Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis
Background The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and...
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| Published in | Lipids in health and disease Vol. 13; no. 1; p. 126 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
08.08.2014
BioMed Central Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1476-511X 1476-511X |
| DOI | 10.1186/1476-511X-13-126 |
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| Abstract | Background
The
CYP7A1
gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of
CYP7A1
gene on the GSD and serum lipid levels.
Methods
According to inclusion/exclusion criteria, eligible studies on
CYP7A1
gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).
Results
Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of
CYP7A1
-204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 − 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between
CYP7A1
-204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of
CYP7A1
-204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 − -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 − 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 − 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 − -0.10, P = 0.007) and AC (MD = −0.35, 95% CI: -0.61 − -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 − -0.09, P < 0.00001).
Conclusions
The
CYP7A1
-204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. |
|---|---|
| AbstractList | Background
The
CYP7A1
gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of
CYP7A1
gene on the GSD and serum lipid levels.
Methods
According to inclusion/exclusion criteria, eligible studies on
CYP7A1
gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).
Results
Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of
CYP7A1
-204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 − 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between
CYP7A1
-204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of
CYP7A1
-204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 − -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 − 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 − 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 − -0.10, P = 0.007) and AC (MD = −0.35, 95% CI: -0.61 − -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 − -0.09, P < 0.00001).
Conclusions
The
CYP7A1
-204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. Background The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels. Methods According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2). Results Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 - 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 - -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 - 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 - 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P = 0.007) and AC (MD = -0.35, 95% CI: -0.61 - -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P < 0.00001). Conclusions The CYP7A1 -204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. Keywords: Gallbladder stone disease, Cholesterol 7[alpha]-hydroxylase, Serum lipids, Polymorphism, Meta-analysis The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A>C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels. According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A>C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2). Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A>C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR=1.05, 95% CI: 0.91 - 1.22, P=0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A>C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A>C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD=-0.42, 95% CI: -0.76 - -0.08, P=0.01). CC genotype in cases had higher levels of TC (MD=0.65, 95% CI: 0.25 - 1.05, P=0.001) and LDL-C (MD=0.40, 95% CI: 0.06 - 0.73, P=0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P=0.007) and AC (MD=-0.35, 95% CI: -0.61 - -0.08, P=0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P<0.00001). The CYP7A1 -204A>C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A>C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels.BACKGROUNDThe CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A>C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels.According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A>C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).METHODSAccording to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A>C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A>C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR=1.05, 95% CI: 0.91 - 1.22, P=0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A>C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A>C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD=-0.42, 95% CI: -0.76 - -0.08, P=0.01). CC genotype in cases had higher levels of TC (MD=0.65, 95% CI: 0.25 - 1.05, P=0.001) and LDL-C (MD=0.40, 95% CI: 0.06 - 0.73, P=0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P=0.007) and AC (MD=-0.35, 95% CI: -0.61 - -0.08, P=0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P<0.00001).RESULTSFive studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A>C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR=1.05, 95% CI: 0.91 - 1.22, P=0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A>C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A>C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD=-0.42, 95% CI: -0.76 - -0.08, P=0.01). CC genotype in cases had higher levels of TC (MD=0.65, 95% CI: 0.25 - 1.05, P=0.001) and LDL-C (MD=0.40, 95% CI: 0.06 - 0.73, P=0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P=0.007) and AC (MD=-0.35, 95% CI: -0.61 - -0.08, P=0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P<0.00001).The CYP7A1 -204A>C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease.CONCLUSIONSThe CYP7A1 -204A>C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. Doc number: 126 Abstract Background: The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels. Methods: According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2). Results: Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 - 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 - -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 - 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 - 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P = 0.007) and AC (MD = -0.35, 95% CI: -0.61 - -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P < 0.00001). Conclusions: The CYP7A1 -204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels. According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2). Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 - 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 - -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 - 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 - 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 - -0.10, P = 0.007) and AC (MD = -0.35, 95% CI: -0.61 - -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 - -0.09, P < 0.00001). The CYP7A1 -204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. |
| ArticleNumber | 126 |
| Audience | Academic |
| Author | Cai, Qu Li, Chen Cai, Qiang Jiang, Zhao-Yan Chen, Er-Zhen Wang, Zhen-Qiang |
| Author_xml | – sequence: 1 givenname: Qiang surname: Cai fullname: Cai, Qiang organization: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine – sequence: 2 givenname: Zhen-Qiang surname: Wang fullname: Wang, Zhen-Qiang organization: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine – sequence: 3 givenname: Qu surname: Cai fullname: Cai, Qu organization: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine – sequence: 4 givenname: Chen surname: Li fullname: Li, Chen organization: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine – sequence: 5 givenname: Er-Zhen surname: Chen fullname: Chen, Er-Zhen organization: Department of Emergency, Ruijin Hospital, Shanghai JiaoTong University School of Medicine – sequence: 6 givenname: Zhao-Yan surname: Jiang fullname: Jiang, Zhao-Yan email: zhaoyanjiang@gmail.com organization: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25103562$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_4254_wjh_v8_i23_961 crossref_primary_10_2478_rjdnmd_2019_0026 crossref_primary_10_1002_hep_31296 crossref_primary_10_1093_eurheartj_ehy068 crossref_primary_10_1007_s10072_021_05597_1 crossref_primary_10_1210_clinem_dgad528 crossref_primary_10_1186_s12944_017_0488_4 crossref_primary_10_1016_j_livres_2020_05_001 crossref_primary_10_17116_terarkh2017891062_65 crossref_primary_10_1146_annurev_nutr_082018_124344 crossref_primary_10_1007_s40495_018_0131_8 crossref_primary_10_1097_MOL_0000000000000175 crossref_primary_10_2217_bmm_2018_0462 crossref_primary_10_1016_j_jasi_2018_05_006 |
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| ContentType | Journal Article |
| Copyright | Cai et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. COPYRIGHT 2014 BioMed Central Ltd. 2014 Cai et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Cai et al.; licensee BioMed Central Ltd. 2014 |
| Copyright_xml | – notice: Cai et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. – notice: COPYRIGHT 2014 BioMed Central Ltd. – notice: 2014 Cai et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. – notice: Cai et al.; licensee BioMed Central Ltd. 2014 |
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| Keywords | Serum lipids Cholesterol 7α-hydroxylase Gallbladder stone disease Polymorphism Meta-analysis |
| Language | English |
| License | This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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| PublicationTitle | Lipids in health and disease |
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The
CYP7A1
gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were... The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent.... Background The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were... Doc number: 126 Abstract Background: The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid... |
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| SubjectTerms | Analysis Biomedical and Life Sciences Blood lipids Cardiovascular disease Case-Control Studies Cholesterol Cholesterol 7-alpha-Hydroxylase - genetics Clinical Nutrition Confidence intervals Enzymes Ethnicity Gallstones - blood Gallstones - genetics Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Hospitals Humans Life Sciences Lipidology Lipids Lipids - blood Measurement Medical Biochemistry Medical research Medicine Medicine, Experimental Meta-analysis Metabolic disorders Polymorphism, Single Nucleotide Population Promoter Regions, Genetic Risk Factors Software reviews Statistical analysis Studies |
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| Title | Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis |
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