Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients
To the Editor: Activation by aeroallergen-specific IgE of bronchial mucosal mast cells in clinically sensitized atopic subjects is an acknowledged exacerbating (some speculate causative) stimulus for asthma, although the existence of the disease in nonatopic subjects, who are conventionally defined...
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| Published in | Journal of allergy and clinical immunology Vol. 133; no. 6; pp. 1770 - 1772.e11 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.06.2014
Elsevier Limited |
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| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1097-6825 |
| DOI | 10.1016/j.jaci.2014.03.027 |
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| Abstract | To the Editor: Activation by aeroallergen-specific IgE of bronchial mucosal mast cells in clinically sensitized atopic subjects is an acknowledged exacerbating (some speculate causative) stimulus for asthma, although the existence of the disease in nonatopic subjects, who are conventionally defined as those with absence of allergen-specific IgE, as determined by using skin prick and in vitro tests, begs the question of whether allergens and IgE play an indispensable role in asthma pathogenesis. Because plasma cells do not express IgE Fc receptors, this expression is likely to reflect endogenous IgE synthesis. |
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| AbstractList | To the Editor: Activation by aeroallergen-specific IgE of bronchial mucosal mast cells in clinically sensitized atopic subjects is an acknowledged exacerbating (some speculate causative) stimulus for asthma, although the existence of the disease in nonatopic subjects, who are conventionally defined as those with absence of allergen-specific IgE, as determined by using skin prick and in vitro tests, begs the question of whether allergens and IgE play an indispensable role in asthma pathogenesis. Because plasma cells do not express IgE Fc receptors, this expression is likely to reflect endogenous IgE synthesis. |
| Author | Fang, Cailong Shamji, Mohamed H. Menzies-Gow, Andrew Harper, Clare Chan, Yih-Chih Pillai, Prathap Corrigan, Chris J. Durham, Stephen R. Rajakulasingam, Raj K. Wu, Shih-Ying Gould, Hannah J. Ohm-Laursen, Line Ying, Sun |
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| Cites_doi | 10.1164/ajrccm.153.6.8665058 10.1067/mai.2000.104783 10.1016/j.jaci.2006.09.045 10.1067/mai.2001.114339 10.1034/j.1399-3003.2000.16d07.x 10.1164/ajrccm.154.5.8912771 10.1016/j.jaci.2007.01.006 10.1111/j.1365-2796.2012.02559.x 10.1164/rccm.200311-1610OC |
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| References | Bachert, Zhang (bib8) 2012; 272 Valenta, Seiberler, Natter, Mahler, Mossabeb, Ring (bib9) 2000; 105 Ying, Humbert, Meng, Pfister, Menz, Gould (bib2) 2001; 107 Beeh, Ksoll, Buhl (bib5) 2000; 16 Humbert, Grant, Taborda-Barata, Durham, Pfister, Menz (bib4) 1996; 153 Rondon, Romero, Lopez, Antunez, Martin-Casanez, Torres (bib6) 2007; 119 Dakhama, Park, Taube, Chayama, Balhorn, Joetham (bib7) 2004; 170 Humbert, Durham, Ying, Kimmitt, Barkans, Assoufi (bib1) 1996; 154 Takhar, Corrigan, Smurthwaite, O'Connor, Durham, Lee (bib3) 2007; 119 Bachert (10.1016/j.jaci.2014.03.027_bib8) 2012; 272 Humbert (10.1016/j.jaci.2014.03.027_bib1) 1996; 154 Takhar (10.1016/j.jaci.2014.03.027_bib3) 2007; 119 Humbert (10.1016/j.jaci.2014.03.027_bib4) 1996; 153 Dakhama (10.1016/j.jaci.2014.03.027_bib7) 2004; 170 Ying (10.1016/j.jaci.2014.03.027_bib2) 2001; 107 Valenta (10.1016/j.jaci.2014.03.027_bib9) 2000; 105 Rondon (10.1016/j.jaci.2014.03.027_bib6) 2007; 119 Beeh (10.1016/j.jaci.2014.03.027_bib5) 2000; 16 |
