Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients’ cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier ( GCLM)...

Full description

Saved in:

Bibliographic Details
Published in	American journal of human genetics Vol. 79; no. 3; pp. 586 - 592
Main Authors	Tosic, Mirjana, Ott, Jurg, Barral, Sandra, Bovet, Pierre, Deppen, Patricia, Gheorghita, Fulvia, Matthey, Marie-Louise, Parnas, Josef, Preisig, Martin, Saraga, Michael, Solida, Alessandra, Timm, Sally, Wang, August G., Werge, Thomas, Cuénod, Michel, Quang Do, Kim
Format	Journal Article
Language	English
Published	Chicago, IL Elsevier Inc 01.09.2006 University of Chicago Press The American Society of Human Genetics
Subjects	Biological and medical sciences Case-Control Studies Down-Regulation Fibroblasts - enzymology Fibroblasts - metabolism Gene Frequency General aspects. Genetic counseling Genetic Predisposition to Disease - genetics Glutamate-Cysteine Ligase - genetics Glutathione - metabolism Humans Medical genetics Medical sciences Oxidative Stress - genetics Polymorphism, Single Nucleotide RNA, Messenger - analysis Schizophrenia - enzymology Schizophrenia - genetics Glutamate-cysteine ligase Human Oxidative stress Carbon-nitrogen ligases Enzyme Schizophrenia Modifier gene Genetic determinism Psychosis Sensitivity Ligases Predisposition Genetics
Online Access	Get full text
ISSN	0002-9297 1537-6605 1537-6605
DOI	10.1086/507566

Cover

Abstract	Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients’ cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier ( GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients’ fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
AbstractList	Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia. Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia. Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients’ cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier ( GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients’ fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Author	Cuénod, Michel Solida, Alessandra Deppen, Patricia Matthey, Marie-Louise Parnas, Josef Preisig, Martin Bovet, Pierre Barral, Sandra Gheorghita, Fulvia Quang Do, Kim Ott, Jurg Wang, August G. Timm, Sally Saraga, Michael Werge, Thomas Tosic, Mirjana
AuthorAffiliation	From the Center for Psychiatric Neuroscience (M.T.; P.D.; F.G.; M.S.; A.S.; M.C.; K.Q.D.) and Department of Psychiatry (M.T.; P.B.; P.D.; F.G.; M.-L.M.; M.P.; M.S.; A.S.; M.C.; K.Q.D.), Lausanne University Hospital, Lausanne, Switzerland; Laboratory of Statistical Genetics, Rockefeller University, New York (J.O.; S.B.); University Department of Psychiatry, Hovedstadens Sygehusfaellsskab (H:S) Hvidovre Hospital, Hvidovre, Denmark (J.P.); University Department of Psychiatry, H:S Frederiksberg Hospital, Frederiksberg, Denmark (S.T.); University Department of Psychiatry, H:S Amager Hospital, Copenhagen, (A.G.W.); and Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, Roskilde, Denmark (T.W.)
AuthorAffiliation_xml	– name: From the Center for Psychiatric Neuroscience (M.T.; P.D.; F.G.; M.S.; A.S.; M.C.; K.Q.D.) and Department of Psychiatry (M.T.; P.B.; P.D.; F.G.; M.-L.M.; M.P.; M.S.; A.S.; M.C.; K.Q.D.), Lausanne University Hospital, Lausanne, Switzerland; Laboratory of Statistical Genetics, Rockefeller University, New York (J.O.; S.B.); University Department of Psychiatry, Hovedstadens Sygehusfaellsskab (H:S) Hvidovre Hospital, Hvidovre, Denmark (J.P.); University Department of Psychiatry, H:S Frederiksberg Hospital, Frederiksberg, Denmark (S.T.); University Department of Psychiatry, H:S Amager Hospital, Copenhagen, (A.G.W.); and Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, Roskilde, Denmark (T.W.)
Author_xml	– sequence: 1 givenname: Mirjana surname: Tosic fullname: Tosic, Mirjana email: Mirjana.Tosic@chuv.ch organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 2 givenname: Jurg surname: Ott fullname: Ott, Jurg organization: Laboratory of Statistical Genetics, Rockefeller University, New York – sequence: 3 givenname: Sandra surname: Barral fullname: Barral, Sandra organization: Laboratory of Statistical Genetics, Rockefeller University, New York – sequence: 4 givenname: Pierre surname: Bovet fullname: Bovet, Pierre organization: Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland – sequence: 5 givenname: Patricia surname: Deppen fullname: Deppen, Patricia organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 6 givenname: Fulvia surname: Gheorghita fullname: Gheorghita, Fulvia organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 7 givenname: Marie-Louise surname: Matthey fullname: Matthey, Marie-Louise organization: Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland – sequence: 8 givenname: Josef surname: Parnas fullname: Parnas, Josef organization: University Department of Psychiatry, Hovedstadens Sygehusfaellsskab (H:S) Hvidovre Hospital, Hvidovre, Denmark – sequence: 9 givenname: Martin surname: Preisig fullname: Preisig, Martin organization: Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland – sequence: 10 givenname: Michael surname: Saraga fullname: Saraga, Michael organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 11 givenname: Alessandra surname: Solida fullname: Solida, Alessandra organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 12 givenname: Sally surname: Timm fullname: Timm, Sally organization: University Department of Psychiatry, H:S Frederiksberg Hospital, Frederiksberg, Denmark – sequence: 13 givenname: August G. surname: Wang fullname: Wang, August G. organization: University Department of Psychiatry, H:S Amager Hospital, Copenhagen – sequence: 14 givenname: Thomas surname: Werge fullname: Werge, Thomas organization: Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, Roskilde, Denmark – sequence: 15 givenname: Michel surname: Cuénod fullname: Cuénod, Michel organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland – sequence: 16 givenname: Kim surname: Quang Do fullname: Quang Do, Kim organization: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18053885$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16909399$$D View this record in MEDLINE/PubMed
