Plasma Circulating Metabolites Associated With Steatotic Liver Disease and Liver Enzymes: A Multiplatform Population-Based Study
Steatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD....
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| Published in | Gastro hep advances Vol. 4; no. 2; p. 100551 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier Inc
01.01.2025
Elsevier |
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| Online Access | Get full text |
| ISSN | 2772-5723 2772-5723 |
| DOI | 10.1016/j.gastha.2024.09.006 |
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| Abstract | Steatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD.
We examined cross-sectionally the association between plasma metabolites and SLD as well as liver enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents and Children, The Insulin Resistance Atherosclerosis Family Study, and Study of Latinos). Metabolites were assessed in the Nightingale platform (n = 225 metabolites) by nuclear magnetic resonance spectroscopy and in the Metabolon platform (n = 991 metabolites) by ultra-high-performance liquid chromatography-mass spectrometry. Serum levels of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase) were measured and SLD was diagnosed by ultrasound or computed tomography scan. Logistic and linear regression models were performed per cohort and meta-analyzed. A false discovery rate < 0.05 was considered as significant threshold.
Several metabolites were significantly associated with SLD and liver enzymes, of which 21 metabolites were associated with both traits. The most significant associations were observed with phenylalanine, triglycerides in (high-density lipoprotein, intermediate-density lipoprotein, and small low-density lipoprotein), fatty acid (FA) ratios of (18:2 linoleic acid-to-total FA, omega 6 FA-to-total FA, and polyunsaturated FA-to-total FA) from the Nightingale and glutamate and sphingomyelin from the Metabolon platform. Other associated metabolites were mainly involved in lipid, amino acid, carbohydrates, and peptide metabolism.
Our study indicates a landscape of circulating metabolites associated with SLD. The identified metabolites may contribute to a better understanding of the metabolic pathways underlying SLD and hold promising for potential biomarkers in early diagnosis and monitoring of the disease. |
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| AbstractList | Background and Aims: Steatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD. Methods: We examined cross-sectionally the association between plasma metabolites and SLD as well as liver enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents and Children, The Insulin Resistance Atherosclerosis Family Study, and Study of Latinos). Metabolites were assessed in the Nightingale platform (n = 225 metabolites) by nuclear magnetic resonance spectroscopy and in the Metabolon platform (n = 991 metabolites) by ultra-high-performance liquid chromatography-mass spectrometry. Serum levels of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase) were measured and SLD was diagnosed by ultrasound or computed tomography scan. Logistic and linear regression models were performed per cohort and meta-analyzed. A false discovery rate < 0.05 was considered as significant threshold. Results: Several metabolites were significantly associated with SLD and liver enzymes, of which 21 metabolites were associated with both traits. The most significant associations were observed with phenylalanine, triglycerides in (high-density lipoprotein, intermediate-density lipoprotein, and small low-density lipoprotein), fatty acid (FA) ratios of (18:2 linoleic acid-to-total FA, omega 6 FA-to-total FA, and polyunsaturated FA-to-total FA) from the Nightingale and glutamate and sphingomyelin from the Metabolon platform. Other associated metabolites were mainly involved in lipid, amino acid, carbohydrates, and peptide metabolism. Conclusion: Our study indicates a landscape of circulating metabolites associated with SLD. The identified metabolites may contribute to a better understanding of the metabolic pathways underlying SLD and hold promising for potential biomarkers in early diagnosis and monitoring of the disease. Steatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD. We examined cross-sectionally the association between plasma metabolites and SLD as well as liver enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents and Children, The Insulin Resistance Atherosclerosis Family Study, and Study of Latinos). Metabolites were assessed in the Nightingale platform (n = 225 metabolites) by nuclear magnetic resonance spectroscopy and in the Metabolon platform (n = 991 metabolites) by ultra-high-performance liquid chromatography-mass spectrometry. Serum levels of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase) were measured and SLD was diagnosed by ultrasound or computed tomography scan. Logistic and linear regression models were performed per cohort and meta-analyzed. A