Fusions between dendritic cells and whole tumor cells as anticancer vaccines

Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecul...

Full description

Saved in:
Bibliographic Details
Published inOncoimmunology Vol. 2; no. 5; p. e24437
Main Authors Koido, Shigeo, Homma, Sadamu, Okamoto, Masato, Namiki, Yoshihisa, Takakura, Kazuki, Uchiyama, Kan, Kajihara, Mikio, Arihiro, Seiji, Imazu, Hiroo, Arakawa, Hiroshi, Kan, Shin, Komita, Hideo, Ito, Masaki, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.05.2013
Landes Bioscience
Subjects
Online AccessGet full text
ISSN2162-402X
2162-4011
2162-402X
DOI10.4161/onci.24437

Cover

Abstract Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.
AbstractList Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.
Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.
Author Tajiri, Hisao
Ohkusa, Toshifumi
Okamoto, Masato
Gong, Jianlin
Kan, Shin
Ito, Masaki
Imazu, Hiroo
Arihiro, Seiji
Homma, Sadamu
Uchiyama, Kan
Kajihara, Mikio
Takakura, Kazuki
Koido, Shigeo
Arakawa, Hiroshi
Namiki, Yoshihisa
Komita, Hideo
Author_xml – sequence: 1
  givenname: Shigeo
  surname: Koido
  fullname: Koido, Shigeo
  email: shigeo_koido@jikei.ac.jp
– sequence: 2
  givenname: Sadamu
  surname: Homma
  fullname: Homma, Sadamu
– sequence: 3
  givenname: Masato
  surname: Okamoto
  fullname: Okamoto, Masato
– sequence: 4
  givenname: Yoshihisa
  surname: Namiki
  fullname: Namiki, Yoshihisa
– sequence: 5
  givenname: Kazuki
  surname: Takakura
  fullname: Takakura, Kazuki
– sequence: 6
  givenname: Kan
  surname: Uchiyama
  fullname: Uchiyama, Kan
– sequence: 7
  givenname: Mikio
  surname: Kajihara
  fullname: Kajihara, Mikio
– sequence: 8
  givenname: Seiji
  surname: Arihiro
  fullname: Arihiro, Seiji
– sequence: 9
  givenname: Hiroo
  surname: Imazu
  fullname: Imazu, Hiroo
– sequence: 10
  givenname: Hiroshi
  surname: Arakawa
  fullname: Arakawa, Hiroshi
– sequence: 11
  givenname: Shin
  surname: Kan
  fullname: Kan, Shin
– sequence: 12
  givenname: Hideo
  surname: Komita
  fullname: Komita, Hideo
– sequence: 13
  givenname: Masaki
  surname: Ito
  fullname: Ito, Masaki
– sequence: 14
  givenname: Toshifumi
  surname: Ohkusa
  fullname: Ohkusa, Toshifumi
– sequence: 15
  givenname: Jianlin
  surname: Gong
  fullname: Gong, Jianlin
– sequence: 16
  givenname: Hisao
  surname: Tajiri
  fullname: Tajiri, Hisao
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23762810$$D View this record in MEDLINE/PubMed
