Severity grading system for acute allergic reactions: A multidisciplinary Delphi study
There is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research. The aim of this study was to develop a severity grading system for a...
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| Published in | Journal of allergy and clinical immunology Vol. 148; no. 1; pp. 173 - 181 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.07.2021
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1097-6825 |
| DOI | 10.1016/j.jaci.2021.01.003 |
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| Abstract | There is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research.
The aim of this study was to develop a severity grading system for acute allergic reactions for use in clinical care and research.
From May to September 2020, we convened a 21-member multidisciplinary panel of allergy and emergency care experts; 9 members formed a writing group to critically appraise and assess the strengths and limitations of prior severity grading systems and develop the structure and content for an optimal severity grading system. The entire study panel then revised the grading system and sought consensus by utilizing Delphi methodology.
The writing group recommended that an optimal grading system encompass the severity of acute allergic reactions on a continuum from mild allergic reactions to anaphylactic shock. Additionally, the severity grading system must be able to discriminate between clinically important differences in reaction severity to be relevant in research while also being intuitive and straightforward to apply in clinical care. Consensus was reached for all elements of the proposed severity grading system.
We developed a consensus severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions. Successful international validation, refinement, dissemination, and application of the grading system will improve communication among providers and patients about the severity of allergic reactions and will help advance future research. |
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| AbstractList | There is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research.BACKGROUNDThere is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research.The aim of this study was to develop a severity grading system for acute allergic reactions for use in clinical care and research.OBJECTIVEThe aim of this study was to develop a severity grading system for acute allergic reactions for use in clinical care and research.From May to September 2020, we convened a 21-member multidisciplinary panel of allergy and emergency care experts; 9 members formed a writing group to critically appraise and assess the strengths and limitations of prior severity grading systems and develop the structure and content for an optimal severity grading system. The entire study panel then revised the grading system and sought consensus by utilizing Delphi methodology.METHODSFrom May to September 2020, we convened a 21-member multidisciplinary panel of allergy and emergency care experts; 9 members formed a writing group to critically appraise and assess the strengths and limitations of prior severity grading systems and develop the structure and content for an optimal severity grading system. The entire study panel then revised the grading system and sought consensus by utilizing Delphi methodology.The writing group recommended that an optimal grading system encompass the severity of acute allergic reactions on a continuum from mild allergic reactions to anaphylactic shock. Additionally, the severity grading system must be able to discriminate between clinically important differences in reaction severity to be relevant in research while also being intuitive and straightforward to apply in clinical care. Consensus was reached for all elements of the proposed severity grading system.RESULTSThe writing group recommended that an optimal grading system encompass the severity of acute allergic reactions on a continuum from mild allergic reactions to anaphylactic shock. Additionally, the severity grading system must be able to discriminate between clinically important differences in reaction severity to be relevant in research while also being intuitive and straightforward to apply in clinical care. Consensus was reached for all elements of the proposed severity