: 1
  year: 2019
  ident: 7795_CR109
  publication-title: Exp Eye Res
  doi: 10.1016/j.exer.2019.02.024
– volume: 4
  start-page: 1515
  year: 2014
  ident: 7795_CR52
  publication-title: G3
  doi: 10.1534/g3.114.012120
– ident: 7795_CR87
  doi: 10.20944/preprints201803.0004.v1
– volume: 107
  start-page: 2729
  year: 1988
  ident: 7795_CR77
  publication-title: J Cell Biol
  doi: 10.1083/jcb.107.6.2729
– ident: 7795_CR42
  doi: 10.1002/0471142727.mb2129s109
– volume: 29
  start-page: 2570
  issue: 10
  year: 2009
  ident: 7795_CR46
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00166-09
– volume: 10
  start-page: 864
  year: 2010
  ident: 7795_CR68
  publication-title: Curr Mol Med
  doi: 10.2174/156652410793937741
– volume: 280
  start-page: 1
  year: 2005
  ident: 7795_CR76
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2005.01.020
– ident: 7795_CR18
  doi: 10.1007/s00424-005-1413-7
– volume: 8
  start-page: 214
  year: 2019
  ident: 7795_CR95
  publication-title: Cells
  doi: 10.3390/cells8030214
– volume: 49
  start-page: 4961
  year: 2008
  ident: 7795_CR82
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.08-2118
– ident: 7795_CR25
  doi: 10.1038/s41467-019-12107-7
– ident: 7795_CR64
  doi: 10.1186/s12886-019-1229-4
– volume: 54
  start-page: 1582
  year: 2013
  ident: 7795_CR89
  publication-title: Investig Ophthalmol Vis Sci
  doi: 10.1167/iovs.12-11357
– volume: 30
  start-page: 2114
  year: 2014
  ident: 7795_CR119
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 144
  start-page: 321
  year: 2017
  ident: 7795_CR73
  publication-title: Dev
– volume: 332
  start-page: 166
  year: 2009
  ident: 7795_CR104
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2009.05.566
– volume: 20
  start-page: e46401
  year: 2019
  ident: 7795_CR48
  publication-title: EMBO Rep
  doi: 10.15252/embr.201846401
– volume: 7
  start-page: e52948
  year: 2012
  ident: 7795_CR94
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0052948
– volume: 238
  start-page: 2280
  year: 2009
  ident: 7795_CR101
  publication-title: Dev Dyn
  doi: 10.1002/dvdy.22035
– volume: 10
  start-page: 161
  year: 2009
  ident: 7795_CR49
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2522
– ident: 7795_CR58
  doi: 10.1016/bs.pmbts.2015.04.007
– volume: 17
  start-page: 315
  year: 2003
  ident: 7795_CR60
  publication-title: FASEB J
  doi: 10.1096/fj.02-0568fje
– volume: 24
  start-page: 1431
  issue: 8
  year: 2017
  ident: 7795_CR105
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.152
– volume: 131
  start-page: 235
  year: 2012
  ident: 7795_CR91
  publication-title: Hum Genet
  doi: 10.1007/s00439-011-1064-z
– ident: 7795_CR47
  doi: 10.1182/blood-2010-10-314427
– volume: 446
  start-page: 444
  year: 2007
  ident: 7795_CR31
  publication-title: Nature
  doi: 10.1038/nature05602
– volume: 88
  start-page: 270
  year: 2009
  ident: 7795_CR99
  publication-title: Exp Eye Res
  doi: 10.1016/j.exer.2008.07.017
– ident: 7795_CR61
  doi: 10.3390/ijms19103093
– volume: 169
  start-page: 28
  year: 2018
  ident: 7795_CR65
  publication-title: Exp Eye Res
  doi: 10.1016/j.exer.2018.01.018
– volume: 33
  start-page: 677
  year: 2017
  ident: 7795_CR74
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2017.08.001
SSID ssj0017825
Score 2.3843265
Snippet Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout...
During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life,...
Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout...
Abstract Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and...