BookMark eNp9kV9rFDEUxYNUbK198QPIPIqyNf8neRFKsSos-KLgW7iTSWwkk6zJTJf99mbdVqsU85KQ-7vnJOc-RUcpJ4fQc4LPOZHkTU42nFPOWf8InVAi6Ypj-vXo3vkYndX6HbclsZBMP0HHlPWSKoJP0PpqqSGn2g1u3jqXutGlsYQ52M66GGsHaey21zm6bl6mXO5u94UGQbKudDdgbUiuPkOPPcTqzm73U_Tl6t3nyw-r9af3Hy8v1isrGJ9XFBhVGFQ_ej5wgbEAj9XAqdbECbCgPLNKiEE5ojWzuicSE24V8R6YHtkpen3QXdIGdluI0WxKmKDsDMFmH4vZx2J-xdLotwd6swyTG61Lc4E_HRmC-buSwrX5lm8Mk7LXRDaBl7cCJf9YXJ3NFOo-B0guL9UQRaXoe6ZJQ1_c9_ptchd4A_ABsCXXWpw3NswwtxE06xAffv-rf1r--1lxgEPyuUywzSWOZoZdzMWXNq5QDXug7yfPVLY9
CitedBy_id crossref_primary_10_1016_j_bbcan_2015_07_004
crossref_primary_10_3748_wjg_v22_i18_4446
crossref_primary_10_1016_j_clim_2017_08_016
crossref_primary_10_1080_21645515_2015_1009336
crossref_primary_10_1517_13543784_2015_985376
crossref_primary_10_3389_fcell_2021_686544
crossref_primary_10_3892_ol_2015_3239
crossref_primary_10_1080_21645515_2023_2276629
crossref_primary_10_3892_ijo_2014_2433
crossref_primary_10_4161_21645515_2014_982993
crossref_primary_10_1016_j_addr_2021_114107
crossref_primary_10_4161_onci_25375
crossref_primary_10_4161_onci_25771
crossref_primary_10_4161_onci_25994
crossref_primary_10_3748_wjg_v22_i17_4275
crossref_primary_10_1080_21645515_2015_1023971
crossref_primary_10_1016_j_actbio_2023_11_029
crossref_primary_10_1038_s41467_019_11157_1
crossref_primary_10_1016_j_bioactmat_2022_10_016
crossref_primary_10_1016_j_bioactmat_2024_12_023
crossref_primary_10_4161_21624011_2014_963424
crossref_primary_10_3109_07357907_2014_958234
crossref_primary_10_1016_j_biologicals_2014_07_004
crossref_primary_10_3390_biomedicines12030699
crossref_primary_10_2217_imt_15_73
crossref_primary_10_3390_ijms17060828
crossref_primary_10_1016_j_ijbiomac_2014_05_018
crossref_primary_10_1021_acs_nanolett_2c00216
crossref_primary_10_3390_cancers12010069
crossref_primary_10_1126_scitranslmed_abb6981
crossref_primary_10_18632_oncotarget_2998
crossref_primary_10_3390_cancers12030590
crossref_primary_10_1002_adfm_202003559
crossref_primary_10_1089_cbr_2017_2259
crossref_primary_10_2217_imt_13_96
Cites_doi 10.1038/nm923
10.4049/jimmunol.168.5.2111
10.1155/2010/516768
10.1016/j.clim.2004.08.004
10.1158/1078-0432.CCR-05-1330
10.1073/pnas.040540197
10.4049/jimmunol.179.7.4874
10.1586/14760584.7.7.1055
10.1371/journal.pone.0059280
10.1084/jem.183.1.283
10.1146/annurev.iy.09.040191.001415
10.1038/nm0398-328
10.1038/nm0597-558
10.4049/jimmunol.178.1.613
10.1084/jem.183.1.317
ContentType Journal Article
Copyright Copyright © 2013 Landes Bioscience 2013
Copyright_xml – notice: Copyright © 2013 Landes Bioscience 2013
DBID 0YH
AAYXX
CITATION
NPM
7X8
5PM
ADTOC
UNPAY
DOI 10.4161/onci.24437
DatabaseName Taylor and Francis Online
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2162-402X
ExternalDocumentID 10.4161/onci.24437
PMC3667916
23762810
10_4161_onci_24437
10924437
Genre Other
Journal Article
GroupedDBID 00X
0YH
53G
AAKDD
ABDBF
ABUPF
ACENM
ACGFS
ACUHS
ADBBV
ADCVX
AENEX
AIJEM