grading system.We developed a consensus severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions. Successful international validation, refinement, dissemination, and application of the grading system will improve communication among providers and patients about the severity of allergic reactions and will help advance future research.CONCLUSIONWe developed a consensus severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions. Successful international validation, refinement, dissemination, and application of the grading system will improve communication among providers and patients about the severity of allergic reactions and will help advance future research. There is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research. The aim of this study was to develop a severity grading system for acute allergic reactions for use in clinical care and research. From May to September 2020, we convened a 21-member multidisciplinary panel of allergy and emergency care experts; 9 members formed a writing group to critically appraise and assess the strengths and limitations of prior severity grading systems and develop the structure and content for an optimal severity grading system. The entire study panel then revised the grading system and sought consensus by utilizing Delphi methodology. The writing group recommended that an optimal grading system encompass the severity of acute allergic reactions on a continuum from mild allergic reactions to anaphylactic shock. Additionally, the severity grading system must be able to discriminate between clinically important differences in reaction severity to be relevant in research while also being intuitive and straightforward to apply in clinical care. Consensus was reached for all elements of the proposed severity grading system. We developed a consensus severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions. Successful international validation, refinement, dissemination, and application of the grading system will improve communication among providers and patients about the severity of allergic reactions and will help advance future research. BackgroundThere is no widely adopted severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions, thus limiting the ability to optimize and standardize management practices and advance research.ObjectiveThe aim of this study was to develop a severity grading system for acute allergic reactions for use in clinical care and research.MethodsFrom May to September 2020, we convened a 21-member multidisciplinary panel of allergy and emergency care experts; 9 members formed a writing group to critically appraise and assess the strengths and limitations of prior severity grading systems and develop the structure and content for an optimal severity grading system. The entire study panel then revised the grading system and sought consensus by utilizing Delphi methodology.ResultsThe writing group recommended that an optimal grading system encompass the severity of acute allergic reactions on a continuum from mild allergic reactions to anaphylactic shock. Additionally, the severity grading system must be able to discriminate between clinically important differences in reaction severity to be relevant in research while also being intuitive and straightforward to apply in clinical care. Consensus was reached for all elements of the proposed severity grading system.ConclusionWe developed a consensus severity grading system for acute allergic reactions, including anaphylactic and nonanaphylactic reactions. Successful international validation, refinement, dissemination, and application of the grading system will improve communication among providers and patients about the severity of allergic reactions and will help advance future research. |
| Author | Schneider, Lynda C. Wang, Julie Zhang, Yin Capucilli, Peter S. Rudders, Susan A. Castells, Mariana Risma, Kimberly A. Dribin, Timothy E. Lee, Juhee Campbell, Ronna L. Mistry, Rakesh D. Sampson, Hugh A. Shaker, Marcus Vyles, David Witry, John K. Michelson, Kenneth A. Schnadower, David Camargo, Carlos A. Pistiner, Michael Spergel, Jonathan M. Neuman, Mark I. Brousseau, David C. Assa’ad, Amal H. |
