Risk factors and long-term health consequences of macrosomia：a prospective study in Jiangsu Province,China
We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of...
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| Published in | Journal of biomedical research Vol. 26; no. 4; pp. 235 - 240 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
Elsevier B.V
01.07.2012
Editorial Department of Journal of Biomedical Research |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8301 |
| DOI | 10.7555/JBR.26.20120037 |
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| Abstract | We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. |
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| AbstractList | We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age of the macrosomia group was 24.74±3.32 years, which is slightly older than that in the control group (24.35±3.14 years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.75±2.81 kg/m 2 , which was also higher than that in the control group (21.76±2.59 kg/m 2 , P = 0.000). About 64.6% of macrosomic neonates were males, compared with 51.0% in the control group ( P = 0.000). Compared with women with normal weight (BMI: 18.5-23.9 kg/m 2 ), women who were overweight (BMI: 24-27.9 kg/m 2 ) or obese (BMI≥28 kg/m 2 ), respectively, had a 1.69-fold ( P = 0.000) and a 1.49-fold ( P = 0.000) increased risks of having a neonate with macrosomia, while light weight (BMI<18.5 kg/m 2 ) women had an approximately 50% reduction of the risk. Furthermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity at the age of 7 years ( P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age of the macrosomia group was 24.74±3.32 years, which is slightly older than that in the control group (24.35±3.14 years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.75±2.81 kg/m(2), which was also higher than that in the control group (21.76±2.59 kg/m(2), P = 0.000). About 64.6% of macrosomic neonates were males, compared with 51.0% in the control group (P = 0.000). Compared with women with normal weight (BMI: 18.5-23.9 kg/m(2)), women who were overweight (BMI: 24-27.9 kg/m(2)) or obese (BMI≥28 kg/m(2)), respectively, had a 1.69-fold (P = 0.000) and a 1.49-fold (P = 0.000) increased risks of having a neonate with macrosomia, while light weight (BMI<18.5 kg/m(2)) women had an approximately 50% reduction of the risk. Furthermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity at the age of 7 years (P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age of the macrosomia group was 24.74±3.32 years, which is slightly older than that in the control group (24.35±3.14 years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.75±2.81 kg/m(2), which was also higher than that in the control group (21.76±2.59 kg/m(2), P = 0.000). About 64.6% of macrosomic neonates were males, compared with 51.0% in the control group (P = 0.000). Compared with women with normal weight (BMI: 18.5-23.9 kg/m(2)), women who were overweight (BMI: 24-27.9 kg/m(2)) or obese (BMI≥28 kg/m(2)), respectively, had a 1.69-fold (P = 0.000) and a 1.49-fold (P = 0.000) increased risks of having a neonate with macrosomia, while light weight (BMI<18.5 kg/m(2)) women had an approximately 50% reduction of the risk. Furthermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity at the age of 7 years (P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood.We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age of the macrosomia group was 24.74±3.32 years, which is slightly older than that in the control group (24.35±3.14 years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.75±2.81 kg/m(2), which was also higher than that in the control group (21.76±2.59 kg/m(2), P = 0.000). About 64.6% of macrosomic neonates were males, compared with 51.0% in the control group (P = 0.000). Compared with women with normal weight (BMI: 18.5-23.9 kg/m(2)), women who were overweight (BMI: 24-27.9 kg/m(2)) or obese (BMI≥28 kg/m(2)), respectively, had a 1.69-fold (P = 0.000) and a 1.49-fold (P = 0.000) increased risks of having a neonate with macrosomia, while light weight (BMI<18.5 kg/m(2)) women had an approximately 50% reduction of the risk. Furthermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity at the age of 7 years (P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age of the macrosomia group was 24.74±3.32 years, which is slightly older than that in the control group (24.35±3.14 years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.75±2.81 kg/m2, which was also higher than that in the control group (21.76±2.59 kg/m2, P = 0.000). About 64.6% of macrosomic ne-onates were males, compared with 51.0% in the control group (P = 0.000). Compared with women with normal weight (BMI: 18.5-23.9 kg/m2), women who were overweight (BMI: 24-27.9 kg/m2) or obese (BMI≥28 kg/m2), respectively, had a 1.69-fold (P = 0.000) and a 1.49-fold (P = 0.000) increased risks of having a neonate with macrosomia, while light weight (BMI<18.5 kg/m2) women had an approximately 50% reduction of the risk. Fur-thermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity at the age of 7 years (P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. |