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BABNJ
BLEHA
CCCUG
DEAQA
DGEBU
DGFLZ
EBD
EBS
EJD
EUPTU
GROUPED_DOAJ
H13
HYE
KRBQP
KSSTO
KTTOD
KWAYT
KYCEM
M4Z
O9-
OK1
OVD
RPM
TDBHL
TEORI
TFL
TFW
TNTFI
4.4
AAYXX
CITATION
EMOBN
LJTGL
TTHFI
NPM
7X8
5PM
ADTOC
UNPAY
ID FETCH-LOGICAL-c534t-2a3280a87df4b45005af08b42991e5aca8f3c855b8e1993c9716014c81ffa39d3
IEDL.DBID 0YH
ISSN 2162-402X
2162-4011
IngestDate Wed Oct 01 16:14:54 EDT 2025
Thu Aug 21 14:02:01 EDT 2025
Thu Sep 04 17:17:30 EDT 2025
Thu Apr 03 06:57:51 EDT 2025
Thu Apr 24 22:53:07 EDT 2025
Wed Oct 01 02:48:19 EDT 2025
Wed Dec 25 09:05:27 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords anticancer vaccines
dendritic cells
cell fusions
Language English
License open-access: http://creativecommons.org/licenses/by-nc/3.0/: This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
cc-by-nc
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c534t-2a3280a87df4b45005af08b42991e5aca8f3c855b8e1993c9716014c81ffa39d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.tandfonline.com/doi/abs/10.4161/onci.24437
PMID 23762810
PQID 1826577391
PQPubID 23479
ParticipantIDs unpaywall_primary_10_4161_onci_24437
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3667916
crossref_primary_10_4161_onci_24437
proquest_miscellaneous_1826577391
pubmed_primary_23762810
crossref_citationtrail_10_4161_onci_24437
informaworld_taylorfrancis_310_4161_onci_24437
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 5/1/2013
2013-05-00
2013-May-01
20130501
PublicationDateYYYYMMDD 2013-05-01
PublicationDate_xml – month: 05
  year: 2013
  text: 5/1/2013
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Oncoimmunology
PublicationTitleAlternate Oncoimmunology
PublicationYear 2013
Publisher Taylor & Francis
Landes Bioscience
Publisher_xml – name: Taylor & Francis
– name: Landes Bioscience
References R2
R3
R4
R5
R6
R7
R8
R9
Koido S (R11) 2013; 33
R10
R12
R14
R13
R16
R15
R1
References_xml – ident: R4
  doi: 10.1038/nm923
– ident: R9
  doi: 10.4049/jimmunol.168.5.2111
– ident: R13
  doi: 10.1155/2010/516768
– ident: R10
  doi: 10.1016/j.clim.2004.08.004
– ident: R12
  doi: 10.1158/1078-0432.CCR-05-1330
– ident: R6
  doi: 10.1073/pnas.040540197
– ident: R16
  doi: 10.4049/jimmunol.179.7.4874
– ident: R8
  doi: 10.1586/14760584.7.7.1055
– ident: R14
  doi: 10.1371/journal.pone.0059280
– ident: R3
  doi: 10.1084/jem.183.1.283
– ident: R1
  doi: 10.1146/annurev.iy.09.040191.001415
– ident: R2
  doi: 10.1038/nm0398-328
– ident: R7
  doi: 10.1038/nm0597-558
– volume: 33
  start-page: 347
  year: 2013
  ident: R11
  publication-title: Anticancer Res
– ident: R15
  doi: 10.4049/jimmunol.178.1.613
– ident: R5
  doi: 10.1084/jem.183.1.317