| AuthorAffiliation | f Dartmouth-Hitchcock Medical Center, Hanover m Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center h Department of Pediatrics, Harvard Medical School, Boston c Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania q Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston d Department of Emergency Medicine, Mayo Clinic, Rochester, Minn g Division of Emergency Medicine, Boston Children’s Hospital i Rochester Regional Health, NY p Section of Emergency Medicine, Department of Pediatrics, Children’s Hospital Colorado, Aurora a Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center b Department of Pediatrics, University of Cincinnati College of Medicine n Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston l Division of Immunology, Boston Children’s Hospital e Dartmo |
| AuthorAffiliation_xml | – name: i Rochester Regional Health, NY – name: a Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center – name: d Department of Emergency Medicine, Mayo Clinic, Rochester, Minn – name: b Department of Pediatrics, University of Cincinnati College of Medicine – name: e Dartmouth Geisel School of Medicine, Hanover – name: l Division of Immunology, Boston Children’s Hospital – name: n Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston – name: f Dartmouth-Hitchcock Medical Center, Hanover – name: g Division of Emergency Medicine, Boston Children’s Hospital – name: p Section of Emergency Medicine, Department of Pediatrics, Children’s Hospital Colorado, Aurora – name: o Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York – name: j Department of Emergency Medicine, Harvard Medical School, Boston – name: q Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – name: k Section of Pediatric Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee – name: r Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center – name: m Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center – name: c Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania – name: h Department of Pediatrics, Harvard Medical School, Boston |
| Author_xml | – sequence: 1 givenname: Timothy E. surname: Dribin fullname: Dribin, Timothy E. email: Timothy.Dribin@cchmc.org organization: Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 2 givenname: David surname: Schnadower fullname: Schnadower, David organization: Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 3 givenname: Jonathan M. surname: Spergel fullname: Spergel, Jonathan M. organization: Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pa – sequence: 4 givenname: Ronna L. surname: Campbell fullname: Campbell, Ronna L. organization: Department of Emergency Medicine, Mayo Clinic, Rochester, Minn – sequence: 5 givenname: Marcus surname: Shaker fullname: Shaker, Marcus organization: Dartmouth Geisel School of Medicine, Hanover, NH – sequence: 6 givenname: Mark I. surname: Neuman fullname: Neuman, Mark I. organization: Division of Emergency Medicine, Boston Children’s Hospital, Boston, Mass – sequence: 7 givenname: Kenneth A. surname: Michelson fullname: Michelson, Kenneth A. organization: Division of Emergency Medicine, Boston Children’s Hospital, Boston, Mass – sequence: 8 givenname: Peter S. surname: Capucilli fullname: Capucilli, Peter S. organization: Rochester Regional Health, Rochester, NY – sequence: 9 givenname: Carlos A. surname: Camargo fullname: Camargo, Carlos A. organization: Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass – sequence: 10 givenname: David C. surname: Brousseau fullname: Brousseau, David C. organization: Section of Pediatric Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee – sequence: 11 givenname: Susan A. surname: Rudders fullname: Rudders, Susan A. organization: Department of Pediatrics, Harvard Medical School, Boston, Mass – sequence: 12 givenname: Amal H. surname: Assa’ad fullname: Assa’ad, Amal H. organization: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 13 givenname: Kimberly A. surname: Risma fullname: Risma, Kimberly A. organization: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 14 givenname: Mariana surname: Castells fullname: Castells, Mariana organization: Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass – sequence: 15 givenname: Lynda C. surname: Schneider fullname: Schneider, Lynda C. organization: Department of Pediatrics, Harvard Medical School, Boston, Mass – sequence: 16 givenname: Julie surname: Wang fullname: Wang, Julie organization: Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 17 givenname: Juhee surname: Lee fullname: Lee, Juhee