SourceID doaj
unpaywall
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 497
SubjectTerms Animal Genetics and Genomics
ATAC-seq
Binding sites
Biomedical and Life Sciences
Cell cycle
Cell Differentiation
Cellular structure
Chi-square test
Chromatin
Chromatin remodeling
CUT&RUN
Deoxyribonucleic acid
Differentiation (biology)
DNA
Embryogenesis
Epithelial cells
Epithelium
Eye lens
Gene expression
Gene regulation
Gene silencing
Genes
Genomes
Genomics
Glycolysis
HIF1α
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Lens, Crystalline
Lenses
Life Sciences
Microarrays
Microbial Genetics and Genomics
Mitochondria
Oxygen
Plant Genetics and Genomics
Proteins
Proteomics
RNA-seq
Statistical tests
Structure-function relationships
Transcription factors
Wnt protein
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3bjtMwELWWrhDwgLgTWJCReGOjjZM4Th4Q6sJWBYkKIVbat8jXpVI3KZtW0M_iR_gmZpzLUoEqXmM7cjwznjPx-AwhL7XjoCdCh4lNOAQomoeFTFUYW82NkQVL_L21j7Nsepp-OONne2TW34XBtMp-T_Qbtak1_iM_Augb51wA4H-z_BZi1Sg8Xe1LaMiutIJ57SnGrpH9GJmxRmT_-GT26fNwrgD-kPdXZ_LsqIHdOUtDTFOIhMCqhVvuybP4_wt6_p1BORyj3iI31tVSbr7LxeIPTzW5Q253EJOOW524S_ZsdY9cb4tObu4TO6bozNp_gPRCLmntKFK1Xsw1nb6fsF8_w3ezMfXJ5vaHbei8ogATqd1YCj6qocj6BH7F0K7ID_VZiTi-obIjOXlATicnX95Ow67YQqgBtK1C8ORaMacYQq6CydQBFFIiZxqCKAU-LMlUajWLFIuFi9McqQgjLlVkC5kJnTwko6qu7GNCFYNXOQNQU2NlY1WkrkhMYpUQhkVOBIT1a1zqjokcC2IsSh-R5FnZyqUEuZReLmURkFfDmGXLw7Gz9zGKbuiJHNr-QX15XnYmWTobs1RnKo-4gbDWFQZGCwcbHnMCYFBADnrBl51hN-WVGgbkxdAMJonnLLKy9Rr7pBA2CwgMA_Ko1ZNhJkmKGCuHFrGlQVtT3W6p5l897TfG8gmHkYe9rl1Na9dSHA76-B8r92T3Rz8lN-PWWsIoOSCj1eXaPgNUtlLPO1P7Dbj6Ml4
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwFLbGEAIeJu4LG8hIvLFAHNtx8jBN5VIVpO2JSnuzbMeGSl3aNa1YfxZ_hN_EsXMZFdXEA6-xT2SdS873xfY5CL02joOfCBNTSzkQFMPjQjEdp9bwslQFoeHe2ulZNhqzL-f8fAd17Y5aBdZbqZ3vJzVeTN9eXa5PIOCPQ8Dn2bsavrEZi_1hg0QI33vwFroNmarwrRxO2fWuAmRD3l2c2Sq3kZxCDf9twPPv85P9Jup9dHdVzdX6h5pO_8hTwwdorwWYeNB4xEO0Y6tH6E7TcnL9GNkB9qms-QOIL9Qczxz2hVovJgaPPg_Jr5_xx7MBDkfN7ZWt8aTCABKxXVsMGarGvuYTZJUSty1-cDiT6OVrrNoSJ0_QePjp64dR3LZaiA1AtmUMedxo4jTxgKsgijkAQlrkxACF0pDBaKaZNSTRJBUuZbkvRJhwpRNbqEwY-hTtVrPK7iOsCbzKlQA0je9rrAvmClpSq4UoSeJEhEinY2naOuS-HcZUBj6SZ7KxiwS7yGAXWUToTS8zb6pw3Dj7vTddP9NX0A4PZotvsg1I6WxKmMl0nvASSK0rSpAWDj53xAkAQRE67AwvO6-UwL_SnAtgnRF61Q9DQPpdFlXZ2crPYUCaBdDCCD1r_KRfCWUeYeUwIjY8aGOpmyPV5Hso-u2ZPOUgedT52vWyblLFUe-P_6C55_9DcwfoXtrEVJzQQ7S7XKzsC0BuS_0yhONvFzU7jQ
  priority: 102
  providerName: Scholars Portal
– databaseName: SpringerLink Journals (ICM)
  dbid: U2A
