Genetic epidemiology of age-related osteoporosis and its clinical applications
Technological innovations have contributed greatly to advancing our knowledge of the genetic basis of osteoporosis. This article reviews the current understanding of osteoporosis genetics with a focus on developments since 2007. The potential clinical implications of this information and future dire...
Saved in:
| Published in | Nature reviews. Rheumatology Vol. 6; no. 9; pp. 507 - 517 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.09.2010
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1759-4790 1759-4804 1759-4804 |
| DOI | 10.1038/nrrheum.2010.106 |
Cover
| Abstract | Technological innovations have contributed greatly to advancing our knowledge of the genetic basis of osteoporosis. This article reviews the current understanding of osteoporosis genetics with a focus on developments since 2007. The potential clinical implications of this information and future directions for research are also discussed.
Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies.
Key Points
Osteoporosis is a complex disease and bone mineral density (BMD) and osteoporotic fractures are highly heritable traits
Genetic studies using linkage and association approaches have identified a number of osteoporosis susceptibility genes and loci that are associated with low BMD and fracture risk
The loci identified by candidate gene association and genome-wide association studies are involved in several well-defined biological pathways related to bone metabolism
This genetic information has potential clinical applications in terms of nosology, risk prediction, pharmacogenetics, and the development of biomarkers and therapeutic agents |
|---|---|
| AbstractList | Technological innovations have contributed greatly to advancing our knowledge of the genetic basis of osteoporosis. This article reviews the current understanding of osteoporosis genetics with a focus on developments since 2007. The potential clinical implications of this information and future directions for research are also discussed.
Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies.
Key Points
Osteoporosis is a complex disease and bone mineral density (BMD) and osteoporotic fractures are highly heritable traits
Genetic studies using linkage and association approaches have identified a number of osteoporosis susceptibility genes and loci that are associated with low BMD and fracture risk
The loci identified by candidate gene association and genome-wide association studies are involved in several well-defined biological pathways related to bone metabolism
This genetic information has potential clinical applications in terms of nosology, risk prediction, pharmacogenetics, and the development of biomarkers and therapeutic agents Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies. Cheung, C.-L. et al. Nat. Rev. Rheumatol. 6, 507-517 (2010); published online 3 August 2010; doi: 10.1038/nrrheum.2010.106 Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies. Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies.Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies. |
| Audience | Academic |
| Author | Kung, Annie W. C. Xiao, Su-Mei Cheung, Ching-Lung |
| Author_xml | – sequence: 1 givenname: Ching-Lung surname: Cheung fullname: Cheung, Ching-Lung organization: Department of Medicine, The University of Hong Kong – sequence: 2 givenname: Su-Mei surname: Xiao fullname: Xiao, Su-Mei organization: Department of Medicine, The University of Hong Kong – sequence: 3 givenname: Annie W. C. surname: Kung fullname: Kung, Annie W. C. email: awckung@hku.hk organization: Department of Medicine, The University of Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20683440$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1r3DAQxUVJaT7ae0_FUGhO3o4s25KPITRpIbSX9iy08nhXQZZcST7kv4-8HzQJbdFBw_B7j-HNnJMT5x0S8p7CigITn10IW5zHVQW7TvuKnFHedGUtoD451ryDU3Ie4z1AW7eie0NOK2gFq2s4I99v0WEyusDJ9Dgab_3mofBDoTZYBrQqYV_4mNBPPvhoYqFcX5gUC22NM1rZQk2TzUUy3sW35PWgbMR3h_-C_Lr58vP6a3n34_bb9dVdqRtWpbKuekFZ09CW0o6DannDtOC8qdka1pzxNQyC6wpFBaoBgKZTwDgXTGlUHWMX5HLvOwX_e8aY5GiiRmuVQz9HmZ0AKBWQyY8vyHs_B5eHkzQnQ0XHG_6H2iiL0rjBp6D04imvKtYK3vF68Vr9hcpvSU7n1Qwm958JPj0RbFHZtI3ezrusnoMfDlPO6xF7OQUzqvAgj4vKQLsHdN5CDDhIbdIu8zyCsZKCXC5CHi5CLheRO20Wwgvh0fs_ErqXxIy6DYYnkf1L8whtM8cb |
| CitedBy_id | crossref_primary_10_1007_s00439_011_0972_2 crossref_primary_10_1016_j_envint_2022_107562 crossref_primary_10_1138_20100466 crossref_primary_10_1007_s43465_023_01012_3 crossref_primary_10_1507_endocrj_EJ13_0308 crossref_primary_10_1089_gtmb_2017_0204 crossref_primary_10_3389_fendo_2016_00141 crossref_primary_10_1038_cddis_2016_249 crossref_primary_10_1371_journal_pone_0080165 crossref_primary_10_1038_nrd_2018_45 crossref_primary_10_1016_j_intimp_2014_06_023 crossref_primary_10_1016_j_archoralbio_2013_02_013 crossref_primary_10_1016_j_intimp_2013_04_008 crossref_primary_10_1080_10255842_2025_2453924 crossref_primary_10_1002_jbmr_1851 crossref_primary_10_1002_jbmr_3358 crossref_primary_10_1007_s11033_012_2322_4 crossref_primary_10_1007_s13353_014_0247_4 crossref_primary_10_1093_ije_dyx172 crossref_primary_10_1186_s12891_024_07765_8 crossref_primary_10_1002_jbt_23601 crossref_primary_10_1016_j_arr_2018_02_002 crossref_primary_10_1080_03008207_2022_2120392 crossref_primary_10_1155_2014_320828 crossref_primary_10_1007_s12520_020_01262_4 crossref_primary_10_1093_hmg_ddr586 crossref_primary_10_1007_s00198_015_3195_x crossref_primary_10_1007_s00198_011_1861_1 crossref_primary_10_1155_2015_760313 crossref_primary_10_1007_s11657_023_01329_4 crossref_primary_10_1038_jhg_2013_84 crossref_primary_10_1007_s00404_014_3378_2 crossref_primary_10_1089_gtmb_2013_0183 crossref_primary_10_1007_s00198_011_1779_7 crossref_primary_10_1007_s11033_011_1380_3 crossref_primary_10_3389_fendo_2024_1455689 crossref_primary_10_1007_s12032_012_0389_3 crossref_primary_10_1016_j_intimp_2013_06_031 crossref_primary_10_1186_gm448 crossref_primary_10_1038_s41598_017_01579_6 crossref_primary_10_3390_cells10051199 crossref_primary_10_1016_j_intimp_2014_05_017 |
| Cites_doi | 10.1359/jbmr.090726 10.1016/j.cell.2006.02.049 10.1007/s001980050099 10.1093/ije/dyi130 10.1007/s00198-009-1043-6 10.1007/s00223-009-9251-9 10.1371/journal.pmed.0030090 10.1038/nrg2344 10.1056/NEJMoa0808692 10.1210/jc.2007-2814 10.1373/clinchem.2007.095489 10.1083/jcb.145.3.527 10.1210/jc.2007-2492 10.1016/j.bone.2009.03.676 10.1359/jbmr.071113 10.1056/NEJMoa0801197 10.7326/0003-4819-151-8-200910200-00006 10.1359/jbmr.060605 10.1210/jc.2006-2136 10.1086/367923 10.1007/s11033-009-9637-9 10.1111/j.1365-2125.2009.03363.x 10.1001/jama.299.11.1277 10.1007/s00198-008-0668-1 10.1359/jbmr.091102 10.1093/hmg/10.5.537 10.1359/jbmr.090524 10.1038/ng.120 10.1016/j.bone.2005.03.003 10.1186/1471-2350-8-S1-S14 10.1056/NEJMoa013444 10.1007/s00296-008-0745-y 10.1210/endo.142.10.8437 10.1126/science.1156849 10.1093/emboj/cdg599 10.1159/000094141 10.1359/jbmr.07s210 10.1016/j.bone.2009.04.197 10.1210/jc.2006-1729 10.1359/jbmr.090530 10.1373/clinchem.2006.074591 10.1359/JBMR.050508 10.1016/S0140-6736(08)60599-1 10.1016/j.bone.2006.09.029 10.1359/jbmr.051002 10.1016/j.bone.2008.07.001 10.1359/jbmr.070416 10.1093/ije/dym159 10.1007/s00198-007-0482-1 10.1159/000112370 10.1210/en.2004-0080 10.1359/jbmr.080707 10.1007/s00439-006-0303-1 10.1001/jama.292.17.2105 10.1159/000095216 10.1038/ng.284 10.1016/j.bone.2009.01.368 10.1093/genetics/153.4.2001 10.1001/archinte.164.10.1108 10.1371/journal.pone.0002031 10.1359/jbmr.070809 10.1074/jbc.M413274200 10.1093/hmg/ddi088 10.1073/pnas.95.7.3597 10.1081/JDI-48241 10.1210/jc.2007-2397 10.1359/jbmr.070317 10.1074/jbc.M301716200 10.1016/j.bone.2009.04.254 10.1359/JBMR.040132 10.1038/ng1071 10.1186/1471-2350-9-55 10.1056/NEJMoa075819 10.1016/j.bone.2005.01.014 10.1359/jbmr.080912 10.1016/j.bone.2009.11.018 10.1007/s00198-005-0035-4 10.1086/379378 10.1016/j.bone.2004.06.017 10.1016/j.bone.2006.02.069 10.1359/jbmr.2002.17.11.2048 10.1359/jbmr.070201 10.1359/jbmr.060806 10.1086/318811 10.1007/s00198-007-0363-7 10.1111/j.1469-1809.2005.00242.x 10.1359/JBMR.050904 10.1093/hmg/ddh084 10.1056/NEJM199410203311604 10.1007/s00223-006-0143-y 10.1007/s00439-006-0220-3 10.1359/jbmr.090404 10.1016/S8756-3282(03)00090-5 10.1359/jbmr.081106 10.1359/jbmr.061002 10.1086/420771 10.1056/NEJMoa0809329 10.1007/s00198-006-0239-2 10.1016/0002-9343(93)90218-E 10.1016/S0092-8674(01)00571-2 10.1016/j.amjmed.2006.07.011 10.1007/s00223-004-0264-0 10.1038/ng.357 10.1038/sj.clpt.6100275 10.1016/j.ajhg.2009.01.025 10.1359/jbmr.091040 10.1530/EJE-06-0753 10.1038/ng.288 10.1001/archinte.165.16.1825 10.1002/gepi.1040 10.1016/j.ajhg.2008.10.006 10.1007/s00223-009-9255-5 10.1086/338450 10.1210/jc.2005-0794 10.1007/s00198-005-1844-1 10.1038/ng.446 10.1007/s00198-007-0543-5 10.1359/jbmr.080802 10.1016/j.ajhg.2008.04.016 10.1016/S8756-3282(03)00173-X 10.1016/j.ajhg.2009.12.014 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2010 COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Sep 2010 |