organization: Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pa – sequence: 18 givenname: Rakesh D. surname: Mistry fullname: Mistry, Rakesh D. organization: Section of Emergency Medicine, Department of Pediatrics, Children’s Hospital Colorado, Aurora – sequence: 19 givenname: David surname: Vyles fullname: Vyles, David organization: Section of Pediatric Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee – sequence: 20 givenname: Michael surname: Pistiner fullname: Pistiner, Michael organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Mass – sequence: 21 givenname: John K. surname: Witry fullname: Witry, John K. organization: Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 22 givenname: Yin surname: Zhang fullname: Zhang, Yin organization: Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 23 givenname: Hugh A. surname: Sampson fullname: Sampson, Hugh A. organization: Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33476673$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1161/01.STR.20.7.864 10.1016/j.jaci.2009.10.060 10.1016/j.jaci.2020.01.017 10.1016/j.jaci.2013.06.015 10.1016/S2468-1253(17)30392-8 10.1016/S1081-1206(10)60714-4 10.1016/j.jaip.2018.10.052 10.1056/NEJMoa1200435 10.1016/j.jaci.2009.07.055 10.1056/NEJMoa022613 10.1016/j.jaip.2016.11.009 10.1016/j.jaip.2020.11.005 10.1007/BF01709751 10.1016/S0194-5998(99)70182-8 10.1056/NEJMoa1414850 10.3389/fpubh.2018.00149 10.1111/all.12765 10.1111/all.13408 10.1164/rccm.201701-0076CP 10.1001/jama.2016.0287 10.1016/j.jaci.2006.12.622 10.1056/NEJM199208063270603 10.1016/j.anai.2019.01.014 10.1016/j.jaci.2016.12.989 10.1016/j.jaci.2020.08.015 10.1016/j.jaci.2004.04.029 10.1016/j.jaip.2019.07.018 10.4168/aair.2015.7.1.22 10.1097/01.PCC.0000149131.72248.E6 10.1001/jama.2016.0289 10.1016/j.jaci.2005.12.1303 10.1016/j.jbi.2008.08.010 10.1016/j.waojou.2019.100066 10.1016/j.jaci.2012.10.017 10.1056/NEJMoa1812856 |
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| References | Sampson, Wijk RG, Carsten Bindslev-Jensen, Teuber, Burks, Dubois (bib7) 2012; 130 Harris, Taylor, Thielke, Payne, Gonzalez, Conde (bib18) 2009; 42 Greenhawt, Gupta, Meadows, Pistiner, Spergel, Camargo (bib25) 2019; 7 Brown (bib6) 2004; 114 Shankar-Hari, Phillips, Levy, Seymour, Liu, Deutschman (bib16) 2016; 315 Goldstein, Giroir, Randolph (bib27) 2005; 6 Andorf, Purington, Block, Long, Tupa, Brittain (bib12) 2018; 3 Sampson, Muñoz-Furlong, Campbell, Adkinson, Bock, Branum (bib20) 2006; 117 Leung, Sampson, Yunginger, Burks, Schneider, Wortel (bib3) 2003; 348 Bilaver, Chadha, Doshi, O’Dweyer, Gupta (bib5) 2019; 122 Mehta, Burns, Machado, Fox-Robichaud, Cook, Calfee (bib30) 2017; 196 Stone, Cotterell, Isbister, Holdgate, Brown (bib33) 2009; 124 Niggemann, Beyer (bib10) 2016; 71 Burks, Jones, Wood, Fleischer, Sicherer, Lindblad (bib11) 2012; 367 Greenberger, Rotskoff, Lifschultz (bib22) 2007; 98 Cox, Larenas-Linnemann, Lockey, Passalacqua (bib23) 2010 Mar 1; 125 Ishoo, Shah, Grillone, Stram, Fuleihan (bib35) 1999; 121 Cox, Sanchez-Borges, Lockey (bib8) 2017; 5 Sampson, Mendelson, Rosen (bib36) 1992; 327 Sampson (bib13) 2003; 111 Pistiner, Mendez-Reyes, Eftekhari, Carver, Lieberman, Wang (bib26) 2021 Brott, Adams, Olinger, Marler, Barsan, Biller (bib38) 1989; 20 Bock, Munoz-Furlong, Sampson (bib24) 2007; 119 (bib2) 2018; 379 Fitch K, Bernstein SJ, Mcdonnell J, Kahan JP. The RAND/UCLA appropriateness method user’s manual. Santa Monica, CA: Rand, 2001. Shaker, Wallace, Golden, Oppenheimer, Bernstein, Campbell (bib1) 2020; 145 Dribin, Sampson, Camargo, Brousseau, Spergel, Neuman (bib15) 2020; 146 Muraro, Fernandez-Rivas, Beyer, Cardona, Clark, Eller (bib9) 2018; 73 Boateng, Neilands, Frongillo, Melgar-Quiñonez, Young (bib31) 2018; 6 Vincent, Moreno, Takala, Willatts, De Mendonça, Bruining (bib28) 1996; 22 Ye, Kim, Kang, Kim, Sohn, Koh (bib32) 2015; 7 Michelson, Dribin, Vyles, Neuman (bib4) 2020; 8 Du Toit, Roberts, Sayre, Bahnson, Radulovic, Santos (bib14) 2015; 372 Turner, Worm, Ansotegui, El-gamal, Rivas, Fineman (bib19) 2019; 12 Summers, Pumphrey, Woods, Mcdowell, Pemberton, Arkwright (bib37) 2008; 121 Brown, Stone, Fatovich, Burrows, Holdgate, Celenza (bib21) 2013; 132 Korosec, Turner, Silar, Kopac, Kosnik, Gibbs (bib34) 2017; 140 Singer, Deutschman, Seymour, Shankar-Hari, Annane, Bauer (bib17) 2016; 315 Sampson (10.1016/j.jaci.2021.01.003_bib7) 2012; 130 Shankar-Hari (10.1016/j.jaci.2021.01.003_bib16) 