Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism - Ladumor, Mayur K.; Bhatt, Deepak Kumar; Gaedigk, Andrea; Sharma, Sheena; Thakur, Aarzoo; Pearce, Robin E.; Leeder, J. Steven; Bolger, Michael B.; Singh, Saranjit; Prasad, Bhagwat (Drug metabolism and disposition, 2019)
Keywords: Acetaminophen; Acetaminophen - pharmacokinetics; Adolescent; Adolescents; Adult; Age; Age Factors; Aged; Analgesics; Area Under Curve; Biological Variation, Population - physiology; Child; Child, Preschool; Children; Chromatography, High Pressure Liquid; Cytochrome P450; Cytochromes P450; Cytosol; Cytosol - metabolism; Drug Interactions - physiology; Enzymes; Ethnicity; Female; Humans; Infant; Infant, Newborn; Isoforms; Liquid chromatography; Liver; Liver - cytology; Liver - metabolism; Male; Mass spectrometry; Mass spectroscopy; Metabolism; Middle Aged; Minority & ethnic groups; Models, Biological; Neonates; Ontogeny; Pharmacokinetics; Protein turnover; Proteins; Proteomics; Regression analysis; Sex Factors; Sulfates - metabolism; Sulfation; Sulfotransferases - analysis; Sulfotransferases - metabolism; Tandem Mass Spectrometry; Young Adult; DHEA; Cmax; Ae; fm; PBPK; CNV; JT; AUC; PCA; SULTs; CV; DDIs; UGTs; DMEs; SNPs; PK