| Copyright_xml | – notice: Springer Nature Limited 2010 – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Sep 2010 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.1038/nrrheum.2010.106 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological science database Proquest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest Central Student MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1759-4804 |
| EndPage | 517 |
| ExternalDocumentID | 4063173531 A236879740 20683440 10_1038_nrrheum_2010_106 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GroupedDBID | --- .XZ 0R~ 29M 39C 3V. 53G 70F 7X7 88E 8FE 8FH 8FI 8FJ AAEEF AARCD AAWTL AAWYQ AAYZH AAZLF ABAWZ ABJNI ABLJU ABUWG ACGFS ADBBV AENEX AFFVI AFKRA AFSHS AGAYW AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALMA_UNASSIGNED_HOLDINGS ARMCB AXYYD BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU DB5 EBS EE. EJD EXGXG F5P FQGFK FSGXE FYUFA HCIFZ HMCUK HZ~ IAO IHR IHW INH INR ITC LK8 M1P M7P NNMJJ ODYON OVD PQQKQ PROAC PSQYO RNR RNT RNTTT S70 SHXYY SIXXV SNYQT SOJ TAOOD TBHMF TDRGL TEORI TSG UKHRP AAYXX AFANA ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB PUEGO ABFSG ACSTC AEZWR AFHIU AHWEU AIXLP CGR CUY CVF ECM EIF NFIDA NPM 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 |
| ID | FETCH-LOGICAL-c532t-42d813551611970a6753c877543b0b737b0f87c2e820a500059a037783acea933 |
| IEDL.DBID | BENPR |
| ISSN | 1759-4790 1759-4804 |
| IngestDate | Thu Oct 02 15:18:56 EDT 2025 Tue Oct 07 06:41:16 EDT 2025 Mon Oct 20 22:33:12 EDT 2025 Mon Oct 20 16:24:21 EDT 2025 Thu May 22 21:13:54 EDT 2025 Mon Jul 21 06:08:05 EDT 2025 Wed Oct 01 05:08:50 EDT 2025 Thu Apr 24 23:04:39 EDT 2025 Fri Feb 21 02:38:52 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c532t-42d813551611970a6753c877543b0b737b0f87c2e820a500059a037783acea933 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| PMID | 20683440 |
| PQID | 1790189757 |
| PQPubID | 2041929 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_754001180 proquest_journals_1790189757 gale_infotracmisc_A236879740 gale_infotracacademiconefile_A236879740 gale_healthsolutions_A236879740 pubmed_primary_20683440 crossref_citationtrail_10_1038_nrrheum_2010_106 crossref_primary_10_1038_nrrheum_2010_106 springer_journals_10_1038_nrrheum_2010_106 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-09-01 |
| PublicationDateYYYYMMDD | 2010-09-01 |
| PublicationDate_xml | – month: 09 year: 2010 text: 2010-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: United States |
| PublicationTitle | Nature reviews. Rheumatology |
| PublicationTitleAbbrev | Nat Rev Rheumatol |
| PublicationTitleAlternate | Nat Rev Rheumatol |
| PublicationYear | 2010 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | SmithEPEstrogen resistance caused by a mutation in the estrogen-receptor gene in a manN. Engl. J. Med.19943311056106110.1056/NEJM1994102033116041:CAS:528:DyaK2MXitFWjt78%3D8090165 MalloyPJHereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor functionEndocrinology20041455106511410.1210/en.2004-00801:CAS:528:DC%2BD2cXptVyhurk%3D15308610 [No authors listed]. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am. J. Med.94, 646–650 (1993). WinklerDGOsteocyte control of bone formation via sclerostin, a novel BMP antagonistEMBO J.2003226267627610.1093/emboj/cdg5991:CAS:528:DC%2BD3sXpvVemsb4%3D14633986291840 GuoYPTH and IL21R may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association studyJ. Bone Miner. Res.201025104210481:CAS:528:DC%2BC3cXnt1Kis74%3D19874204 KleinTEEstimation of the warfarin dose with clinical and pharmacogenetic dataN. Engl. J. Med.200936075376410.1056/NEJMoa08093291:STN:280:DC%2BD1M7ls1Smuw%3D%3D19228618 SeddonJMGeorgeSRosnerBKleinMLCFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degenerationHum. Hered.20066115716510.1159/0000941411:CAS:528:DC%2BD28XptlCjtrs%3D16816528 BrownerWSLuiLYCummingsSRAssociations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly womenJ. Clin. Endocrinol. Metab.2001866316371:CAS:528:DC%2BD3MXht1Knsbc%3D11158021 CheungCLHip geometry variation is associated with bone mineralization pathway gene variants: The Framingham StudyJ. Bone Miner. Res.201025156415711:CAS:528:DC%2BC3cXhtFKrtbnK19888898 RichardsJBCollaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fractureAnn. Intern. Med.200915152853710.7326/0003-4819-151-8-200910200-00006198414542842981 CummingsSRLasofoxifene in postmenopausal women with osteoporosisN. Engl. J. Med.201036268669610.1056/NEJMoa08086921:CAS:528:DC%2BC3cXisFOqsro%3D20181970 van MeursJBLarge-scale analysis of association between LRP5 and LRP6 variants and osteoporosisJAMA20082991277129010.1001/jama.299.11.12771:CAS:528:DC%2BD1cXjsVyntLg%3D183490893282142 StolkLThe catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly menJ. Clin. Endocrinol. Metab.2007923206321210.1210/jc.2006-21361:CAS:528:DC%2BD2sXptl2ht70%3D17504906 van BezooijenRLWnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formationJ. Bone Miner. Res.200722192810.1359/jbmr.0610021:CAS:528:DC%2BD2sXhtVWntbo%3D17032150 RianchoJAAssociation of the aromatase gene alleles with BMD: epidemiological and functional evidenceJ. Bone Miner. Res.2009241709171810.1359/jbmr.0904041:CAS:528:DC%2BD1MXhtlGgurfI19419293 WilsonSGCommon sequence variation in FLNB regulates bone structure in women in the general population and FLNB mRNA expression in osteoblasts in vitroJ. Bone Miner. Res.2009241989199710.1359/jbmr.0905301:CAS:528:DC%2BC3cXht1WnsrY%3D19453265 WangCLAssociation of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysisOsteoporos. Int.20071829530510.1007/s00198-006-0239-21:CAS:528:DC%2BD2sXhsV2js7w%3D17089081 Bouatia-NajiNA polymorphism within the G6PC2 gene is associated with fasting plasma glucose levelsScience20083201085108810.1126/science.11568491:CAS:528:DC%2BD1cXmtVKnsLc%3D18451265 SamelsonEJIncreased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hipJ. Clin. Endocrinol. Metab.2008931789179510.1210/jc.2007-24921:CAS:528:DC%2BD1cXlvFWgsLs%3D183030762386280 LeeYHWooJHChoiSJJiJDSongGGAssociations between osteoprotegerin polymorphisms and bone mineral density: a meta-analysisMol. Biol. Rep.20103722723410.1007/s11033-009-9637-91:CAS:528:DC%2BC3cXisFWitg%3D%3D19642016 RivadeneiraFTwenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesNat. Genet.2009411199120610.1038/ng.4461:CAS:528:DC%2BD1MXht1Wgsb7L198019822783489 LewieckiEMTwo-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMDJ. Bone Miner. Res.2007221832184110.1359/jbmr.0708091:CAS:528:DC%2BD2sXhsVyjtrjF17708711 YamadaYAndoFShimokataHAssociation of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and menInt. J. Mol. Med.2007197918011:CAS:528:DC%2BD2sXlsFCnur0%3D17390085 ErmakovSAssociation of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian populationBone2010461244125010.1016/j.bone.2009.11.0181:CAS:528:DC%2BC3cXksFClt7w%3D19931660 GreendaleGA et al. The association of bone mineral density with estrogen receptor gene polymorphismsAm. J. Med.2006119S79S8610.1016/j.amjmed.2006.07.0111:CAS:528:DC%2BD28XhtVOqt7%2FK16949392 ChenZHormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the Women's Health Initiative hormone intervention trialsJ. Bone Miner. Res.2008231935194510.1359/jbmr.0807071:CAS:528:DC%2BD1MXosVylsbg%3D186657882686920 DobnigHHofbauerLCViereckVObermayer-PietschBFahrleitner-PammerAChanges in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patientsOsteoporos. Int.20061769370310.1007/s00198-005-0035-41:CAS:528:DC%2BD28XjsVertrw%3D16435076 KudlacekSSchneiderBWoloszczukWPietschmannPWillvonsederRSerum levels of osteoprotegerin increase with age in a healthy adult populationBone20033268168610.1016/S8756-3282(03)00090-51:CAS:528:DC%2BD3sXks1WksLc%3D12810175 HuangQYIdentification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in ChineseHum. Hered.20066123724310.1159/0000952161:CAS:528:DC%2BD28XptlagtLc%3D16926538 LorentzonMErikssonALNilssonSMellstromDOhlssonCAssociation between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD studyJ. Bone Miner. Res.2007221165117210.1359/jbmr.0704161:CAS:528:DC%2BD2sXptlGmu7k%3D17451372 RivadeneiraFEstrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor α (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal womenJ. Bone Miner. Res.2006211443145610.1359/jbmr.0606051:CAS:528:DC%2BD28XhtVSrtrrI16939403 LohmuellerKEPearceCLPikeMLanderESHirschhornJNMeta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseNat. Genet.20033317718210.1038/ng10711:CAS:528:DC%2BD3sXnsFSltQ%3D%3D12524541 CheungWMA family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 geneBone20063947047610.1016/j.bone.2006.02.0691:CAS:528:DC%2BD28XotFyksLc%3D16679074 BoneHGEffects of denosumab on bone mineral density and bone turnover in postmenopausal womenJ. Clin. Endocrinol. Metab.2008932149215710.1210/jc.2007-28141:CAS:528:DC%2BD1cXntFamtrg%3D18381571 ChoiJYGenetic polymorphisms of OPG, RANK, and ESR1, and bone mineral density in Korean postmenopausal womenCalcif. Tissue Int.20057715215910.1007/s00223-004-0264-01:CAS:528:DC%2BD2MXhtFKqt7jI16151677 LauHHNgMYHoAYLukKDKungAWGenetic and environmental determinants of bone mineral density in Chinese womenBone20053670070910.1016/j.bone.2005.01.0141:STN:280:DC%2BD2M3hvFCltA%3D%3D15781005 Uusi-RasiKEffects of teriparatide [rhPTH (1–34)] treatment on structural geometry of the proximal femur in elderly osteoporotic womenBone20053694895810.1016/j.bone.2005.03.0031:CAS:528:DC%2BD2MXltFSlt7Y%3D15878318 TronteljJMarcJZavratnikABogatajMMaharAEffect of UGT1A1*28 Polymorphism on raloxifene pharmacokinetics and pharmacodynamicsBr. J. Clin. Pharmacol.20096743744410.1111/j.1365-2125.2009.03363.x1:CAS:528:DC%2BD1MXlvFSju74%3D193713172679107 FangYVitamin D binding protein genotype and osteoporosisCalcif. Tissue Int.200985859310.1007/s00223-009-9251-91:CAS:528:DC%2BD1MXhtVait7%2FN194886702729412 LaiBMCheungCLLukKDKungAWEstrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal womenOsteoporos. Int.20081957157910.1007/s00198-007-0482-11:STN:280:DC%2BD1c7nvFaisw%3D%3D17896124 NgMYShamPCPatersonADChanVKungAWEffect of environmental factors and gender on the heritability of bone mineral density and bone sizeAnn. Hum. Genet.20067042843810.1111/j.1469-1809.2005.00242.x1:STN:280:DC%2BD28zks1SjsA%3D%3D16759177 JohnsonKAEditorial: The SERM of my dreamsJ. Clin. Endocrinol. Metab.2006913754375610.1210/jc.2006-17291:CAS:528:DC%2BD28XhtFSjtLfM17028288 MullinBHFurther genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosisBone20094538739110.1016/j.bone.2009.04.2541:CAS:528:DC%2BD1MXotFyltro%3D19427924 LiXSclerostin binds to LRP5/6 and antagonizes canonical Wnt signalingJ. Biol. Chem.2005280198831988710.1074/jbc.M4132742001:CAS:528:DC%2BD2MXktFylsbs%3D15778503 IoannidisJPAssessment of cumulative evidence on genetic associations: interim guidelinesInt. J. Epidemiol.20083712013210.1093/ije/dym15917898028 ZhengSLCumulative association of five genetic variants with prostate cancerN. Engl. J. Med.200835891091910.1056/NEJMoa0758191:CAS:528:DC%2BD1cXisF2mtrg%3D18199855 WangJTPolymorphisms in the estrogen receptor genes are associated with hip fractures in ChineseBone20084391091410.1016/j.bone.2008.07.0011:CAS:528:DC%2BD1cXht1ejtLnF18678289 KaptogeSPrediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fracturesJ. Bone Miner. Res.2008231892190410.1359/jbmr.080802186840922686919 HumphriesSECooperJATalmudPJMillerGJCandidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in heal Z Chen (BFnrrheum2010106_CR35) 2008; 23 R Koren (BFnrrheum2010106_CR79) 2006; 3 SP Moffett (BFnrrheum2010106_CR116) 2007; 22 L Stolk (BFnrrheum2010106_CR104) 2007; 92 DP Kiel (BFnrrheum2010106_CR96) 2007; 8 JB Richards (BFnrrheum2010106_CR14) 2008; 371 GH Li (BFnrrheum2010106_CR112) 2010; 21 KA Johnson (BFnrrheum2010106_CR36) 2006; 91 CL Cheung (BFnrrheum2010106_CR110) 2010; 25 M Farrall (BFnrrheum2010106_CR61) 2004; 13 BH Mullin (BFnrrheum2010106_CR102) 2008; 82 BM Lai (BFnrrheum2010106_CR46) 2008; 19 BFnrrheum2010106_CR1 HW Deng (BFnrrheum2010106_CR6) 2002; 22 Y Guo (BFnrrheum2010106_CR121) 2010; 25 KE Lohmueller (BFnrrheum2010106_CR63) 2003; 33 A Stern (BFnrrheum2010106_CR92) 2007; 156 LM Yerges (BFnrrheum2010106_CR101) 2009; 24 DH Xiong (BFnrrheum2010106_CR120) 2009; 84 S Kaptoge (BFnrrheum2010106_CR2) 2008; 23 TE Klein (BFnrrheum2010106_CR76) 2009; 360 HG Bone (BFnrrheum2010106_CR84) 2008; 93 MI McCarthy (BFnrrheum2010106_CR24) 2008; 9 Q Yang (BFnrrheum2010106_CR68) 2005; 34 MY Ng (BFnrrheum2010106_CR5) 2006; 70 EP Smith (BFnrrheum2010106_CR38) 1994; 331 V Lyssenko (BFnrrheum2010106_CR65) 2009; 41 KL Limer (BFnrrheum2010106_CR107) 2009; 24 EJ Samelson (BFnrrheum2010106_CR94) 2008; 93 JB van Meurs (BFnrrheum2010106_CR48) 2006; 21 Y Fang (BFnrrheum2010106_CR80) 2009; 85 EM Lewiecki (BFnrrheum2010106_CR85) 2007; 22 G Livshits (BFnrrheum2010106_CR62) 2004; 19 P Szulc (BFnrrheum2010106_CR90) 2001; 86 F Rivadeneira (BFnrrheum2010106_CR34) 2009; 41 JA Kanis (BFnrrheum2010106_CR75) 2008; 19 YS Cho (BFnrrheum2010106_CR119) 2009; 41 SR Cummings (BFnrrheum2010106_CR37) 2010; 362 TL Yang (BFnrrheum2010106_CR117) 2008; 83 ME Brunkow (BFnrrheum2010106_CR52) 2001; 68 JP Ioannidis (BFnrrheum2010106_CR29) 2008; 37 K Michaelsson (BFnrrheum2010106_CR7) 2005; 165 HH Lau (BFnrrheum2010106_CR40) 2005; 36 ES Siris (BFnrrheum2010106_CR64) 2004; 164 EP Smith (BFnrrheum2010106_CR39) 2008; 93 M Stephens (BFnrrheum2010106_CR125) 2003; 73 U Styrkarsdottir (BFnrrheum2010106_CR11) 2008; 358 AW Kung (BFnrrheum2010106_CR123) 2010; 86 SH Ralston (BFnrrheum2010106_CR97) 2006; 3 B Bost (BFnrrheum2010106_CR60) 1999; 153 M Lorentzon (BFnrrheum2010106_CR105) 2007; 22 S Cauchi (BFnrrheum2010106_CR69) 2008; 3 CL Cheung (BFnrrheum2010106_CR27) 2006; 120 RL van Bezooijen (BFnrrheum2010106_CR56) 2007; 22 Q Yang (BFnrrheum2010106_CR67) 2003; 72 JA Kanis (BFnrrheum2010106_CR8) 2004; 35 SS Dong (BFnrrheum2010106_CR32) 2009; 85 K Uusi-Rasi (BFnrrheum2010106_CR4) 2005; 36 QY Huang (BFnrrheum2010106_CR25) 2009; 44 C Banziger (BFnrrheum2010106_CR59) 2006; 125 Y Gong (BFnrrheum2010106_CR17) 2001; 107 IP Heilberg (BFnrrheum2010106_CR81) 2005; 27 S Kudlacek (BFnrrheum2010106_CR93) 2003; 32 U Styrkarsdottir (BFnrrheum2010106_CR118) 2009; 41 QY Huang (BFnrrheum2010106_CR21) 2006; 61 H Yasuda (BFnrrheum2010106_CR31) 1998; 95 UA Liberman (BFnrrheum2010106_CR78) 2007; 22 N Bouatia-Naji (BFnrrheum2010106_CR66) 2008; 320 SL Zheng (BFnrrheum2010106_CR71) 2008; 358 JT Wang (BFnrrheum2010106_CR45) 2008; 43 DP Kiel (BFnrrheum2010106_CR50) 2007; 40 WM Cheung (BFnrrheum2010106_CR16) 2006; 39 YJ Liu (BFnrrheum2010106_CR15) 2006; 21 JP Ioannidis (BFnrrheum2010106_CR43) 2002; 17 YH Lee (BFnrrheum2010106_CR99) 2009; 29 E Zeggini (BFnrrheum2010106_CR70) 2008; 40 JB Richards (BFnrrheum2010106_CR13) 2009; 151 SL Greenspan (BFnrrheum2010106_CR3) 2005; 20 WS Browner (BFnrrheum2010106_CR88) 2001; 86 E Grundberg (BFnrrheum2010106_CR115) 2007; 22 P Mezquita-Raya (BFnrrheum2010106_CR91) 2005; 16 CL Wang (BFnrrheum2010106_CR44) 2007; 18 SG Wilson (BFnrrheum2010106_CR111) 2009; 24 Y Yamada (BFnrrheum2010106_CR103) 2007; 19 MS Ominsky (BFnrrheum2010106_CR87) 2007; 18 PJ Talmud (BFnrrheum2010106_CR73) 2008; 54 SH Ralston (BFnrrheum2010106_CR23) 2005; 14 BH Mullin (BFnrrheum2010106_CR114) 2009; 45 F Rivadeneira (BFnrrheum2010106_CR42) 2006; 21 JY Choi (BFnrrheum2010106_CR126) 2005; 77 A Kuipers (BFnrrheum2010106_CR113) 2009; 45 W Balemans (BFnrrheum2010106_CR51) 2001; 10 BFnrrheum2010106_CR124 TL Burgess (BFnrrheum2010106_CR30) 1999; 145 LM Boyden (BFnrrheum2010106_CR19) 2002; 346 A Rogers (BFnrrheum2010106_CR89) 2005; 90 SE Humphries (BFnrrheum2010106_CR72) 2007; 53 JA Riancho (BFnrrheum2010106_CR108) 2009; 24 CL Cheung (BFnrrheum2010106_CR10) 2008; 65 YH Lee (BFnrrheum2010106_CR33) 2010; 37 JP Ioannidis (BFnrrheum2010106_CR12) 2004; 292 KM Fox (BFnrrheum2010106_CR9) 1998; 8 RD Little (BFnrrheum2010106_CR18) 2002; 70 H Dobnig (BFnrrheum2010106_CR95) 2006; 17 D Karasik (BFnrrheum2010106_CR22) 2003; 33 LJ Zhao (BFnrrheum2010106_CR122) 2009; 25 DG Winkler (BFnrrheum2010106_CR54) 2003; 22 PJ Kostenuik (BFnrrheum2010106_CR86) 2001; 142 X Li (BFnrrheum2010106_CR55) 2005; 280 PJ Malloy (BFnrrheum2010106_CR77) 2004; 145 X Hong (BFnrrheum2010106_CR106) 2007; 121 N Kusu (BFnrrheum2010106_CR53) 2003; 278 AM Sims (BFnrrheum2010106_CR58) 2008; 23 JM Seddon (BFnrrheum2010106_CR74) 2006; 61 J Trontelj (BFnrrheum2010106_CR82) 2009; 67 JM Zmuda (BFnrrheum2010106_CR127) 2009; 24 SL Ferrari (BFnrrheum2010106_CR49) 2004; 74 GA Greendale (BFnrrheum2010106_CR41) 2006; 119 JA Riancho (BFnrrheum2010106_CR100) 2006; 79 JP Ioannidis (BFnrrheum2010106_CR20) 2007; 22 BFnrrheum2010106_CR28 S Ermakov (BFnrrheum2010106_CR109) 2010; 46 BN Tran (BFnrrheum2010106_CR98) 2008; 9 H Zhang (BFnrrheum2010106_CR26) 2009; 20 Y Shu (BFnrrheum2010106_CR83) 2008; 83 QY Huang (BFnrrheum2010106_CR57) 2009; 45 JB van Meurs (BFnrrheum2010106_CR47) 2008; 299 11719191 - Cell. 2001 Nov 16;107(4):513-23 18684092 - J Bone Miner Res. 2008 Dec;23 (12 ):1892-904 11564687 - Endocrinology. 2001 Oct;142(10):4295-304 16679074 - Bone. 2006 Sep;39(3):470-6 18398418 - Nat Rev Genet. 2008 May;9(5):356-69 20175129 - J Bone Miner Res. 2010 Feb;25(2):320-9 10225954 - J Cell Biol. 1999 May 3;145(3):527-38 15125790 - J Bone Miner Res. 2004 Jun;19(6):914-23 9520411 - Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602 18372903 - Nat Genet. 2008 May;40(5):638-45 10581302 - Genetics. 1999 Dec;153(4):2001-12 16475872 - PLoS Med. 2006 Apr;3(4):e90 17903296 - BMC Med Genet. 2007 Sep 19;8 Suppl 1:S14 19727905 - Osteoporos Int. 2010 Jun;21(6):1009-20 11181578 - Hum Mol Genet. 2001 Mar 1;10(5):537-43 19419293 - J Bone Miner Res. 2009 Oct;24(10):1709-18 17708711 - J Bone Miner Res. 2007 Dec;22(12):1832-41 18381571 - J Clin Endocrinol Metab. 2008 Jun;93(6):2149-57 19079262 - Nat Genet. 2009 Jan;41(1):15-7 12592605 - Am J Hum Genet. 2003 Mar;72(3):636-49 14574645 - Am J Hum Genet. 2003 Nov;73(5):1162-9 16435076 - Osteoporos Int. 2006;17 (5):693-703 10326061 - Osteoporos Int. 1998;8(6):557-62 15308610 - Endocrinology. 2004 Nov;145(11):5106-14 18303076 - J Clin Endocrinol Metab. 2008 May;93(5):1789-95 13678771 - Bone. 2003 Sep;33(3):308-16 19453261 - J Bone Miner Res. 2009 Dec;24(12):2039-49 11443182 - J Clin Endocrinol Metab. 2001 Jul;86(7):3162-5 19396169 - Nat Genet. 2009 May;41(5):527-34 15778503 - J Biol Chem. 2005 May 20;280(20):19883-7 15523071 - JAMA. 2004 Nov 3;292(17):2105-14 17554300 - Nature. 2007 Jun 7;447(7145):661-78 16995806 - J Bone Miner Res. 2006 Oct;21(10):1511-35 16355283 - J Bone Miner Res. 2006 Jan;21(1):141-50 12015390 - N Engl J Med. 2002 May 16;346(20):1513-21 17898028 - Int J Epidemiol. 2008 Feb;37(1):120-32 17390085 - Int J Mol Med. 2007 May;19(5):791-801 17115239 - Calcif Tissue Int. 2006 Nov;79(5):289-93 19488670 - Calcif Tissue Int. 2009 Aug;85(2):85-93 11179006 - Am J Hum Genet. 2001 Mar;68(3):577-89 15807179 - Ren Fail. 2005;27(2):155-61 18021006 - J Bone Miner Res. 2008 Apr;23(4):499-506 16105967 - J Clin Endocrinol Metab. 2005 Nov;90(11):6323-31 17280526 - J Bone Miner Res. 2007 May;22(5):730-6 15746152 - Hum Mol Genet. 2005 Apr 1;14(7):943-51 16043441 - Int J Epidemiol. 2005 Oct;34(5):1129-37 17032150 - J Bone Miner Res. 2007 Jan;22(1):19-28 8090165 - N Engl J Med. 1994 Oct 20;331(16):1056-61 18290711 - J Bone Miner Res. 2007 Dec;22 Suppl 2:V105-7 15542027 - Bone. 2004 Nov;35(5):1029-37 19642016 - Mol Biol Rep. 2010 Jan;37(1):227-34 19458885 - Calcif Tissue Int. 2009 Aug;85(2):104-12 18461161 - PLoS One. 2008 May 07;3(5):e2031 18665788 - J Bone Miner Res. 2008 Dec;23(12):1935-45 20096396 - Am J Hum Genet. 2010 Feb 12;86(2):229-39 17609683 - Clin Pharmacol Ther. 2008 Feb;83(2):273-80 19888898 - J Bone Miner Res. 2010 Jul;25(7):1564-71 19841454 - Ann Intern Med. 2009 Oct 20;151(8):528-37 19371798 - Bone. 2009 Aug;45(2):289-94 18292978 - Osteoporos Int. 2008 Apr;19(4):385-97 15077203 - Am J Hum Genet. 2004 May;74(5):866-75 14633986 - EMBO J. 2003 Dec 1;22(23):6267-76 19060908 - Nat Genet. 2009 Jan;41(1):82-8 17371163 - J Bone Miner Res. 2007 Jun;22(6):832-40 19801982 - Nat Genet. 2009 Nov;41(11):1199-206 17896124 - Osteoporos Int. 2008 Apr;19(4):571-9 12810175 - Bone. 2003 Jun;32(6):681-6 18767927 - J Bone Miner Res. 2009 Feb;24(2):314-23 19249006 - Am J Hum Genet. 2009 Mar;84(3):388-98 18250146 - Clin Chem. 2008 Mar;54(3):467-74 17216495 - Hum Genet. 2007 May;121(3-4):491-500 12412813 - J Bone Miner Res. 2002 Nov;17(11):2048-60 18992858 - Am J Hum Genet. 2008 Dec;83(6):663-74 15878318 - Bone. 2005 Jun;36(6):948-58 11741193 - Am J Hum Genet. 2002 Jan;70(1):11-9 16759177 - Ann Hum Genet. 2006 Jul;70(Pt 4):428-38 16939403 - J Bone Miner Res. 2006 Sep;21(9):1443-56 8506892 - Am J Med. 1993 Jun;94(6):646-50 19427924 - Bone. 2009 Aug;45(2):387-91 19016593 - J Bone Miner Res. 2009 Mar;24(3):437-47 17384898 - Osteoporos Int. 2007 Aug;18(8):1073-82 17137849 - Bone. 2007 Mar;40(3):587-96 12524541 - Nat Genet. 2003 Feb;33(2):177-82 18505767 - J Clin Endocrinol Metab. 2008 Aug;93(8):3088-96 18073493 - Hum Hered. 2008;65(4):232-9 16926538 - Hum Hered. 2006;61(4):237-43 17504906 - J Clin Endocrinol Metab. 2007 Aug;92(8):3206-12 20181970 - N Engl J Med. 2010 Feb 25;362(8):686-96 19064610 - Hum Mol Genet. 2009 Feb 15;18(4):679-87 17089081 - Osteoporos Int. 2007 Mar;18(3):295-305 18199855 - N Engl J Med. 2008 Feb 28;358(9):910-9 19442614 - Bone. 2009 May;44(5):984-8 18451265 - Science. 2008 May 23;320(5879):1085-8 18678289 - Bone. 2008 Nov;43(5):910-4 16151677 - Calcif Tissue Int. 2005 Sep;77(3):152-9 16816528 - Hum Hered. 2006;61(3):157-65 17130180 - Clin Chem. 2007 Jan;53(1):8-16 17468191 - Eur J Endocrinol. 2007 May;156(5):555-62 12702725 - J Biol Chem. 2003 Jun 27;278(26):24113-7 18588671 - BMC Med Genet. 2008 Jun 27;9:55 18455228 - Lancet. 2008 May 3;371(9623):1505-12 19228618 - N Engl J Med. 2009 Feb 19;360(8):753-64 16157825 - Arch Intern Med. 2005 Sep 12;165(16):1825-30 17551468 - Pediatr Endocrinol Rev. 2006 Aug;3 Suppl 3:470-5 15159268 - Arch Intern Med. 2004 May 24;164(10):1108-12 16949392 - Am J Med. 2006 Sep;119(9 Suppl 1):S79-86 17451372 - J Bone Miner Res. 2007 Aug;22(8):1165-72 16678095 - Cell. 2006 May 5;125(3):509-22 18349089 - JAMA. 2008 Mar 19;299(11):1277-90 19931660 - Bone. 2010 May;46(5):1244-50 17228994 - J Bone Miner Res. 2007 Feb;22(2):173-83 18445777 - N Engl J Med. 2008 May 29;358(22):2355-65 18499081 - Am J Hum Genet. 2008 Jun;82(6):1262-9 19376282 - Bone. 2009 Aug;45(2):295-300 11158021 - J Clin Endocrinol Metab. 2001 Feb;86(2):631-7 18597038 - Osteoporos Int. 2009 Feb;20(2):341-6 19371317 - Br J Clin Pharmacol. 2009 Apr;67(4):437-44 17028288 - J Clin Endocrinol Metab. 2006 Oct;91(10):3754-6 16847694 - Hum Genet. 2006 Oct;120(3):354-9 15711777 - Osteoporos Int. 2005 Nov;16(11):1368-74 15781005 - Bone. 2005 Apr;36(4):700-9 18932002 - Rheumatol Int. 2009 Mar;29(5):539-44 19453265 - J Bone Miner Res. 2009 Dec;24(12):1989-97 19874204 - J Bone Miner Res. 2010 May;25(5):1042-8 16059624 - J Bone Miner Res. 2005 Sep;20(9):1525-32 11754470 - Genet Epidemiol. 2002 Jan;22(1):12-25 14962979 - Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R1-7 |
