Cooperative Involvement of the S1 and S2 Subunits of the Murine Coronavirus Spike Protein in Receptor Binding and Extended Host Range

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Published inJournal of Virology Vol. 80; no. 22; pp. 10909 - 10918
Main Authors de Haan, Cornelis A. M., te Lintelo, Eddie, Li, Zhen, Raaben, Matthijs, Wurdinger, Tom, Bosch, Berend Jan, Rottier, Peter J. M.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2006
Subjects
Amino Acid Substitution
Animals
Biological and medical sciences
Carcinoembryonic Antigen - metabolism
Cats
Cell Line
Coronavirus
Fundamental and applied biological sciences. Psychology
Genes, Reporter
Heparitin Sulfate
Humans
Luciferases - analysis
Luciferases - genetics
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Mice
Microbiology
Murine coronavirus
Murine hepatitis virus
Murine hepatitis virus - genetics
Murine hepatitis virus - physiology
Mutation, Missense
Protein Binding
Receptors, Virus - metabolism
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins - genetics
Viral Envelope Proteins - metabolism
Virology
Virus Attachment
Virus-Cell Interactions
Zelus
Virus
Ligand binding
Coronavirus
Host range
Coronaviridae
Subunit
Host virus relation
Spicule
Nidovirales
Protein
Murine hepatitis virus
Online AccessGet full text
ISSN0022-538X
1098-5514
DOI10.1128/JVI.00950-06

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Present address: Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Science, Beidi Road 2901, Shanghai 201106, People's Republic of China.
Corresponding author. Mailing address: Virology Division, Department of Infectious Diseases and Immunology, Yalelaan 1, 3584 CL Utrecht, The Netherlands. Phone: 31-30-2534195. Fax: 31-30-2536723. E-mail: c.a.m.dehaan@vet.uu.nl.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00950-06