The proto CpG island methylator phenotype of sessile serrated adenomas/polyps

Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (...

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Published inEpigenetics Vol. 13; no. 10-11; pp. 1088 - 1105
Main Authors Parker, Hannah R., Orjuela, Stephany, Martinho Oliveira, Andreia, Cereatti, Fabrizio, Sauter, Matthias, Heinrich, Henriette, Tanzi, Giulia, Weber, Achim, Komminoth, Paul, Vavricka, Stephan, Albanese, Luca, Buffoli, Federico, Robinson, Mark D., Marra, Giancarlo
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 02.11.2018
Taylor & Francis Group
Subjects
Adenoma - genetics
Adenoma - pathology
adenomatous polyp
Aged
Aged, 80 and over
colon cancer
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Colonic Polyps - genetics
Colonic Polyps - pathology
CpG Islands
DNA Methylation
Female
Humans
Male
Middle Aged
Phenotype
Research Paper
Sessile serrated adenoma/polyp
DNA methylation
Sessile serrated adenoma/polyp
colon cancer
adenomatous polyp
Online AccessGet full text
ISSN1559-2294
1559-2308
1559-2308
DOI10.1080/15592294.2018.1543504

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Abstract Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (cADNs), each with a matched sample of normal mucosa. Their DNA was subjected to bisulfite next-generation sequencing to assess methylation levels at ~2.7 million CpGs located predominantly in gene regulatory regions and spanning 80.5Mb; RNA was sequenced to define the samples' transcriptomes. Compared with normal mucosa, SSA/Ps and cADNs exhibited markedly remodeled methylomes. In cADNs, hypomethylated regions were far more numerous (18,417 vs 4288 in SSA/Ps) and rarely affected CpG islands/shores. SSA/Ps seemed to have escaped this wave of demethylation. Cytosine hypermethylation in SSA/Ps was more pervasive (hypermethylated regions: 22,147 vs 15,965 in cADNs; hypermethylated genes: 4938 vs 3443 in cADNs) and more extensive (region for region), and it occurred mainly within CpG islands and shores. Given its resemblance to the CIMP typical of SSA/Ps' putative descendant colon cancers, we refer to the SSA/P methylation phenotype as proto-CIMP. Verification studies of six hypermethylated regions in an independent series of precancers demonstrated DNA methylation markers' high potential for predicting the diagnosis of SSA/Ps and cADNs. Surprisingly, proto-CIMP in SSA/Ps was associated with upregulated gene expression; downregulation was more common in cADNs. In conclusion, the epigenetic landscape of SSA/Ps differs markedly from that of cADNs. These differences are a potentially rich source of novel tissue-based and noninvasive biomarkers.
AbstractList Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (cADNs), each with a matched sample of normal mucosa. Their DNA was subjected to bisulfite next-generation sequencing to assess methylation levels at ~2.7 million CpGs located predominantly in gene regulatory regions and spanning 80.5Mb; RNA was sequenced to define the samples' transcriptomes. Compared with normal mucosa, SSA/Ps and cADNs exhibited markedly remodeled methylomes. In cADNs, hypomethylated regions were far more numerous (18,417 vs 4288 in SSA/Ps) and rarely affected CpG islands/shores. SSA/Ps seemed to have escaped this wave of demethylation. Cytosine hypermethylation in SSA/Ps was more pervasive (hypermethylated regions: 22,147 vs 15,965 in cADNs; hypermethylated genes: 4938 vs 3443 in cADNs) and more extensive (region for region), and it occurred mainly within CpG islands and shores. Given its resemblance to the CIMP typical of SSA/Ps' putative descendant colon cancers, we refer to the SSA/P methylation phenotype as proto-CIMP. Verification studies of six hypermethylated regions in an independent series of precancers demonstrated DNA methylation markers' high potential for predicting the diagnosis of SSA/Ps and cADNs. Surprisingly, proto-CIMP in SSA/Ps was associated with upregulated gene expression; downregulation was more common in cADNs. In conclusion, the epigenetic landscape of SSA/Ps differs markedly from that of cADNs. These differences are a potentially rich source of novel tissue-based and noninvasive biomarkers.
Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (cADNs), each with a matched sample of normal mucosa. Their DNA was subjected to bisulfite next-generation sequencing to assess methylation levels at ~2.7 million CpGs located predominantly in gene regulatory regions and spanning 80.5Mb; RNA was sequenced to define the samples' transcriptomes. Compared with normal mucosa, SSA/Ps and cADNs exhibited markedly remodeled methylomes. In cADNs, hypomethylated regions were far more numerous (18,417 vs 4288 in SSA/Ps) and rarely affected CpG islands/shores. SSA/Ps seemed to have escaped this wave of demethylation. Cytosine hypermethylation in SSA/Ps was more pervasive (hypermethylated regions: 22,147 vs 15,965 in cADNs; hypermethylated genes: 4938 vs 3443 in cADNs) and more extensive (region for region), and it occurred mainly within CpG islands and shores. Given its resemblance to the CIMP typical of SSA/Ps' putative descendant colon cancers, we refer to the SSA/P methylation phenotype as proto-CIMP. Verification studies of six hypermethylated regions in an independent series of precancers demonstrated DNA methylation markers' high potential for predicting the diagnosis of SSA/Ps and cADNs. Surprisingly, proto-CIMP in SSA/Ps was associated with upregulated gene expression; downregulation was more common in cADNs. In conclusion, the epigenetic landscape of SSA/Ps differs markedly from that of cADNs. These differences are a potentially rich source of novel tissue-based and noninvasive biomarkers.Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (cADNs), each with a matched sample of normal mucosa. Their DNA was subjected to bisulfite next-generation sequencing to assess methylation levels at ~2.7 million CpGs located predominantly in gene regulatory regions and spanning 80.5Mb; RNA was sequenced to define the samples' transcriptomes. Compared with normal mucosa, SSA/Ps and cADNs exhibited markedly remodeled methylomes. In cADNs, hypomethylated regions were far more numerous (18,417 vs 4288 in SSA/Ps) and rarely affected CpG islands/shores. SSA/Ps seemed to have escaped this wave of demethylation. Cytosine hypermethylation in SSA/Ps was more pervasive (hypermethylated regions: 22,147 vs 15,965 in cADNs; hypermethylated genes: 4938 vs 3443 in cADNs) and more extensive (region for region), and it occurred mainly within CpG islands and shores. Given its resemblance to the CIMP typical of SSA/Ps' putative descendant colon cancers, we refer to the SSA/P methylation phenotype as proto-CIMP. Verification studies of six hypermethylated regions in an independent series of precancers demonstrated DNA methylation markers' high potential for predicting the diagnosis of SSA/Ps and cADNs. Surprisingly, proto-CIMP in SSA/Ps was associated with upregulated gene expression; downregulation was more common in cADNs. In conclusion, the epigenetic landscape of SSA/Ps differs markedly from that of cADNs. These differences are a potentially rich source of novel tissue-based and noninvasive biomarkers.
Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To investigate the epigenetic phenotype of these precancers, we prospectively collected fresh-tissue samples of 17 SSA/Ps and 15 conventional adenomas (cADNs), each with a matched sample of normal mucosa. Their DNA was subjected to bisulfite next-generation sequencing to assess methylation levels at ~2.7 million CpGs located predominantly in gene regulatory regions and spanning 80.5Mb; RNA was sequenced to define the samples’ transcriptomes. Compared with normal mucosa, SSA/Ps and cADNs exhibited markedly remodeled methylomes. In cADNs, hypo methylated regions were far more numerous (18,417 vs 4288 in SSA/Ps) and rarely affected CpG islands/shores. SSA/Ps seemed to have escaped this wave of demethylation. Cytosine hyper methylation in SSA/Ps was more pervasive (hypermethylated regions: 22,147 vs 15,965 in cADNs; hypermethylated genes: 4938 vs 3443 in cADNs) and more extensive (region for region), and it occurred mainly within CpG islands and shores. Given its resemblance to the CIMP typical of SSA/Ps' putative descendant colon cancers, we refer to the SSA/P methylation phenotype as proto-CIMP . Verification studies of six hypermethylated regions in an independent series of precancers demonstrated DNA methylation markers’ high potential for predicting the diagnosis of SSA/Ps and cADNs. Surprisingly, proto-CIMP in SSA/Ps was associated with upregulated gene expression; downregulation was more common in cADNs. In conclusion, the epigenetic landscape of SSA/Ps differs markedly from that of cADNs. These differences are a potentially rich source of novel tissue-based and noninvasive biomarkers.
Author Heinrich, Henriette
Komminoth, Paul
Martinho Oliveira, Andreia
Vavricka, Stephan
Orjuela, Stephany
Albanese, Luca
Cereatti, Fabrizio
Tanzi, Giulia
Marra, Giancarlo
Parker, Hannah R.
Robinson, Mark D.
Sauter, Matthias
Weber, Achim
Buffoli, Federico
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Cites_doi 10.1038/nm.2305
10.1053/j.gastro.2005.01.056
10.1126/science.aaj2239
10.1038/nrg3230
10.1172/JCI69735
10.1093/bioinformatics/btt263
10.1038/ng1834
10.1002/emmm.201000099
10.1038/oncsis.2013.21
10.1038/nm.3174
10.1038/onc.2008.444
10.1002/ijc.23840
10.1136/gut.2003.037671
10.1016/j.ccr.2013.05.014
10.1016/j.ccr.2007.10.014
10.1038/ng1330
10.1038/ajg.2017.496
10.1053/j.gastro.2012.09.043
10.1038/nsmb.2518
10.1038/nature16490
10.1053/j.gastro.2009.12.064
10.1055/s-2005-861352
10.1038/nrg1748
10.1158/1940-6207.CAPR-15-0363
10.1136/gutjnl-2014-309041
10.1016/0022-2836(78)90243-7
10.1186/1476-4598-8-124
10.1016/j.cell.2013.12.019
10.1016/j.cell.2007.01.029
10.1002/ijc.25847
10.1056/NEJMoa1500596
10.1038/nmeth.4197
10.1038/ajg.2012.161
10.1371/journal.pone.0088367
10.1053/j.gastro.2014.09.038
10.1016/j.humpath.2015.01.003
10.1016/S0002-9440(10)63878-3
10.1007/s00428-014-1683-6
10.1158/0008-5472.CAN-12-3869
10.1042/BJ20121585
10.1101/gr.131169.111
10.1186/s12885-015-1087-2
10.3892/etm.2011.249
10.1101/gad.2037511
10.1016/j.molcel.2008.05.007
10.15252/embj.201797038
10.1038/nrgastro.2015.73