BookMark	eNqFkUGP0zAQhS20iO0u8BOQL8CFgJ3UTrIHJFRBQSraQ-FsTZzJdlDqBNsplF-PV63UZRHiNIf55unNexfszA0OGXsqxWspKv1GiVJp_YDNpCrKTGuhzthMCJFndV6X5-wihG9CSFmJ4hE7l7oWdVHXM2bWdkO_hnHj0RFwcC2__kktRNohX0ePIVzxZT9F2EJEvtiHiOSQr-gGAvLPQ0sdoecQOPD1FCyOkRrqKe75Eh0-Zg876AM-Oc5L9vXD-y-Lj9nqevlp8W6VWVXkMUMBXdPlqPIKrLDQiEpVubYStZ5DWpZVIctkWnSNrTuRC60lKmvnLTY1lMUle3nQndwI-x_Q92b0tAW_N1KY24jMIaJEvj2Q49RssbXooocTPQCZPzeONuZm2BmpVK2USgIvjgJ--D5hiGZL6e--B4fDFIyuyrkuk-H_gTLJlWWRJ_DZXUsn58eaEvD8CECw0HcenKVw4iqhiqq6Y836IQSP3b9DeHUPtBRT6cPty9T_jYsDjqnCXerbBEvoLLbk0UbTDnT_5DeP281z
CODEN	AJHGAG
CitedBy_id	crossref_primary_10_1038_mp_2017_47 crossref_primary_10_1038_sj_mp_4002147 crossref_primary_10_1016_j_neuron_2014_07_028 crossref_primary_10_3390_antiox9060538 crossref_primary_10_1016_j_neuropharm_2011_01_049 crossref_primary_10_1016_j_neuropharm_2009_06_002 crossref_primary_10_1016_j_bcp_2007_02_003 crossref_primary_10_1007_s12640_014_9473_0 crossref_primary_10_1111_j_1471_4159_2009_05908_x crossref_primary_10_1016_j_brainresbull_2008_10_015 crossref_primary_10_1186_1471_244X_11_26 crossref_primary_10_1002_ajmg_b_32391 crossref_primary_10_1002_ajmg_b_31062 crossref_primary_10_1016_j_bbamcr_2014_12_028 crossref_primary_10_1016_j_schres_2015_06_022 crossref_primary_10_1016_j_schres_2017_03_041 crossref_primary_10_1371_journal_pone_0022875 crossref_primary_10_1016_j_schres_2017_02_002 crossref_primary_10_1159_000324366 crossref_primary_10_1523_JNEUROSCI_3857_09_2010 crossref_primary_10_1016_j_plefa_2007_08_006 crossref_primary_10_1016_j_pharmthera_2020_107520 crossref_primary_10_3389_fpsyt_2023_1142608 crossref_primary_10_3389_fnmol_2018_00270 crossref_primary_10_1016_j_freeradbiomed_2007_12_006 crossref_primary_10_1038_tp_2012_36 crossref_primary_10_1177_0004867414533012 crossref_primary_10_1038_cdd_2013_70 crossref_primary_10_1111_j_1440_1819_2010_02157_x crossref_primary_10_1016_j_bihy_2008_10_005 crossref_primary_10_1017_S1461145707008401 crossref_primary_10_1097_YPG_0b013e32832cef21 crossref_primary_10_1016_j_biopsych_2011_07_035 crossref_primary_10_1016_j_freeradbiomed_2010_12_002 crossref_primary_10_3390_jpm13111526 crossref_primary_10_1038_s41380_021_01374_w crossref_primary_10_1016_j_neuropharm_2009_12_009 crossref_primary_10_1038_mp_2011_165 crossref_primary_10_1093_schbul_sbu048 crossref_primary_10_1007_s11836_007_0018_y crossref_primary_10_1038_tp_2017_175 crossref_primary_10_1371_journal_pone_0001944 crossref_primary_10_1016_j_mehy_2010_07_034 crossref_primary_10_1016_j_plefa_2017_10_005 crossref_primary_10_1016_j_neulet_2011_05_027 crossref_primary_10_2165_11586650_000000000_00000 crossref_primary_10_1089_ars_2018_7606 crossref_primary_10_1016_j_ntt_2012_04_009 crossref_primary_10_1007_s11011_022_01090_6 crossref_primary_10_24075_vrgmu_2019_013 crossref_primary_10_1089_ars_2012_4858 crossref_primary_10_3390_ijms24097680 crossref_primary_10_3390_antiox11101870 crossref_primary_10_1523_JNEUROSCI_4457_08_2008 crossref_primary_10_1016_j_plefa_2015_07_001 crossref_primary_10_3389_fnagi_2021_785727 crossref_primary_10_1016_j_nbd_2008_11_018 crossref_primary_10_1016_j_pnpbp_2012_07_013 crossref_primary_10_1016_j_tips_2008_05_001 crossref_primary_10_1073_pnas_0706778104 crossref_primary_10_1089_ars_2010_3508 crossref_primary_10_1186_1471_2350_9_39 crossref_primary_10_24075_brsmu_2019_013 crossref_primary_10_1016_j_neuroscience_2016_01_067 crossref_primary_10_1016_j_biopsych_2014_12_026 crossref_primary_10_1089_ars_2012_4907 crossref_primary_10_1152_jn_90548_2008 crossref_primary_10_1016_j_jad_2010_12_019 crossref_primary_10_1042_BST20140044 crossref_primary_10_1016_j_schres_2016_03_031 crossref_primary_10_1038_mp_2009_53 crossref_primary_10_1016_j_biopsych_2012_09_020 crossref_primary_10_1093_ijnp_pyad012 crossref_primary_10_1016_j_schres_2014_06_021 crossref_primary_10_3390_ijms25052952 crossref_primary_10_1016_j_bbr_2008_11_017 crossref_primary_10_3390_brainsci11070941 crossref_primary_10_1016_j_neubiorev_2015_05_014 crossref_primary_10_1016_j_tox_2008_08_014 crossref_primary_10_3892_br_2014_308 crossref_primary_10_1007_s13311_017_0552_9 crossref_primary_10_1016_j_freeradbiomed_2009_05_003 crossref_primary_10_1016_j_mehy_2011_03_051 crossref_primary_10_4306_pi_2017_14_4_383 crossref_primary_10_3390_antiox10111703 crossref_primary_10_1007_s00580_013_1854_x crossref_primary_10_1093_schbul_sbx093 crossref_primary_10_1111_jnc_14116 crossref_primary_10_1089_ars_2010_3453 crossref_primary_10_1177_0269881119875979 crossref_primary_10_17116_jnevro2021121091131 crossref_primary_10_1016_j_biopsych_2008_06_025 crossref_primary_10_1016_j_neubiorev_2023_105064 crossref_primary_10_1016_j_nbd_2007_03_001 crossref_primary_10_1007_s11064_007_9328_7 crossref_primary_10_1016_j_neuint_2024_105771 crossref_primary_10_1196_annals_1432_022 crossref_primary_10_1016_j_arcmed_2019_08_003 crossref_primary_10_3390_ijms22126171 crossref_primary_10_1097_YPG_0b013e32832cec76 crossref_primary_10_1073_pnas_1300454110 crossref_primary_10_3389_fncel_2020_571216 crossref_primary_10_1016_j_ab_2016_12_022 crossref_primary_10_1016_j_neubiorev_2010_10_008 crossref_primary_10_1007_s43440_024_00607_3 crossref_primary_10_1016_j_biopsych_2008_04_022 crossref_primary_10_1007_s11033_020_05647_5 crossref_primary_10_1016_j_fct_2013_07_008 crossref_primary_10_1016_j_mam_2008_08_009 crossref_primary_10_1093_schbul_sbs058 crossref_primary_10_1517_14728222_2014_934225 crossref_primary_10_47102_annals_acadmedsg_V38N5p396 crossref_primary_10_1093_toxsci_kfm165 crossref_primary_10_1038_mp_2014_88 crossref_primary_10_3727_096368911X600957 crossref_primary_10_1089_ars_2010_3463 crossref_primary_10_3390_biom12050723 crossref_primary_10_1016_j_schres_2011_01_009 crossref_primary_10_1371_journal_pone_0029341 crossref_primary_10_1016_j_schres_2014_10_044 crossref_primary_10_1038_sj_npp_1301624 crossref_primary_10_1111_ijcp_14711 crossref_primary_10_2174_0929867326666191015091346 crossref_primary_10_1055_a_1147_1552 crossref_primary_10_1016_j_scitotenv_2013_06_029 crossref_primary_10_1038_tp_2017_138 crossref_primary_10_1016_j_nbd_2012_11_001 crossref_primary_10_1155_2011_157687 crossref_primary_10_1097_01_IDT_0000345193_21201_89 crossref_primary_10_1016_j_bbr_2011_10_020 