Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects - Ali, Zahid; Laurijssens, Bart; Ostenfeld, Thor; McHugh, Simon; Stylianou, Anastasia; Scott‐Stevens, Paul; Hosking, Louise; Dewit, Odile; Richardson, Jill C.; Chen, Chao (British journal of clinical pharmacology, 2013)
Keywords: Adult; Aged; Allosteric Regulation; clinical pharmacology; Female; first‐in‐human; GSK1482160; Humans; Il‐1β; Interleukin-1beta - biosynthesis; Male; Middle Aged; P2X7 receptor; Pharmacokinetic Dynamic Relationships; Pilot Projects; population pharmacokinetic‐pharmacodynamic modelling; Receptors, Purinergic P2X7 - drug effects; Single-Blind Method