| References_xml | – volume: 105 start-page: 432 year: 2000 end-page: 437 ident: bib9 article-title: Autoallergy: a pathogenetic factor in atopic dermatitis? publication-title: J Allergy Clin Immunol – volume: 153 start-page: 1931 year: 1996 end-page: 1937 ident: bib4 article-title: High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma publication-title: Am J Respir Crit Care Med – volume: 119 start-page: 899 year: 2007 end-page: 905 ident: bib6 article-title: Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis publication-title: J Allergy Clin Immunol – volume: 154 start-page: 1497 year: 1996 end-page: 1504 ident: bib1 article-title: IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against “intrinsic” asthma being a distinct immunopathologic entity publication-title: Am J Respir Crit Care Med – volume: 16 start-page: 609 year: 2000 end-page: 614 ident: bib5 article-title: Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals publication-title: Eur Respir J – volume: 272 start-page: 133 year: 2012 end-page: 143 ident: bib8 article-title: Chronic rhinosinusitis and asthma: novel understanding of the role of IgE “above atopy” publication-title: J Intern Med – volume: 170 start-page: 952 year: 2004 end-page: 959 ident: bib7 article-title: The role of virus-specific immunoglobulin E in airway hyperresponsiveness publication-title: Am J Respir Crit Care Med – volume: 119 start-page: 213 year: 2007 end-page: 218 ident: bib3 article-title: Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma publication-title: J Allergy Clin Immunol – volume: 107 start-page: 686 year: 2001 end-page: 692 ident: bib2 article-title: Local expression of epsilon germ line gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and non-atopic asthma publication-title: J Allergy and Clin Immunol – volume: 153 start-page: 1931 year: 1996 ident: 10.1016/j.jaci.2014.03.027_bib4 article-title: High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.153.6.8665058 – volume: 105 start-page: 432 year: 2000 ident: 10.1016/j.jaci.2014.03.027_bib9 article-title: Autoallergy: a pathogenetic factor in atopic dermatitis? publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2000.104783 – volume: 119 start-page: 213 year: 2007 ident: 10.1016/j.jaci.2014.03.027_bib3 article-title: Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.09.045 – volume: 107 start-page: 686 year: 2001 ident: 10.1016/j.jaci.2014.03.027_bib2 article-title: Local expression of epsilon germ line gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and non-atopic asthma publication-title: J Allergy and Clin Immunol doi: 10.1067/mai.2001.114339 – volume: 16 start-page: 609 year: 2000 ident: 10.1016/j.jaci.2014.03.027_bib5 article-title: Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals publication-title: Eur Respir J doi: 10.1034/j.1399-3003.2000.16d07.x – volume: 154 start-page: 1497 year: 1996 ident: 10.1016/j.jaci.2014.03.027_bib1 article-title: IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against “intrinsic” asthma being a distinct immunopathologic entity publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.5.8912771 – volume: 119 start-page: 899 year: 2007 ident: 10.1016/j.jaci.2014.03.027_bib6 article-title: Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.01.006 – volume: 272 start-page: 133 year: 2012 ident: 10.1016/j.jaci.2014.03.027_bib8 article-title: Chronic rhinosinusitis and asthma: novel understanding of the role of IgE “above atopy” publication-title: J Intern Med doi: 10.1111/j.1365-2796.2012.02559.x – volume: 170 start-page: 952 year: 2004 ident: 10.1016/j.jaci.2014.03.027_bib7 article-title: The role of virus-specific immunoglobulin E in airway hyperresponsiveness publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200311-1610OC |
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| SubjectTerms | Allergens - immunology Allergies Allergy and Immunology Antibody Specificity Asthma Asthma - diagnosis Asthma - immunology Biopsy Bronchi - immunology Humans Hypotheses Immunoglobulin E - immunology Mucous membrane Patients Respiratory Mucosa - immunology Rodents |
| Title | Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients |
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