Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis - Liesenfeld, Karl‐Heinz; Schäfer, Hans G.; Trocóniz, Iñaki F.; Tillmann, Christiane; Eriksson, Bengt I.; Stangier, Joachim (British journal of clinical pharmacology, 2006)
Keywords: 80 and over; Aged; Aged, 80 and over; Anticoagulants - therapeutic use; Arthroplasty; Arthroplasty, Replacement, Hip - methods; Benzimidazoles - therapeutic use; Biological and medical sciences; Blood Coagulation - drug effects; coagulation time; Dabigatran; dabigatran etexilate; direct thrombin inhibitor; Dose-Response Relationship; Dose-Response Relationship, Drug; Drug; Female; Hip/methods; Humans; Kirurgi; Male; Medical sciences; Middle Aged; Pharmacodynamics; Pharmacology. Drug treatments; Pyridines - therapeutic use; Replacement; Surgery; Thrombin - antagonists & inhibitors; Thromboembolism - prevention & control; total hip replacement; Human; Blood coagulation; Serine endopeptidases; Enzyme; Enzyme inhibitor; total hip replacement; Patient; Thrombin; Anticoagulant; Dabigatran etexilate; coagulation time; direct thrombin inhibitor; Peptidases; In vivo; Hip prosthesis; Orthopedic surgery; Treatment; Ex vivo; Antithrombotic agent; Hydrolases; Models