Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling - Byrne, Nikole J.; Koentges, Christoph; Khan, Elisabeth; Pfeil, Katharina; Sandulescu, Robert; Bakshi, Sayan; Költgen, Carolin; Vosko, Ivan; Gollmer, Johannes; Rathner, Thomas; Roth, Günter; Hoffmann, Michael M.; et al. (Journal of Molecular and Cellular Cardiology Plus (Online), 2025)
Keywords: Fibrosis; Heart failure; Original; Oxidative stress; Reactive oxygen species; SIRT4; Sirtuin; MnSOD/SOD2; LVID; MVO2; PLOD3; HR; LV; MTPΑ; ADP; GPX; HW; NPPB; 4-HNE; LOXL; MitoQ; NPPA; Heart failure; EF; POSTN; GPX1; SIRT4; CYBB; CYBA; DCM; ACTA2; MMP; LVPW; TGF; TMX1; CAT; ROS; Fibrosis; CGRP; PPIA; RCP; SIRT; ERK; Oxidative stress; Ac; Reactive oxygen species; MAOB; MAOA; PXN; TGFB; EsV; FS; PRDX3; ANT2; BW; FRZB; PDH; IL-2RΒ; WT; XDH; COL; LVAW; SV; d; FN1; CO; CTGF/CCN2; Sirtuin; MCD; WGA; EGR; FZD; s; FAO; EdV; SFRP; TAC; TGIF; CYPA; NOX4; TGFBI; VIM; ATP; HF; BMPR1A; TIMP