false discovery rate < 0.05 was considered as significant threshold. Several metabolites were significantly associated with SLD and liver enzymes, of which 21 metabolites were associated with both traits. The most significant associations were observed with phenylalanine, triglycerides in (high-density lipoprotein, intermediate-density lipoprotein, and small low-density lipoprotein), fatty acid (FA) ratios of (18:2 linoleic acid-to-total FA, omega 6 FA-to-total FA, and polyunsaturated FA-to-total FA) from the Nightingale and glutamate and sphingomyelin from the Metabolon platform. Other associated metabolites were mainly involved in lipid, amino acid, carbohydrates, and peptide metabolism. Our study indicates a landscape of circulating metabolites associated with SLD. The identified metabolites may contribute to a better understanding of the metabolic pathways underlying SLD and hold promising for potential biomarkers in early diagnosis and monitoring of the disease. Steatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD.Background and AimsSteatotic liver disease (SLD) is the most common chronic liver disease strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD.We examined cross-sectionally the association between plasma metabolites and SLD as well as liver enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents and Children, The Insulin Resistance Atherosclerosis Family Study, and Study of Latinos). Metabolites were assessed in the Nightingale platform (n = 225 metabolites) by nuclear magnetic resonance spectroscopy and in the Metabolon platform (n = 991 metabolites) by ultra-high-performance liquid chromatography-mass spectrometry. Serum levels of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase) were measured and SLD was diagnosed by ultrasound or computed tomography scan. Logistic and linear regression models were performed per cohort and meta-analyzed. A false discovery rate < 0.05 was considered as significant threshold.MethodsWe examined cross-sectionally the association between plasma metabolites and SLD as well as liver enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents and Children, The Insulin Resistance Atherosclerosis Family Study, and Study of Latinos). Metabolites were assessed in the Nightingale platform (n = 225 metabolites) by nuclear magnetic resonance spectroscopy and in the Metabolon platform (n = 991 metabolites) by ultra-high-performance liquid chromatography-mass spectrometry. Serum levels of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase) were measured and SLD was diagnosed by ultrasound or computed tomography scan. Logistic and linear regression models were performed per cohort and meta-analyzed. A false discovery rate < 0.05 was considered as significant threshold.Several metabolites were significantly associated with SLD and liver enzymes, of which 21 metabolites were associated with both traits. The most significant associations were observed with phenylalanine, triglycerides in (high-density lipoprotein, intermediate-density lipoprotein, and small low-density lipoprotein), fatty acid (FA) ratios of (18:2 linoleic acid-to-total FA, omega 6 FA-to-total FA, and polyunsaturated FA-to-total FA) from the Nightingale and glutamate and sphingomyelin from the Metabolon platform. Other associated metabolites were mainly involved in lipid, amino acid, carbohydrates, and peptide metabolism.ResultsSeveral metabolites were significantly associated with SLD and liver enzymes, of which 21 metabolites were associated with both traits. The most significant associations were observed with phenylalanine, triglycerides in (high-density lipoprotein, intermediate-density lipoprotein, and small low-density lipoprotein), fatty acid (FA) ratios of (18:2 linoleic acid-to-total FA, omega 6 FA-to-total FA, and polyunsaturated FA-to-total FA) from the Nightingale and glutamate and sphingomyelin from the Metabolon platform. Other associated metabolites were mainly involved in lipid, amino acid, carbohydrates, and peptide metabolism.Our study indicates a landscape of circulating metabolites associated with SLD. The identified metabolites may contribute to a better understanding of the metabolic pathways underlying SLD and hold promising for potential biomarkers in early diagnosis and monitoring of the disease.ConclusionOur study indicates a landscape of circulating metabolites associated with SLD. The identified metabolites may contribute to a better understanding of the metabolic pathways underlying SLD and hold promising for potential biomarkers in early diagnosis and monitoring of the disease. |
| ArticleNumber | 100551 |
| Author | Brouwer, Willem Pieter Ida Chen, Yii-Der Kaplan, Robert C. Palmer, Nicholette D. Timpson, Nicholas J. Ghanbari, Mohsen Abozaid, Yasir J. Norris, Jill M. Goulding, Neil J. de Knegt, Robert J. Ikram, M. Arfan Wagenknecht, Lynne E. van Kleef, Laurens A. Williams-Nguyen, Jessica S. Ayada, Ibrahim |