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwEB7BIgQcEO8NLMhI3NiIOLbj5FgeVUFiT1Tam2U7NlTqptWm1dKfxR_hNzF2HlCxWsG19kSWZ8bzTT3-BuCV9QLtRNqUOSYwQbEirTQ3ae6sqGtdURbfrX0-KWZz_ulUnPaPwtqh2n24kowndXTrsnjT4kla8DSUFGRShg6D1-GGCHReaMXzfDLeHWDME8PzmEvl9kJQZOq_DF7-XSU5XpXegVvbZq13F3q5_CMaTe_B3R5Gkkmn9_twzTUP4GbXWHL3ENyEhIDV_c9HzvSarDwJdKxnC0tmH6f054_0_cmExIJy9921ZNEQhILE7RzBONSSwOyEsaMmfSMfEisPg3xLdE9k8gjm0w9f3s3SvqFCahGYbVKM1tZQb2iAVRXV3CPcMbKkFhMlg3GKFYY7SzNDc-lzXga6wUxok7lKF9Kyx3DQrBp3CMRQ_JSvEU7a0L3YVNxXrGbOSFnTzMsE6LDHyvZs46HpxVLFrKMsVKcXhXpRUS-qSuD1KLPuuDaunP02qG6cGXiy4w-r86-qdzvlXU65LUyZiRpTV1_VKC09HmrUS4Q6CRwNile987YKs6y8FBJzywRejsPoduEuRTdutQ1zOKbGEpO_BJ50djKuhPGAo0ockXsWtLfU_ZFm8S1Se4d8nQmUPB5s7feyrtqK49Ee_2Hnnv7f15_B7bzznjRjR3CwOd-654jENuZFdLxfp6Uo8A
  priority: 102
  providerName: Springer Nature
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwEB5BVwg48H4EFmQkbqy7cV5OjuVRFSQqDlRaTpHt2FDRplXTCsq_4o_wmxjbadjCagUS19hOnMnY840z8w3AU2VS1BOuaKzjFB0UldJCJJJGWqVVJQoWu7y1t-NsNEnenKQnbXq0zYWRc2XJSedT1fRPJ6DPfH6DrZ-gV8fLyvjlnmfHDe6wWUJtqEHIua08eBEOshSReQ8OJuN3gw8uwYgzGqFrsMubOXPgnm1yFP5n4c4_wye7f6hX4fKmXortFzGbnTJTw-sw372gj0753N-sZV99-4378X9J4AZca_EsGXgFvAkXdH0LLvkKl9vboAfEWk5_4EjmYkkWhrQPJqPXQ_bjO305HhAX2a6_6oZMa4KYlOitJmgQG2IpptCIVaStKERcCKSbOBEto8odmAxfvX8xom1lB6oQIa4pwgYlmZHM4ruCicQg7pI8Zwo9NokGM85kohULJYu4iZLc8h6GqZChLkTGVXwXevWi1veBSIa3MhXiWmXLKMsiMUVcxVpyXrHQ8ADY7puWqqU9t9U3ZqVzf_Ks9OIrUXylE19ZBPCsG7P0pB_n9n5uVaXraQm73YXF6mPZrv_S6IglKpN5mFboQ5uiwtHc4O7KDEfMFcDhTtHKdhdpSnT3ojzl6OQG8KRrxvVvf-qIWi82tk-CPjpHLzSAe14vu5nEiQV0ObbwPY3dm-p-Sz395DjG7cFBnOLIo51u_5rWeaI46vT_LyT34N-6P4QrkVdyGsaH0FuvNvoRQsK1fNyu9J-UMVhH
  priority: 102
  providerName: Unpaywall
Title A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
URI https://link.springer.com/article/10.1186/s12864-021-07795-9
https://www.ncbi.nlm.nih.gov/pubmed/34215186
https://www.proquest.com/docview/2552857261
https://www.proquest.com/docview/2548407666
https://pubmed.ncbi.nlm.nih.gov/PMC8254356
https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-021-07795-9
https://doaj.org/article/fe214c6b805d407f9d0777f0111f7129
UnpaywallVersion publishedVersion
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMedCentral
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: RBZ
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: KQ8
  dateStart: 20000701
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: KQ8
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Open Access Journals
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: DOA
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: ABDBF
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: DIK
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: GX1
  dateStart: 0
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: M~E
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: RPM