SSID ssj0000605639
Score 2.1754751
Snippet Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer...
SourceID unpaywall
pubmedcentral
proquest
pubmed
crossref
informaworld
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e24437
SubjectTerms anticancer vaccines
cell fusions
dendritic cells
Point of View
SummonAdditionalLinks – databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9swED-6lLGnfX94tEVjfdmDM1sftvJQShgNZYyyhwWyJyPJ1lqWOSGxV7q_fnf-CE0XxmBvxpItJN3p7qTT7wdwjDGyNCmXoRlZG0rto1BbbkKvnENzlGNQ0mRbXCTnU_lxpmZ7MOnvwlBaJcXQvgWKaNZqUu5l7knByR1_vyjd1RDNkkhPS1zixw2z4Em1qot7sJ8ojKIHsD-9-Dz-SsxyMV0Lihoi3u6Zz1qc0js_27JMW7ilu7zPP5MoH9Tl0txcm_n8loWaPIJvfd_axJTvw7qyQ_frDuzj_3f-MTzsnFg2bqXuCewV5VO439Ja3jyDT5Oa9uDWrEsCY7i25Q2lAqNzgjXDxtk1EfOyqv6xWPVvqYC21lEOV-yncXTmv34O08nZlw_nYcfaEDolZBVyI7iOjE5zL61UqOXGR9qS3YsLZZzRXjitlNUFJQ86wrDCOM3p2HsjRrl4AYNyURavgMlc4GTywnGbSBMpHQnPk5Qbj142ylgA7_oZy1wHaU7MGvMMQxsarYxGK2tGK4C3m7rLFshjZ63h7YnPqmbbxLccJ5nY9cGbXjQyVEwaL1MWi3qdUeCm0lSM4gBetqKyaZhSkbiOowDSLSHaVCDQ7-2S8uqyAf8WSZKiSx_A8Ubc_tKf1_9W7QAGJEGH6F9V9qhTnt_yISmo
  priority: 102
  providerName: Unpaywall
Title Fusions between dendritic cells and whole tumor cells as anticancer vaccines
URI https://www.tandfonline.com/doi/abs/10.4161/onci.24437
https://www.ncbi.nlm.nih.gov/pubmed/23762810
https://www.proquest.com/docview/1826577391
https://pubmed.ncbi.nlm.nih.gov/PMC3667916
https://www.tandfonline.com/doi/pdf/10.4161/onci.24437?needAccess=true
UnpaywallVersion publishedVersion
Volume 2
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 2162-402X
  dateEnd: 20150731
  omitProxy: true
  ssIdentifier: ssj0000605639
  issn: 2162-402X
  databaseCode: ABDBF
  dateStart: 20120301
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVAQN
  databaseName: PubMed Central (WRLC)
  customDbUrl:
  eissn: 2162-402X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000605639
  issn: 2162-402X
  databaseCode: RPM
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED-6lrG-jH3P21o01pc9uHP0YSmPabsQxih7WKB9MpJssULmlMRu6X-_OzkxzRYGfTLYEkZ3J93vzuffARxhjCyt5jK1Q-dSaUKWGsdtGpT36I5KDEpitcV5PpnKbxfqYgfy9b8wVFZJMXToiCLiWU2b27rYgYTg-Jd57a-O0S0J_Qj2uEYAgXacXU763EqGGB09b8dG-teUDf-zwU66DWP-Wyr5pK2v7d2tnc3u-aHxM3i6ApBs1Gn8OexU9Qt43LWUvHsJ38ct5b-WbFWAxfBcKWM7A0Y5-iXDVbNbaorLmvb3fLG-Sw8orY02sGA31tP39uUrmI6__jydpKuOCalXQjYpt4KbzBpdBumkwh1mQ2Yc-ZxBpay3JghvlHKmosI9T_xRGCN5MwjBimEpXsNuPa-rt8BkKYZG88pzl0ubKZOJwHPNbUCEi_pN4PNajoVf0YlTV4tZgWEFybwgmRdR5gl86sdedyQaW0cd31dH0cSURej6ixRi24SPa4UVuClIXrau5u2yoKBJaS2GgwTedArsX0xlQNwMsgT0hmr7AUS4vfmkvvoVibdFnmuE0wkc9Ubwn_W8e-h63sM-j802qJzyA-w2i7Y6QMjTuMNo34ewNzo5OxnjdXr-Y3T5Bx8KBfI
linkProvider Taylor & Francis
