A Polygenic Risk Score to Refine Risk Stratification and Prediction for Severe Liver Disease by Clinical Fibrosis Scores - De Vincentis, Antonio; Tavaglione, Federica; Jamialahmadi, Oveis; Picardi, Antonio; Antonelli Incalzi, Raffaele; Valenti, Luca; Romeo, Stefano; Vespasiani-Gentilucci, Umberto (Clinical gastroenterology and hepatology, 2022)
Keywords: Cardiology and Cardiovascular Disease; Fibrosis; Gastroenterology and Hepatology; Genetics; Humans; Kardiologi och kardiovaskulära sjukdomar; Liver - pathology; Liver Cirrhosis - diagnosis; Liver Neoplasms - pathology; Non-alcoholic Fatty Liver Disease - epidemiology; Nonalcoholic Fatty Liver Disease (NAFLD); PNPLA3; Prospective Studies; Risk Assessment; Risk Factors; UK Biobank; FLI; NAFLD; PRS2; AUROC; HCC; aHR; HR; SLD; Nonalcoholic Fatty Liver Disease (NAFLD); PRS-HFC; PNPLA3; APRI; Genetics; FIB-4; NFS; UK Biobank; BMI; severe liver disease; adjusted hazard ratio; simplified version of the polygenic risk score-hepatic fat content; polygenic risk score-hepatic fat content; aspartate aminotransferase–to–platelet ratio; hepatocellular carcinoma; nonalcoholic fatty liver disease fibrosis score; area under the receiver operating characteristic; body mass index; Fibrosis-4; fatty liver index; nonalcoholic fatty liver disease; hazard ratio