2016; 315 Greenhawt (10.1016/j.jaci.2021.01.003_bib25) 2019; 7 Korosec (10.1016/j.jaci.2021.01.003_bib34) 2017; 140 Sampson (10.1016/j.jaci.2021.01.003_bib36) 1992; 327 Brott (10.1016/j.jaci.2021.01.003_bib38) 1989; 20 Pistiner (10.1016/j.jaci.2021.01.003_bib26) 2021 Vincent (10.1016/j.jaci.2021.01.003_bib28) 1996; 22 Niggemann (10.1016/j.jaci.2021.01.003_bib10) 2016; 71 Mehta (10.1016/j.jaci.2021.01.003_bib30) 2017; 196 Ye (10.1016/j.jaci.2021.01.003_bib32) 2015; 7 Summers (10.1016/j.jaci.2021.01.003_bib37) 2008; 121 Greenberger (10.1016/j.jaci.2021.01.003_bib22) 2007; 98 Brown (10.1016/j.jaci.2021.01.003_bib21) 2013; 132 Stone (10.1016/j.jaci.2021.01.003_bib33) 2009; 124 Boateng (10.1016/j.jaci.2021.01.003_bib31) 2018; 6 Andorf (10.1016/j.jaci.2021.01.003_bib12) 2018; 3 Dribin (10.1016/j.jaci.2021.01.003_bib15) 2020; 146 10.1016/j.jaci.2021.01.003_bib29 Ishoo (10.1016/j.jaci.2021.01.003_bib35) 1999; 121 Brown (10.1016/j.jaci.2021.01.003_bib6) 2004; 114 Cox (10.1016/j.jaci.2021.01.003_bib8) 2017; 5 Du Toit (10.1016/j.jaci.2021.01.003_bib14) 2015; 372 Cox (10.1016/j.jaci.2021.01.003_bib23) 2010; 125 Michelson (10.1016/j.jaci.2021.01.003_bib4) 2020; 8 Bilaver (10.1016/j.jaci.2021.01.003_bib5) 2019; 122 Harris (10.1016/j.jaci.2021.01.003_bib18) 2009; 42 Sampson (10.1016/j.jaci.2021.01.003_bib13) 2003; 111 Shaker (10.1016/j.jaci.2021.01.003_bib1) 2020; 145 Muraro (10.1016/j.jaci.2021.01.003_bib9) 2018; 73 Singer (10.1016/j.jaci.2021.01.003_bib17) 2016; 315 Leung (10.1016/j.jaci.2021.01.003_bib3) 2003; 348 Burks (10.1016/j.jaci.2021.01.003_bib11) 2012; 367 Bock (10.1016/j.jaci.2021.01.003_bib24) 2007; 119 (10.1016/j.jaci.2021.01.003_bib2) 2018; 379 Sampson (10.1016/j.jaci.2021.01.003_bib20) 2006; 117 Turner (10.1016/j.jaci.2021.01.003_bib19) 2019; 12 Goldstein (10.1016/j.jaci.2021.01.003_bib27) 2005; 6 |
| References_xml | – volume: 348 start-page: 986 year: 2003 end-page: 993 ident: bib3 article-title: Effect of anti-IgE therapy in patients with peanut allergy publication-title: N Engl J Med – volume: 367 start-page: 233 year: 2012 end-page: 243 ident: bib11 article-title: Oral immunotherapy for treatment of egg allergy in children publication-title: N Engl J Med – volume: 111 year: 2003 ident: bib13 article-title: Anaphylaxis and emergency treatment publication-title: Pediatrics – volume: 124 start-page: 786 year: 2009 end-page: 792.e4 ident: bib33 article-title: Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions publication-title: J Allergy Clin Immunol – volume: 140 start-page: 750 year: 2017 end-page: 758.e15 ident: bib34 article-title: Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis publication-title: J Allergy Clin Immunol – volume: 130 start-page: 1260 year: 2012 end-page: 1274 ident: bib7 article-title: Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology - European Academy of Allergy and Clinical Immunology PRACTALL consensus report publication-title: J Allergy Clin Immunol – volume: 114 start-page: 371 year: 2004 end-page: 376 ident: bib6 article-title: Clinical features and severity grading of anaphylaxis publication-title: J Allergy Clin Immunol – volume: 372 start-page: 803 year: 2015 end-page: 813 ident: bib14 article-title: Randomized trial of peanut consumption in infants at risk for peanut allergy publication-title: N Engl J Med – volume: 121 start-page: 263 year: 1999 end-page: 268 ident: bib35 article-title: Predicting airway risk in angioedema: staging system based on presentation publication-title: Otolaryngol Neck Surg – volume: 71 start-page: 135 year: 2016 end-page: 136 ident: bib10 article-title: Time for a new grading system for allergic reactions? publication-title: Allergy – volume: 146 start-page: 1089 year: 2020 end-page: 1096 ident: bib15 article-title: Persistent, refractory, and biphasic anaphylaxis: a multidisciplinary Delphi study publication-title: J Allergy Clin Immunol – volume: 6 start-page: 149 year: 2018 ident: bib31 article-title: Best practices for developing and validating scales for health, social, and behavioral research: a primer publication-title: Front Public Health – volume: 125 start-page: 569 year: 2010 Mar 1 end-page: 574.e7 ident: bib23 article-title: Speaking the same language: the World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System publication-title: J Allergy Clin Immunol – volume: 22 start-page: 707 year: 1996 end-page: 710 ident: bib28 article-title: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure publication-title: Intensive Care Med – volume: 20 start-page: 864 year: 1989 end-page: 870 ident: bib38 article-title: Measurements of acute cerebral infarction: a clinical examination scale publication-title: Stroke – volume: 42 start-page: 377 year: 2009 end-page: 381 ident: bib18 article-title: Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inf – reference: Fitch K, Bernstein SJ, Mcdonnell J, Kahan JP. The RAND/UCLA appropriateness method user’s manual. Santa Monica, CA: Rand, 2001. – volume: 117 start-page: 391 year: 2006 end-page: 397 ident: bib20 article-title: Second Symposium on the Definition and Management of Anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium publication-title: J Allergy Clin Immunol – volume: 6 start-page: 2 year: 2005 end-page: 8 ident: bib27 article-title: The M of, Sepsis ICC on P. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics publication-title: Pediatr Crit Care Med – volume: 8 start-page: 767 year: 2020 end-page: 768.e2 ident: bib4 article-title: Trends in emergency care for anaphylaxis publication-title: J Allergy Clin Immunol Pract – volume: 119 start-page: 1016 year: 2007 end-page: 1018 ident: bib24 article-title: Further fatalities caused by anaphylactic reactions to food, 2001-2006 publication-title: J Allergy Clin Immunol – volume: 98 start-page: 252 year: 2007 end-page: 257 ident: bib22 article-title: Fatal anaphylaxis: postmortem findings and associated comorbid diseases publication-title: Ann Allergy Asthma Immunol – volume: 327 start-page: 380 year: 1992 end-page: 384 ident: bib36 article-title: Fatal and near-fatal anaphylactic reactions to food in children and adolescents publication-title: N Engl J Med – volume: 379 start-page: 1991 year: 2018 end-page: 2001 ident: bib2 article-title: AR101 oral immunotherapy for peanut allergy publication-title: N Engl J Med – volume: 3 start-page: 85 year: 2018 end-page: 94 ident: bib12 article-title: Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial publication-title: Lancet Gastroenterol Hepatol – volume: 315 start-page: 775 year: 2016 end-page: 787 ident: bib16 article-title: Developing a new definition and assessing new clinical criteria for septic shock for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA – volume: 7 start-page: 22 year: 2015 end-page: 29 ident: bib32 article-title: Predictors of the severity and serious outcomes of anaphylaxis in Korean adults: a multicenter retrospective case study publication-title: Allergy Asthma Immunol Res – volume: 145 start-page: 1082 year: 2020 end-page: 1123 ident: bib1 article-title: Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis publication-title: J Allergy Clin Immunol – volume: 315 start-page: 801 year: 2016 end-page: 810 ident: bib17 article-title: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA – volume: 5 start-page: 58 year: 2017 end-page: 62.e5 ident: bib8 article-title: World Allergy Organization Systemic Allergic Reaction Grading System: is a modification needed? publication-title: J Allergy Clin Immunol Pract – volume: 7 start-page: 1148 year: 2019 end-page: 1156.e5 ident: bib25 article-title: Guiding principles for the recognition, diagnosis, and management of infants with anaphylaxis: an expert panel consensus publication-title: J Allergy Clin Immunol Pract – volume: 73 start-page: 1792 year: 2018 end-page: 1800 ident: bib9 article-title: The urgent need for a harmonized severity scoring system for acute allergic reactions publication-title: Allergy – volume: 122 start-page: 373 year: 2019 end-page: 380 ident: bib5 article-title: Economic burden of food allergy- a systematic review publication-title: Ann Allergy Asthma Immunol – start-page: 311 year: 2021 end-page: 320.e2 ident: bib26 article-title: Caregiver reported presentation of severe food-induced allergic reactions in infants and toddlers publication-title: J Allergy Clin Immunol Pract – volume: 12 start-page: 1 year: 2019 end-page: 5 ident: bib19 article-title: Time to revisit the definition and clinical criteria for anaphylaxis? publication-title: World Allergy Organ J – volume: 132 start-page: 1141 year: 2013 end-page: 1149.e5 ident: bib21 article-title: Anaphylaxis: clinical patterns, mediator release, and severity publication-title: J Allergy Clin Immunol – volume: 196 start-page: 425 year: 