Increased expression of α7nAChR in chronic rhinosinusitis: The intranasal cholinergic anti-inflammatory hypothesis
Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infectio...
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Published in | Auris, nasus, larynx Vol. 43; no. 2; pp. 176 - 181 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ireland Ltd
01.04.2016
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Subjects | |
Online Access | Get full text |
ISSN | 0385-8146 1879-1476 |
DOI | 10.1016/j.anl.2015.08.011 |
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Abstract | Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infection; acetylcholine released by peripheral nerves interacts with nicotinic acetylcholine receptor subunit α7 – α7nAChR – of innate immune cells, inhibiting pro-inflammatory signalling. This work aims to investigate whether cholinergic function is implicated in chronic rhinosinusitis.
α7nAChR mRNA and protein levels were measured in nasal biopsy specimens of 14 patients with CRSwNP, 8 with CRSsNP and 10 control subjects, undergoing surgery.
Gene expression levels of α7nAChR did not differ between groups; protein expression was significantly higher in CRSwNP than in CRSsNP (p=0.041), and both of these patient groups showed significant higher levels than controls (CRSwNP vs Controls – p=0.001; CRSsNP vs Controls – p=0.041).
Elevated α7nAChR protein levels suggest that the cholinergic system is involved in the inflammatory response of chronic rhinosinusitis. This can shed light on both, the disease pathophysiology and the development of future treatment options. |
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AbstractList | Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infection; acetylcholine released by peripheral nerves interacts with nicotinic acetylcholine receptor subunit α7 – α7nAChR – of innate immune cells, inhibiting pro-inflammatory signalling. This work aims to investigate whether cholinergic function is implicated in chronic rhinosinusitis.
α7nAChR mRNA and protein levels were measured in nasal biopsy specimens of 14 patients with CRSwNP, 8 with CRSsNP and 10 control subjects, undergoing surgery.
Gene expression levels of α7nAChR did not differ between groups; protein expression was significantly higher in CRSwNP than in CRSsNP (p=0.041), and both of these patient groups showed significant higher levels than controls (CRSwNP vs Controls – p=0.001; CRSsNP vs Controls – p=0.041).
Elevated α7nAChR protein levels suggest that the cholinergic system is involved in the inflammatory response of chronic rhinosinusitis. This can shed light on both, the disease pathophysiology and the development of future treatment options. OBJECTIVEChronic rhinosinusitis results from a dysfunctional host-environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infection; acetylcholine released by peripheral nerves interacts with nicotinic acetylcholine receptor subunit α7 - α7nAChR - of innate immune cells, inhibiting pro-inflammatory signalling. This work aims to investigate whether cholinergic function is implicated in chronic rhinosinusitis.METHODSα7nAChR mRNA and protein levels were measured in nasal biopsy specimens of 14 patients with CRSwNP, 8 with CRSsNP and 10 control subjects, undergoing surgery.RESULTSGene expression levels of α7nAChR did not differ between groups; protein expression was significantly higher in CRSwNP than in CRSsNP (p=0.041), and both of these patient groups showed significant higher levels than controls (CRSwNP vs Controls - p=0.001; CRSsNP vs Controls - p=0.041).CONCLUSIONElevated α7nAChR protein levels suggest that the cholinergic system is involved in the inflammatory response of chronic rhinosinusitis. This can shed light on both, the disease pathophysiology and the development of future treatment options. Abstract Objective Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal sinuses. A parasympathetic-mediated anti-inflammatory reflex is known to have a pivotal role in the control of damage induced by immune response to injury and infection; acetylcholine released by peripheral nerves interacts with nicotinic acetylcholine receptor subunit α7 – α7nAChR – of innate immune cells, inhibiting pro-inflammatory signalling. This work aims to investigate whether cholinergic function is implicated in chronic rhinosinusitis. Methods α7nAChR mRNA and protein levels were measured in nasal biopsy specimens of 14 patients with CRSwNP, 8 with CRSsNP and 10 control subjects, undergoing surgery. Results Gene expression levels of α7nAChR did not differ between groups; protein expression was significantly higher in CRSwNP than in CRSsNP ( p = 0.041), and both of these patient groups showed significant higher levels than controls (CRSwNP vs Controls – p = 0.001; CRSsNP vs Controls – p = 0.041). Conclusion Elevated α7nAChR protein levels suggest that the cholinergic system is involved in the inflammatory response of chronic rhinosinusitis. This can shed light on both, the disease pathophysiology and the development of future treatment options. |
Author | Pinto Moura, Carla Cerejeira, Rui Fernandes, Susana |
Author_xml | – sequence: 1 givenname: Rui surname: Cerejeira fullname: Cerejeira, Rui email: r.cerejeira@netcabo.pt organization: Department of Otolaryngology, Tâmega e Sousa Hospital Center, Penafiel, Portugal – sequence: 2 givenname: Susana surname: Fernandes fullname: Fernandes, Susana organization: Department of Genetics, Faculty of Medicine, University of Porto, Portugal – sequence: 3 givenname: Carla surname: Pinto Moura fullname: Pinto Moura, Carla organization: Department of Genetics, Faculty of Medicine, University of Porto, Portugal |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26410356$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.otohns.2007.02.004 10.1034/j.1600-065X.2000.917304.x 10.1002/(SICI)1097-4695(199601)29:1<115::AID-NEU9>3.0.CO;2-E 10.1016/j.jneumeth.2008.05.003 10.1146/annurev-immunol-020711-075015 10.1196/annals.1254.009 10.1038/nri2566 10.1067/mai.2001.118891 10.1016/S0022-3565(24)38304-1 10.1111/all.12644 10.1016/j.lfs.2013.02.014 10.1152/physrev.00015.2008 10.1111/j.1398-9995.2011.02646.x 10.1038/35013070 10.1124/mol.60.6.1201 10.1016/j.ab.2012.08.015 10.4193/Rhin14.078 10.1111/j.1600-065X.2012.01138.x 10.1016/0896-6273(91)90378-D 10.1016/j.coi.2007.08.004 10.1016/j.otohns.2009.10.005 10.1007/s11095-010-0283-7 |
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Snippet | Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal sinuses. A... Abstract Objective Chronic rhinosinusitis results from a dysfunctional host–environment interaction at the site of interface, in the nose and paranasal... Chronic rhinosinusitis results from a dysfunctional host-environment interaction at the site of interface, in the nose and paranasal sinuses. A... OBJECTIVEChronic rhinosinusitis results from a dysfunctional host-environment interaction at the site of interface, in the nose and paranasal sinuses. A... |
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SubjectTerms | Adolescent Adult Aged alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - metabolism Case-Control Studies Chronic Disease Female Gene Expression Humans Inflammation Male Middle Aged Nasal cavity Nasal Polyps - genetics Nasal Polyps - metabolism Otolaryngology Parasympathetic Nervous System - metabolism Parasympathetic system Rhinitis Rhinitis - genetics Rhinitis - metabolism RNA, Messenger - metabolism Sinusitis Sinusitis - genetics Sinusitis - metabolism Young Adult |
Title | Increased expression of α7nAChR in chronic rhinosinusitis: The intranasal cholinergic anti-inflammatory hypothesis |
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