| References_xml | – reference: LiuYJMolecular genetic studies of gene identification for osteoporosis: a 2004 updateJ. Bone Miner. Res.2006211511153510.1359/jbmr.0510021:CAS:528:DC%2BD28XhtFekt7%2FF169958061829484 – reference: GrundbergEVitamin D receptor 3′ haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong KongJ. Bone Miner. Res.20072283284010.1359/jbmr.0703171:CAS:528:DC%2BD2sXpt12jsbc%3D17371163 – reference: RianchoJAAssociation of the aromatase gene alleles with BMD: epidemiological and functional evidenceJ. Bone Miner. Res.2009241709171810.1359/jbmr.0904041:CAS:528:DC%2BD1MXhtlGgurfI19419293 – reference: LiXSclerostin binds to LRP5/6 and antagonizes canonical Wnt signalingJ. Biol. Chem.2005280198831988710.1074/jbc.M4132742001:CAS:528:DC%2BD2MXktFylsbs%3D15778503 – reference: McCarthyMIGenome-wide association studies for complex traits: consensus, uncertainty and challengesNat. Rev. Genet.2008935636910.1038/nrg23441:CAS:528:DC%2BD1cXkvVOhs7Y%3D18398418 – reference: KanisJAJohnellOOdenAJohanssonHMcCloskeyEFRAX and the assessment of fracture probability in men and women from the UKOsteoporos. Int.20081938539710.1007/s00198-007-0543-51:STN:280:DC%2BD1c7nvF2ntA%3D%3D182929782267485 – reference: ErmakovSAssociation of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian populationBone2010461244125010.1016/j.bone.2009.11.0181:CAS:528:DC%2BC3cXksFClt7w%3D19931660 – reference: IoannidisJPMeta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone massJ. Bone Miner. Res.20072217318310.1359/jbmr.0608061:CAS:528:DC%2BD2sXhvFCgsrg%3D172289944016811 – reference: Uusi-RasiKEffects of teriparatide [rhPTH (1–34)] treatment on structural geometry of the proximal femur in elderly osteoporotic womenBone20053694895810.1016/j.bone.2005.03.0031:CAS:528:DC%2BD2MXltFSlt7Y%3D15878318 – reference: [No authors listed]. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am. J. Med.94, 646–650 (1993). – reference: DengHWRelevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseasesGenet. Epidemiol.200222122510.1002/gepi.104011754470 – reference: ChoiJYGenetic polymorphisms of OPG, RANK, and ESR1, and bone mineral density in Korean postmenopausal womenCalcif. Tissue Int.20057715215910.1007/s00223-004-0264-01:CAS:528:DC%2BD2MXhtFKqt7jI16151677 – reference: SzulcPHofbauerLCHeufelderAERothSDelmasPDOsteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone statusJ. Clin. Endocrinol. Metab.200186316231651:CAS:528:DC%2BD3MXlt1Gjt78%3D11443182 – reference: StyrkarsdottirUNew sequence variants associated with bone mineral densityNat. Genet.200941151710.1038/ng.2841:CAS:528:DC%2BD1cXhsV2hsrjK19079262 – reference: BanzigerCWntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cellsCell200612550952210.1016/j.cell.2006.02.0491:CAS:528:DC%2BD28XkslCjtLk%3D16678095 – reference: HuangQYLiGHKungAWMultiple osteoporosis susceptibility genes on chromosome 1p36 in ChineseBone20094498498810.1016/j.bone.2009.01.3681:CAS:528:DC%2BD1MXktFagtrw%3D19442614 – reference: YangQKhouryMJFriedmanJLittleJFlandersWDHow many genes underlie the occurrence of common complex diseases in the population?Int. J. Epidemiol.2005341129113710.1093/ije/dyi13016043441 – reference: TranBNNguyenNDEismanJANguyenTVAssociation between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysisBMC Med. Genet.200895510.1186/1471-2350-9-551:CAS:528:DC%2BD1cXpvF2ktrs%3D185886712459152 – reference: YamadaYAndoFShimokataHAssociation of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and menInt. J. Mol. Med.2007197918011:CAS:528:DC%2BD2sXlsFCnur0%3D17390085 – reference: LibermanUAVitamin D-resistant diseasesJ. Bone Miner. Res.200722Suppl. 2V105V10710.1359/jbmr.07s21018290711 – reference: ZhangHHigh resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral densityOsteoporos. Int.20092034134610.1007/s00198-008-0668-11:STN:280:DC%2BD1M%2FlvVGrtw%3D%3D18597038 – reference: SamelsonEJIncreased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hipJ. Clin. Endocrinol. Metab.2008931789179510.1210/jc.2007-24921:CAS:528:DC%2BD1cXlvFWgsLs%3D183030762386280 – reference: KungAWAssociation of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studiesAm. J. Hum. Genet.20108622923910.1016/j.ajhg.2009.12.0141:CAS:528:DC%2BC3cXlt1Kmu70%3D200963962820171 – reference: DongSSAssociation analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in CaucasiansCalcif. Tissue Int.20098510411210.1007/s00223-009-9255-51:CAS:528:DC%2BD1MXhtVait7%2FP194588852916082 – reference: BoneHGEffects of denosumab on bone mineral density and bone turnover in postmenopausal womenJ. Clin. Endocrinol. Metab.2008932149215710.1210/jc.2007-28141:CAS:528:DC%2BD1cXntFamtrg%3D18381571 – reference: StolkLThe catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly menJ. Clin. Endocrinol. Metab.2007923206321210.1210/jc.2006-21361:CAS:528:DC%2BD2sXptl2ht70%3D17504906 – reference: HeilbergIPEstrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysisRen. Fail.20052715516110.1081/JDI-482411:CAS:528:DC%2BD2MXjsVyitL0%3D15807179 – reference: BostBDillmannCde VienneDFluxes and metabolic pools as model traits for quantitative genetics. I. The L-shaped distribution of gene effectsGenetics1999153200120121:CAS:528:DC%2BD3cXhvV2rtg%3D%3D105813021460848 – reference: CheungCLHip geometry variation is associated with bone mineralization pathway gene variants: The Framingham StudyJ. Bone Miner. Res.201025156415711:CAS:528:DC%2BC3cXhtFKrtbnK19888898 – reference: CheungWMA family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 geneBone20063947047610.1016/j.bone.2006.02.0691:CAS:528:DC%2BD28XotFyksLc%3D16679074 – reference: CummingsSRLasofoxifene in postmenopausal women with osteoporosisN. Engl. J. Med.201036268669610.1056/NEJMoa08086921:CAS:528:DC%2BC3cXisFOqsro%3D20181970 – reference: KarasikDCupplesLAHannanMTKielDPAge, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham StudyBone20033330831610.1016/S8756-3282(03)00173-X1:STN:280:DC%2BD3svjvVSmsg%3D%3D13678771 – reference: van BezooijenRLWnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formationJ. Bone Miner. Res.200722192810.1359/jbmr.0610021:CAS:528:DC%2BD2sXhtVWntbo%3D17032150 – reference: Cheung, C. L. et al. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Hum. Mol. Genet.18, 679–687 (2009). – reference: CheungCLHuangQYChanVKungAWAssociation of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese womenHum. Hered.20086523223910.1159/0001123701:CAS:528:DC%2BD1cXht1ShtLw%3D18073493 – reference: MalloyPJHereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor functionEndocrinology20041455106511410.1210/en.2004-00801:CAS:528:DC%2BD2cXptVyhurk%3D15308610 – reference: ChenZHormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the Women's Health Initiative hormone intervention trialsJ. Bone Miner. Res.2008231935194510.1359/jbmr.0807071:CAS:528:DC%2BD1MXosVylsbg%3D186657882686920 – reference: KaptogeSPrediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fracturesJ. Bone Miner. Res.2008231892190410.1359/jbmr.080802186840922686919 – reference: WangJTPolymorphisms in the estrogen receptor genes are associated with hip fractures in ChineseBone20084391091410.1016/j.bone.2008.07.0011:CAS:528:DC%2BD1cXht1ejtLnF18678289 – reference: FoxKMCummingsSRPowell-ThreetsKStoneKFamily history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research GroupOsteoporos. Int.1998855756210.1007/s0019800500991:STN:280:DyaK1M3lsl2isw%3D%3D10326061 – reference: JohnsonKAEditorial: The SERM of my dreamsJ. Clin. Endocrinol. Metab.2006913754375610.1210/jc.2006-17291:CAS:528:DC%2BD28XhtFSjtLfM17028288 – reference: RianchoJAValeroCZarrabeitiaMTMTHFR polymorphism and bone mineral density: meta-analysis of published studiesCalcif. Tissue Int.20067928929310.1007/s00223-006-0143-y1:CAS:528:DC%2BD28Xht1Kmt7vN17115239 – reference: GuoYPTH and IL21R may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association studyJ. Bone Miner. Res.201025104210481:CAS:528:DC%2BC3cXnt1Kis74%3D19874204 – reference: SeddonJMGeorgeSRosnerBKleinMLCFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degenerationHum. Hered.20066115716510.1159/0000941411:CAS:528:DC%2BD28XptlCjtrs%3D16816528 – reference: KleinTEEstimation of the warfarin dose with