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| Cites_doi | 10.3748/wjg.v22.i16.4079 10.1039/b910205a 10.1016/j.isci.2022.104513 10.1126/science.1204265 10.1016/j.jhep.2016.04.023 10.1002/hep.28899 10.1016/j.aohep.2020.03.008 10.7326/0003-4819-143-10-200511150-00009 10.1194/jlr.P056002 10.3390/nu9070642 10.1038/s41591-024-02958-z 10.1016/j.jhep.2016.01.002 10.1007/s00216-006-0687-8 10.1093/bioinformatics/btq340 10.1093/ajcn/nqab392 10.1210/jc.2006-0075 10.1093/ije/dys064 10.1111/j.1445-5994.2006.01210.x 10.1111/j.1572-0241.2007.01526.x 10.1016/j.molmet.2020.101092 10.3109/07853890.2014.966752 10.1111/liv.12311 10.3390/biomedicines10061444 10.1016/j.biochi.2018.07.021 10.1002/hep.29465 10.1016/bs.acr.2018.05.002 10.1210/clinem/dgaa693 10.14309/ajg.0000000000000661 10.1038/ncomms11122 10.1136/bmj.327.7414.557 10.3892/br.2014.309 10.1111/liv.12226 10.1016/j.cgh.2021.12.002 10.1038/s41598-018-31865-w 10.3389/fphar.2020.603926 10.1016/j.metabol.2016.01.011 10.1007/s00535-013-0758-5 10.1002/hep.31417 10.12688/wellcomeopenres.15132.1 10.1093/ajcn/nqac150 10.1016/j.cgh.2016.05.046 10.1016/S1047-2797(02)00412-X 10.1093/ije/dys066 10.12688/wellcomeopenres.14974.1 10.1007/s00018-018-2860-6 10.1007/s10654-023-01094-1 10.1161/CIRCGENETICS.114.000216 10.1016/j.atherosclerosis.2006.07.007 10.1038/s41575-021-00502-9 10.1136/gut.2010.221382 10.1002/hep.23593 10.1042/CS20220572 |
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| Keywords | Metabolomics Liver Enzymes RS AST ALT SLD ALSPAC MASH CT SOL Plasma Metabolites GGT LDL General Population FA IRASFS US BMI |
| Language | English |
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| References | Nikolova-Karakashian (bib50) 2018; 140 Walle, Takkunen, Männistö (bib44) 2016; 65 Kaikkonen, Würtz, Suomela (bib38) 2017; 65 Tomizawa, Kawanabe, Shinozaki (bib41) 2014; 2 Goffredo, Santoro, Tricò (bib52) 2017; 9 Burra, Becchetti, Germani (bib4) 2020; 2 Northstone, Lewcock, Groom (bib24) 2019; 4 Masoodi, Gastaldelli, Hyötyläinen (bib39) 2021; 18 Fraser, Macdonald-Wallis, Tilling (bib23) 2013; 42 Koehler, Sanna, Hansen (bib34) 2014; 34 Craven, Rahman, Parvathy (bib17) 2020; 115 Soininen, Kangas, Würtz (bib28) 2009; 134 Alferink, Radjabzadeh, Erler (bib18) 2021; 73 Verma, Jensen, Hart (bib33) 2013; 33 Badmus, Hillhouse, Anderson (bib7) 2022; 136 Le, Yeo, Li (bib2) 2022; 20 Barrera-Saldana, Fernandez-Garza, Barrera-Barrera (bib14) 2021; 20 Proffitt, Bidkhori, Lee (bib53) 2022; 25 Speliotes, Massaro, Hoffmann (bib8) 2010; 51 Hamaguchi, Kojima, Itoh (bib29) 2007; 102 Boyd, Golding, Macleod (bib22) 2013; 42 Lovric, Granér, Bjornson (bib47) 2018; 8 Peng, Stewart, Woodman (bib3) 2020; 11 Higgins, Thompson, Deeks (bib37) 2003; 327 Pan, Raftery (bib55) 2007; 387 Roulot, Costes, Buyck (bib32) 2011; 60 Régnier, Polizzi, Guillou (bib51) 2019; 159 Henkin, Bergman, Bowden (bib25) 2003; 13 Lo, Xu, Zhan (bib48) 2022; 10 Fotbolcu, Zorlu (bib1) 2016; 22 Deprince, Haas, Staels (bib40) 2020; 42 Lazarus, Ivancovsky Wajcman, Mark (bib12) 2024; 30 Hamaguchi, Kojima, Takeda (bib9) 2005; 143 Kawano, Cohen (bib5) 2013; 48 Cohen, Horton, Hobbs (bib10) 2011; 332 Suomela, Oikonen, Virtanen (bib11) 2015; 47 Gaggini, Carli, Rosso (bib46) 2018; 67 Lee, Yoon, Nakajima (bib56) 2022; 10 Gorden, Myers, Ivanova (bib20) 2015; 56 Odink, van der Lugt, Hofman (bib30) 2007; 193 Ikram, Kieboom, Brouwer (bib21) 2024; 39 Boursier, Vergniol, Guillet (bib31) 2016; 65 Moon, Shin, Heo (bib49) 2020; 9 (bib35) 2006 Shackel, McCaughan (bib13) 2006; 36 Zhou, Orešič, Leivonen (bib15) 2016; 14 Lind, Salihovic, Risérus (bib45) 2021; 106 Chalasani, Vuppalanchi, Raikwar (bib54) 2006; 91 Pang, Kartsonaki, Lv (bib19) 2022; 115 Ipsen, Lykkesfeldt, Tveden-Nyborg (bib6) 2018; 75 Soininen, Kangas, Würtz (bib26) 2015; 8 Willer, Li, Abecasis (bib36) 2010; 26 Hartley, Ferreira, Anderson (bib42) 2018; 3 Kettunen, Demirkan, Würtz (bib27) 2016; 7 Luukkonen, Zhou, Sädevirta (bib16) 2016; 64 Mäkelä, Tuomainen, Hantunen (bib43) 2022; 116 Lazarus (10.1016/j.gastha.2024.09.006_bib12) 2024; 30 Northstone (10.1016/j.gastha.2024.09.006_bib24) 2019; 4 Willer (10.1016/j.gastha.2024.09.006_bib36) 2010; 26 Pang (10.1016/j.gastha.2024.09.006_bib19) 2022; 115 Gorden (10.1016/j.gastha.2024.09.006_bib20) 2015; 56 Fotbolcu (10.1016/j.gastha.2024.09.006_bib1) 2016; 22 Soininen (10.1016/j.gastha.2024.09.006_bib26) 2015; 8 Boyd (10.1016/j.gastha.2024.09.006_bib22) 2013; 42 Roulot (10.1016/j.gastha.2024.09.006_bib32) 2011; 60 Kettunen (10.1016/j.gastha.2024.09.006_bib27) 2016; 7 Hamaguchi (10.1016/j.gastha.2024.09.006_bib29) 2007; 102 Tomizawa (10.1016/j.gastha.2024.09.006_bib41) 2014; 2 Speliotes (10.1016/j.gastha.2024.09.006_bib8) 2010; 51 Burra (10.1016/j.gastha.2024.09.006_bib4) 2020; 2 Kaikkonen (10.1016/j.gastha.2024.09.006_bib38) 2017; 65 Fraser (10.1016/j.gastha.2024.09.006_bib23) 2013; 42 Masoodi (10.1016/j.gastha.2024.09.006_bib39) 2021; 18 Cohen (10.1016/j.gastha.2024.09.006_bib10) 2011; 332 Deprince (10.1016/j.gastha.2024.09.006_bib40) 2020; 42 Hamaguchi (10.1016/j.gastha.2024.09.006_bib9) 2005; 143 Odink (10.1016/j.gastha.2024.09.006_bib30) 2007; 193 Luukkonen (10.1016/j.gastha.2024.09.006_bib16) 2016; 64 Gaggini (10.1016/j.gastha.2024.09.006_bib46) 2018; 67 Moon (10.1016/j.gastha.2024.09.006_bib49) 2020; 9 Le (10.1016/j.gastha.2024.09.006_bib2) 2022; 20 Zhou (10.1016/j.gastha.2024.09.006_bib15) 2016; 14 Koehler (10.1016/j.gastha.2024.09.006_bib34) 2014; 34 Walle (10.1016/j.gastha.2024.09.006_bib44) 2016; 65 Badmus (10.1016/j.gastha.2024.09.006_bib7) 2022; 136 Proffitt (10.1016/j.gastha.2024.09.006_bib53) 2022; 25 Soininen (10.1016/j.gastha.2024.09.006_bib28) 2009; 134 Verma (10.1016/j.gastha.2024.09.006_bib33) 2013; 33 Régnier (10.1016/j.gastha.2024.09.006_bib51) 2019; 159 Shackel (10.1016/j.gastha.2024.09.006_bib13) 2006; 36 Barrera-Saldana (10.1016/j.gastha.2024.09.006_bib14) 2021; 20 Boursier (10.1016/j.gastha.2024.09.006_bib31) 2016; 65 Mäkelä (10.1016/j.gastha.2024.09.006_bib43) 2022; 116 Kawano (10.1016/j.gastha.2024.09.006_bib5) 2013; 48 Henkin (10.1016/j.gastha.2024.09.006_bib25) 2003; 13 Lovric (10.1016/j.gastha.2024.09.006_bib47) 2018; 8 Lee (10.1016/j.gastha.2024.09.006_bib56) 2022; 10 (10.1016/j.gastha.2024.09.006_bib35) 2006 Peng (10.1016/j.gastha.2024.09.006_bib3) 2020; 11 Suomela (10.1016/j.gastha.2024.09.006_bib11) 2015; 47 Chalasani (10.1016/j.gastha.2024.09.006_bib54) 2006; 91 Ipsen (10.1016/j.gastha.2024.09.006_bib6) 2018; 75 Craven (10.1016/j.gastha.2024.09.006_bib17) 2020; 115 Nikolova-Karakashian (10.1016/j.gastha.2024.09.006_bib50) 2018; 140 Higgins (10.1016/j.gastha.2024.09.006_bib37) 2003; 327 Lind (10.1016/j.gastha.2024.09.006_bib45) 2021; 106 Goffredo (10.1016/j.gastha.2024.09.006_bib52) 2017; 9 Ikram (10.1016/j.gastha.2024.09.006_bib21) 2024; 39 Hartley (10.1016/j.gastha.2024.09.006_bib42) 2018; 3 Lo (10.1016/j.gastha.2024.09.006_bib48) 2022; 10 Pan (10.1016/j.gastha.2024.09.006_bib55) 2007; 387 Alferink (10.1016/j.gastha.2024.09.006_bib18) 2021; 73 |
| References_xml | – volume: 42 year: 2020 ident: bib40 article-title: Dysregulated lipid metabolism links NAFLD to cardiovascular disease publication-title: Mol Metabol – volume: 2 start-page: 633 year: 2014 end-page: 636 ident: bib41 article-title: Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes publication-title: Biomed Rep – volume: 67 start-page: 145 year: 2018 end-page: 158 ident: bib46 article-title: Altered amino acid concentrations in NAFLD: impact of obesity and insulin resistance publication-title: Hepatology – volume: 64 start-page: 1167 year: 2016 end-page: 1175 ident: bib16 article-title: Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease publication-title: J Hepatol – volume: 4 start-page: 51 year: 2019 ident: bib24 article-title: The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019 publication-title: Wellcome Open Res – volume: 22 start-page: 4079 year: 2016 ident: bib1 article-title: Nonalcoholic fatty liver disease as a multi-systemic disease publication-title: World J Gastroenterol – volume: 8 start-page: 1 year: 2018 end-page: 14 ident: bib47 article-title: Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome publication-title: Sci Rep – volume: 9 start-page: 642 year: 2017 ident: bib52 article-title: A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease publication-title: Nutrients – volume: 91 start-page: 2279 year: 2006 end-page: 2285 ident: bib54 article-title: Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study publication-title: J Clin Endocrinol Metabol – year: 2006 ident: bib35 article-title: Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation – volume: 48 start-page: 434 year: 2013 end-page: 441 ident: bib5 article-title: Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease publication-title: J Gastroenterol – volume: 51 start-page: 1979 year: 2010 end-page: 1987 ident: bib8 article-title: Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study publication-title: Hepatology – volume: 332 start-page: 1519 year: 2011 end-page: 1523 ident: bib10 article-title: Human fatty liver disease: old questions and new insights publication-title: Science – volume: 42 start-page: 97 year: 2013 end-page: 110 ident: bib23 article-title: Cohort profile: the Avon longitudinal study of parents and children: ALSPAC mothers cohort publication-title: Int J Epidemiol – volume: 13 start-page: 211 year: 2003 end-page: 217 ident: bib25 article-title: Genetic epidemiology of insulin resistance and visceral adiposity: the IRAS Family Study design and methods publication-title: Ann Epidemiol – volume: 3 start-page: 166 year: 2018 ident: bib42 article-title: Metabolic profiling of adolescent non-alcoholic fatty liver disease publication-title: Wellcome Open Res – volume: 18 start-page: 835 year: 2021 end-page: 856 ident: bib39 article-title: Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests publication-title: Nat Rev Gastroenterol Hepatol – volume: 42 start-page: 111 year: 2013 end-page: 127 ident: bib22 article-title: Cohort profile: the ‘children of the 90s’—the index offspring of the Avon longitudinal study of parents and children publication-title: Int J Epidemiol – volume: 8 start-page: 192 