Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation - Yan, Tingting; Wang, Hong; Cao, Lijuan; Wang, Qiong; Takahashi, Shogo; Yagai, Tomoki; Li, Guolin; Krausz, Kristopher W.; Wang, Guangji; Gonzalez, Frank J.; Hao, Haiping (Drug metabolism and disposition, 2018)
Keywords: Acids; Animal models; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Bile; Bile acids; Bile Acids and Salts - physiology; Choline; Cirrhosis; Deoxycholic acid; Diet; Disruption; Fatty liver; Fibrosis; Glycyrrhizic Acid - pharmacology; Glycyrrhizic Acid - therapeutic use; Glycyrrhizin; Hep G2 Cells; Herbal medicine; Homeostasis; Humans; Inflammasomes; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Lipids; Liquorice; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Liver X receptors; Macrophages; Male; Metabolites; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Nutrient deficiency; Oral administration; Pyrin protein; Random Allocation; RAW 264.7 Cells; Restoration; Steatosis; Traditional Chinese medicine; FXR; NAFLD; ALT; FACS; ACTD; TNF; LPS; SREPB; NF-κB; T; GA; SHP; TLR; CA; GW4064; AST; DCA; IL; CASP; GL; MCA; NASH; MCD; TC; MCC950; TG; MCS; DAMP