Fusions between dendritic cells and whole tumor cells as anticancer vaccines
Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecul...
Saved in:
Published in | Oncoimmunology Vol. 2; no. 5; p. e24437 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
01.05.2013
Landes Bioscience |
Subjects | |
Online Access | Get full text |
ISSN | 2162-402X 2162-4011 2162-402X |
DOI | 10.4161/onci.24437 |
Cover
Abstract | Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions. |
---|---|
AbstractList | Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions.Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions. Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer cells can process a broad array of TAAs, including hitherto unidentified molecules, and present them in complex with MHC Class I and II molecules and in the context of co-stimulatory signals. DC-cancer cell fusions have been shown to stimulate potent antitumor immune responses in animal models. In early clinical trials, however, the antitumor effects of DC-cancer cell fusions are not as vigorous as in preclinical settings. This mini-review summarizes recent advances in anticancer vaccines based on DC-cancer cell fusions. |
Author | Tajiri, Hisao Ohkusa, Toshifumi Okamoto, Masato Gong, Jianlin Kan, Shin Ito, Masaki Imazu, Hiroo Arihiro, Seiji Homma, Sadamu Uchiyama, Kan Kajihara, Mikio Takakura, Kazuki Koido, Shigeo Arakawa, Hiroshi Namiki, Yoshihisa Komita, Hideo |
Author_xml | – sequence: 1 givenname: Shigeo surname: Koido fullname: Koido, Shigeo email: shigeo_koido@jikei.ac.jp – sequence: 2 givenname: Sadamu surname: Homma fullname: Homma, Sadamu – sequence: 3 givenname: Masato surname: Okamoto fullname: Okamoto, Masato – sequence: 4 givenname: Yoshihisa surname: Namiki fullname: Namiki, Yoshihisa – sequence: 5 givenname: Kazuki surname: Takakura fullname: Takakura, Kazuki – sequence: 6 givenname: Kan surname: Uchiyama fullname: Uchiyama, Kan – sequence: 7 givenname: Mikio surname: Kajihara fullname: Kajihara, Mikio – sequence: 8 givenname: Seiji surname: Arihiro fullname: Arihiro, Seiji – sequence: 9 givenname: Hiroo surname: Imazu fullname: Imazu, Hiroo – sequence: 10 givenname: Hiroshi surname: Arakawa fullname: Arakawa, Hiroshi – sequence: 11 givenname: Shin surname: Kan fullname: Kan, Shin – sequence: 12 givenname: Hideo surname: Komita fullname: Komita, Hideo – sequence: 13 givenname: Masaki surname: Ito fullname: Ito, Masaki – sequence: 14 givenname: Toshifumi surname: Ohkusa fullname: Ohkusa, Toshifumi – sequence: 15 givenname: Jianlin surname: Gong fullname: Gong, Jianlin – sequence: 16 givenname: Hisao surname: Tajiri fullname: Tajiri, Hisao |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23762810$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kV9rFDEUxYNUbK198QPIPIqyNf8neRFKsSos-KLgW7iTSWwkk6zJTJf99mbdVqsU85KQ-7vnJOc-RUcpJ4fQc4LPOZHkTU42nFPOWf8InVAi6Ypj-vXo3vkYndX6HbclsZBMP0HHlPWSKoJP0PpqqSGn2g1u3jqXutGlsYQ52M66GGsHaey21zm6bl6mXO5u94UGQbKudDdgbUiuPkOPPcTqzm73U_Tl6t3nyw-r9af3Hy8v1isrGJ9XFBhVGFQ_ej5wgbEAj9XAqdbECbCgPLNKiEE5ojWzuicSE24V8R6YHtkpen3QXdIGdluI0WxKmKDsDMFmH4vZx2J-xdLotwd6swyTG61Lc4E_HRmC-buSwrX5lm8Mk7LXRDaBl7cCJf9YXJ3NFOo-B0guL9UQRaXoe6ZJQ1_c9_ptchd4A_ABsCXXWpw3NswwtxE06xAffv-rf1r--1lxgEPyuUywzSWOZoZdzMWXNq5QDXug7yfPVLY9 |
CitedBy_id | crossref_primary_10_1016_j_bbcan_2015_07_004 crossref_primary_10_3748_wjg_v22_i18_4446 crossref_primary_10_1016_j_clim_2017_08_016 crossref_primary_10_1080_21645515_2015_1009336 crossref_primary_10_1517_13543784_2015_985376 crossref_primary_10_3389_fcell_2021_686544 crossref_primary_10_3892_ol_2015_3239 crossref_primary_10_1080_21645515_2023_2276629 crossref_primary_10_3892_ijo_2014_2433 crossref_primary_10_4161_21645515_2014_982993 crossref_primary_10_1016_j_addr_2021_114107 crossref_primary_10_4161_onci_25375 crossref_primary_10_4161_onci_25771 crossref_primary_10_4161_onci_25994 crossref_primary_10_3748_wjg_v22_i17_4275 crossref_primary_10_1080_21645515_2015_1023971 crossref_primary_10_1016_j_actbio_2023_11_029 crossref_primary_10_1038_s41467_019_11157_1 crossref_primary_10_1016_j_bioactmat_2022_10_016 crossref_primary_10_1016_j_bioactmat_2024_12_023 crossref_primary_10_4161_21624011_2014_963424 crossref_primary_10_3109_07357907_2014_958234 crossref_primary_10_1016_j_biologicals_2014_07_004 crossref_primary_10_3390_biomedicines12030699 crossref_primary_10_2217_imt_15_73 crossref_primary_10_3390_ijms17060828 crossref_primary_10_1016_j_ijbiomac_2014_05_018 crossref_primary_10_1021_acs_nanolett_2c00216 crossref_primary_10_3390_cancers12010069 crossref_primary_10_1126_scitranslmed_abb6981 crossref_primary_10_18632_oncotarget_2998 crossref_primary_10_3390_cancers12030590 crossref_primary_10_1002_adfm_202003559 crossref_primary_10_1089_cbr_2017_2259 crossref_primary_10_2217_imt_13_96 |
Cites_doi | 10.1038/nm923 10.4049/jimmunol.168.5.2111 10.1155/2010/516768 10.1016/j.clim.2004.08.004 10.1158/1078-0432.CCR-05-1330 10.1073/pnas.040540197 10.4049/jimmunol.179.7.4874 10.1586/14760584.7.7.1055 10.1371/journal.pone.0059280 10.1084/jem.183.1.283 10.1146/annurev.iy.09.040191.001415 10.1038/nm0398-328 10.1038/nm0597-558 10.4049/jimmunol.178.1.613 10.1084/jem.183.1.317 |
ContentType | Journal Article |
Copyright | Copyright © 2013 Landes Bioscience 2013 |
Copyright_xml | – notice: Copyright © 2013 Landes Bioscience 2013 |
DBID | 0YH AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY |
DOI | 10.4161/onci.24437 |
DatabaseName | Taylor and Francis Online CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 0YH name: Taylor & Francis Open Access url: https://www.tandfonline.com sourceTypes: Publisher – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2162-402X |