crossref_primary_10_3109_15622975_2010_526146 crossref_primary_10_1002_ajmg_b_30703 crossref_primary_10_1016_j_bbrc_2010_04_105 crossref_primary_10_1016_j_brainresrev_2009_05_005 crossref_primary_10_1093_ijnp_pyv110 crossref_primary_10_1016_j_pnpbp_2012_06_013 crossref_primary_10_1038_s41380_022_01494_x crossref_primary_10_2478_v10011_011_0002_x crossref_primary_10_1111_pcn_12779 crossref_primary_10_1016_j_schres_2024_05_018 crossref_primary_10_1016_j_genrep_2016_07_007 crossref_primary_10_1016_j_schres_2017_07_008 crossref_primary_10_1016_j_pneurobio_2011_05_006 crossref_primary_10_1016_j_ejphar_2010_09_035 crossref_primary_10_1017_S1740925X12000130 crossref_primary_10_1186_1471_244X_11_124 crossref_primary_10_1016_j_psychres_2013_01_033 crossref_primary_10_1093_schbul_sbu053 crossref_primary_10_1007_s11064_018_2521_z crossref_primary_10_3389_fnbeh_2017_00106 crossref_primary_10_1186_1476_069X_10_33 crossref_primary_10_1016_j_psychres_2013_09_014 crossref_primary_10_3390_molecules24234253 crossref_primary_10_1038_s41380_021_01313_9 crossref_primary_10_1016_j_biopsych_2008_03_004 crossref_primary_10_1016_j_schres_2016_12_017 crossref_primary_10_1093_labmed_lmw017 crossref_primary_10_3389_fpsyt_2023_1142682 crossref_primary_10_1038_s41598_018_27830_2 crossref_primary_10_1289_ehp_10804 crossref_primary_10_1002_ajmg_b_30776 crossref_primary_10_1016_j_schres_2009_12_017 crossref_primary_10_1038_tp_2017_30 crossref_primary_10_1016_j_conb_2009_05_001 crossref_primary_10_1039_c2mb25118c crossref_primary_10_1002_ajmg_b_32044 crossref_primary_10_1155_2021_8881770 crossref_primary_10_3390_ijms18030651 crossref_primary_10_1017_S1461145710000805 crossref_primary_10_1111_j_1399_5618_2010_00834_x crossref_primary_10_1111_eip_12781
Cites_doi	10.1146/annurev.bi.52.070183.003431 10.1016/j.nbd.2006.01.003 10.1001/archpsyc.1994.03950030035004 10.1016/S0920-9964(03)00011-2 10.1016/S0074-7742(04)59019-0 10.1016/S0021-9258(20)80764-9 10.1016/S0021-9258(19)36569-X 10.1176/appi.ajp.162.6.1200 10.1074/jbc.M504604200 10.1016/S0022-3956(99)00029-1 10.1016/S0006-3223(99)00289-9 10.1097/00041444-200409000-00005 10.1007/PL00000638 10.1006/geno.1995.1293 10.1016/0920-9964(95)00049-6 10.1016/S0140-6736(03)12379-3 10.1016/0896-6273(94)90311-5 10.1016/j.neuroscience.2005.10.014 10.1006/bbrc.2001.4347 10.1016/j.nbd.2003.09.005 10.1046/j.1471-4159.1998.71052071.x 10.1016/S0278-5846(03)00043-5 10.1038/sj.mp.4001532 10.1016/j.biopsych.2005.03.031 10.1074/jbc.M209372200 10.1001/archpsyc.1994.03950110009002 10.1155/2006/248387 10.1097/00041444-200409000-00012 10.1038/sj.mp.4000789 10.2144/jun0204 10.1046/j.1460-9568.2000.00229.x 10.1161/01.CIR.0000019739.66514.1E 10.1016/S0920-9964(02)00405-X 10.1016/j.neuroscience.2003.11.012 10.1038/sj.mp.4000814 10.1086/498122 10.1038/nrn1648 10.1046/j.1471-4159.1995.65062652.x
ContentType	Journal Article
Copyright	2006 The American Society of Human Genetics 2006 INIST-CNRS 2006 by The American Society of Human Genetics. All rights reserved. 2006
Copyright_xml	– notice: 2006 The American Society of Human Genetics – notice: 2006 INIST-CNRS – notice: 2006 by The American Society of Human Genetics. All rights reserved. 2006
DBID	6I. AAFTH AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TK 8FD FR3 P64 RC3 7X8 5PM ADTOC UNPAY
DOI	10.1086/507566
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Engineering Research Database Technology Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Genetics Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	Schizophrenia and Glutathione-Related Genes
EISSN	1537-6605
EndPage	592
ExternalDocumentID	10.1086/507566 PMC1559555 16909399 18053885 10_1086_507566 S0002929707627608
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIMH NIH HHS grantid: MH44292 – fundername: NIMH NIH HHS grantid: R01 MH044292 – fundername: NIMH NIH HHS grantid: R37 MH044292
GroupedDBID	--- --K --Z -~X .55 .GJ 0R~ 123 1~5 23M 2WC 34R 3O- 4.4 41~ 457 4G. 53G 5GY 62- 6I. 6J9 7-5 85S AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AALRI AAQXK AAUCE AAVLU AAWTL AAXJY AAXUO ABJNI ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACGOD ACKIV ACNCT ACPRK ADBBV ADEZE ADJPV ADMUD AENEX AEXQZ AFMIJ AFRAH AFTJW AGCDD AGHFR AGKMS AHMBA AI. AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS ASPBG AVWKF AZFZN BAWUL C1A CS3 D0L DIK E3Z EBS ECV EJD F20 F5P FA8 FCP FDB FEDTE FGOYB GX1 HVGLF HYE HZ~ IH2 IHE IXB JIG KQ8 L7B M41 MVM NCXOZ NEJ O-L O9- OHT OK1 OZT P2P PQQKQ R2- RCE RIG RNS ROL RPM RPZ SES SJN SSZ TN5 TR2 TWZ UHB UKR UNMZH UPT VH1 VQA WH7 WOQ WQ6 X7M XOL ZA5 ZCA ZCG ZGI ZXP AAFWJ AAMRU AAYWO AAYXX ABDGV ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN ADXHL AEUPX AFPUW AGQPQ AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION EFKBS AGCQF IQODW 0SF CGR CUY CVF ECM EIF NPM VXZ Z5M 7TK 8FD FR3 P64 RC3 7X8 5PM ADTOC UNPAY
ID	FETCH-LOGICAL-c532t-e0afbf2e528ac0cab085826c1e664a0af783179090fbc9f020661e5cc4deb9a73
IEDL.DBID	IXB
ISSN	0002-9297 1537-6605
IngestDate	Wed Oct 01 16:15:06 EDT 2025 Tue Sep 30 17:00:39 EDT 2025 Fri Sep 05 05:25:10 EDT 2025 Sun Sep 28 08:32:29 EDT 2025 Wed Feb 19 01:54:11 EST 2025 Mon Jul 21 09:14:19 EDT 2025 Wed Oct 01 03:11:25 EDT 2025 Thu Apr 24 23:04:09 EDT 2025 Fri Feb 23 02:34:49 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	Glutamate-cysteine ligase Human Oxidative stress Carbon-nitrogen ligases Enzyme Schizophrenia Modifier gene Genetic determinism Psychosis Sensitivity Ligases Predisposition Genetics
Language	English
License	http://www.elsevier.com/open-access/userlicense/1.0 https://www.elsevier.com/tdm/userlicense/1.0 https://www.elsevier.com/open-access/userlicense/1.0 CC BY 4.0 publisher-specific-oa
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c532t-e0afbf2e528ac0cab085826c1e664a0af783179090fbc9f020661e5cc4deb9a73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://www.sciencedirect.com/science/article/pii/S0002929707627608
PMID	16909399
PQID	19557732
PQPubID	23462
PageCount	7
ParticipantIDs	unpaywall_primary_10_1086_507566 pubmedcentral_primary_oai_pubmedcentral_nih_gov_1559555 proquest_miscellaneous_68746778 proquest_miscellaneous_19557732 pubmed_primary_16909399 pascalfrancis_primary_18053885 crossref_primary_10_1086_507566 crossref_citationtrail_10_1086_507566 elsevier_sciencedirect_doi_10_1086_507566
