DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specifi...
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| Published in | Cell metabolism Vol. 18; no. 2; pp. 296 - 302 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.08.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1550-4131 1932-7420 1932-7420 |
| DOI | 10.1016/j.cmet.2013.07.004 |
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| Abstract | Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2. Intraindividual comparison of liver biopsies before and after bariatric surgery showed NAFLD-associated methylation changes to be partially reversible. Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites. Our findings provide an example of treatment-induced epigenetic organ remodeling in humans.
•Nonalcoholic fatty liver disease has a specific methylation signature•Consistent expression and methylation may point to epigenetic drivers of disease•The epigenetic signature after bariatric surgery is distinct from disease patterns•ENCODE analysis points to candidate transcription factors for liver remodeling |
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| AbstractList | Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2. Intraindividual comparison of liver biopsies before and after bariatric surgery showed NAFLD-associated methylation changes to be partially reversible. Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites. Our findings provide an example of treatment-induced epigenetic organ remodeling in humans. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2. Intraindividual comparison of liver biopsies before and after bariatric surgery showed NAFLD-associated methylation changes to be partially reversible. Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites. Our findings provide an example of treatment-induced epigenetic organ remodeling in humans.Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2. Intraindividual comparison of liver biopsies before and after bariatric surgery showed NAFLD-associated methylation changes to be partially reversible. Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites. Our findings provide an example of treatment-induced epigenetic organ remodeling in humans. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2. Intraindividual comparison of liver biopsies before and after bariatric surgery showed NAFLD-associated methylation changes to be partially reversible. Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites. Our findings provide an example of treatment-induced epigenetic organ remodeling in humans. •Nonalcoholic fatty liver disease has a specific methylation signature•Consistent expression and methylation may point to epigenetic drivers of disease•The epigenetic signature after bariatric surgery is distinct from disease patterns•ENCODE analysis points to candidate transcription factors for liver remodeling |
| Author | Sipos, Bence Egberts, Jan Ahrens, Markus Brosch, Mario Siebert, Reiner Röcken, Christoph Hampe, Jochen von Schönfels, Witigo Kolarova, Julia Krawczak, Michael Stickel, Felix Becker, Thomas Ammerpohl, Ole Herrmann, Alexander Bens, Susanne Itzel, Timo Erhart, Wiebke Schreiber, Stefan Teufel, Andreas Häsler, Robert Schafmayer, Clemens Hinrichsen, Holger |
| Author_xml | – sequence: 1 givenname: Markus surname: Ahrens fullname: Ahrens, Markus organization: Department of General and Thoracic Surgery, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 2 givenname: Ole surname: Ammerpohl fullname: Ammerpohl, Ole organization: Institute of Human Genetics, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 3 givenname: Witigo surname: von Schönfels fullname: von Schönfels, Witigo organization: Department of General and Thoracic Surgery, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 4 givenname: Julia surname: Kolarova fullname: Kolarova, Julia organization: Institute of Human Genetics, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 5 givenname: Susanne surname: Bens fullname: Bens, Susanne organization: Institute of Human Genetics, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 6 givenname: Timo surname: Itzel fullname: Itzel, Timo organization: Department of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany – sequence: 7 givenname: Andreas surname: Teufel fullname: Teufel, Andreas organization: Department of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany – sequence: 8 givenname: Alexander surname: Herrmann fullname: Herrmann, Alexander organization: Department of Internal Medicine I, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 9 givenname: Mario surname: Brosch fullname: Brosch, Mario organization: Department of Internal Medicine I, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 10 givenname: Holger surname: Hinrichsen fullname: Hinrichsen, Holger organization: Gastroenterology and Hepatology Center Kiel, 24105 Kiel, Germany – sequence: 11 givenname: Wiebke surname: Erhart fullname: Erhart, Wiebke organization: Department of Internal Medicine I, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 12 givenname: Jan surname: Egberts fullname: Egberts, Jan organization: Department of General and Thoracic Surgery, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 13 givenname: Bence surname: Sipos fullname: Sipos, Bence organization: Institute of Pathology, University Hospital Tübingen, 72074 Tübingen, Germany – sequence: 14 givenname: Stefan surname: Schreiber fullname: Schreiber, Stefan organization: Department of Internal Medicine I, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 15 givenname: Robert surname: Häsler fullname: Häsler, Robert organization: Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 16 givenname: Felix surname: Stickel fullname: Stickel, Felix organization: Department of Clinical Research - Hepatology, University of Berne, CH-3010 Berne, Switzerland – sequence: 17 givenname: Thomas surname: Becker fullname: Becker, Thomas organization: Department of General and Thoracic Surgery, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 18 givenname: Michael surname: Krawczak fullname: Krawczak, Michael organization: Institute for Medical Statistics and Informatics, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 19 givenname: Christoph surname: Röcken fullname: Röcken, Christoph organization: Institute of Pathology, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 20 givenname: Reiner surname: Siebert fullname: Siebert, Reiner organization: Institute of Human Genetics, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 21 givenname: Clemens surname: Schafmayer fullname: Schafmayer, Clemens organization: Department of General and Thoracic Surgery, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany – sequence: 22 givenname: Jochen surname: Hampe fullname: Hampe, Jochen email: jochen.hampe@uniklinikum-dresden.de organization: Department of Internal Medicine I, Christian-Albrechts-University Kiel/University Hospital Schleswig-Holstein, 24015 Kiel, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23931760$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.cmet.2008.04.004 10.1002/ijc.26136 10.1038/sj.onc.1208773 10.1002/hep.23927 10.1210/en.2007-0908 10.1038/nature11245 10.1002/hep.20701 10.1016/j.bbrc.2012.04.144 10.1016/j.cmet.2012.01.001 10.1038/nature10716 10.1074/jbc.M109.014308 10.1053/j.gastro.2006.02.024 10.1002/hep.22774 10.1159/000336674 10.1038/nature11247 10.1002/hep.20251 10.1007/s11695-007-9087-1 10.1016/j.cmet.2009.11.007 10.1507/endocrj.EJ12-0322 10.1038/nm.2899 10.1093/bioinformatics/btl140 10.1016/j.jhep.2009.03.021 10.1053/j.gastro.2010.07.057 10.1097/MOL.0b013e3283346ccc 10.1053/j.gastro.2012.04.001 10.1038/nature11212 10.1038/ng.257 |
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| References | Gerstein, Kundaje, Hariharan, Landt, Yan, Cheng, Mu, Khurana, Rozowsky, Alexander (bib14) 2012; 489 Ammerpohl, Pratschke, Schafmayer, Haake, Faber, Von Kampen, Brosch, Sipos, Von Schönfels, Balschun (bib3) 2012; 130 Pogribny, Tryndyak, Bagnyukova, Melnyk, Montgomery, Ross, Latendresse, Rusyn, Beland (bib21) 2009; 51 Chalasani, Guo, Loomba, Goodarzi, Haritunians, Kwon, Cui, Taylor, Wilson, Cummings (bib7) 2010; 139 García-Galiano, Sánchez-Garrido, Espejo, Montero, Costán, Marchal, Membrives, Gallardo-Valverde, Muñoz-Castañeda, Arévalo (bib13) 2007; 17 Kleiner, Brunt, Van Natta, Behling, Contos, Cummings, Ferrell, Liu, Torbenson, Unalp-Arida (bib16) 2005; 41 Romeo, Kozlitina, Xing, Pertsemlidis, Cox, Pennacchio, Boerwinkle, Cohen, Hobbs (bib23) 2008; 40 Dunham, Kundaje, Aldred, Collins, Davis, Doyle, Epstein, Frietze, Harrow, Kaul (bib11) 2012; 489 Chalasani, Younossi, Lavine, Diehl, Brunt, Cusi, Charlton, Sanyal (bib8) 2012; 142 Dixon, Bhathal, Hughes, O’Brien (bib10) 2004; 39 Mathurin, Gonzalez, Kerdraon, Leteurtre, Arnalsteen, Hollebecque, Louvet, Dharancy, Cocq, Jany (bib19) 2006; 130 Bauer, Hatzivassiliou, Zhao, Andreadis, Thompson (bib5) 2005; 24 Neph, Vierstra, Stergachis, Reynolds, Haugen, Vernot, Thurman, John, Sandstrom, Johnson (bib20) 2012; 489 Fan, Menon, Cohen, Hwang, Clemens, DiGirolamo, Kopchick, Le Roith, Trucco, Sperling (bib12) 2009; 284 Takahashi (bib26) 2012; 59 (bib22) 2010 