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVPQU
  databaseName: ProQuest Health & Medical Collection
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: 7X7
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest One Academic
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: BENPR
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 20250331
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: M48
  dateStart: 20000701
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
– providerCode: PRVAVX
  databaseName: Springer Nature HAS Fully OA
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: AAJSJ
  dateStart: 20001201
  isFulltext: true
  titleUrlDefault: https://www.springernature.com
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: Springer Nature OA Free Journals
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: C6C
  dateStart: 20000112
  isFulltext: true
  titleUrlDefault: http://www.springeropen.com/
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: SpringerLink Journals (ICM)
  customDbUrl:
  eissn: 1471-2164
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0017825
  issn: 1471-2164
  databaseCode: U2A
  dateStart: 20001201
  isFulltext: true
  titleUrlDefault: http://www.springerlink.com/journals/
  providerName: Springer Nature
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NjtMwELZgVwg4IP4JLJWRuLHRxrEdO8du2aogbbVCVCony3ZsUambVqQV9LF4EZ6Jcf7YCrRw4BK1tR25M-PMfPH4G4ReW8_BToSNqaMcAIrlca6ZiVNneVHonND63Nr5NJvM2Ps5n18p9RVywhp64EZwJ96lhNnMyIQXAD58XiRCCB9KpHsBzio8fROZd2Cq3T8Av8e7IzIyO6ngKZyxOKQjwOhQnXDPDdVs_X8KMX_PlOy3S--i29tyrXdf9XJ5xSON76N7bSiJh81feIBuuPIhutUUl9w9Qm6Ig9Nq3vXhS73GK48DJevlwuLJuzH58T1-Ox3iOqncfXMVXpQYwkHsdg6DL6pwYHcC_1HgtpgPrrMPw_gK65bM5DGajc8-jiZxW1QhthCcbWLw2NYQb0gIrXKimYeQxwhJLIAlA76KZoY5SxJDUuFTJgPlYMK1SVyuM2HpE3RQrkr3DGFD4Fa-gJDShgrGJmc-pwV1RoiCJF5EiHQyVrZlHA-FL5aqRh4yU41eFOhF1XpReYTe9GPWDd_Gtb1Pg-r6noEru_4BLEi1FqT-ZkEROuoUr9oFXClAWqnkAvBlhF71zbD0wn6KLt1qG_owgMcCAGCEnjZ20s-EshBLSWgRexa0N9X9lnLxuab3Dpidchh53Nnar2ldJ4rj3h7_QXLP_4fkXqA7abOm4oQeoYPNl617CTHaxgzQTTEXA3R4eja9-ADfRtloUC9RuJ4zCddZCp8PZ9OL4aefGXs6Jg
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbhMxELZKK1Q4IP5ZKGAkONFV12vvevdQoZQ2SmgbIdRKvRnba0OkdDd0E5U8Fi_AI_BMjPevRKCIS6-xvXI845lv7PF8CL3WNgI94dqnhkYQoOjITyVTfmh0lGUyJbR6t3Y8igen7MNZdLaGfrZvYVxaZWsTK0OdFdqdke8A9A2TiAPgfzf95jvWKHe72lJoyIZaIdutSow1DzsOzeISQrhyd7gP8n4Thv2Dk_cDv2EZ8DWglZkPLkwrYhVxWCMlklnAAIonREP0oMB401gxo0mgSMhtyBJXgy-IpApMKmOuKXz3BtpglKUQ_G3sHYw-furuMcD_Ru1TnSTeKcEbxMx3aREB544lcckdVqwB_4K6f2dsdte2t9HmPJ_KxaWcTP7wjP276E4DaXGv1sF7aM3k99HNmuRy8QCZHnbOsz5zxOdyiguLXWnY87HGg2Gf_Prh7496uEpuN99Nicc5BliKzcJg8IkldlWmwI9luCEVwlUWpBtfYtkUVXmITq9l2R-h9bzIzROEFYFP2QygrXZMyiplNqUZNYrzjASWe4i0ayx0U_ncEXBMRBUBJbGo5SJALqKSi0g99LYbM63rfqzsvedE1_V0NburH4qLL6IxAcKakDAdqySIMgijbZrBaG7BwBLLAXZ5aKsVvGgMSSmu1N5Dr7pmMAHuXkfmppi7PgzCdA6BqIce13rSzYQyh-kSaOFLGrQ01eWWfPy1KjPuzg5oBCO3W127mtaqpdju9PE_Vu7p6j_9Em0OTo6PxNFwdPgM3QrrneMHdAutzy7m5jkgwpl60Ww7jD5f907_DbGabPI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagCEoPiFdLoICRuNGocWzHyXG7ZbXlseJApd4s27HpStvsqtkV7M_ij_CbGDsPuqKq4Bp7Isszk_kmHn-D0FvjONiJMDG1lEOCYnhcKKbj1BpelqogNNxb-zzJxqfswxk_u3KLP1S7d0eSzZ0Gz9JULQ8XpWtcPM8Oa_iqZiz25QWJEL7b4G10h0F08z0MhtmwP0eA-Me7qzLXym2Eo8Dafx3U_Ltisj823UHbq2qh1t_VbHYlMo0eogctpMSDxgYeoVu2eozuNk0m10-QHWAfvJp_fvhCLfDcYU_NejE1eHwyIr9-xseTAQ7F5faHrfG0wgALsV1bDDGpxp7lCeJIidumPjhUIXr5GquW1OQpOh29_zocx21zhdgASFvGELmNJk4TD7EKopgD6KNFTgwkTRpiFs00s4YkmqTCpSz31IMJVzqxhcqEobtoq5pX9hnCmsCrXAnQ0vhOxrpgrqAltVqIkiRORIh0eyxNyzzuG2DMZMhA8kw2epGgFxn0IosIvetlFg3vxo2zj7zq-pmeMzs8mF9-k60LSmdTwkym84SXkMa6ogRp4eADR5wA2BOh_U7xsnXkWkLGleZcQJ4ZoTf9MLigP1dRlZ2v_BwGabKARDBCe42d9CuhzGOqHEbEhgVtLHVzpJqeB5pvn7tTDpIHna39WdZNW3HQ2-M_7Nzz_3v7a3Tvy_FIfjqZfHyB7qeNI8UJ3Udby8uVfQkAbalfBR_8DXQbMAI
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwEB5BVwg48H4EFmQkbqy7cV5OjuVRFSQqDlRaTpHt2FDRplXTCsq_4o_wmxjbadjCagUS19hOnMnY840z8w3AU2VS1BOuaKzjFB0UldJCJJJGWqVVJQoWu7y1t-NsNEnenKQnbXq0zYWRc2XJSedT1fRPJ6DPfH6DrZ-gV8fLyvjlnmfHDe6wWUJtqEHIua08eBEOshSReQ8OJuN3gw8uwYgzGqFrsMubOXPgnm1yFP5n4c4_wye7f6hX4fKmXortFzGbnTJTw-sw372gj0753N-sZV99-4378X9J4AZca_EsGXgFvAkXdH0LLvkKl9vboAfEWk5_4EjmYkkWhrQPJqPXQ_bjO305HhAX2a6_6oZMa4KYlOitJmgQG2IpptCIVaStKERcCKSbOBEto8odmAxfvX8xom1lB6oQIa4pwgYlmZHM4ruCicQg7pI8Zwo9NokGM85kohULJYu4iZLc8h6GqZChLkTGVXwXevWi1veBSIa3MhXiWmXLKMsiMUVcxVpyXrHQ8ADY7puWqqU9t9U3ZqVzf_Ks9OIrUXylE19ZBPCsG7P0pB_n9n5uVaXraQm73YXF6mPZrv_S6IglKpN5mFboQ5uiwtHc4O7KDEfMFcDhTtHKdhdpSnT3ojzl6OQG8KRrxvVvf-qIWi82tk-CPjpHLzSAe14vu5nEiQV0ObbwPY3dm-p-Sz395DjG7cFBnOLIo51u_5rWeaI46vT_LyT34N-6P4QrkVdyGsaH0FuvNvoRQsK1fNyu9J-UMVhH
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+functional+map+of+genomic+HIF1%CE%B1-DNA+complexes+in+the+eye+lens+revealed+through+multiomics+analysis&rft.jtitle=BMC+genomics&rft.au=Joshua+Disatham&rft.au=Lisa+Brennan&rft.au=Daniel+Chauss&rft.au=Jason+Kantorow&rft.date=2021-07-03&rft.pub=BMC&rft.eissn=1471-2164&rft.volume=22&rft.issue=1&rft.spage=1&rft.epage=20&rft_id=info:doi/10.1186%2Fs12864-021-07795-9&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_fe214c6b805d407f9d0777f0111f7129
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2164&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2164&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2164&client=summon