Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice - Kim, Minjee; Laramy, Janice K.; Mohammad, Afroz S.; Talele, Surabhi; Fisher, James; Sarkaria, Jann N.; Elmquist, William F. (Drug metabolism and disposition, 2019)
Keywords: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; ATP-Binding Cassette Transporters - metabolism; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain - metabolism; Brain cancer; Brain tumors; Breast cancer; Cancer; Clinical trials; Dosage; Efflux; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - metabolism; Female; Gefitinib; Glioblastoma; Glioblastoma - metabolism; Glycoproteins; Growth factors; Inhibitors; Kinases; Lung cancer; Male; Medical research; Membrane permeability; Metastases; Mice; Non-small cell lung carcinoma; P-Glycoprotein; Permeability; Physicochemical properties; Protein Kinase Inhibitors - metabolism; Protein Kinase Inhibitors - pharmacology; Protein-tyrosine kinase; Proteins; Signal transduction; Signal Transduction - drug effects; Tumors; Tyrosine; Vulnerability; BCRP; AEE788; BBB; P-gp; NSCLC; DMSO; CNS; AZD3759; MPO; NCA; EGFR; AUC; LC-MS/MS; Mdr1; FVB; TKO; DA; WT