ExternalDocumentID | 10.4161/onci.24437 PMC3667916 23762810 10_4161_onci_24437 10924437 |
Genre | Other Journal Article |
GroupedDBID | 00X 0YH 53G AAKDD ABDBF ABUPF ACENM ACGFS ACUHS ADBBV ADCVX AENEX AIJEM ALMA_UNASSIGNED_HOLDINGS AOIJS BABNJ BLEHA CCCUG DEAQA DGEBU DGFLZ EBD EBS EJD EUPTU GROUPED_DOAJ H13 HYE KRBQP KSSTO KTTOD KWAYT KYCEM M4Z O9- OK1 OVD RPM TDBHL TEORI TFL TFW TNTFI 4.4 AAYXX CITATION EMOBN LJTGL TTHFI NPM 7X8 5PM ADTOC UNPAY |
ID | FETCH-LOGICAL-c534t-2a3280a87df4b45005af08b42991e5aca8f3c855b8e1993c9716014c81ffa39d3 |
IEDL.DBID | 0YH |
ISSN | 2162-402X 2162-4011 |
IngestDate | Wed Oct 01 16:14:54 EDT 2025 Thu Aug 21 14:02:01 EDT 2025 Thu Sep 04 17:17:30 EDT 2025 Thu Apr 03 06:57:51 EDT 2025 Thu Apr 24 22:53:07 EDT 2025 Wed Oct 01 02:48:19 EDT 2025 Wed Dec 25 09:05:27 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | anticancer vaccines dendritic cells cell fusions |
Language | English |
License | open-access: http://creativecommons.org/licenses/by-nc/3.0/: This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. cc-by-nc |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c534t-2a3280a87df4b45005af08b42991e5aca8f3c855b8e1993c9716014c81ffa39d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.tandfonline.com/doi/abs/10.4161/onci.24437 |
PMID | 23762810 |
PQID | 1826577391 |
PQPubID | 23479 |
ParticipantIDs | unpaywall_primary_10_4161_onci_24437 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3667916 crossref_primary_10_4161_onci_24437 proquest_miscellaneous_1826577391 pubmed_primary_23762810 crossref_citationtrail_10_4161_onci_24437 informaworld_taylorfrancis_310_4161_onci_24437 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 5/1/2013 2013-05-00 2013-May-01 20130501 |
PublicationDateYYYYMMDD | 2013-05-01 |
PublicationDate_xml | – month: 05 year: 2013 text: 5/1/2013 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Oncoimmunology |
PublicationTitleAlternate | Oncoimmunology |
PublicationYear | 2013 |
Publisher | Taylor & Francis Landes Bioscience |
Publisher_xml | – name: Taylor & Francis – name: Landes Bioscience |
References | R2 R3 R4 R5 R6 R7 R8 R9 Koido S (R11) 2013; 33 R10 R12 R14 R13 R16 R15 R1 |
References_xml | – ident: R4 doi: 10.1038/nm923 – ident: R9 doi: 10.4049/jimmunol.168.5.2111 – ident: R13 doi: 10.1155/2010/516768 – ident: R10 doi: 10.1016/j.clim.2004.08.004 – ident: R12 doi: 10.1158/1078-0432.CCR-05-1330 – ident: R6 doi: 10.1073/pnas.040540197 – ident: R16 doi: 10.4049/jimmunol.179.7.4874 – ident: R8 doi: 10.1586/14760584.7.7.1055 – ident: R14 doi: 10.1371/journal.pone.0059280 – ident: R3 doi: 10.1084/jem.183.1.283 – ident: R1 doi: 10.1146/annurev.iy.09.040191.001415 – ident: R2 doi: 10.1038/nm0398-328 – ident: R7 doi: 10.1038/nm0597-558 – volume: 33 start-page: 347 year: 2013 ident: R11 publication-title: Anticancer Res – ident: R15 doi: 10.4049/jimmunol.178.1.613 – ident: R5 doi: 10.1084/jem.183.1.317 |
