Effects of Food, Gastric Acid Reduction, and Strong CYP3A Induction on the Pharmacokinetics of Tasurgratinib, a Novel Selective Fibroblast Growth Factor Receptor Inhibitor - Nomoto, Maiko; Hasunuma, Tomoko; Cai, Cuiyuan; Suzuki, Ippei; Mikubo, Ayano; Funasaka, Setsuo; Otake, Yohei; Nakai, Kenya; Yasuda, Sanae (Journal of clinical pharmacology, 2024)
Keywords: Adult; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inducers - pharmacology; Drug Interactions; drug‐drug interactions; Fasting - metabolism; Female; FGFR; food effect; Food-Drug Interactions; Gastric Acid - metabolism; Humans; Male; Middle Aged; pharmacokinetics; Pyrroles; Rabeprazole - administration & dosage; Rabeprazole - pharmacokinetics; Rabeprazole - pharmacology; Receptors, Fibroblast Growth Factor - antagonists & inhibitors; Rifampin - pharmacokinetics; Rifampin - pharmacology; Sulfonamides - administration & dosage; Sulfonamides - pharmacokinetics; tasurgratinib; Young Adult; pharmacokinetics; tasurgratinib; drug‐drug interactions; food effect; FGFR