Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents - Wang, Bing; Liu, Teng; Wu, Zhongyu; Zhang, Lei; Sun, Jie; Wang, Xiaojing (Journal of enzyme inhibition and medicinal chemistry, 2018)
Keywords: AGEs formation inhibitor; Aldehyde Reductase - antagonists & inhibitors; Aldehyde Reductase - metabolism; alpha-Glucosidases - metabolism; Animals; antidiabetic; Biochemistry & Molecular Biology; Chemistry, Medicinal; Diabetes Complications - drug therapy; Diabetes Complications - metabolism; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Glycation End Products, Advanced - antagonists & inhibitors; Glycation End Products, Advanced - metabolism; Hypoglycemic Agents - chemical synthesis; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Life Sciences & Biomedicine; Mice; Mice, Inbred Strains; Molecular Structure; Nitrates - chemistry; Nitrates - pharmacology; Nitric Oxide - metabolism; nitric oxide donor; Pharmacology & Pharmacy; Research Paper; Science & Technology; stilbene; Stilbenes - chemical synthesis; Stilbenes - chemistry; Stilbenes - pharmacology; Streptozocin; Structure-Activity Relationship; α-Glucosidase inhibitor; DESIGN; ACID; alpha-Glucosidase inhibitor; AGEs formation inhibitor; IN-VITRO; METABOLISM; PATHWAY; stilbene; NITRIC-OXIDE; antidiabetic; INHIBITORS; STIMULATES GLUCOSE-TRANSPORT; nitric oxide donor; ALDOSE REDUCTASE; GLYCATION END-PRODUCTS; α-Glucosidase inhibitor