Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts) - Barcia-Macay, Maritza; Mouaden, Fatima; Mingeot-Leclercq, Marie-Paule; Tulkens, Paul M.; Van Bambeke, Françoise (Journal of antimicrobial chemotherapy, 2008)
Keywords: Aminoglycosides - metabolism; Aminoglycosides - toxicity; Animals; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - toxicity; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Carbon Radioisotopes - metabolism; Cell Fractionation; Cell Line; Cells, Cultured; Cellular biology; cellular pharmacokinetics; Cholesterol - analysis; Drug resistance; Fibroblasts - chemistry; Fibroblasts - drug effects; glycopeptides; Kinetics; lipids; Lysosomes - chemistry; Lysosomes - drug effects; Lysosomes - ultrastructure; Macrophages - drug effects; Medical sciences; membrane; Mice; Microbiology; Microscopy, Electron, Transmission; Original Research; oritavancin; Pharmacology; Pharmacology. Drug treatments; Phospholipids - analysis; Rats; Staphylococcus aureus; Staphylococcus infections; Time Factors; vancomycin; vancomycin; glycopeptides; lipids; oritavancin; membrane; cellular pharmacokinetics; Peptides; Rat; Rodentia; Lysosome; Lipids; Vancomycin; In vitro; Telavancin; Vertebrata; Antibiotic; Mammalia; Mouse; Polypeptide; Glycopeptide; Animal; Antibacterial agent; Oritavancin; Pharmacokinetics; Fibroblast; Macrophage