Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children

This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed...

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Published inScientific reports Vol. 14; no. 1; pp. 31940 - 12
Main Authors Watanabe, Daisuke, Otawa, Sanae, Kushima, Megumi, Yui, Hideki, Shinohara, Ryoji, Yamagata, Zentaro, Sakurai, Daiju, Miyake, Kunio
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.12.2024
Nature Publishing Group
Nature Portfolio
Subjects
692/308/174
692/700/478/174
Allergens
Allergens - immunology
Allergic rhinitis
Allergies
Animals
Child
Children
Cryptomeria - immunology
Female
Hay fever
House dust
Humanities and Social Sciences
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunoglobulins
Japan - epidemiology
Male
multidisciplinary
Pollen
Pollen - immunology
Pyroglyphidae - immunology
Quality of Life
Rhinitis
Rhinitis, Allergic - epidemiology
Rhinitis, Allergic - immunology
School-aged children
Science
Science (multidisciplinary)
Seasonal allergic rhinitis (SAR)
Severity
Specific IgE antibodies
Japan
Seasonal allergic rhinitis (SAR)
Severity
School-aged children
Allergic rhinitis
Specific IgE antibodies
Quality of life
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-024-83471-8

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Abstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.
AbstractList This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.
This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.
Abstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.
ArticleNumber 31940
Author Miyake, Kunio
Yui, Hideki
Kushima, Megumi
Yamagata, Zentaro
Sakurai, Daiju
Watanabe, Daisuke
Shinohara, Ryoji
Otawa, Sanae
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Issue 1
Keywords Seasonal allergic rhinitis (SAR)
Severity
School-aged children
Allergic rhinitis
Specific IgE antibodies
Quality of life
Language English
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Snippet This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in...
Abstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in...
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StartPage 31940
SubjectTerms 692/308/174
692/700/478/174
Allergens
Allergens - immunology
Allergic rhinitis
Allergies
Animals
Child
Children
Cryptomeria - immunology
Female
Hay fever
House dust
Humanities and Social Sciences
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunoglobulins
Japan - epidemiology
Male
multidisciplinary
Pollen
Pollen - immunology
Pyroglyphidae - immunology
Quality of Life
Rhinitis
Rhinitis, Allergic - epidemiology
Rhinitis, Allergic - immunology
School-aged children
Science
Science (multidisciplinary)
Seasonal allergic rhinitis (SAR)
Severity
Specific IgE antibodies
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Title Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children
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https://www.nature.com/articles/s41598-024-83471-8.pdf
https://doaj.org/article/0081d9a1edf440db9e1ed84bcafb654e
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