year: 2015 end-page: 206 ident: bib26 article-title: Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics publication-title: Circ Cardiovasc Genet – volume: 30 start-page: 3402 year: 2024 end-page: 3405 ident: bib12 article-title: Opportunities and challenges following approval of resmetirom for MASH liver disease publication-title: Nat Med – volume: 33 start-page: 1398 year: 2013 end-page: 1405 ident: bib33 article-title: Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD) publication-title: Liver Int – volume: 34 start-page: 296 year: 2014 end-page: 304 ident: bib34 article-title: Serum liver enzymes are associated with all-cause mortality in an elderly population publication-title: Liver Int – volume: 387 start-page: 525 year: 2007 end-page: 527 ident: bib55 article-title: Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics publication-title: Anal Bioanal Chem – volume: 26 start-page: 2190 year: 2010 end-page: 2191 ident: bib36 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics – volume: 2 year: 2020 ident: bib4 article-title: NAFLD and liver transplantation: disease burden, current management and future challenges publication-title: JHEP Rep – volume: 143 start-page: 722 year: 2005 end-page: 728 ident: bib9 article-title: The metabolic syndrome as a predictor of nonalcoholic fatty liver disease publication-title: Ann Intern Med – volume: 65 start-page: 491 year: 2017 end-page: 500 ident: bib38 article-title: Metabolic profiling of fatty liver in young and middle-aged adults: cross-sectional and prospective analyses of the Young Finns Study publication-title: Hepatology – volume: 159 start-page: 9 year: 2019 end-page: 22 ident: bib51 article-title: Sphingolipid metabolism in non-alcoholic fatty liver diseases publication-title: Biochimie – volume: 60 start-page: 977 year: 2011 end-page: 984 ident: bib32 article-title: Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years publication-title: Gut – volume: 10 start-page: 1444 year: 2022 ident: bib48 article-title: The emerging role of branched-chain amino acids in liver diseases publication-title: Biomedicines – volume: 106 start-page: e118 year: 2021 end-page: e129 ident: bib45 article-title: The plasma metabolomic profile is differently associated with liver fat, visceral adipose tissue, and pancreatic fat publication-title: J Clin Endocrinol Metabol – volume: 140 start-page: 155 year: 2018 end-page: 190 ident: bib50 article-title: Sphingolipids at the crossroads of NAFLD and senescence publication-title: Adv Cancer Res – volume: 65 start-page: 570 year: 2016 end-page: 578 ident: bib31 article-title: Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease publication-title: J Hepatol – volume: 115 start-page: 799 year: 2022 end-page: 810 ident: bib19 article-title: Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study publication-title: Am J Clin Nutr – volume: 14 start-page: 1463 year: 2016 end-page: 1472.e6 ident: bib15 article-title: Noninvasive detection of nonalcoholic steatohepatitis using clinical markers and circulating levels of lipids and metabolites publication-title: Clin Gastroenterol Hepatol – volume: 73 start-page: 968 year: 2021 end-page: 982 ident: bib18 article-title: Microbiomics, metabolomics, predicted Metagenomics, and hepatic steatosis in a population-based study of 1,355 adults publication-title: Hepatology – volume: 102 start-page: 2708 year: 2007 end-page: 2715 ident: bib29 article-title: The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation publication-title: Am J Gastroenterol – volume: 47 start-page: 40 year: 2015 end-page: 46 ident: bib11 article-title: Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study publication-title: Ann Med – volume: 116 start-page: 759 year: 2022 end-page: 770 ident: bib43 article-title: Associations of serum n–3 and n–6 polyunsaturated fatty acids with prevalence and incidence of nonalcoholic fatty liver disease publication-title: Am J Clin Nutr – volume: 20 start-page: 2809 year: 2022 end-page: 2817.e28 ident: bib2 article-title: 2019 Global NAFLD prevalence: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol – volume: 193 start-page: 408 year: 2007 end-page: 413 ident: bib30 article-title: Association between calcification in the coronary arteries, aortic arch and carotid arteries: the Rotterdam study publication-title: Atherosclerosis – volume: 56 start-page: 722 year: 2015 end-page: 736 ident: bib20 article-title: Biomarkers of NAFLD progression: a lipidomics approach to an epidemic publication-title: J Lipid Res – volume: 11 year: 2020 ident: bib3 article-title: Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments publication-title: Front Pharmacol – volume: 75 start-page: 3313 year: 2018 end-page: 3327 ident: bib6 article-title: Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease publication-title: Cell Mol Life Sci – volume: 20 year: 2021 ident: bib14 article-title: Liquid biopsy in chronic liver disease publication-title: Ann Hepatol – volume: 134 start-page: 1781 year: 2009 end-page: 