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2006-09-01
PublicationDateYYYYMMDD	2006-09-01
PublicationDate_xml	– month: 09 year: 2006 text: 2006-09-01 day: 01
PublicationDecade	2000
PublicationPlace	Chicago, IL
PublicationPlace_xml	– name: Chicago, IL – name: United States
PublicationTitle	American journal of human genetics
PublicationTitleAlternate	Am J Hum Genet
PublicationYear	2006
Publisher	Elsevier Inc University of Chicago Press The American Society of Human Genetics
Publisher_xml	– name: Elsevier Inc – name: University of Chicago Press – name: The American Society of Human Genetics
References	Altar, Jurata, Charles, Lemire, Liu, Bukhman, Young, Bullard, Yokoe, Webster, Knable, Brockman (bib11) 2005; 58 Gysin R, Tosic M, Chappuis C, Deppen P, Ruiz V, Bovet P, Cuenod M, Do KQ (2005) Dysregulation of glutamate cysteine ligase in schizophrenia. Paper presented at the 36th Annual Meeting of the Society for Neuroscience, Washington, DC, November 12–16 Choi, Lipton (bib17) 2000; 57 Steullet, Neijt, Cuenod, Do (bib24) 2005; 137 Pulver, Mulle, Nestadt, Swartz, Blouin, Dombroski, Liang, Housman, Kazazian, Antonarakis, Lasseter, Wolyniec, Thornquist, McGrath (bib34) 2000; 5 Cabungcal, Singer, Hornung, Cuenod, Do, Schenk (bib44) 2004; 67 Do, Lauer, Schreiber, Zollinger, Gutteck-Amsler, Cuenod, Holsboer (bib18) 1995; 65 Shinkai, Luca, Zai, Shaikh, Matsumoto, Arnold, Hwang, King, Trakalo, Potapova, Wong, Hori, Wong, Ohmori, Nakamura, Kennedy (bib39) 2004; 14 Lewis, Hashimoto, Volk (bib42) 2005; 6 Prabakaran, Swatton, Ryan, Huffaker, Huang, Griffin, Wayland, Freeman, Dudbridge, Lilley, Karp, Hester, Tkachev, Mimmack, Yolken, Webster, Torrey, Bahn (bib10) 2004; 9 Grima, Benz, Parpura, Cuenod, Do (bib21) 2003; 62 Meister, Anderson (bib14) 1983; 52 Tsuchiya, Mulcahy, Reid, Disteche, Kavanagh (bib29) 1995; 30 Do, Trebesinger, Kirsten-Kruger, Lauer, Dydak, Hell, Holsboer, Boesinger, Cuenod (bib19) 2000; 12 Yang, Dieter, Chen, Shertzer, Nebert, Dalton (bib41) 2002; 277 Arinami, Ohtsuki, Ishiguro, Ujike, Tanaka, Morita, Mineta (bib35) 2005; 77 Tsuang (bib5) 2000; 47 Harrison, Owen (bib6) 2003; 361 Kohr, Eckardt, Luddens, Monyer, Seeburg (bib16) 1994; 12 Krystal, Karper, Seibyl, Freeman, Delaney, Bremner, Heninger, Bowers, Charney (bib45) 1994; 51 Yao, Leonard, Reddy (bib20) 2006; 22 Huang, Chang, Anderson, Meister (bib28) 1993; 268 Mahadik, Mukherjee (bib7) 1996; 19 Cabungcal, Nicolas, Kraftsik, Cuenod, Do, Hornung (bib25) 2006; 22 Rodi, Darnhofer-Patel, Stanssens, Zabeau, van den Boom (bib33) 2002; 32 Huang, Anderson, Meister (bib27) 1993; 268 Kolluri, Sun, Sampson, Lewis (bib43) 2005; 162 Chen, Shertzer, Schneider, Nebert, Dalton (bib40) 2005; 280 Pae, Yu, Kim, Kim, Lee, Lee, Jun, Lee, Paik, Serretti (bib37) 2004; 14 American Psychiatric Association (bib30) 1994 Nurnberger, Blehar, Kaufmann, York-Cooler, Simpson, Harkavy-Friedman, Severe, Malaspina, Reich (bib31) 1994; 51 Coyle, Tsai (bib13) 2004; 59 Nakamura, Kugiyama, Sugiyama, Miyamoto, Koide, Fukushima, Honda, Yoshimura, Ogawa (bib32) 2002; 105 Pae, Kim, Lee, Lee, Lee, Paik, Park, Yang, Serretti (bib38) 2003; 27 Rabinovic, Hastings (bib15) 1998; 71 Castagne, Rougemont, Cuenod, Do (bib22) 2004; 15 Castagne, Cuenod, Do (bib23) 2004; 123 Herken, Uz, Ozyurt, Sogut, Virit, Akyol (bib8) 2001; 6 Marchbanks, Ryan, Day, Owen, McGuffin, Whatley (bib9) 2003; 65 Harada, Tachikawa, Kawanishi (bib36) 2001; 281 Olney, Newcomer, Farber (bib12) 1999; 33 Choi (10.1086/507566_bib17) 2000; 57 Harrison (10.1086/507566_bib6) 2003; 361 Tsuchiya (10.1086/507566_bib29) 1995; 30 Yang (10.1086/507566_bib41) 2002; 277 Pulver (10.1086/507566_bib34) 2000; 5 Pae (10.1086/507566_bib38) 2003; 27 Tsuang (10.1086/507566_bib5) 2000; 47 Castagne (10.1086/507566_bib23) 2004; 123 Rodi (10.1086/507566_bib33) 2002; 32 Nakamura (10.1086/507566_bib32) 2002; 105 Huang (10.1086/507566_bib27) 1993; 268 Meister (10.1086/507566_bib14) 1983; 52 Coyle (10.1086/507566_bib13) 2004; 59 Do (10.1086/507566_bib18) 1995; 65 Cabungcal (10.1086/507566_bib25) 2006; 22 Harada (10.1086/507566_bib36) 2001; 281 Rabinovic (10.1086/507566_bib15) 1998; 71 Chen (10.1086/507566_bib40) 2005; 280 Kolluri (10.1086/507566_bib43) 2005; 162 Krystal (10.1086/507566_bib45) 1994; 51 Prabakaran (10.1086/507566_bib10) 2004; 9 Arinami (10.1086/507566_bib35) 2005; 77 Castagne (10.1086/507566_bib22) 2004; 15 Mahadik (10.1086/507566_bib7) 1996; 19 Huang (10.1086/507566_bib28) 1993; 268 American Psychiatric Association (10.1086/507566_bib30) 1994 Do (10.1086/507566_bib19) 2000; 12 Steullet (10.1086/507566_bib24) 2005; 137 Shinkai (10.1086/507566_bib39) 2004; 14 Lewis (10.1086/507566_bib42) 2005; 6 Grima (10.1086/507566_bib21) 2003; 62 10.1086/507566_bib26 Altar (10.1086/507566_bib11) 2005; 58 Olney (10.1086/507566_bib12) 1999; 33 Nurnberger (10.1086/507566_bib31) 1994; 51 Herken (10.1086/507566_bib8) 2001; 6 Cabungcal (10.1086/507566_bib44) 2004; 67 Kohr (10.1086/507566_bib16) 1994; 12 Marchbanks (10.1086/507566_bib9) 2003; 65 Yao (10.1086/507566_bib20) 2006; 22 Pae (10.1086/507566_bib37) 2004; 14 16038679 - Biol Psychiatry. 2005 Jul 15;58(2):85-96 12384496 - J Biol Chem. 2002 Dec 20;277(51):49446-52 7595563 - J Neurochem. 1995 Dec;65(6):2652-62 16380906 - Am J Hum Genet. 2005 Dec;77(6):937-44 7944874 - Arch Gen Psychiatry. 1994 Nov;51(11):849-59; discussion 863-4 8825659 - Genomics. 1995 Dec 10;30(3):630-2 14751276 - Neuroscience. 2004;123(4):821-34 12691788 - Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):519-23 14751774 - Neurobiol Dis. 2004 Feb;15(1):93-105 12081989 - Circulation. 2002 Jun 25;105(25):2968-73 15803162 - Nat Rev Neurosci. 2005 Apr;6(4):312-24 11126395 - Mol Psychiatry. 2000 Nov;5(6):650-3 15318035 - Psychiatr Genet. 2004 Sep;14(3):177-80 8103521 - J Biol Chem. 1993 Sep 15;268(26):19675-80 12837517 - Schizophr Res. 2003 Aug 1;62(3):213-24 11029642 - Eur J Neurosci. 2000 Oct;12(10):3721-8 11092448 - Cell Mol Life Sci. 2000 Oct;57(11):1535-41 11181039 - Biochem Biophys Res Commun. 2001 Feb 23;281(2):267-71 15318028 - Psychiatr Genet. 2004 Sep;14(3):147-50 14623372 - Schizophr Res. 2003 Dec 1;65(1):33-8 9798932 - J Neurochem. 1998 Nov;71(5):2071-8 7514425 - Neuron. 1994 May;12(5):1031-40 16330153 - Neuroscience. 2006 Feb;137(3):807-19 10628529 - J Psychiatr Res. 1999 Nov-Dec;33(6):523-33 9147491 - Schizophr Res. 1996 Mar;19(1):1-17 12573388 - Lancet. 2003 Feb 1;361(9355):417-9 16081425 - J Biol Chem. 2005 Oct 7;280(40):33766-74 15098003 - Mol Psychiatry. 2004 Jul;9(7):684-97, 643 6137189 - Annu Rev Biochem. 1983;52:711-60 12083400 - Biotechniques. 2002 Jun;Suppl:62-6, 68-9 8104188 - J Biol Chem. 1993 Sep 25;268(27):20578-83 15930070 - Am J Psychiatry. 2005 Jun;162(6):1200-2 10682218 - Biol Psychiatry. 2000 Feb 1;47(3):210-20 15006500 - Int Rev Neurobiol. 2004;59:491-515 8122957 - Arch Gen Psychiatry. 1994 Mar;51(3):199-214 16481179 - Neurobiol Dis. 2006 Jun;22(3):624-37 11244487 - Mol Psychiatry. 2001 Jan;6(1):66-73 16410648 - Dis Markers. 2006;22(1-2):83-93
