Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available...
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Published in | Hepatology international Vol. 10; no. 1; pp. 1 - 98 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New Delhi
Springer India
01.01.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
ISSN | 1936-0533 1936-0541 1936-0541 |
DOI | 10.1007/s12072-015-9675-4 |
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Abstract | Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts’ personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information. |
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AbstractList | Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information. Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information.Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information. |
Author | Sollano, J. Chan, H. L. Y. Sharma, B. C. Sarin, S. K. Chen, H. L. Chen, C. J. Kim, J. H. Al Mahtab, M. Liu, C. J. Wang, F. S. Kumar, M. Zheng, S. S. Lau, G. K. Dokmeci, A. K. Locarnini, S. Omata, M. Piratvisuth, T. Abbas, Z. Chen, P. J. Jia, J. Wei, L. Lai, C. L. Jafri, W. Gane, Ed Chien, R. N. Hou, J. L. Mohamed, R. Lee, H. C. Park, J. Lim, S. G. Chen, D. S. Yuen, M. F. Kao, J. H. |
Author_xml | – sequence: 1 givenname: S. K. surname: Sarin fullname: Sarin, S. K. email: shivsarin@gmail.com organization: Department of Hepatology, Institute of Liver and Biliary Sciences – sequence: 2 givenname: M. surname: Kumar fullname: Kumar, M. organization: Department of Hepatology, Institute of Liver and Biliary Sciences – sequence: 3 givenname: G. K. surname: Lau fullname: Lau, G. K. organization: Division of Gastroenterology and Hepatology, Humanity and Health Medical Centre, The Institute of Translational Hepatology – sequence: 4 givenname: Z. surname: Abbas fullname: Abbas, Z. organization: Department of Hepatogastroenterlogy, Sindh Institute of Urology and Transplantation – sequence: 5 givenname: H. L. Y. surname: Chan fullname: Chan, H. L. Y. organization: Institute of Digestive Disease, The Chinese University of Hong Kong – sequence: 6 givenname: C. J. surname: Chen fullname: Chen, C. J. organization: Genomics Research Center, Academia Sinica, National Taiwan University – sequence: 7 givenname: D. S. surname: Chen fullname: Chen, D. S. organization: Department of Internal Medicine, National Taiwan University College of Medicine – sequence: 8 givenname: H. L. surname: Chen fullname: Chen, H. L. organization: Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine – sequence: 9 givenname: P. J. surname: Chen fullname: Chen, P. J. organization: Department of Internal Medicine, National Taiwan University Hospital – sequence: 10 givenname: R. N. surname: Chien fullname: Chien, R. N. organization: Liver Research Unit, Chang Gung Memorial Hospital and University – sequence: 11 givenname: A. K. surname: Dokmeci fullname: Dokmeci, A. K. organization: Department of Gastroenterology, Ankara University School of Medicine – sequence: 12 givenname: Ed surname: Gane fullname: Gane, Ed organization: New Zealand Liver Transplant Unit, Auckland City Hospital – sequence: 13 givenname: J. L. surname: Hou fullname: Hou, J. L. organization: Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital – sequence: 14 givenname: W. surname: Jafri fullname: Jafri, W. organization: Department of Medicine, Aga Khan University – sequence: 15 givenname: J. surname: Jia fullname: Jia, J. organization: Beijing Friendship Hospital, Capital Medical University – sequence: 16 givenname: J. H. surname: Kim fullname: Kim, J. H. – sequence: 17 givenname: C. L. surname: Lai fullname: Lai, C. L. organization: Department of Medicine, University of Hong Kong – sequence: 18 givenname: H. C. surname: Lee fullname: Lee, H. C. organization: Internal Medicine Asan Medical Center – sequence: 19 givenname: S. G. surname: Lim fullname: Lim, S. G. organization: Division of Gastroenterology and Hepatology, National University Health System – sequence: 20 givenname: C. J. surname: Liu fullname: Liu, C. J. organization: Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine – sequence: 21 givenname: S. surname: Locarnini fullname: Locarnini, S. organization: Research and Molecular Development, Victorian Infectious Diseases Reference Laboratory – sequence: 22 givenname: M. surname: Al Mahtab fullname: Al Mahtab, M. organization: Bangabandhu Sheikh Mujib Medical University – sequence: 23 givenname: R. surname: Mohamed fullname: Mohamed, R. organization: Department of Medicine, Faculty of Medicine, University Malaya – sequence: 24 givenname: M. surname: Omata fullname: Omata, M. organization: Yamanashi Hospitals (Central and Kita) Organization – sequence: 25 givenname: J. surname: Park fullname: Park, J. organization: Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine – sequence: 26 givenname: T. surname: Piratvisuth fullname: Piratvisuth, T. organization: NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University – sequence: 27 givenname: B. C. surname: Sharma fullname: Sharma, B. C. organization: Department of Gastroenterology, G.B. Pant Hospital – sequence: 28 givenname: J. surname: Sollano fullname: Sollano, J. organization: Department of Medicine, University of Santo Tomas – sequence: 29 givenname: F. S. surname: Wang fullname: Wang, F. S. organization: Treatment and Research Center for Infectious Diseases, Beijing 302 Hospital – sequence: 30 givenname: L. surname: Wei fullname: Wei, L. organization: Peking University Hepatology Institute – sequence: 31 givenname: M. F. surname: Yuen fullname: Yuen, M. F. organization: Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong – sequence: 32 givenname: S. S. surname: Zheng fullname: Zheng, S. S. organization: Department of Hepatobiliary and Pancreatic Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine – sequence: 33 givenname: J. H. surname: Kao fullname: Kao, J. H. organization: Graduate Institute of Clinical Medicine and Hepatitis Research Center, National Taiwan University College of Medicine, National Taiwan University Hospital |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26563120$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Acute Disease Africa Antiviral Agents - therapeutic use Asia Colorectal Surgery Disease Management Female Guidelines Hepatitis B - diagnosis Hepatitis B - therapy Hepatitis B virus - isolation & purification Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - therapy Hepatology Humans Male Medicine Medicine & Public Health Surgery |
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Title | Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update |
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