1785 ident: bib28 article-title: High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism publication-title: Analyst – volume: 36 start-page: 689 year: 2006 end-page: 691 ident: bib13 article-title: Liver biopsy: is it still relevant? publication-title: Intern Med J – volume: 25 year: 2022 ident: bib53 article-title: Genome-scale metabolic modelling of the human gut microbiome reveals changes in the glyoxylate and dicarboxylate metabolism in metabolic disorders publication-title: iScience – volume: 9 start-page: 765 year: 2020 ident: bib49 article-title: Metabolic alterations associated with early-stage hepatocellular carcinoma and their correlation with aging and enzymatic activity in patients with viral hepatitis-induced liver cirrhosis: a preliminary study publication-title: J Clin Med – volume: 136 start-page: 1347 year: 2022 end-page: 1366 ident: bib7 article-title: Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways publication-title: Clin Sci – volume: 10 year: 2022 ident: bib56 article-title: A reappraisal of the diagnostic performance of B-mode ultrasonography for mild liver steatosis publication-title: Am J Gastroenterol – volume: 65 start-page: 655 year: 2016 end-page: 666 ident: bib44 article-title: Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity publication-title: Metabolism – volume: 115 start-page: 1055 year: 2020 end-page: 1065 ident: bib17 article-title: Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial publication-title: Am J Gastroenterol – volume: 327 start-page: 557 year: 2003 end-page: 560 ident: bib37 article-title: Measuring inconsistency in meta-analyses publication-title: BMJ – volume: 7 start-page: 1 year: 2016 end-page: 9 ident: bib27 article-title: Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA publication-title: Nat Commun – volume: 39 start-page: 183 year: 2024 end-page: 206 ident: bib21 article-title: The Rotterdam Study. Design update and major findings between 2020 and 2024 publication-title: Eur J Epidemiol – volume: 22 start-page: 4079 issue: 16 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib1 article-title: Nonalcoholic fatty liver disease as a multi-systemic disease publication-title: World J Gastroenterol doi: 10.3748/wjg.v22.i16.4079 – volume: 134 start-page: 1781 issue: 9 year: 2009 ident: 10.1016/j.gastha.2024.09.006_bib28 article-title: High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism publication-title: Analyst doi: 10.1039/b910205a – volume: 25 issue: 7 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib53 article-title: Genome-scale metabolic modelling of the human gut microbiome reveals changes in the glyoxylate and dicarboxylate metabolism in metabolic disorders publication-title: iScience doi: 10.1016/j.isci.2022.104513 – volume: 332 start-page: 1519 issue: 6037 year: 2011 ident: 10.1016/j.gastha.2024.09.006_bib10 article-title: Human fatty liver disease: old questions and new insights publication-title: Science doi: 10.1126/science.1204265 – volume: 65 start-page: 570 issue: 3 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib31 article-title: Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease publication-title: J Hepatol doi: 10.1016/j.jhep.2016.04.023 – volume: 65 start-page: 491 issue: 2 year: 2017 ident: 10.1016/j.gastha.2024.09.006_bib38 article-title: Metabolic profiling of fatty liver in young and middle-aged adults: cross-sectional and prospective analyses of the Young Finns Study publication-title: Hepatology doi: 10.1002/hep.28899 – volume: 20 year: 2021 ident: 10.1016/j.gastha.2024.09.006_bib14 article-title: Liquid biopsy in chronic liver disease publication-title: Ann Hepatol doi: 10.1016/j.aohep.2020.03.008 – volume: 143 start-page: 722 issue: 10 year: 2005 ident: 10.1016/j.gastha.2024.09.006_bib9 article-title: The metabolic syndrome as a predictor of nonalcoholic fatty liver disease publication-title: Ann Intern Med doi: 10.7326/0003-4819-143-10-200511150-00009 – volume: 10 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib56 article-title: A reappraisal of the diagnostic performance of B-mode ultrasonography for mild liver steatosis publication-title: Am J Gastroenterol – volume: 56 start-page: 722 issue: 3 year: 2015 ident: 10.1016/j.gastha.2024.09.006_bib20 article-title: Biomarkers of NAFLD progression: a lipidomics approach to an epidemic publication-title: J Lipid Res doi: 10.1194/jlr.P056002 – volume: 9 start-page: 642 issue: 7 year: 2017 ident: 10.1016/j.gastha.2024.09.006_bib52 article-title: A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease publication-title: Nutrients doi: 10.3390/nu9070642 – volume: 30 start-page: 3402 issue: 12 year: 2024 ident: 10.1016/j.gastha.2024.09.006_bib12 article-title: Opportunities and challenges following approval of resmetirom for MASH liver disease publication-title: Nat Med doi: 10.1038/s41591-024-02958-z – volume: 64 start-page: 1167 issue: 5 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib16 article-title: Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease publication-title: J Hepatol doi: 10.1016/j.jhep.2016.01.002 – volume: 387 start-page: 525 issue: 2 year: 2007 ident: 10.1016/j.gastha.2024.09.006_bib55 article-title: Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics publication-title: Anal Bioanal Chem doi: 10.1007/s00216-006-0687-8 – volume: 26 start-page: 2190 issue: 17 year: 2010 ident: 10.1016/j.gastha.2024.09.006_bib36 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 115 start-page: 799 issue: 3 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib19 article-title: Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqab392 – volume: 91 start-page: 2279 issue: 6 year: 2006 ident: 10.1016/j.gastha.2024.09.006_bib54 article-title: Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.2006-0075 – volume: 42 start-page: 111 issue: 1 year: 2013 ident: 10.1016/j.gastha.2024.09.006_bib22 article-title: Cohort profile: the ‘children of the 90s’—the index offspring of the Avon longitudinal study of parents and children publication-title: Int J Epidemiol doi: 10.1093/ije/dys064 – volume: 36 start-page: 689 issue: 11 year: 2006 ident: 10.1016/j.gastha.2024.09.006_bib13 article-title: Liver biopsy: is it still relevant? publication-title: Intern Med J doi: 10.1111/j.1445-5994.2006.01210.x – volume: 102 start-page: 2708 issue: 12 year: 2007 ident: 10.1016/j.gastha.2024.09.006_bib29 article-title: The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2007.01526.x – volume: 42 year: 2020 ident: 10.1016/j.gastha.2024.09.006_bib40 article-title: Dysregulated lipid metabolism links NAFLD to cardiovascular disease publication-title: Mol Metabol doi: 10.1016/j.molmet.2020.101092 – volume: 47 start-page: 40 issue: 1 year: 2015 ident: 10.1016/j.gastha.2024.09.006_bib11 article-title: Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study publication-title: Ann Med doi: 10.3109/07853890.2014.966752 – volume: 34 start-page: 296 issue: 2 year: 2014 ident: 10.1016/j.gastha.2024.09.006_bib34 article-title: Serum liver enzymes are associated with all-cause mortality in an elderly population publication-title: Liver Int doi: 10.1111/liv.12311 – volume: 2 issue: 6 year: 2020 ident: 10.1016/j.gastha.2024.09.006_bib4 article-title: NAFLD and liver transplantation: disease burden, current management and future challenges publication-title: JHEP Rep – volume: 10 start-page: 1444 issue: 6 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib48 article-title: The emerging role of branched-chain amino acids in liver diseases publication-title: Biomedicines doi: 10.3390/biomedicines10061444 – volume: 159 start-page: 9 year: 2019 ident: 10.1016/j.gastha.2024.09.006_bib51 article-title: Sphingolipid metabolism in non-alcoholic fatty liver diseases publication-title: Biochimie doi: 10.1016/j.biochi.2018.07.021 – volume: 67 start-page: 145 issue: 1 year: 2018 ident: 10.1016/j.gastha.2024.09.006_bib46 article-title: Altered amino acid concentrations in NAFLD: impact of obesity and insulin resistance publication-title: Hepatology doi: 10.1002/hep.29465 – volume: 140 start-page: 155 year: 2018 ident: 10.1016/j.gastha.2024.09.006_bib50 article-title: Sphingolipids at the crossroads of NAFLD and senescence publication-title: Adv Cancer Res doi: 10.1016/bs.acr.2018.05.002 – volume: 106 start-page: e118 issue: 1 year: 2021 ident: 10.1016/j.gastha.2024.09.006_bib45 article-title: The plasma metabolomic profile is differently associated with liver fat, visceral adipose tissue, and pancreatic fat publication-title: J Clin Endocrinol Metabol doi: 10.1210/clinem/dgaa693 – volume: 115 start-page: 1055 issue: 7 year: 2020 ident: 10.1016/j.gastha.2024.09.006_bib17 article-title: Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial publication-title: Am J Gastroenterol doi: 10.14309/ajg.0000000000000661 – volume: 7 start-page: 1 issue: 1 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib27 article-title: Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA publication-title: Nat Commun doi: 10.1038/ncomms11122 – volume: 327 start-page: 557 issue: 7414 year: 2003 ident: 10.1016/j.gastha.2024.09.006_bib37 article-title: Measuring inconsistency in meta-analyses publication-title: BMJ doi: 10.1136/bmj.327.7414.557 – volume: 2 start-page: 633 issue: 5 year: 2014 ident: 10.1016/j.gastha.2024.09.006_bib41 article-title: Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes publication-title: Biomed Rep doi: 10.3892/br.2014.309 – volume: 33 start-page: 1398 issue: 9 year: 2013 ident: 10.1016/j.gastha.2024.09.006_bib33 article-title: Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD) publication-title: Liver Int doi: 10.1111/liv.12226 – volume: 20 start-page: 2809 issue: 12 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib2 article-title: 2019 Global NAFLD prevalence: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2021.12.002 – volume: 8 start-page: 1 issue: 1 year: 2018 ident: 10.1016/j.gastha.2024.09.006_bib47 article-title: Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome publication-title: Sci Rep doi: 