clinical and pharmacogenetic dataN. Engl. J. Med.200936075376410.1056/NEJMoa08093291:STN:280:DC%2BD1M7ls1Smuw%3D%3D19228618 – reference: YangTLGenome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosisAm. J. Hum. Genet.20088366367410.1016/j.ajhg.2008.10.0061:CAS:528:DC%2BD1MXit1Gg189928582667994 – reference: LimerKLGenetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)J. Bone Miner. Res.20092431432310.1359/jbmr.0809121:CAS:528:DC%2BD1MXitlWktLY%3D18767927 – reference: GongYLDL receptor-related protein 5 (LRP5) affects bone accrual and eye developmentCell200110751352310.1016/S0092-8674(01)00571-21:CAS:528:DC%2BD3MXovVCnsb4%3D11719191 – reference: ZegginiEMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesNat. Genet.20084063864510.1038/ng.1201:CAS:528:DC%2BD1cXltFylurY%3D183729032672416 – reference: HongXCYP19A1 polymorphisms are associated with bone mineral density in Chinese menHum. Genet.200712149150010.1007/s00439-006-0303-11:CAS:528:DC%2BD2sXjvVOgtb0%3D17216495 – reference: KusuNSclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificityJ. Biol. Chem.2003278241132411710.1074/jbc.M3017162001:CAS:528:DC%2BD3sXkslyns7o%3D12702725 – reference: MoffettSPAssociation of the VDR translation start site polymorphism and fracture risk in older womenJ. Bone Miner. Res.20072273073610.1359/jbmr.07020117280526 – reference: KanisJAA family history of fracture and fracture risk: a meta-analysisBone2004351029103710.1016/j.bone.2004.06.0171:STN:280:DC%2BD2crmvV2kug%3D%3D15542027 – reference: IoannidisJPDifferential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomesJAMA20042922105211410.1001/jama.292.17.21051:CAS:528:DC%2BD2cXpsVeku7g%3D15523071 – reference: SirisESBone mineral density thresholds for pharmacological intervention to prevent fracturesArch. Intern. Med.20041641108111210.1001/archinte.164.10.110815159268 – reference: ZhaoLJGenome-wide association study for femoral neck bone geometryJ. Bone Miner. Res.20092532032910.1359/jbmr.0907261:CAS:528:DC%2BC3cXksl2ksLw%3D3153387 – reference: HuangQYIdentification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in ChineseHum. Hered.20066123724310.1159/0000952161:CAS:528:DC%2BD28XptlagtLc%3D16926538 – reference: CauchiSPost genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive valuePLoS ONE20083e203110.1371/journal.pone.00020311:CAS:528:DC%2BD1cXmt1Whs74%3D184611612346547 – reference: GreendaleGA et al. The association of bone mineral density with estrogen receptor gene polymorphismsAm. J. Med.2006119S79S8610.1016/j.amjmed.2006.07.0111:CAS:528:DC%2BD28XhtVOqt7%2FK16949392 – reference: KielDP et al. Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in menBone20074058759610.1016/j.bone.2006.09.0291:CAS:528:DC%2BD2sXhtlSksrg%3D17137849 – reference: IoannidisJPAssessment of cumulative evidence on genetic associations: interim guidelinesInt. J. Epidemiol.20083712013210.1093/ije/dym15917898028 – reference: BalemansWIncreased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)Hum. Mol. Genet.20011053754310.1093/hmg/10.5.5371:CAS:528:DC%2BD3MXhslSitbw%3D11181578 – reference: GreenspanSLBeckTJResnickNMBhattacharyaRParkerRAEffect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double-blind, placebo-controlled clinical trialJ. Bone Miner. Res.2005201525153210.1359/JBMR.0505081:CAS:528:DC%2BD2MXhtVOltrrK16059624 – reference: IoannidisJP et al. Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysisJ. Bone Miner. Res.2002172048206010.1359/jbmr.2002.17.11.20481:CAS:528:DC%2BD38Xoslems7Y%3D12412813 – reference: RivadeneiraFTwenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesNat. Genet.2009411199120610.1038/ng.4461:CAS:528:DC%2BD1MXht1Wgsb7L198019822783489 – reference: LeeYHWooJHChoiSJJiJDSongGGAssociations between osteoprotegerin polymorphisms and bone mineral density: a meta-analysisMol. Biol. Rep.20103722723410.1007/s11033-009-9637-91:CAS:528:DC%2BC3cXisFWitg%3D%3D19642016 – reference: RivadeneiraFEstrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor α (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal womenJ. Bone Miner. Res.2006211443145610.1359/jbmr.0606051:CAS:528:DC%2BD28XhtVSrtrrI16939403 – reference: OminskyMSKostenuikPJCranmerPSmithSYAtkinsonJEThe RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeysOsteoporos. Int.2007181073108210.1007/s00198-007-0363-71:CAS:528:DC%2BD2sXntVOlsrk%3D17384898 – reference: MichaelssonKMelhusHFermHAhlbomAPedersenNLGenetic liability to fractures in the elderlyArch. Intern. Med.20051651825183010.1001/archinte.165.16.182516157825 – reference: ZmudaJMAssociation analysis of WNT10B with bone mass and structure among individuals of African ancestryJ. Bone Miner. Res.20092443744710.1359/jbmr.0811061:CAS:528:DC%2BD1MXjslKru70%3D19016593 – reference: RichardsJBCollaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fractureAnn. Intern. Med.200915152853710.7326/0003-4819-151-8-200910200-00006198414542842981 – reference: BrownerWSLuiLYCummingsSRAssociations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly womenJ. Clin. Endocrinol. Metab.2001866316371:CAS:528:DC%2BD3MXht1Knsbc%3D11158021 – reference: HuangQYLiGHKungAWThe −9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosisBone20094528929410.1016/j.bone.2009.03.6761:CAS:528:DC%2BD1MXotFylsbk%3D19371798 – reference: LewieckiEMTwo-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMDJ. Bone Miner. Res.2007221832184110.1359/jbmr.0708091:CAS:528:DC%2BD2sXhsVyjtrjF17708711 – reference: YangQKhouryMJBottoLFriedmanJMFlandersWDImproving the prediction of complex diseases by testing for multiple disease-susceptibility genesAm. J. Hum. Genet.20037263664910.1086/3679231:CAS:528:DC%2BD3sXitFajsr0%3D125926051180239 – reference: RichardsJBBone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association studyLancet20083711505151210.1016/S0140-6736(08)60599-11:CAS:528:DC%2BD1cXlsFGisr0%3D184552282679414 – reference: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature447, 661–678 (2007). – reference: LivshitsGGenetics of bone mineral density: evidence for a major pleiotropic effect from an intercontinental studyJ. Bone Miner. Res.20041991492310.1359/JBMR.04013215125790 – reference: KuipersAAssociation of a high mobility group gene (HMGA2) variant with bone mineral densityBone20094529530010.1016/j.bone.2009.04.1971:CAS:528:DC%2BD1MXotFylsbY%3D193762822795567 – reference: LauHHNgMYHoAYLukKDKungAWGenetic and environmental determinants of bone mineral density in Chinese womenBone20053670070910.1016/j.bone.2005.01.0141:STN:280:DC%2BD2M3hvFCltA%3D%3D15781005 – reference: KudlacekSSchneiderBWoloszczukWPietschmannPWillvonsederRSerum levels of osteoprotegerin increase with age in a healthy adult populationBone20033268168610.1016/S8756-3282(03)00090-51:CAS:528:DC%2BD3sXks1WksLc%3D12810175 – reference: BurgessTL et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclastsJ. Cell Biol.199914552753810.1083/jcb.145.3.5271:CAS:528:DyaK1MXivFKntr8%3D102259542185088 – reference: RogersAEastellRCirculating osteoprotegerin and receptor activator for nuclear factor kappaB ligand: clinical utility in metabolic bone disease assessmentJ. Clin. Endocrinol. Metab.2005906323633110.1210/jc.2005-07941:CAS:528:DC%2BD2MXht1altLzO16105967 – reference: XiongDHGenome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groupsAm. J. Hum. Genet.20098438839810.1016/j.ajhg.2009.01.0251:CAS:528:DC%2BD1MXmvFClsrg%3D192490062667986 – reference: BoydenLMHigh bone density due to a mutation in LDL-receptor-related protein 5N. Engl. J. Med.20023461513152110.1056/NEJMoa0134441:CAS:528:DC%2BD38Xjs1Smurs%3D12015390 – reference: Mezquita-RayaPThe contribution of serum osteoprotegerin to bone mass and vertebral fractures in postmenopausal womenOsteoporos. Int.2005161368137410.1007/s00198-005-1844-115711777 – reference: ShuYEffect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokineticsClin. Pharmacol. Ther.20088327328010.1038/sj.clpt.61002751:CAS:528:DC%2BD1cXitFKjtbo%3D17609683 – reference: TronteljJMarcJZavratnikABogatajMMaharAEffect of UGT1A1*28 Polymorphism on raloxifene pharmacokinetics and