References_xml	– volume: 361 start-page: 417 year: 2003 end-page: 419 ident: bib6 article-title: Genes for schizophrenia?. Recent findings and their pathophysiological implications publication-title: Lancet – volume: 32 start-page: S62 year: 2002 end-page: S69 ident: bib33 article-title: A strategy for the rapid discovery of disease markers using the MassARRAY system publication-title: Biotechniques – volume: 22 start-page: 83 year: 2006 end-page: 93 ident: bib20 article-title: Altered glutathione redox state in schizophrenia publication-title: Dis Markers – volume: 58 start-page: 85 year: 2005 end-page: 96 ident: bib11 article-title: Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts publication-title: Biol Psychiatry – volume: 137 start-page: 807 year: 2005 end-page: 819 ident: bib24 article-title: Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia publication-title: Neuroscience – volume: 12 start-page: 1031 year: 1994 end-page: 1040 ident: bib16 article-title: NMDA receptor channels: subunit-specific potentiation by reducing agents publication-title: Neuron – volume: 33 start-page: 523 year: 1999 end-page: 533 ident: bib12 article-title: NMDA receptor hypofunction model of schizophrenia publication-title: J Psychiatr Res – reference: Gysin R, Tosic M, Chappuis C, Deppen P, Ruiz V, Bovet P, Cuenod M, Do KQ (2005) Dysregulation of glutamate cysteine ligase in schizophrenia. Paper presented at the 36th Annual Meeting of the Society for Neuroscience, Washington, DC, November 12–16 – volume: 281 start-page: 267 year: 2001 end-page: 271 ident: bib36 article-title: Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia publication-title: Biochem Biophys Res Commun – volume: 6 start-page: 312 year: 2005 end-page: 324 ident: bib42 article-title: Cortical inhibitory neurons and schizophrenia publication-title: Nat Rev Neurosci – volume: 15 start-page: 93 year: 2004 end-page: 105 ident: bib22 article-title: Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat’s development induce long-term cognitive deficit: relevance to schizophrenia publication-title: Neurobiol Dis – volume: 5 start-page: 650 year: 2000 end-page: 653 ident: bib34 article-title: Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes publication-title: Mol Psychiatry – volume: 47 start-page: 210 year: 2000 end-page: 220 ident: bib5 article-title: Schizophrenia: genes and environment publication-title: Biol Psychiatry – volume: 51 start-page: 849 year: 1994 end-page: 859 ident: bib31 article-title: Diagnostic interview for genetic studies: rationale, unique features, and training: NIMH Genetics Initiative publication-title: Arch Gen Psychiatry – year: 1994 ident: bib30 publication-title: Diagnostic and statistical manual of mental disorders – volume: 19 start-page: 1 year: 1996 end-page: 17 ident: bib7 article-title: Free radical pathology and antioxidant defense in schizophrenia: a review publication-title: Schizophr Res – volume: 65 start-page: 2652 year: 1995 end-page: 2662 ident: bib18 article-title: Gamma-glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders publication-title: J Neurochem – volume: 268 start-page: 20578 year: 1993 end-page: 20583 ident: bib27 article-title: Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase publication-title: J Biol Chem – volume: 30 start-page: 630 year: 1995 end-page: 632 ident: bib29 article-title: Mapping of the glutamate-cysteine ligase catalytic subunit gene ( publication-title: Genomics – volume: 27 start-page: 519 year: 2003 end-page: 523 ident: bib38 article-title: Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 62 start-page: 213 year: 2003 end-page: 224 ident: bib21 article-title: Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia publication-title: Schizophr Res – volume: 51 start-page: 199 year: 1994 end-page: 214 ident: bib45 article-title: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses publication-title: Arch Gen Psychiatry – volume: 268 start-page: 19675 year: 1993 end-page: 19680 ident: bib28 article-title: Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase publication-title: J Biol Chem – volume: 123 start-page: 821 year: 2004 end-page: 834 ident: bib23 article-title: An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development publication-title: Neuroscience – volume: 9 start-page: 684 year: 2004 end-page: 697 ident: bib10 article-title: Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress publication-title: Mol Psychiatry – volume: 52 start-page: 711 year: 1983 end-page: 760 ident: bib14 article-title: Glutathione publication-title: Annu Rev Biochem – volume: 162 start-page: 1200 year: 2005 end-page: 1202 ident: bib43 article-title: Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia publication-title: Am J Psychiatry – volume: 277 start-page: 49446 year: 2002 end-page: 49452 ident: bib41 article-title: Initial characterization of the glutamate-cysteine ligase modifier subunit publication-title: J Biol Chem – volume: 14 start-page: 177 year: 2004 end-page: 180 ident: bib39 article-title: No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia publication-title: Psychiatr Genet – volume: 59 start-page: 491 year: 2004 end-page: 515 ident: bib13 article-title: NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia publication-title: Int