Kusminski, Holland, Sun, Park, Spurgin, Lin, Askew, Simcox, McClain, Li, Scherer (bib17) 2012; 18 Sookoian, Rosselli, Gemma, Burgueño, Fernández Gianotti, Castaño, Pirola (bib24) 2010; 52 Alexa, Rahnenführer, Lengauer (bib2) 2006; 22 Blüher (bib6) 2010; 21 Tran, Yamamoto, Gesta, Kahn (bib27) 2008; 7 Chypre, Zaidi, Smans (bib9) 2012; 422 Aga-Mizrachi, Brutman-Barazani, Jacob, Bak, Elson, Sampson (bib1) 2008; 149 Stadler, Murr, Burger, Ivanek, Lienert, Schöler, van Nimwegen, Wirbelauer, Oakeley, Gaidatzis (bib25) 2011; 480 Hedbacker, Birsoy, Wysocki, Asilmaz, Ahima, Farooqi, Friedman (bib15) 2010; 11 Lundell (bib18) 2012; 30 Wang, Jiang, Wang, Li, Yu, You, Zeng, Gao, Rui, Li, Liu (bib28) 2009; 49 Barrès, Yan, Egan, Treebak, Rasmussen, Fritz, Caidahl, Krook, O’Gorman, Zierath (bib4) 2012; 15 Wang (10.1016/j.cmet.2013.07.004_bib28) 2009; 49 Chalasani (10.1016/j.cmet.2013.07.004_bib8) 2012; 142 Neph (10.1016/j.cmet.2013.07.004_bib20) 2012; 489 Hedbacker (10.1016/j.cmet.2013.07.004_bib15) 2010; 11 Kleiner (10.1016/j.cmet.2013.07.004_bib16) 2005; 41 Stadler (10.1016/j.cmet.2013.07.004_bib25) 2011; 480 Blüher (10.1016/j.cmet.2013.07.004_bib6) 2010; 21 (10.1016/j.cmet.2013.07.004_bib22) 2010 Aga-Mizrachi (10.1016/j.cmet.2013.07.004_bib1) 2008; 149 García-Galiano (10.1016/j.cmet.2013.07.004_bib13) 2007; 17 Pogribny (10.1016/j.cmet.2013.07.004_bib21) 2009; 51 Chalasani (10.1016/j.cmet.2013.07.004_bib7) 2010; 139 Mathurin (10.1016/j.cmet.2013.07.004_bib19) 2006; 130 Dixon (10.1016/j.cmet.2013.07.004_bib10) 2004; 39 Ammerpohl (10.1016/j.cmet.2013.07.004_bib3) 2012; 130 Dunham (10.1016/j.cmet.2013.07.004_bib11) 2012; 489 Gerstein (10.1016/j.cmet.2013.07.004_bib14) 2012; 489 Bauer (10.1016/j.cmet.2013.07.004_bib5) 2005; 24 Kusminski (10.1016/j.cmet.2013.07.004_bib17) 2012; 18 Barrès (10.1016/j.cmet.2013.07.004_bib4) 2012; 15 Fan (10.1016/j.cmet.2013.07.004_bib12) 2009; 284 Romeo (10.1016/j.cmet.2013.07.004_bib23) 2008; 40 Chypre (10.1016/j.cmet.2013.07.004_bib9) 2012; 422 Lundell (10.1016/j.cmet.2013.07.004_bib18) 2012; 30 Takahashi (10.1016/j.cmet.2013.07.004_bib26) 2012; 59 Tran (10.1016/j.cmet.2013.07.004_bib27) 2008; 7 Sookoian (10.1016/j.cmet.2013.07.004_bib24) 2010; 52 Alexa (10.1016/j.cmet.2013.07.004_bib2) 2006; 22 |
| References_xml | – volume: 7 start-page: 410 year: 2008 end-page: 420 ident: bib27 article-title: Beneficial effects of subcutaneous fat transplantation on metabolism publication-title: Cell Metab. – volume: 142 start-page: 1592 year: 2012 end-page: 1609 ident: bib8 article-title: The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology publication-title: Gastroenterology – volume: 17 start-page: 493 year: 2007 end-page: 503 ident: bib13 article-title: IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients publication-title: Obes. Surg. – volume: 480 start-page: 490 year: 2011 end-page: 495 ident: bib25 article-title: DNA-binding factors shape the mouse methylome at distal regulatory regions publication-title: Nature – volume: 11 start-page: 11 year: 2010 end-page: 22 ident: bib15 article-title: Antidiabetic effects of IGFBP2, a leptin-regulated gene publication-title: Cell Metab. – volume: 130 start-page: 1319 year: 2012 end-page: 1328 ident: bib3 article-title: Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. International Journal of Cancer publication-title: Journal International Du Cancer – volume: 30 start-page: 173 year: 2012 end-page: 177 ident: bib18 article-title: Principles and results of bariatric surgery publication-title: Dig. Dis. – volume: 52 start-page: 1992 year: 2010 end-page: 2000 ident: bib24 article-title: Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter publication-title: Hepatology – volume: 489 start-page: 57 year: 2012 end-page: 74 ident: bib11 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature – volume: 39 start-page: 1647 year: 2004 end-page: 1654 ident: bib10 article-title: Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss publication-title: Hepatology – volume: 18 start-page: 1539 year: 2012 end-page: 1549 ident: bib17 article-title: MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity publication-title: Nat. Med. – volume: 15 start-page: 405 year: 2012 end-page: 411 ident: bib4 article-title: Acute exercise remodels promoter methylation in human skeletal muscle publication-title: Cell Metab. – volume: 21 start-page: 38 year: 2010 end-page: 43 ident: bib6 article-title: The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals publication-title: Curr. Opin. Lipidol. – volume: 149 start-page: 605 year: 2008 end-page: 614 ident: bib1 article-title: Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle publication-title: Endocrinology – volume: 49 start-page: 1166 year: 2009 end-page: 1175 ident: bib28 article-title: Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice publication-title: Hepatology – volume: 40 start-page: 1461 year: 2008 end-page: 1465 ident: bib23 article-title: Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease publication-title: Nat. Genet. – volume: 489 start-page: 91 year: 2012 end-page: 100 ident: bib14 article-title: Architecture of the human regulatory network derived from ENCODE data publication-title: Nature – volume: 130 start-page: 1617 year: 2006 end-page: 1624 ident: bib19 article-title: The evolution of severe steatosis after bariatric surgery is related to insulin resistance publication-title: Gastroenterology – volume: 59 start-page: 955 year: 2012 end-page: 962 ident: bib26 article-title: Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver publication-title: Endocr J. – volume: 489 start-page: 83 year: 2012 end-page: 90 ident: bib20 article-title: An expansive human regulatory lexicon encoded in transcription factor footprints publication-title: Nature – volume: 41 start-page: 1313 year: 2005 end-page: 1321 ident: bib16 article-title: Design and validation of a histological scoring system for nonalcoholic fatty liver disease publication-title: Hepatology – volume: 22 start-page: 1600 year: 2006 end-page: 1607 ident: bib2 article-title: Improved scoring of functional groups from gene expression data by decorrelating GO graph structure publication-title: Bioinformatics – volume: 284 start-page: 19937 year: 2009 end-page: 19944 ident: bib12 article-title: Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism publication-title: J. Biol. Chem. – volume: 422 start-page: 1 year: 2012 end-page: 4 ident: bib9 article-title: ATP-citrate lyase: a mini-review publication-title: Biochem. Biophys. Res. Commun. – year: 2010 ident: bib22 article-title: R: A Language and Environment for Statistical Computing – volume: 51 start-page: 176 year: 2009 end-page: 186 ident: bib21 article-title: Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet publication-title: J. Hepatol. – volume: 24 start-page: 6314 year: 2005 end-page: 6322 ident: bib5 article-title: ATP citrate lyase is an important component of cell growth and transformation publication-title: Oncogene – volume: 139 start-page: 1567 year: 2010 end-page: 1576 ident: bib7 article-title: Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease publication-title: Gastroenterology – volume: 7 start-page: 410 year: 2008 ident: 10.1016/j.cmet.2013.07.004_bib27 article-title: Beneficial effects of subcutaneous fat transplantation on metabolism publication-title: Cell Metab. doi: 10.1016/j.cmet.2008.04.004 – volume: 130 start-page: 1319 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib3 article-title: Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. International Journal of Cancer publication-title: Journal International Du Cancer doi: 10.1002/ijc.26136 – volume: 24 start-page: 6314 year: 2005 ident: 10.1016/j.cmet.2013.07.004_bib5 article-title: ATP citrate lyase is an important component of cell growth and transformation publication-title: Oncogene doi: 10.1038/sj.onc.1208773 – volume: 52 start-page: 1992 year: 2010 ident: 10.1016/j.cmet.2013.07.004_bib24 article-title: Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter publication-title: Hepatology doi: 10.1002/hep.23927 – volume: 149 start-page: 605 year: 2008 ident: 10.1016/j.cmet.2013.07.004_bib1 article-title: Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle publication-title: Endocrinology doi: 10.1210/en.2007-0908 – volume: 489 start-page: 91 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib14 article-title: Architecture of the human regulatory network derived from ENCODE data publication-title: Nature doi: 10.1038/nature11245 – volume: 41 start-page: 1313 year: 2005 ident: 10.1016/j.cmet.2013.07.004_bib16 article-title: Design and validation of a histological scoring system for nonalcoholic fatty liver disease publication-title: Hepatology doi: 10.1002/hep.20701 – volume: 422 start-page: 1 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib9 article-title: ATP-citrate lyase: a mini-review publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2012.04.144 – volume: 15 start-page: 405 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib4 article-title: Acute exercise remodels promoter methylation in human skeletal muscle publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.01.001 – volume: 480 start-page: 490 year: 2011 ident: 