10.1136/gutjnl-2015-310456
10.7554/eLife.20331
10.1097/01.pas.0000213313.36306.85
10.1038/modpathol.2009.150
10.1371/journal.pone.0192499
10.1101/gr.136101.111
10.1053/j.gastro.2015.07.011
10.1038/ncponc0248
10.1053/j.gastro.2003.12.023
10.1053/j.gastro.2006.10.022
10.1053/j.gastro.2012.06.001
10.1038/onc.2009.449
10.1016/j.ajpath.2012.08.007
10.1073/pnas.95.12.6870
10.1097/PAS.0000000000000103
10.1093/bioinformatics/btp616
10.1038/onc.2015.423
10.1038/nature21373
10.1002/path.4200
10.1056/NEJMoa1311194
10.1073/pnas.96.15.8681
10.1155/2014/374926
10.1038/ng1941
10.1111/his.12055
10.1007/s00428-009-0731-0
10.1053/j.gastro.2010.06.052
10.1101/gr.117523.110
10.1038/ng1950
10.1038/nature09165
10.1016/j.molcel.2014.08.010
10.1158/0008-5472.CAN-12-3462
10.1136/gutjnl-2016-313573
10.1186/s12920-017-0317-7
10.1073/pnas.1217415110
10.1093/bioinformatics/btr167
10.1038/nrg3663
10.1053/j.gastro.2005.06.028
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Keywords DNA methylation
Sessile serrated adenoma/polyp
colon cancer
adenomatous polyp
Language English
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  doi: 10.1038/nm.2305
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  doi: 10.1053/j.gastro.2005.01.056
– ident: CIT0067
  doi: 10.1126/science.aaj2239
– ident: CIT0044
  doi: 10.1038/nrg3230
– ident: CIT0011
  doi: 10.1172/JCI69735
– ident: CIT0084
  doi: 10.1093/bioinformatics/btt263
– ident: CIT0015
  doi: 10.1038/ng1834
– ident: CIT0023
  doi: 10.1002/emmm.201000099
– ident: CIT0037
  doi: 10.1038/oncsis.2013.21
– ident: CIT0078
  doi: 10.1038/nm.3174
– ident: CIT0036
  doi: 10.1038/onc.2008.444
– ident: CIT0045
  doi: 10.1002/ijc.23840
– ident: CIT0020
  doi: 10.1136/gut.2003.037671
– ident: CIT0024
  doi: 10.1016/j.ccr.2013.05.014
– ident: CIT0043
  doi: 10.1016/j.ccr.2007.10.014
– ident: CIT0038
  doi: 10.1038/ng1330
– ident: CIT0029
  doi: 10.1038/ajg.2017.496
– ident: CIT0030
  doi: 10.1053/j.gastro.2012.09.043
– ident: CIT0059
  doi: 10.1038/nsmb.2518
– ident: CIT0068
  doi: 10.1038/nature16490
– ident: CIT0013
  doi: 10.1053/j.gastro.2009.12.064
– ident: CIT0081
  doi: 10.1055/s-2005-861352
– ident: CIT0009
  doi: 10.1038/nrg1748
– ident: CIT0079
  doi: 10.1158/1940-6207.CAPR-15-0363
– ident: CIT0028
  doi: 10.1136/gutjnl-2014-309041
– volume-title: WHO classification of tumors of the digestive system
  year: 2010
  ident: CIT0019
– ident: CIT0033
  doi: 10.1016/0022-2836(78)90243-7
– ident: CIT0035
  doi: 10.1186/1476-4598-8-124
– ident: CIT0034
  doi: 10.1016/j.cell.2013.12.019
– ident: CIT0010
  doi: 10.1016/j.cell.2007.01.029
– ident: CIT0048
  doi: 10.1002/ijc.25847
– ident: CIT0018
  doi: 10.1056/NEJMoa1500596
– ident: CIT0083
  doi: 10.1038/nmeth.4197
– ident: CIT0021
  doi: 10.1038/ajg.2012.161
– ident: CIT0074
  doi: 10.1371/journal.pone.0088367
– ident: CIT0002
  doi: 10.1053/j.gastro.2014.09.038
– ident: CIT0073
  doi: 10.1016/j.humpath.2015.01.003
– ident: CIT0053
  doi: 10.1016/S0002-9440(10)63878-3
– ident: CIT0075
  doi: 10.1007/s00428-014-1683-6
– ident: CIT0039
  doi: 10.1158/0008-5472.CAN-12-3869
– ident: CIT0063