Rev Neurobiol – volume: 57 start-page: 1535 year: 2000 end-page: 1541 ident: bib17 article-title: Redox modulation of the NMDA receptor publication-title: Cell Mol Life Sci – volume: 22 start-page: 624 year: 2006 end-page: 637 ident: bib25 article-title: Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: relevance to schizophrenia publication-title: Neurobiol Dis – volume: 280 start-page: 33766 year: 2005 end-page: 33774 ident: bib40 article-title: Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels publication-title: J Biol Chem – volume: 14 start-page: 147 year: 2004 end-page: 150 ident: bib37 article-title: Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population publication-title: Psychiatr Genet – volume: 105 start-page: 2968 year: 2002 end-page: 2973 ident: bib32 article-title: Polymorphism in the 5′-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction publication-title: Circulation – volume: 77 start-page: 937 year: 2005 end-page: 944 ident: bib35 article-title: Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p publication-title: Am J Hum Genet – volume: 6 start-page: 66 year: 2001 end-page: 73 ident: bib8 article-title: Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia publication-title: Mol Psychiatry – volume: 65 start-page: 33 year: 2003 end-page: 38 ident: bib9 article-title: A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress publication-title: Schizophr Res – volume: 12 start-page: 3721 year: 2000 end-page: 3728 ident: bib19 article-title: Schizophrenia: glutathione deficit in cerebro spinal fluid and prefrontal cortex in vivo publication-title: Eur J Neurosci – volume: 67 start-page: 118 year: 2004 ident: bib44 article-title: Special bias deficit in rats with low glutathione during development: a behaviour model with relevance to schizophrenia publication-title: Schizophr Res – volume: 71 start-page: 2071 year: 1998 end-page: 2078 ident: bib15 article-title: Role of endogenous glutathione in the oxidation of dopamine publication-title: J Neurochem – volume: 52 start-page: 711 year: 1983 ident: 10.1086/507566_bib14 article-title: Glutathione publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.52.070183.003431 – volume: 22 start-page: 624 year: 2006 ident: 10.1086/507566_bib25 article-title: Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: relevance to schizophrenia publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2006.01.003 – volume: 51 start-page: 199 year: 1994 ident: 10.1086/507566_bib45 article-title: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1994.03950030035004 – volume: 65 start-page: 33 year: 2003 ident: 10.1086/507566_bib9 article-title: A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress publication-title: Schizophr Res doi: 10.1016/S0920-9964(03)00011-2 – volume: 59 start-page: 491 year: 2004 ident: 10.1086/507566_bib13 article-title: NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia publication-title: Int Rev Neurobiol doi: 10.1016/S0074-7742(04)59019-0 – volume: 268 start-page: 20578 year: 1993 ident: 10.1086/507566_bib27 article-title: Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase publication-title: J Biol Chem doi: 10.1016/S0021-9258(20)80764-9 – volume: 268 start-page: 19675 year: 1993 ident: 10.1086/507566_bib28 article-title: Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)36569-X – volume: 162 start-page: 1200 year: 2005 ident: 10.1086/507566_bib43 article-title: Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.162.6.1200 – volume: 280 start-page: 33766 year: 2005 ident: 10.1086/507566_bib40 article-title: Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels publication-title: J Biol Chem doi: 10.1074/jbc.M504604200 – volume: 33 start-page: 523 year: 1999 ident: 10.1086/507566_bib12 article-title: NMDA receptor hypofunction model of schizophrenia publication-title: J Psychiatr Res doi: 10.1016/S0022-3956(99)00029-1 – volume: 47 start-page: 210 year: 2000 ident: 10.1086/507566_bib5 article-title: Schizophrenia: genes and environment publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(99)00289-9 – volume: 14 start-page: 147 year: 2004 ident: 10.1086/507566_bib37 article-title: Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population publication-title: Psychiatr Genet doi: 10.1097/00041444-200409000-00005 – volume: 57 start-page: 1535 year: 2000 ident: 10.1086/507566_bib17 article-title: Redox modulation of the NMDA receptor publication-title: Cell Mol Life Sci doi: 10.1007/PL00000638 – ident: 10.1086/507566_bib26 – volume: 30 start-page: 630 year: 1995 ident: 10.1086/507566_bib29 article-title: Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3 publication-title: Genomics doi: 10.1006/geno.1995.1293 – volume: 19 start-page: 1 year: 1996 ident: 10.1086/507566_bib7 article-title: Free radical pathology and antioxidant defense in schizophrenia: a review publication-title: Schizophr Res doi: 10.1016/0920-9964(95)00049-6 – volume: 361 start-page: 417 year: 2003 ident: 10.1086/507566_bib6 article-title: Genes for schizophrenia?. Recent findings and their pathophysiological implications publication-title: Lancet doi: 10.1016/S0140-6736(03)12379-3 – volume: 12 start-page: 1031 year: 1994 ident: 10.1086/507566_bib16 article-title: NMDA receptor channels: subunit-specific potentiation by reducing agents publication-title: Neuron doi: 10.1016/0896-6273(94)90311-5 – volume: 137 start-page: 807 year: 2005 ident: 10.1086/507566_bib24 article-title: Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.10.014 – volume: 281 start-page: 267 year: 2001 ident: 10.1086/507566_bib36 article-title: Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2001.4347 – volume: 15 start-page: 93 year: 2004 ident: 10.1086/507566_bib22 article-title: Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat’s development induce long-term cognitive deficit: relevance to schizophrenia publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2003.09.005 – volume: 71 start-page: 2071 year: 1998 ident: 10.1086/507566_bib15 article-title: Role of endogenous glutathione in the oxidation of dopamine publication-title: J Neurochem doi: 10.1046/j.1471-4159.1998.71052071.x – volume: 27 