2017 end-page: 429 ident: bib30 article-title: Gender parity in critical care medicine publication-title: Am J Respir Crit Care Med – volume: 121 start-page: 632 year: 2008 end-page: 638.e2 ident: bib37 article-title: Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center publication-title: JACI – volume: 20 start-page: 864 year: 1989 ident: 10.1016/j.jaci.2021.01.003_bib38 article-title: Measurements of acute cerebral infarction: a clinical examination scale publication-title: Stroke doi: 10.1161/01.STR.20.7.864 – volume: 125 start-page: 569 year: 2010 ident: 10.1016/j.jaci.2021.01.003_bib23 article-title: Speaking the same language: the World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2009.10.060 – volume: 145 start-page: 1082 year: 2020 ident: 10.1016/j.jaci.2021.01.003_bib1 article-title: Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2020.01.017 – volume: 132 start-page: 1141 year: 2013 ident: 10.1016/j.jaci.2021.01.003_bib21 article-title: Anaphylaxis: clinical patterns, mediator release, and severity publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2013.06.015 – volume: 3 start-page: 85 year: 2018 ident: 10.1016/j.jaci.2021.01.003_bib12 article-title: Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial publication-title: Lancet Gastroenterol Hepatol doi: 10.1016/S2468-1253(17)30392-8 – volume: 98 start-page: 252 year: 2007 ident: 10.1016/j.jaci.2021.01.003_bib22 article-title: Fatal anaphylaxis: postmortem findings and associated comorbid diseases publication-title: Ann Allergy Asthma Immunol doi: 10.1016/S1081-1206(10)60714-4 – ident: 10.1016/j.jaci.2021.01.003_bib29 – volume: 7 start-page: 1148 year: 2019 ident: 10.1016/j.jaci.2021.01.003_bib25 article-title: Guiding principles for the recognition, diagnosis, and management of infants with anaphylaxis: an expert panel consensus publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2018.10.052 – volume: 367 start-page: 233 year: 2012 ident: 10.1016/j.jaci.2021.01.003_bib11 article-title: Oral immunotherapy for treatment of egg allergy in children publication-title: N Engl J Med doi: 10.1056/NEJMoa1200435 – volume: 124 start-page: 786 year: 2009 ident: 10.1016/j.jaci.2021.01.003_bib33 article-title: Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2009.07.055 – volume: 348 start-page: 986 year: 2003 ident: 10.1016/j.jaci.2021.01.003_bib3 article-title: Effect of anti-IgE therapy in patients with peanut allergy publication-title: N Engl J Med doi: 10.1056/NEJMoa022613 – volume: 5 start-page: 58 year: 2017 ident: 10.1016/j.jaci.2021.01.003_bib8 article-title: World Allergy Organization Systemic Allergic Reaction Grading System: is a modification needed? publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2016.11.009 – start-page: 311 year: 2021 ident: 10.1016/j.jaci.2021.01.003_bib26 article-title: Caregiver reported presentation of severe food-induced allergic reactions in infants and toddlers publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2020.11.005 – volume: 22 start-page: 707 year: 1996 ident: 10.1016/j.jaci.2021.01.003_bib28 article-title: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure publication-title: Intensive Care Med doi: 10.1007/BF01709751 – volume: 121 start-page: 632 year: 2008 ident: 10.1016/j.jaci.2021.01.003_bib37 article-title: Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center publication-title: JACI – volume: 121 start-page: 263 year: 1999 ident: 10.1016/j.jaci.2021.01.003_bib35 article-title: Predicting airway risk in angioedema: staging system based on presentation publication-title: Otolaryngol Neck Surg doi: 10.1016/S0194-5998(99)70182-8 – volume: 372 start-page: 803 year: 2015 ident: 10.1016/j.jaci.2021.01.003_bib14 article-title: Randomized trial of peanut consumption in infants at risk for peanut allergy publication-title: N Engl J Med doi: 10.1056/NEJMoa1414850 – volume: 6 start-page: 149 year: 2018 ident: 10.1016/j.jaci.2021.01.003_bib31 article-title: Best practices for developing and validating scales for health, social, and behavioral research: a primer publication-title: Front Public Health doi: 10.3389/fpubh.2018.00149 – volume: 71 start-page: 135 year: 2016 ident: 10.1016/j.jaci.2021.01.003_bib10 article-title: Time for a new grading system for allergic reactions? publication-title: Allergy doi: 10.1111/all.12765 – volume: 73 start-page: 1792 year: 2018 ident: 