Physical activity and cancer risk. Actual knowledge and possible biological mechanisms

Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like gr...

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Published inRadiology and oncology Vol. 55; no. 1; pp. 7 - 17
Main Author Jurdana, Mihaela
Format Journal Article
LanguageEnglish
Published Poland Sciendo 12.01.2021
De Gruyter Poland
Subjects
Adiponectin
biological mechanisms
Breast cancer
Cancer
Colon
Colon cancer
Cytokines
Exercise
Growth factors
Health risks
Hormones
Hyperinsulinemia
Immune response
Inflammation
Insulin
Insulin-like growth factor I
Leptin
Microbiota
Physical activity
pro-inflammatory and anti-inflammatory cytokines
Review
Sex hormones
cancer
biological mechanisms
pro-inflammatory and anti-inflammatory cytokines
physical activity
Online AccessGet full text
ISSN1581-3207
1318-2099
1581-3207
0485-893X
DOI10.2478/raon-2020-0063

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Abstract Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations. There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.
AbstractList Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations.
Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations. There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.
Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations.BACKGROUNDScientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations.There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.CONCLUSIONSThere is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.
Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations.Conclusions There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.
Author Jurdana, Mihaela
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Copyright 2021 Mihaela Jurdana, published by Sciendo.
2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 Mihaela Jurdana, published by Sciendo 2021 Mihaela Jurdana, published by Sciendo
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Keywords cancer
biological mechanisms
pro-inflammatory and anti-inflammatory cytokines
physical activity
Language English
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Snippet Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential...
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SubjectTerms Adiponectin
biological mechanisms
Breast cancer
Cancer
Colon
Colon cancer
Cytokines
Exercise
Growth factors
Health risks
Hormones
Hyperinsulinemia
Immune response
Inflammation
Insulin
Insulin-like growth factor I
Leptin
Microbiota
Physical activity
pro-inflammatory and anti-inflammatory cytokines
Review
Sex hormones
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Title Physical activity and cancer risk. Actual knowledge and possible biological mechanisms
URI https://www.degruyter.com/doi/10.2478/raon-2020-0063
https://www.ncbi.nlm.nih.gov/pubmed/33885236
https://www.proquest.com/docview/2479957067
https://www.proquest.com/docview/2516839677
https://pubmed.ncbi.nlm.nih.gov/PMC7877262
https://doaj.org/article/b9ca03f160ad4c89bd929dbf0fcb9d19
Volume 55
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