start-page: 519 year: 2003 ident: 10.1086/507566_bib38 article-title: Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/S0278-5846(03)00043-5 – year: 1994 ident: 10.1086/507566_bib30 – volume: 9 start-page: 684 year: 2004 ident: 10.1086/507566_bib10 article-title: Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001532 – volume: 58 start-page: 85 year: 2005 ident: 10.1086/507566_bib11 article-title: Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2005.03.031 – volume: 277 start-page: 49446 year: 2002 ident: 10.1086/507566_bib41 article-title: Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(−/−) knockout mouse: novel model system for a severely compromised oxidative stress response publication-title: J Biol Chem doi: 10.1074/jbc.M209372200 – volume: 67 start-page: 118 issue: Suppl 1 year: 2004 ident: 10.1086/507566_bib44 article-title: Special bias deficit in rats with low glutathione during development: a behaviour model with relevance to schizophrenia publication-title: Schizophr Res – volume: 51 start-page: 849 year: 1994 ident: 10.1086/507566_bib31 article-title: Diagnostic interview for genetic studies: rationale, unique features, and training: NIMH Genetics Initiative publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1994.03950110009002 – volume: 22 start-page: 83 year: 2006 ident: 10.1086/507566_bib20 article-title: Altered glutathione redox state in schizophrenia publication-title: Dis Markers doi: 10.1155/2006/248387 – volume: 14 start-page: 177 year: 2004 ident: 10.1086/507566_bib39 article-title: No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia publication-title: Psychiatr Genet doi: 10.1097/00041444-200409000-00012 – volume: 6 start-page: 66 year: 2001 ident: 10.1086/507566_bib8 article-title: Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000789 – volume: 32 start-page: S62 year: 2002 ident: 10.1086/507566_bib33 article-title: A strategy for the rapid discovery of disease markers using the MassARRAY system publication-title: Biotechniques doi: 10.2144/jun0204 – volume: 12 start-page: 3721 year: 2000 ident: 10.1086/507566_bib19 article-title: Schizophrenia: glutathione deficit in cerebro spinal fluid and prefrontal cortex in vivo publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2000.00229.x – volume: 105 start-page: 2968 year: 2002 ident: 10.1086/507566_bib32 article-title: Polymorphism in the 5′-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction publication-title: Circulation doi: 10.1161/01.CIR.0000019739.66514.1E – volume: 62 start-page: 213 year: 2003 ident: 10.1086/507566_bib21 article-title: Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia publication-title: Schizophr Res doi: 10.1016/S0920-9964(02)00405-X – volume: 123 start-page: 821 year: 2004 ident: 10.1086/507566_bib23 article-title: An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development publication-title: Neuroscience doi: 10.1016/j.neuroscience.2003.11.012 – volume: 5 start-page: 650 year: 2000 ident: 10.1086/507566_bib34 article-title: Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000814 – volume: 77 start-page: 937 year: 2005 ident: 10.1086/507566_bib35 article-title: Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p publication-title: Am J Hum Genet doi: 10.1086/498122 – volume: 6 start-page: 312 year: 2005 ident: 10.1086/507566_bib42 article-title: Cortical inhibitory neurons and schizophrenia publication-title: Nat Rev Neurosci doi: 10.1038/nrn1648 – volume: 65 start-page: 2652 year: 1995 ident: 10.1086/507566_bib18 article-title: Gamma-glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders publication-title: J Neurochem doi: 10.1046/j.1471-4159.1995.65062652.x – reference: 12081989 - Circulation. 2002 Jun 25;105(25):2968-73 – reference: 15318028 - Psychiatr Genet. 2004 Sep;14(3):147-50 – reference: 11244487 - Mol Psychiatry. 2001 Jan;6(1):66-73 – reference: 15930070 - Am J Psychiatry. 2005 Jun;162(6):1200-2 – reference: 9798932 - J Neurochem. 1998 Nov;71(5):2071-8 – reference: 8122957 - Arch Gen Psychiatry. 1994 Mar;51(3):199-214 – reference: 14623372 - Schizophr Res. 2003 Dec 1;65(1):33-8 – reference: 16081425 - J Biol Chem. 2005 Oct 7;280(40):33766-74 – reference: 6137189 - Annu Rev Biochem. 1983;52:711-60 – reference: 16038679 - Biol Psychiatry. 2005 Jul 15;58(2):85-96 – reference: 8104188 - J Biol Chem. 1993 Sep 25;268(27):20578-83 – reference: 16330153 - Neuroscience. 2006 Feb;137(3):807-19 – reference: 11181039 - Biochem Biophys Res Commun. 2001 Feb 23;281(2):267-71 – reference: 14751774 - Neurobiol Dis. 2004 Feb;15(1):93-105 – reference: 8103521 - J Biol Chem. 1993 Sep 15;268(26):19675-80 – reference: 15803162 - Nat Rev Neurosci. 2005 Apr;6(4):312-24 – reference: 15098003 - Mol Psychiatry. 2004 Jul;9(7):684-97, 643 – reference: 12573388 - Lancet. 2003 Feb 1;361(9355):417-9 – reference: 15006500 - Int Rev Neurobiol. 2004;59:491-515 – reference: 12691788 - Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):519-23 – reference: 10628529 - J Psychiatr Res. 1999 Nov-Dec;33(6):523-33 – reference: 16481179 - Neurobiol Dis. 2006 Jun;22(3):624-37 – reference: 16410648 - Dis Markers. 2006;22(1-2):83-93 – reference: 11092448 - Cell Mol Life Sci. 2000 Oct;57(11):1535-41 – reference: 15318035 - Psychiatr Genet. 2004 Sep;14(3):177-80 – reference: 14751276 - Neuroscience. 2004;123(4):821-34 – reference: 8825659 - Genomics. 1995 Dec 10;30(3):630-2 – reference: 7595563 - J Neurochem. 1995 Dec;65(6):2652-62 – reference: 12837517 - Schizophr Res. 2003 Aug 1;62(3):213-24 – reference: 7514425 - Neuron. 1994 May;12(5):1031-40 – reference: 11029642 - Eur J Neurosci. 2000 Oct;12(10):3721-8 – reference: 7944874 - Arch Gen Psychiatry. 1994 Nov;51(11):849-59; discussion 863-4 – reference: 10682218 - Biol Psychiatry. 2000 Feb 1;47(3):210-20 – reference: 12384496 - J Biol Chem. 2002 Dec 20;277(51):49446-52 – reference: 11126395 - Mol Psychiatry. 2000 Nov;5(6):650-3 – reference: 12083400 - Biotechniques. 2002 Jun;Suppl:62-6, 68-9 – reference: 9147491 - Schizophr Res. 1996 Mar;19(1):1-17 – reference: 16380906 - Am J Hum Genet. 2005 Dec;77(6):937-44
SSID	ssj0011803
Score	2.331836
Snippet	Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in...