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB7RIlQuCCiF8KoRvXBIm_Uj9h4RYrXQpadWKifLcWK10pKtNkmr_vvOJNmoW1ZIXGNbkWc8nvkmk28ADhAjS6e5jN04y2JpQhKbjLs4KO_RHeUIStpqi5N0eiZ_nqvzPnVR9WWVhKFDRxTR3tVk3JSMJgunePxoUfrLQ_RLQm_BY_rTklBX8ns6JFcSDNLR9XZ0pA-WrDmgNXrSTUHm37WSO0155W5v3Hx-zxFNnsOzPoJkXzuVv4BHRfkSnnQ9JW93YTZpKAFWsb4Ci-HFkrf9DBgl6SuG22Y31BWX1c2fxXL1lAYor42HYMmunacP7tUrOJt8P_02jfuWCbFXQtYxd4KbxBmdB5lJhSbmQmIycjqjQjnvTBDeKJWZgir3PBFIIUjyZhSCE-Nc7MF2uSiLN8BkLsZG88LzLJUuUSYRgaeau4AhLio4gi8rOVrf84lTW4u5RVxBMrckc9vKPILPw9yrjkVj46zD--qwdZuzCF2DESs2Lfi0UphFqyB5ubJYNJUl1KS0FuNRBK87BQ4vpjogbkZJBHpNtcMEYtxeHykvL1rmbZGmGuPpCA6GQ_CP_bz93_3sw8709NfMzn6cHL-Dp7ztvEG1le9hu142xQeMf-rsY3vW7wDgcAZF
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NT9swFH8CpgGXaRtsZJ-exoVDutQfsXuctlWFIbTDkOBkOU4skLq0ahMQ__3eS9qIjgpp19hW5Pfh9-Hn3wM4xBhZOs1l7AZZFksTkthk3MVBeY_mKMegpKm2OEtH5_LkQl1sQLp8C0NllRRDhxYoojmrSbmneSAFJ3f8y6T01z00S0JvwhN6aEmSnVyOutxKgj46Wt4WjfSfJSv2ZwWddJ2P-bBUcqcup-7u1o3H9-zQ8Dk8WziQ7GvL8RewUZQv4WnbUvJuD06HNeW_5mxRgMXwXMmbdgaMcvRzhrtmt9QUl1X1n8ls-ZUGKK2NMjBjN87Tfft8H86HP35_G8WLjgmxV0JWMXeCm8QZnQeZSYUa5kJiMrI5_UI570wQ3iiVmYIK9zzhR2GM5E0_BCcGuXgFW-WkLA6AyVwMjOaF51kqXaJMIgJPNXcBPVzkbwRHSzpav4ATp64WY4thBdHcEs1tQ_MIPndzpy2IxtpZvfvssFWTsghtfxEr1i34tGSYRaUgermymNRzS0GT0loM-hG8bhnY_ZjKgLjpJxHoFdZ2Ewhwe3WkvL5qgLdFmmp0pyM47ITgkf28-d_9fITtX9-H9vT47Odb2OVN3w2qrHwHW9WsLt6j91NlHxpR_wtDmgVu
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9swED-6lLGnfX94tEVjfdmDM1sftvJQShgNZYyyhwWyJyPJ1lqWOSGxV7q_fnf-CE0XxmBvxpItJN3p7qTT7wdwjDGyNCmXoRlZG0rto1BbbkKvnENzlGNQ0mRbXCTnU_lxpmZ7MOnvwlBaJcXQvgWKaNZqUu5l7knByR1_vyjd1RDNkkhPS1zixw2z4Em1qot7sJ8ojKIHsD-9-Dz-SsxyMV0Lihoi3u6Zz1qc0js_27JMW7ilu7zPP5MoH9Tl0txcm_n8loWaPIJvfd_axJTvw7qyQ_frDuzj_3f-MTzsnFg2bqXuCewV5VO439Ja3jyDT5Oa9uDWrEsCY7i25Q2lAqNzgjXDxtk1EfOyqv6xWPVvqYC21lEOV-yncXTmv34O08nZlw_nYcfaEDolZBVyI7iOjE5zL61UqOXGR9qS3YsLZZzRXjitlNUFJQ86wrDCOM3p2HsjRrl4AYNyURavgMlc4GTywnGbSBMpHQnPk5Qbj142ylgA7_oZy1wHaU7MGvMMQxsarYxGK2tGK4C3m7rLFshjZ63h7YnPqmbbxLccJ5nY9cGbXjQyVEwaL1MWi3qdUeCm0lSM4gBetqKyaZhSkbiOowDSLSHaVCDQ7-2S8uqyAf8WSZKiSx_A8Ubc_tKf1_9W7QAGJEGH6F9V9qhTnt_yISmo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fusions+between+dendritic+cells+and+whole+tumor+cells+as+anticancer+vaccines&rft.jtitle=Oncoimmunology&rft.au=Koido%2C+Shigeo&rft.au=Homma%2C+Sadamu&rft.au=Okamoto%2C+Masato&rft.au=Namiki%2C+Yoshihisa&rft.date=2013-05-01&rft.pub=Taylor+%26+Francis&rft.eissn=2162-402X&rft.volume=2&rft.issue=5&rft_id=info:doi/10.4161%2Fonci.24437&rft.externalDBID=0YH&rft.externalDocID=10924437
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2162-402X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2162-402X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2162-402X&client=summon