Nucleocytoplasmic Shuttling of p53 Is Essential for MDM2-Mediated Cytoplasmic Degradation but Not Ubiquitination - O'Keefe, Kevin; Li, Huiping; Zhang, Yanping (Molecular and Cellular Biology, 2003)
Keywords: Active Transport, Cell Nucleus - physiology; Amino Acid Sequence; Amino Acids - chemistry; Cell Growth and Development; Cell Nucleus - metabolism; Cells, Cultured; Conserved Sequence; Cytoplasm - metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nuclear Localization Signals; Nuclear Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-mdm2; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Ubiquitin - metabolism