pharmacodynamicsBr. J. Clin. Pharmacol.20096743744410.1111/j.1365-2125.2009.03363.x1:CAS:528:DC%2BD1MXlvFSju74%3D193713172679107 – reference: WinklerDGOsteocyte control of bone formation via sclerostin, a novel BMP antagonistEMBO J.2003226267627610.1093/emboj/cdg5991:CAS:528:DC%2BD3sXpvVemsb4%3D14633986291840 – reference: BrunkowMEBone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing proteinAm. J. Hum. Genet.20016857758910.1086/3188111:CAS:528:DC%2BD3MXit1altbk%3D111790061274471 – reference: TalmudPJChromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged menClin. Chem.20085446747410.1373/clinchem.2007.0954891:CAS:528:DC%2BD1cXivVansrk%3D18250146 – reference: ChoYSA large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traitsNat. Genet.20094152753410.1038/ng.3571:CAS:528:DC%2BD1MXltValt7k%3D19396169 – reference: SternALaughlinGABergstromJBarrett-ConnorEThe sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineral density in older adults: the Rancho Bernardo studyEur. J. Endocrinol.200715655556210.1530/EJE-06-07531:CAS:528:DC%2BD2sXls1ynsbw%3D174681912642656 – reference: LyssenkoVCommon variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretionNat. Genet.200941828810.1038/ng.2881:CAS:528:DC%2BD1cXhsVKlt77J19060908 – reference: FarrallMQuantitative genetic variation: a post-modern viewHum. Mol. Genet.200413Spec. No. 1R1R710.1093/hmg/ddh0841:CAS:528:DC%2BD2cXivFCktbY%3D14962979 – reference: LohmuellerKEPearceCLPikeMLanderESHirschhornJNMeta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseNat. Genet.20033317718210.1038/ng10711:CAS:528:DC%2BD3sXnsFSltQ%3D%3D12524541 – reference: DobnigHHofbauerLCViereckVObermayer-PietschBFahrleitner-PammerAChanges in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patientsOsteoporos. Int.20061769370310.1007/s00198-005-0035-41:CAS:528:DC%2BD28XjsVertrw%3D16435076 – reference: SmithEPImpact on bone of an estrogen receptor-alpha gene loss of function mutationJ. Clin. Endocrinol. Metab.2008933088309610.1210/jc.2007-23971:CAS:528:DC%2BD1cXpvVOlsrk%3D185057672729204 – reference: KielDPGenome-wide association with bone mass and geometry in the Framingham Heart StudyBMC Med. Genet.20078Suppl. 1S1410.1186/1471-2350-8-S1-S141:CAS:528:DC%2BD1cXjsFelsLo%3D179032961995606 – reference: RalstonSHLoci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS studyHum. Mol. Genet.20051494395110.1093/hmg/ddi0881:CAS:528:DC%2BD2MXis1yjt7Y%3D15746152 – reference: LiGHKungAWHuangQYCommon variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese womenOsteoporos. Int.2010211009102010.1007/s00198-009-1043-61:CAS:528:DC%2BC3cXlsFaitLo%3D19727905 – reference: MullinBHIdentification of a role for the ARHGEF3 gene in postmenopausal osteoporosisAm. J. Hum. Genet.2008821262126910.1016/j.ajhg.2008.04.0161:CAS:528:DC%2BD1cXntlWqsr8%3D184990812427258 – reference: SimsAMGenetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genesJ. Bone Miner. Res.20082349950610.1359/jbmr.0711131:CAS:528:DC%2BD1cXltFyhsLs%3D18021006 – reference: RalstonSHLarge-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS studyPLoS Med.20063e9010.1371/journal.pmed.00300901:CAS:528:DC%2BD28Xks1Kksrg%3D164758721370920 – reference: LaiBMCheungCLLukKDKungAWEstrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal womenOsteoporos. Int.20081957157910.1007/s00198-007-0482-11:STN:280:DC%2BD1c7nvFaisw%3D%3D17896124 – reference: HumphriesSECooperJATalmudPJMillerGJCandidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK menClin. Chem.20075381610.1373/clinchem.2006.0745911:CAS:528:DC%2BD2sXmsFGjtg%3D%3D17130180 – reference: KostenuikPJ et al. OPG and PTH-(1–34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized ratsEndocrinology20011424295430410.1210/endo.142.10.84371:CAS:528:DC%2BD3MXnt1ert70%3D11564687 – reference: StyrkarsdottirUMultiple genetic loci for bone mineral density and fracturesN. Engl. J. Med.20083582355236510.1056/NEJMoa08011971:CAS:528:DC%2BD1cXmsVKgtb4%3D18445777 – reference: YasudaHOsteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLProc. Natl Acad. Sci. USA1998953597360210.1073/pnas.95.7.35971:CAS:528:DyaK1cXitlKjsLY%3D9520411 – reference: ZhengSLCumulative association of five genetic variants with prostate cancerN. Engl. J. Med.200835891091910.1056/NEJMoa0758191:CAS:528:DC%2BD1cXisF2mtrg%3D18199855 – reference: van MeursJBLarge-scale analysis of association between LRP5 and LRP6 variants and osteoporosisJAMA20082991277129010.1001/jama.299.11.12771:CAS:528:DC%2BD1cXjsVyntLg%3D183490893282142 – reference: NgMYShamPCPatersonADChanVKungAWEffect of environmental factors and gender on the heritability of bone mineral density and bone sizeAnn. Hum. Genet.20067042843810.1111/j.1469-1809.2005.00242.x1:STN:280:DC%2BD28zks1SjsA%3D%3D16759177 – reference: WilsonSGCommon sequence variation in FLNB regulates bone structure in women in the general population and FLNB mRNA expression in osteoblasts in vitroJ. Bone Miner. Res.2009241989199710.1359/jbmr.0905301:CAS:528:DC%2BC3cXht1WnsrY%3D19453265 – reference: YergesLM et al. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older menJ. Bone Miner. Res.2009242039204910.1359/jbmr.0905241:CAS:528:DC%2BC3cXht1Wns7w%3D194532612791518 – reference: WangCLAssociation of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysisOsteoporos. Int.20071829530510.1007/s00198-006-0239-21:CAS:528:DC%2BD2sXhsV2js7w%3D17089081 – reference: van MeursJBCommon genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white menJ. Bone Miner. Res.20062114115010.1359/JBMR.0509041:CAS:528:DC%2BD28Xpt1Smsw%3D%3D16355283 – reference: Bouatia-NajiNA polymorphism within the G6PC2 gene is associated with fasting plasma glucose levelsScience20083201085108810.1126/science.11568491:CAS:528:DC%2BD1cXmtVKnsLc%3D18451265 – reference: SmithEPEstrogen resistance caused by a mutation in the estrogen-receptor gene in a manN. Engl. J. Med.19943311056106110.1056/NEJM1994102033116041:CAS:528:DyaK2MXitFWjt78%3D8090165 – reference: FerrariSLPolymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whitesAm. J. Hum. Genet.20047486687510.1086/4207711:CAS:528:DC%2BD2cXjvVeis7k%3D150772031181981 – reference: StephensMDonnellyPA comparison of Bayesian methods for haplotype reconstruction from population genotype dataAm. J. Hum. Genet.2003731162116910.1086/3793781:CAS:528:DC%2BD3sXptVGnsL4%3D145746451180495 – reference: CheungCL et al. Confirmation of linkage to chromosome 1q for spine bone mineral density in southern ChineseHum. Genet.200612035435910.1007/s00439-006-0220-31:CAS:528:DC%2BD28Xps1Ort7Y%3D16847694 – reference: LeeYHWooJHChoiSJJiJDSongGGAssociation between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density: a meta-analysisRheumatol. Int.20092953954410.1007/s00296-008-0745-y1:CAS:528:DC%2BD1MXitlSqsbw%3D18932002 – reference: FangYVitamin D binding protein genotype and osteoporosisCalcif. Tissue Int.200985859310.1007/s00223-009-9251-91:CAS:528:DC%2BD1MXhtVait7%2FN194886702729412 – reference: KorenRVitamin D receptor defects: the story of hereditary resistance to vitamin DPediatr. Endocrinol. Rev.20063Suppl. 