ESX-5-targeted export of ESAT-6 in BCG combines enhanced immunogenicity & efficacy against murine tuberculosis with low virulence and reduced persistence - Heijmenberg, Isis; Husain, Aliabbas; Sathkumara, Harindra D.; Muruganandah, Visai; Seifert, Julia; Miranda-Hernandez, Socorro; Kashyap, Rajpal Singh; Field, Matt A.; Krishnamoorthy, Gopinath; Kupz, Andreas (Vaccine, 2021)
Keywords: Allergy and Immunology; Animal models; Animals; Antigens; Antigens, Bacterial - genetics; Bacterial Proteins - genetics; BCG; BCG Vaccine; Biomedical materials; death; Diabetes; ESAT-6; ESAT-6 antigen; exports; Genes; Genomes; HIV; Human immunodeficiency virus; humans; Immunogenicity; In vivo methods and tests; Infections; live vaccines; Live-attenuated; lungs; Lymphocytes; Lymphocytes T; Mice; Mucosa; Mycobacterium tuberculosis; people; Proteins; Recombinant; secretion; Tuberculosis; Tuberculosis - prevention & control; Tuberculosis Vaccines; Vaccine; Vaccines; Virulence; Vaccine; Tuberculosis; ESAT-6; BCG; Recombinant; Live-attenuated