SSID | ssj0000605639 |
Score | 2.1754751 |
Snippet | Various strategies have been developed to deliver tumor-associated antigens (TAAs) to dendritic cells (DCs). Among these, the fusion of DCs and whole cancer... |
SourceID | unpaywall pubmedcentral proquest pubmed crossref informaworld |
SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
StartPage | e24437 |
SubjectTerms | anticancer vaccines cell fusions dendritic cells Point of View |
SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9swED-6lLGnfX94tEVjfdmDM1sftvJQShgNZYyyhwWyJyPJ1lqWOSGxV7q_fnf-CE0XxmBvxpItJN3p7qTT7wdwjDGyNCmXoRlZG0rto1BbbkKvnENzlGNQ0mRbXCTnU_lxpmZ7MOnvwlBaJcXQvgWKaNZqUu5l7knByR1_vyjd1RDNkkhPS1zixw2z4Em1qot7sJ8ojKIHsD-9-Dz-SsxyMV0Lihoi3u6Zz1qc0js_27JMW7ilu7zPP5MoH9Tl0txcm_n8loWaPIJvfd_axJTvw7qyQ_frDuzj_3f-MTzsnFg2bqXuCewV5VO439Ja3jyDT5Oa9uDWrEsCY7i25Q2lAqNzgjXDxtk1EfOyqv6xWPVvqYC21lEOV-yncXTmv34O08nZlw_nYcfaEDolZBVyI7iOjE5zL61UqOXGR9qS3YsLZZzRXjitlNUFJQ86wrDCOM3p2HsjRrl4AYNyURavgMlc4GTywnGbSBMpHQnPk5Qbj142ylgA7_oZy1wHaU7MGvMMQxsarYxGK2tGK4C3m7rLFshjZ63h7YnPqmbbxLccJ5nY9cGbXjQyVEwaL1MWi3qdUeCm0lSM4gBetqKyaZhSkbiOowDSLSHaVCDQ7-2S8uqyAf8WSZKiSx_A8Ubc_tKf1_9W7QAGJEGH6F9V9qhTnt_yISmo priority: 102 providerName: Unpaywall |
Title | Fusions between dendritic cells and whole tumor cells as anticancer vaccines |
URI | https://www.tandfonline.com/doi/abs/10.4161/onci.24437 https://www.ncbi.nlm.nih.gov/pubmed/23762810 https://www.proquest.com/docview/1826577391 https://pubmed.ncbi.nlm.nih.gov/PMC3667916 https://www.tandfonline.com/doi/pdf/10.4161/onci.24437?needAccess=true |
UnpaywallVersion | publishedVersion |
Volume | 2 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2162-402X dateEnd: 20150731 omitProxy: true ssIdentifier: ssj0000605639 issn: 2162-402X databaseCode: ABDBF dateStart: 20120301 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVAQN databaseName: PubMed Central (WRLC) customDbUrl: eissn: 2162-402X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000605639 issn: 2162-402X databaseCode: RPM dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED-6lrG-jH3P21o01pc9uHP0YSmPabsQxih7WKB9MpJssULmlMRu6X-_OzkxzRYGfTLYEkZ3J93vzuffARxhjCyt5jK1Q-dSaUKWGsdtGpT36I5KDEpitcV5PpnKbxfqYgfy9b8wVFZJMXToiCLiWU2b27rYgYTg-Jd57a-O0S0J_Qj2uEYAgXacXU763EqGGB09b8dG-teUDf-zwU66DWP-Wyr5pK2v7d2tnc3u-aHxM3i6ApBs1Gn8OexU9Qt43LWUvHsJ38ct5b-WbFWAxfBcKWM7A0Y5-iXDVbNbaorLmvb3fLG-Sw8orY02sGA31tP39uUrmI6__jydpKuOCalXQjYpt4KbzBpdBumkwh1mQ2Yc-ZxBpay3JghvlHKmosI9T_xRGCN5MwjBimEpXsNuPa-rt8BkKYZG88pzl0ubKZOJwHPNbUCEi_pN4PNajoVf0YlTV4tZgWEFybwgmRdR5gl86sdedyQaW0cd31dH0cSURej6ixRi24SPa4UVuClIXrau5u2yoKBJaS2GgwTedArsX0xlQNwMsgT0hmr7AUS4vfmkvvoVibdFnmuE0wkc9Ubwn_W8e-h63sM-j802qJzyA-w2i7Y6QMjTuMNo34ewNzo5OxnjdXr-Y3T5Bx8KBfI |