10.1038/s41598-018-31865-w – volume: 11 year: 2020 ident: 10.1016/j.gastha.2024.09.006_bib3 article-title: Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments publication-title: Front Pharmacol doi: 10.3389/fphar.2020.603926 – volume: 65 start-page: 655 issue: 5 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib44 article-title: Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity publication-title: Metabolism doi: 10.1016/j.metabol.2016.01.011 – volume: 48 start-page: 434 issue: 4 year: 2013 ident: 10.1016/j.gastha.2024.09.006_bib5 article-title: Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease publication-title: J Gastroenterol doi: 10.1007/s00535-013-0758-5 – year: 2006 ident: 10.1016/j.gastha.2024.09.006_bib35 – volume: 73 start-page: 968 issue: 3 year: 2021 ident: 10.1016/j.gastha.2024.09.006_bib18 article-title: Microbiomics, metabolomics, predicted Metagenomics, and hepatic steatosis in a population-based study of 1,355 adults publication-title: Hepatology doi: 10.1002/hep.31417 – volume: 4 start-page: 51 year: 2019 ident: 10.1016/j.gastha.2024.09.006_bib24 article-title: The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019 publication-title: Wellcome Open Res doi: 10.12688/wellcomeopenres.15132.1 – volume: 116 start-page: 759 issue: 3 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib43 article-title: Associations of serum n–3 and n–6 polyunsaturated fatty acids with prevalence and incidence of nonalcoholic fatty liver disease publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqac150 – volume: 9 start-page: 765 issue: 3 year: 2020 ident: 10.1016/j.gastha.2024.09.006_bib49 article-title: Metabolic alterations associated with early-stage hepatocellular carcinoma and their correlation with aging and enzymatic activity in patients with viral hepatitis-induced liver cirrhosis: a preliminary study publication-title: J Clin Med – volume: 14 start-page: 1463 issue: 10 year: 2016 ident: 10.1016/j.gastha.2024.09.006_bib15 article-title: Noninvasive detection of nonalcoholic steatohepatitis using clinical markers and circulating levels of lipids and metabolites publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2016.05.046 – volume: 13 start-page: 211 issue: 4 year: 2003 ident: 10.1016/j.gastha.2024.09.006_bib25 article-title: Genetic epidemiology of insulin resistance and visceral adiposity: the IRAS Family Study design and methods publication-title: Ann Epidemiol doi: 10.1016/S1047-2797(02)00412-X – volume: 42 start-page: 97 issue: 1 year: 2013 ident: 10.1016/j.gastha.2024.09.006_bib23 article-title: Cohort profile: the Avon longitudinal study of parents and children: ALSPAC mothers cohort publication-title: Int J Epidemiol doi: 10.1093/ije/dys066 – volume: 3 start-page: 166 year: 2018 ident: 10.1016/j.gastha.2024.09.006_bib42 article-title: Metabolic profiling of adolescent non-alcoholic fatty liver disease publication-title: Wellcome Open Res doi: 10.12688/wellcomeopenres.14974.1 – volume: 75 start-page: 3313 year: 2018 ident: 10.1016/j.gastha.2024.09.006_bib6 article-title: Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease publication-title: Cell Mol Life Sci doi: 10.1007/s00018-018-2860-6 – volume: 39 start-page: 183 issue: 2 year: 2024 ident: 10.1016/j.gastha.2024.09.006_bib21 article-title: The Rotterdam Study. Design update and major findings between 2020 and 2024 publication-title: Eur J Epidemiol doi: 10.1007/s10654-023-01094-1 – volume: 8 start-page: 192 issue: 1 year: 2015 ident: 10.1016/j.gastha.2024.09.006_bib26 article-title: Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics publication-title: Circ Cardiovasc Genet doi: 10.1161/CIRCGENETICS.114.000216 – volume: 193 start-page: 408 issue: 2 year: 2007 ident: 10.1016/j.gastha.2024.09.006_bib30 article-title: Association between calcification in the coronary arteries, aortic arch and carotid arteries: the Rotterdam study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2006.07.007 – volume: 18 start-page: 835 issue: 12 year: 2021 ident: 10.1016/j.gastha.2024.09.006_bib39 article-title: Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/s41575-021-00502-9 – volume: 60 start-page: 977 issue: 7 year: 2011 ident: 10.1016/j.gastha.2024.09.006_bib32 article-title: Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years publication-title: Gut doi: 10.1136/gut.2010.221382 – volume: 51 start-page: 1979 issue: 6 year: 2010 ident: 10.1016/j.gastha.2024.09.006_bib8 article-title: Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study publication-title: Hepatology doi: 10.1002/hep.23593 – volume: 136 start-page: 1347 issue: 18 year: 2022 ident: 10.1016/j.gastha.2024.09.006_bib7 article-title: Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways publication-title: Clin Sci doi: 10.1042/CS20220572 |
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| Title | Plasma Circulating Metabolites Associated With Steatotic Liver Disease and Liver Enzymes: A Multiplatform Population-Based Study |
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