| Author | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen |
| AuthorAffiliation | Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 210029,Chin Department of Endocrinology,Jiangsu Province Hospital of Chinese Medicine,Nanjing,Jiangsu 210029,China Department of Science and Technology,Jiangsu Population and Family Planning Committee,Nanjing,Jiangsu 210008,China Genitalia Hygiene Research Center,Jiangsu Institute of Planned Parenthood Research,Nanjing,Jiangsu 210036,Chin |
| AuthorAffiliation_xml | – name: b Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, China – name: a Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – name: c Department of Science and Technology, Jiangsu Population and Family Planning Committee, Nanjing, Jiangsu 210008, China – name: d Genitalia Hygiene Research Center, Jiangsu Institute of Planned Parenthood Research, Nanjing, Jiangsu 210036, China |
| Author_xml | – sequence: 1 givenname: Shouyong surname: Gu fullname: Gu, Shouyong organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 2 givenname: Xiaofei surname: An fullname: An, Xiaofei organization: Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, China – sequence: 3 givenname: Liang surname: Fang fullname: Fang, Liang organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 4 givenname: Xiaomin surname: Zhang fullname: Zhang, Xiaomin organization: Department of Science and Technology, Jiangsu Population and Family Planning Committee, Nanjing, Jiangsu 210008, China – sequence: 5 givenname: Chunyan surname: Zhang fullname: Zhang, Chunyan organization: Department of Science and Technology, Jiangsu Population and Family Planning Committee, Nanjing, Jiangsu 210008, China – sequence: 6 givenname: Jingling surname: Wang fullname: Wang, Jingling organization: Department of Science and Technology, Jiangsu Population and Family Planning Committee, Nanjing, Jiangsu 210008, China – sequence: 7 givenname: Qilan surname: Liu fullname: Liu, Qilan organization: Genitalia Hygiene Research Center, Jiangsu Institute of Planned Parenthood Research, Nanjing, Jiangsu 210036, China – sequence: 8 givenname: Yanfang surname: Zhang fullname: Zhang, Yanfang organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 9 givenname: Yongyue surname: Wei fullname: Wei, Yongyue organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 10 givenname: Zhibin surname: Hu fullname: Hu, Zhibin organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 11 givenname: Feng surname: Chen fullname: Chen, Feng organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China – sequence: 12 givenname: Hongbing surname: Shen fullname: Shen, Hongbing email: hbshen@njmu.edu.cn organization: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23554754$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2012 The Editorial Board of Journal of Biomedical Research 2012 by the Journal of Biomedical Research. All rights reserved. 2012 |
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| Keywords | health consequences risk factors macrosomia long-term |
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| Notes | Shouyong Gu a,Xiaofei An b,Liang Fang a,Xiaomin Zhang c,Chunyan Zhang c,Jingling Wang c,Qilan Liu d,Yanfang Zhang a,Yongyue Wei a,Zhibin Hu a,Feng Chen a,Hongbing Shen a,（ a Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 210029,China;b Department of Endocrinology,Jiangsu Province Hospital of Chinese Medicine,Nanjing,Jiangsu 210029,China;c Department of Science and Technology,Jiangsu Population and Family Planning Committee,Nanjing,Jiangsu 210008,China;d Genitalia Hygiene Research Center,Jiangsu Institute of Planned Parenthood Research,Nanjing,Jiangsu 210036,China.） 32-1810/R risk factors； long-term； health consequences； macrosomia We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors reported no conflict of interest. |
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| Snippet | We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A... We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years. A... |
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| SubjectTerms | BMI health consequences long-term macrosomia Research Paper risk factors 中国 健康 孕产妇 平均年龄 早期妊娠 江苏省 风险因素 |
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| Title | Risk factors and long-term health consequences of macrosomia：a prospective study in Jiangsu Province,China |
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