linkProvider | Taylor & Francis |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB7RIlQuCCiF8KoRvXBIm_Uj9h4RYrXQpadWKifLcWK10pKtNkmr_vvOJNmoW1ZIXGNbkWc8nvkmk28ADhAjS6e5jN04y2JpQhKbjLs4KO_RHeUIStpqi5N0eiZ_nqvzPnVR9WWVhKFDRxTR3tVk3JSMJgunePxoUfrLQ_RLQm_BY_rTklBX8ns6JFcSDNLR9XZ0pA-WrDmgNXrSTUHm37WSO0155W5v3Hx-zxFNnsOzPoJkXzuVv4BHRfkSnnQ9JW93YTZpKAFWsb4Ci-HFkrf9DBgl6SuG22Y31BWX1c2fxXL1lAYor42HYMmunacP7tUrOJt8P_02jfuWCbFXQtYxd4KbxBmdB5lJhSbmQmIycjqjQjnvTBDeKJWZgir3PBFIIUjyZhSCE-Nc7MF2uSiLN8BkLsZG88LzLJUuUSYRgaeau4AhLio4gi8rOVrf84lTW4u5RVxBMrckc9vKPILPw9yrjkVj46zD--qwdZuzCF2DESs2Lfi0UphFqyB5ubJYNJUl1KS0FuNRBK87BQ4vpjogbkZJBHpNtcMEYtxeHykvL1rmbZGmGuPpCA6GQ_CP_bz93_3sw8709NfMzn6cHL-Dp7ztvEG1le9hu142xQeMf-rsY3vW7wDgcAZF |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NT9swFH8CpgGXaRtsZJ-exoVDutQfsXuctlWFIbTDkOBkOU4skLq0ahMQ__3eS9qIjgpp19hW5Pfh9-Hn3wM4xBhZOs1l7AZZFksTkthk3MVBeY_mKMegpKm2OEtH5_LkQl1sQLp8C0NllRRDhxYoojmrSbmneSAFJ3f8y6T01z00S0JvwhN6aEmSnVyOutxKgj46Wt4WjfSfJSv2ZwWddJ2P-bBUcqcup-7u1o3H9-zQ8Dk8WziQ7GvL8RewUZQv4WnbUvJuD06HNeW_5mxRgMXwXMmbdgaMcvRzhrtmt9QUl1X1n8ls-ZUGKK2NMjBjN87Tfft8H86HP35_G8WLjgmxV0JWMXeCm8QZnQeZSYUa5kJiMrI5_UI570wQ3iiVmYIK9zzhR2GM5E0_BCcGuXgFW-WkLA6AyVwMjOaF51kqXaJMIgJPNXcBPVzkbwRHSzpav4ATp64WY4thBdHcEs1tQ_MIPndzpy2IxtpZvfvssFWTsghtfxEr1i34tGSYRaUgermymNRzS0GT0loM-hG8bhnY_ZjKgLjpJxHoFdZ2Ewhwe3WkvL5qgLdFmmp0pyM47ITgkf28-d_9fITtX9-H9vT47Odb2OVN3w2qrHwHW9WsLt6j91NlHxpR_wtDmgVu |
linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9swED-6lLGnfX94tEVjfdmDM1sftvJQShgNZYyyhwWyJyPJ1lqWOSGxV7q_fnf-CE0XxmBvxpItJN3p7qTT7wdwjDGyNCmXoRlZG0rto1BbbkKvnENzlGNQ0mRbXCTnU_lxpmZ7MOnvwlBaJcXQvgWKaNZqUu5l7knByR1_vyjd1RDNkkhPS1zixw2z4Em1qot7sJ8ojKIHsD-9-Dz-SsxyMV0Lihoi3u6Zz1qc0js_27JMW7ilu7zPP5MoH9Tl0txcm_n8loWaPIJvfd_axJTvw7qyQ_frDuzj_3f-MTzsnFg2bqXuCewV5VO439Ja3jyDT5Oa9uDWrEsCY7i25Q2lAqNzgjXDxtk1EfOyqv6xWPVvqYC21lEOV-yncXTmv34O08nZlw_nYcfaEDolZBVyI7iOjE5zL61UqOXGR9qS3YsLZZzRXjitlNUFJQ86wrDCOM3p2HsjRrl4AYNyURavgMlc4GTywnGbSBMpHQnPk5Qbj142ylgA7_oZy1wHaU7MGvMMQxsarYxGK2tGK4C3m7rLFshjZ63h7YnPqmbbxLccJ5nY9cGbXjQyVEwaL1MWi3qdUeCm0lSM4gBetqKyaZhSkbiOowDSLSHaVCDQ7-2S8uqyAf8WSZKiSx_A8Ubc_tKf1_9W7QAGJEGH6F9V9qhTnt_yISmo |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fusions+between+dendritic+cells+and+whole+tumor+cells+as+anticancer+vaccines&rft.jtitle=Oncoimmunology&rft.au=Koido%2C+Shigeo&rft.au=Homma%2C+Sadamu&rft.au=Okamoto%2C+Masato&rft.au=Namiki%2C+Yoshihisa&rft.date=2013-05-01&rft.pub=Taylor+%26+Francis&rft.eissn=2162-402X&rft.volume=2&rft.issue=5&rft_id=info:doi/10.4161%2Fonci.24437&rft.externalDBID=0YH&rft.externalDocID=10924437 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2162-402X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2162-402X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2162-402X&client=summon |