SourceID	unpaywall pubmedcentral proquest pubmed pascalfrancis crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	586
SubjectTerms	Biological and medical sciences Case-Control Studies Down-Regulation Fibroblasts - enzymology Fibroblasts - metabolism Gene Frequency General aspects. Genetic counseling Genetic Predisposition to Disease - genetics Glutamate-Cysteine Ligase - genetics Glutathione - metabolism Humans Medical genetics Medical sciences Oxidative Stress - genetics Polymorphism, Single Nucleotide RNA, Messenger - analysis Schizophrenia - enzymology Schizophrenia - genetics
Title	Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene
URI	https://dx.doi.org/10.1086/507566 https://www.ncbi.nlm.nih.gov/pubmed/16909399 https://www.proquest.com/docview/19557732 https://www.proquest.com/docview/68746778 https://pubmed.ncbi.nlm.nih.gov/PMC1559555 http://www.cell.com/article/S0002929707627608/pdf
UnpaywallVersion	publishedVersion
Volume	79
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1537-6605 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: KQ8 dateStart: 20050101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVESC databaseName: ScienceDirect Free & Delayed Access Titles customDbUrl: eissn: 1537-6605 dateEnd: 20250401 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: IXB dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1537-6605 dateEnd: 20250401 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: DIK dateStart: 19490101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1537-6605 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1537-6605 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: AKRWK dateStart: 19970601 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1537-6605 dateEnd: 20250401 omitProxy: true ssIdentifier: ssj0011803 issn: 1537-6605 databaseCode: RPM dateStart: 19490101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwELYQEqJSVVGg7bYUfIADh4jEjmOHG6wKCPE4LEh7iyaODZFW2VV3V-3--46dZB9aOPSajJxkPJ75HM98Q8ixRb8oighwIYEIYq1ZAJDgnocXXEjAGOYZb-4fkpvn-LYv-huk29bCuLTKxvfXPt176-bKWaPNs1FZuhrfkGFwl7gTZzLxBb88lr6Ir385P0mIVMhbCOykl_oLIRQSnh3xzYD0cQRjVJOt-1u8BUDX8yi3p9UIZn9gMFgKUlc75FODLulF_QGfyYapdslW3W9ytkey3nKKHYWqoI9_y8Jzf9Oerxo5p9doi4A41tCuY3lGFErvyhcMdvR-WJQW35rCmALtTcc-JcZn186o46_eJ89Xv566N0HTYSHQgrNJYEKwuWVGMAU61JAjAMP9ho5MksSAN6XijsIrDW2uUxs67vfICK3jwuQpSP6FbFbDynwjtNCcAYQpqFzH1uo8YhocX3vsGOiZ7pCTVs2ZbujHXReMQeaPwVWS1dPRIUdzuVFNuLEmcdrOUrZiKhlGgTXZw5VpXAyp0PsoJfBx7bxmuLDcaQlUZjgdZ1EqhJScvS-RKNerRaoO-VrbwWL0BHWG0K9D5IqFzAUcqffqnap89eTe7phYCHwvOreld_Tw_T_08IN8qP8dueS4A7I5-T01PxFNTfJDv1z-AVLyHwk
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9swDBaKDkMHDMO6Z9aXDtthB6O2bFnybm2wNt2S7pAWyE2gZakzEDjBkmDLvx8l22mCtIdeLUKWKYr8ZFEfCfls0S_yIgJcSMCDRGsWAKS454mLmAvAGOYZbwbXae82-THiox3Sbe_CuLTKxvfXPt176-bJaaPN02lZuju-IcPgLnAnzkTqLvw-QzQQuryuq9H56ighkmHcYmAnvlZgCLEQ9_SID0akl1OYoZ5sXeDiIQS6nUi5t6imsPwL4_FalLp4TV418JKe1V-wT3ZM9YY8rwtOLt8SNVzPsaNQFfTXv7Lw5N906K-NfKOXaIyAQNbQrqN5RhhK--UdRjs6mBSlxVFTmFGgw8XM58T49NoldQTW78jtxfebbi9oSiwEmsdsHpgQbG6Z4UyCDjXkiMBww6Ejk6YJYKOQsePwykKb68yGjvw9MlzrpDB5BiJ-T3arSWU-ElromAGEGchcJ9bqPGIaHGF74ijome6QL62alW74x10ZjLHy5-AyVfV0dMjJSm5aM25sSXxtZ0lt2IrCMLAle7wxjfddSnQ_UnJ8XTuvCleWOy6BykwWMxVlnAsRs8clUumKtQjZIR9qO7jvPUWdIfbrELFhISsBx-q92VKVvz27tzsn5hzHRVe29IgePj1BDydkr3cz6Kv-1fXPA_Ki_pHkMuUOye78z8IcIbSa58d-6fwHvqIiKg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Schizophrenia+and+Oxidative+Stress%3A+Glutamate+Cysteine+Ligase+Modifier+as+a+Susceptibility+Gene&rft.jtitle=American+journal+of+human+genetics&rft.au=Tosic%2C+Mirjana&rft.au=Ott%2C+Jurg&rft.au=Barral%2C+Sandra&rft.au=Bovet%2C+Pierre&rft.date=2006-09-01&rft.pub=Elsevier+Inc&rft.issn=0002-9297&rft.eissn=1537-6605&rft.volume=79&rft.issue=3&rft.spage=586&rft.epage=592&rft_id=info:doi/10.1086%2F507566&rft.externalDocID=S0002929707627608
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9297&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9297&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9297&client=summon