Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish

The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish....

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Published inCommunications biology Vol. 2; no. 1; p. 364
Main Authors Mano, Hiroaki, Asaoka, Yoichi, Kojima, Daisuke, Fukada, Yoshitaka
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 07.10.2019
Nature Publishing Group
Subjects
13/31
14/19
38/39
38/77
38/90
631/181/2806
631/378/2571/2573
631/378/2613/1786
631/378/87
64/116
Animals
Animals, Genetically Modified
Biology
Biomedical and Life Sciences
Danio rerio
Ectopic expression
Endocrine system
Gene expression
Gene Expression Regulation, Developmental
Homeobox
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Life Sciences
Otx Transcription Factors - metabolism
PAX6 Transcription Factor - metabolism
Pineal gland
Pineal Gland - cytology
Pineal Gland - growth & development
Pineal Gland - metabolism
Promoter Regions, Genetic
Retina
Rhodopsin - metabolism
Trans-Activators - metabolism
Transcription Factors - metabolism
Zebrafish
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
Cell type diversity
Retina
Cellular neuroscience
Evolutionary developmental biology
Online AccessGet full text
ISSN2399-3642
2399-3642
DOI10.1038/s42003-019-0613-1

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Abstract The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh , the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho , a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis -element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level. Hiroaki Mano et al. show that brain-specific homeobox, Bsx, is a regulator in pineal gland development. They show that Bsx depletion in zebrafish reduces the expression of a pineal-specific gene responsible for photoreception, affecting the identity of pineal photoreceptive neurons.
AbstractList The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh , the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho , a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis -element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of , the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of , a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA -element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis-element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.Hiroaki Mano et al. show that brain-specific homeobox, Bsx, is a regulator in pineal gland development. They show that Bsx depletion in zebrafish reduces the expression of a pineal-specific gene responsible for photoreception, affecting the identity of pineal photoreceptive neurons.
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis-element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis-element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh , the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho , a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis -element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level. Hiroaki Mano et al. show that brain-specific homeobox, Bsx, is a regulator in pineal gland development. They show that Bsx depletion in zebrafish reduces the expression of a pineal-specific gene responsible for photoreception, affecting the identity of pineal photoreceptive neurons.
ArticleNumber 364
Author Kojima, Daisuke
Fukada, Yoshitaka
Asaoka, Yoichi
Mano, Hiroaki
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Issue 1
Keywords Cell type diversity
Retina
Cellular neuroscience
Evolutionary developmental biology
Language English
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Snippet The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox...
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springer
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Animals
Animals, Genetically Modified
Biology
Biomedical and Life Sciences
Danio rerio
Ectopic expression
Endocrine system
Gene expression
Gene Expression Regulation, Developmental
Homeobox
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Life Sciences
Otx Transcription Factors - metabolism
PAX6 Transcription Factor - metabolism
Pineal gland
Pineal Gland - cytology
Pineal Gland - growth & development
Pineal Gland - metabolism
Promoter Regions, Genetic
Retina
Rhodopsin - metabolism
Trans-Activators - metabolism
Transcription Factors - metabolism
Zebrafish
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Title Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish
URI https://link.springer.com/article/10.1038/s42003-019-0613-1
https://www.ncbi.nlm.nih.gov/pubmed/31602413
https://www.proquest.com/docview/2389679295
https://www.proquest.com/docview/2305039782
https://pubmed.ncbi.nlm.nih.gov/PMC6779754
Volume 2
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