10.1016/j.cmet.2013.07.004_bib25 article-title: DNA-binding factors shape the mouse methylome at distal regulatory regions publication-title: Nature doi: 10.1038/nature10716 – volume: 284 start-page: 19937 year: 2009 ident: 10.1016/j.cmet.2013.07.004_bib12 article-title: Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.014308 – volume: 130 start-page: 1617 year: 2006 ident: 10.1016/j.cmet.2013.07.004_bib19 article-title: The evolution of severe steatosis after bariatric surgery is related to insulin resistance publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.02.024 – volume: 49 start-page: 1166 year: 2009 ident: 10.1016/j.cmet.2013.07.004_bib28 article-title: Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice publication-title: Hepatology doi: 10.1002/hep.22774 – volume: 30 start-page: 173 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib18 article-title: Principles and results of bariatric surgery publication-title: Dig. Dis. doi: 10.1159/000336674 – volume: 489 start-page: 57 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib11 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature doi: 10.1038/nature11247 – volume: 39 start-page: 1647 year: 2004 ident: 10.1016/j.cmet.2013.07.004_bib10 article-title: Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss publication-title: Hepatology doi: 10.1002/hep.20251 – volume: 17 start-page: 493 year: 2007 ident: 10.1016/j.cmet.2013.07.004_bib13 article-title: IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients publication-title: Obes. Surg. doi: 10.1007/s11695-007-9087-1 – volume: 11 start-page: 11 year: 2010 ident: 10.1016/j.cmet.2013.07.004_bib15 article-title: Antidiabetic effects of IGFBP2, a leptin-regulated gene publication-title: Cell Metab. doi: 10.1016/j.cmet.2009.11.007 – volume: 59 start-page: 955 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib26 article-title: Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver publication-title: Endocr J. doi: 10.1507/endocrj.EJ12-0322 – volume: 18 start-page: 1539 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib17 article-title: MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity publication-title: Nat. Med. doi: 10.1038/nm.2899 – year: 2010 ident: 10.1016/j.cmet.2013.07.004_bib22 – volume: 22 start-page: 1600 year: 2006 ident: 10.1016/j.cmet.2013.07.004_bib2 article-title: Improved scoring of functional groups from gene expression data by decorrelating GO graph structure publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl140 – volume: 51 start-page: 176 year: 2009 ident: 10.1016/j.cmet.2013.07.004_bib21 article-title: Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet publication-title: J. Hepatol. doi: 10.1016/j.jhep.2009.03.021 – volume: 139 start-page: 1567 year: 2010 ident: 10.1016/j.cmet.2013.07.004_bib7 article-title: Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.07.057 – volume: 21 start-page: 38 year: 2010 ident: 10.1016/j.cmet.2013.07.004_bib6 article-title: The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals publication-title: Curr. Opin. Lipidol. doi: 10.1097/MOL.0b013e3283346ccc – volume: 142 start-page: 1592 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib8 article-title: The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.04.001 – volume: 489 start-page: 83 year: 2012 ident: 10.1016/j.cmet.2013.07.004_bib20 article-title: An expansive human regulatory lexicon encoded in transcription factor footprints publication-title: Nature doi: 10.1038/nature11212 – volume: 40 start-page: 1461 year: 2008 ident: 10.1016/j.cmet.2013.07.004_bib23 article-title: Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease publication-title: Nat. Genet. doi: 10.1038/ng.257 |
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| Snippet | Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n =... Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n =... |
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| SubjectTerms | Adult Aged bariatric surgery Bariatric Surgery - adverse effects binding sites biopsy developed countries DNA methylation DNA Methylation - genetics enzymes epigenetics fatty liver Fatty Liver - genetics Female gene expression Gene Expression Regulation genes Humans Insulin - metabolism liver Liver - metabolism Male messenger RNA metabolism Middle Aged Non-alcoholic Fatty Liver Disease Obesity, Morbid - genetics Obesity, Morbid - metabolism Obesity, Morbid - surgery patients Signal Transduction - genetics transcription factors |
| Title | DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery |
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