  doi: 10.1042/BJ20121585
– ident: CIT0065
  doi: 10.1101/gr.131169.111
– ident: CIT0057
  doi: 10.1186/s12885-015-1087-2
– ident: CIT0047
  doi: 10.3892/etm.2011.249
– ident: CIT0008
  doi: 10.1101/gad.2037511
– ident: CIT0062
  doi: 10.1016/j.molcel.2008.05.007
– ident: CIT0064
  doi: 10.15252/embj.201797038
– ident: CIT0005
  doi: 10.1038/nrgastro.2015.73
– ident: CIT0016
  doi: 10.1136/gutjnl-2015-310456
– ident: CIT0025
  doi: 10.7554/eLife.20331
– ident: CIT0014
  doi: 10.1097/01.pas.0000213313.36306.85
– ident: CIT0046
  doi: 10.1038/modpathol.2009.150
– ident: CIT0041
  doi: 10.1371/journal.pone.0192499
– ident: CIT0069
  doi: 10.1101/gr.136101.111
– ident: CIT0004
  doi: 10.1053/j.gastro.2015.07.011
– ident: CIT0001
  doi: 10.1038/ncponc0248
– ident: CIT0017
  doi: 10.1053/j.gastro.2003.12.023
– ident: CIT0032
  doi: 10.1053/j.gastro.2006.10.022
– ident: CIT0026
  doi: 10.1053/j.gastro.2012.06.001
– ident: CIT0052
  doi: 10.1038/onc.2009.449
– ident: CIT0051
  doi: 10.1016/j.ajpath.2012.08.007
– ident: CIT0055
  doi: 10.1073/pnas.95.12.6870
– ident: CIT0031
  doi: 10.1097/PAS.0000000000000103
– ident: CIT0085
  doi: 10.1093/bioinformatics/btp616
– ident: CIT0070
  doi: 10.1038/onc.2015.423
– ident: CIT0071
  doi: 10.1038/nature21373
– ident: CIT0077
  doi: 10.1002/path.4200
– ident: CIT0054
  doi: 10.1056/NEJMoa1311194
– ident: CIT0007
  doi: 10.1073/pnas.96.15.8681
– ident: CIT0050
  doi: 10.1155/2014/374926
– ident: CIT0061
  doi: 10.1038/ng1941
– ident: CIT0006
  doi: 10.1111/his.12055
– ident: CIT0076
  doi: 10.1007/s00428-009-0731-0
– ident: CIT0027
  doi: 10.1053/j.gastro.2010.06.052
– ident: CIT0003
  doi: 10.1101/gr.117523.110
– ident: CIT0060
  doi: 10.1038/ng1950
– ident: CIT0072
  doi: 10.1038/nature09165
– ident: CIT0022
  doi: 10.1016/j.molcel.2014.08.010
– ident: CIT0049
  doi: 10.1158/0008-5472.CAN-12-3462
– ident: CIT0040
  doi: 10.1136/gutjnl-2016-313573
– ident: CIT0080
  doi: 10.1186/s12920-017-0317-7
– ident: CIT0058
  doi: 10.1073/pnas.1217415110
– ident: CIT0082
  doi: 10.1093/bioinformatics/btr167
– ident: CIT0066
  doi: 10.1038/nrg3663
– ident: CIT0042
  doi: 10.1053/j.gastro.2005.06.028
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Snippet Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ~20% of colon cancers with the CpG island methylator phenotype (CIMP). To...
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SubjectTerms Adenoma - genetics
Adenoma - pathology
adenomatous polyp
Aged
Aged, 80 and over
colon cancer
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Colonic Polyps - genetics
Colonic Polyps - pathology
CpG Islands
DNA Methylation
Female
Humans
Male
Middle Aged
Phenotype
Research Paper
Sessile serrated adenoma/polyp
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Title The proto CpG island methylator phenotype of sessile serrated adenomas/polyps
URI https://www.tandfonline.com/doi/abs/10.1080/15592294.2018.1543504
https://www.ncbi.nlm.nih.gov/pubmed/30398409
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Volume 13
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