10.1016/j.jaci.2021.01.003_bib9 article-title: The urgent need for a harmonized severity scoring system for acute allergic reactions publication-title: Allergy doi: 10.1111/all.13408 – volume: 196 start-page: 425 year: 2017 ident: 10.1016/j.jaci.2021.01.003_bib30 article-title: Gender parity in critical care medicine publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201701-0076CP – volume: 315 start-page: 801 year: 2016 ident: 10.1016/j.jaci.2021.01.003_bib17 article-title: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA doi: 10.1001/jama.2016.0287 – volume: 119 start-page: 1016 year: 2007 ident: 10.1016/j.jaci.2021.01.003_bib24 article-title: Further fatalities caused by anaphylactic reactions to food, 2001-2006 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.12.622 – volume: 327 start-page: 380 year: 1992 ident: 10.1016/j.jaci.2021.01.003_bib36 article-title: Fatal and near-fatal anaphylactic reactions to food in children and adolescents publication-title: N Engl J Med doi: 10.1056/NEJM199208063270603 – volume: 122 start-page: 373 year: 2019 ident: 10.1016/j.jaci.2021.01.003_bib5 article-title: Economic burden of food allergy- a systematic review publication-title: Ann Allergy Asthma Immunol doi: 10.1016/j.anai.2019.01.014 – volume: 140 start-page: 750 year: 2017 ident: 10.1016/j.jaci.2021.01.003_bib34 article-title: Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2016.12.989 – volume: 111 issue: suppl 3 year: 2003 ident: 10.1016/j.jaci.2021.01.003_bib13 article-title: Anaphylaxis and emergency treatment publication-title: Pediatrics – volume: 146 start-page: 1089 year: 2020 ident: 10.1016/j.jaci.2021.01.003_bib15 article-title: Persistent, refractory, and biphasic anaphylaxis: a multidisciplinary Delphi study publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2020.08.015 – volume: 114 start-page: 371 year: 2004 ident: 10.1016/j.jaci.2021.01.003_bib6 article-title: Clinical features and severity grading of anaphylaxis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.04.029 – volume: 8 start-page: 767 year: 2020 ident: 10.1016/j.jaci.2021.01.003_bib4 article-title: Trends in emergency care for anaphylaxis publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2019.07.018 – volume: 7 start-page: 22 year: 2015 ident: 10.1016/j.jaci.2021.01.003_bib32 article-title: Predictors of the severity and serious outcomes of anaphylaxis in Korean adults: a multicenter retrospective case study publication-title: Allergy Asthma Immunol Res doi: 10.4168/aair.2015.7.1.22 – volume: 6 start-page: 2 year: 2005 ident: 10.1016/j.jaci.2021.01.003_bib27 article-title: The M of, Sepsis ICC on P. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics publication-title: Pediatr Crit Care Med doi: 10.1097/01.PCC.0000149131.72248.E6 – volume: 315 start-page: 775 year: 2016 ident: 10.1016/j.jaci.2021.01.003_bib16 article-title: Developing a new definition and assessing new clinical criteria for septic shock for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA doi: 10.1001/jama.2016.0289 – volume: 117 start-page: 391 year: 2006 ident: 10.1016/j.jaci.2021.01.003_bib20 article-title: Second Symposium on the Definition and Management of Anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.12.1303 – volume: 42 start-page: 377 year: 2009 ident: 10.1016/j.jaci.2021.01.003_bib18 article-title: Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inf doi: 10.1016/j.jbi.2008.08.010 – volume: 12 start-page: 1 year: 2019 ident: 10.1016/j.jaci.2021.01.003_bib19 article-title: Time to revisit the definition and clinical criteria for anaphylaxis? publication-title: World Allergy Organ J doi: 10.1016/j.waojou.2019.100066 – volume: 130 start-page: 1260 year: 2012 ident: 10.1016/j.jaci.2021.01.003_bib7 article-title: Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology - European Academy of Allergy and Clinical Immunology PRACTALL consensus report publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2012.10.017 – volume: 379 start-page: 1991 year: 2018 ident: 10.1016/j.jaci.2021.01.003_bib2 article-title: AR101 oral immunotherapy for peanut allergy publication-title: N Engl J Med doi: 10.1056/NEJMoa1812856 |
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| Title | Severity grading system for acute allergic reactions: A multidisciplinary Delphi study |
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