347047517551468 – reference: LorentzonMErikssonALNilssonSMellstromDOhlssonCAssociation between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD studyJ. Bone Miner. Res.2007221165117210.1359/jbmr.0704161:CAS:528:DC%2BD2sXptlGmu7k%3D17451372 – reference: LittleRDA mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass traitAm. J. Hum. Genet.200270111910.1086/3384501:CAS:528:DC%2BD38XlvVKhtw%3D%3D11741193 – reference: MullinBHFurther genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosisBone20094538739110.1016/j.bone.2009.04.2541:CAS:528:DC%2BD1MXotFyltro%3D19427924 – volume: 25 start-page: 320 year: 2009 ident: BFnrrheum2010106_CR122 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.090726 – volume: 125 start-page: 509 year: 2006 ident: BFnrrheum2010106_CR59 publication-title: Cell doi: 10.1016/j.cell.2006.02.049 – volume: 8 start-page: 557 year: 1998 ident: BFnrrheum2010106_CR9 publication-title: Osteoporos. Int. doi: 10.1007/s001980050099 – volume: 34 start-page: 1129 year: 2005 ident: BFnrrheum2010106_CR68 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyi130 – volume: 21 start-page: 1009 year: 2010 ident: BFnrrheum2010106_CR112 publication-title: Osteoporos. Int. doi: 10.1007/s00198-009-1043-6 – volume: 85 start-page: 85 year: 2009 ident: BFnrrheum2010106_CR80 publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-009-9251-9 – volume: 3 start-page: e90 year: 2006 ident: BFnrrheum2010106_CR97 publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030090 – volume: 9 start-page: 356 year: 2008 ident: BFnrrheum2010106_CR24 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2344 – volume: 362 start-page: 686 year: 2010 ident: BFnrrheum2010106_CR37 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0808692 – volume: 93 start-page: 2149 year: 2008 ident: BFnrrheum2010106_CR84 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2007-2814 – volume: 54 start-page: 467 year: 2008 ident: BFnrrheum2010106_CR73 publication-title: Clin. Chem. doi: 10.1373/clinchem.2007.095489 – volume: 145 start-page: 527 year: 1999 ident: BFnrrheum2010106_CR30 publication-title: J. Cell Biol. doi: 10.1083/jcb.145.3.527 – volume: 93 start-page: 1789 year: 2008 ident: BFnrrheum2010106_CR94 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2007-2492 – volume: 45 start-page: 289 year: 2009 ident: BFnrrheum2010106_CR57 publication-title: Bone doi: 10.1016/j.bone.2009.03.676 – volume: 23 start-page: 499 year: 2008 ident: BFnrrheum2010106_CR58 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.071113 – volume: 358 start-page: 2355 year: 2008 ident: BFnrrheum2010106_CR11 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0801197 – volume: 151 start-page: 528 year: 2009 ident: BFnrrheum2010106_CR13 publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-151-8-200910200-00006 – volume: 21 start-page: 1443 year: 2006 ident: BFnrrheum2010106_CR42 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.060605 – volume: 92 start-page: 3206 year: 2007 ident: BFnrrheum2010106_CR104 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2006-2136 – volume: 72 start-page: 636 year: 2003 ident: BFnrrheum2010106_CR67 publication-title: Am. J. Hum. Genet. doi: 10.1086/367923 – volume: 37 start-page: 227 year: 2010 ident: BFnrrheum2010106_CR33 publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-009-9637-9 – volume: 67 start-page: 437 year: 2009 ident: BFnrrheum2010106_CR82 publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/j.1365-2125.2009.03363.x – volume: 299 start-page: 1277 year: 2008 ident: BFnrrheum2010106_CR47 publication-title: JAMA doi: 10.1001/jama.299.11.1277 – volume: 20 start-page: 341 year: 2009 ident: BFnrrheum2010106_CR26 publication-title: Osteoporos. Int. doi: 10.1007/s00198-008-0668-1 – volume: 25 start-page: 1564 year: 2010 ident: BFnrrheum2010106_CR110 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.091102 – volume: 10 start-page: 537 year: 2001 ident: BFnrrheum2010106_CR51 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/10.5.537 – volume: 24 start-page: 2039 year: 2009 ident: BFnrrheum2010106_CR101 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.090524 – volume: 40 start-page: 638 year: 2008 ident: BFnrrheum2010106_CR70 publication-title: Nat. Genet. doi: 10.1038/ng.120 – volume: 36 start-page: 948 year: 2005 ident: BFnrrheum2010106_CR4 publication-title: Bone doi: 10.1016/j.bone.2005.03.003 – volume: 8 start-page: S14 issue: Suppl. 1 year: 2007 ident: BFnrrheum2010106_CR96 publication-title: BMC Med. Genet. doi: 10.1186/1471-2350-8-S1-S14 – volume: 346 start-page: 1513 year: 2002 ident: BFnrrheum2010106_CR19 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa013444 – volume: 29 start-page: 539 year: 2009 ident: BFnrrheum2010106_CR99 publication-title: Rheumatol. Int. doi: 10.1007/s00296-008-0745-y – volume: 142 start-page: 4295 year: 2001 ident: BFnrrheum2010106_CR86 publication-title: Endocrinology doi: 10.1210/endo.142.10.8437 – volume: 320 start-page: 1085 year: 2008 ident: BFnrrheum2010106_CR66 publication-title: Science doi: 10.1126/science.1156849 – volume: 22 start-page: 6267 year: 2003 ident: BFnrrheum2010106_CR54 publication-title: EMBO J. doi: 10.1093/emboj/cdg599 – volume: 61 start-page: 157 year: 2006 ident: BFnrrheum2010106_CR74 publication-title: Hum. Hered. doi: 10.1159/000094141 – volume: 22 start-page: V105 issue: Suppl. 2 year: 2007 ident: BFnrrheum2010106_CR78 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.07s210 – volume: 45 start-page: 295 year: 2009 ident: BFnrrheum2010106_CR113 publication-title: Bone doi: 10.1016/j.bone.2009.04.197 – volume: 91 start-page: 3754 year: 2006 ident: BFnrrheum2010106_CR36 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2006-1729 – volume: 24 start-page: 1989 year: 2009 ident: BFnrrheum2010106_CR111 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.090530 – volume: 53 start-page: 8 year: 2007 ident: BFnrrheum2010106_CR72 publication-title: Clin. Chem. doi: 10.1373/clinchem.2006.074591 – volume: 20 start-page: 1525 year: 2005 ident: BFnrrheum2010106_CR3 publication-title: J. Bone Miner. Res. doi: 10.1359/JBMR.050508 – volume: 371 start-page: 1505 year: 2008 ident: BFnrrheum2010106_CR14 publication-title: Lancet doi: 10.1016/S0140-6736(08)60599-1 – volume: 40 start-page: 587 year: 2007 ident: BFnrrheum2010106_CR50 publication-title: Bone doi: 10.1016/j.bone.2006.09.029 – volume: 21 start-page: 1511 year: 2006 ident: BFnrrheum2010106_CR15 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.051002 – volume: 43 start-page: 910 year: 2008 ident: BFnrrheum2010106_CR45 publication-title: Bone doi: 10.1016/j.bone.2008.07.001 – volume: 22 start-page: 1165 year: 2007 ident: BFnrrheum2010106_CR105 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.070416 – volume: 37 start-page: 120 year: 2008 ident: BFnrrheum2010106_CR29 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dym159 – volume: 19 start-page: 571 year: 2008 ident: BFnrrheum2010106_CR46 publication-title: Osteoporos. Int. doi: 10.1007/s00198-007-0482-1 – volume: 65 start-page: 232 year: 2008 ident: BFnrrheum2010106_CR10 publication-title: Hum. Hered. doi: 10.1159/000112370 – volume: 145 start-page: 5106 year: 2004 ident: BFnrrheum2010106_CR77 publication-title: Endocrinology doi: 10.1210/en.2004-0080 – volume: 23 start-page: 1935 year: 2008 ident: BFnrrheum2010106_CR35 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.080707 – volume: 121 start-page: 491 year: 2007 ident: BFnrrheum2010106_CR106 publication-title: Hum. Genet. doi: 10.1007/s00439-006-0303-1 – volume: 292 start-page: 2105 year: 2004 ident: BFnrrheum2010106_CR12 publication-title: JAMA doi: 10.1001/jama.292.17.2105 – volume: 61 start-page: 237 year: 2006 ident: BFnrrheum2010106_CR21 publication-title: Hum. Hered. doi: 10.1159/000095216 – volume: 41 start-page: 15 year: 2009 ident: BFnrrheum2010106_CR118 publication-title: Nat. Genet. doi: 10.1038/ng.284 – ident: BFnrrheum2010106_CR124 – volume: 44 start-page: 984 year: 2009 ident: BFnrrheum2010106_CR25 publication-title: Bone doi: 10.1016/j.bone.2009.01.368 – volume: 153 start-page: 2001 year: 1999 ident: BFnrrheum2010106_CR60 publication-title: Genetics doi: 10.1093/genetics/153.4.2001 – volume: 164 start-page: 1108 year: 2004 ident: BFnrrheum2010106_CR64 publication-title: Arch. Intern. Med. doi: 10.1001/archinte.164.10.1108 – volume: 3 start-page: e2031 year: 2008 ident: BFnrrheum2010106_CR69 publication-title: PLoS ONE doi: 10.1371/journal.pone.0002031 – volume: 22 start-page: 1832 year: 2007 ident: BFnrrheum2010106_CR85 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.070809 – volume: 280 start-page: 19883 year: 2005 ident: BFnrrheum2010106_CR55 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M413274200 – volume: 14 start-page: 943 year: 2005 ident: BFnrrheum2010106_CR23 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddi088 – volume: 95 start-page: 3597 year: 1998 ident: BFnrrheum2010106_CR31 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.95.7.3597 – volume: 27 start-page: 155 year: 2005 ident: BFnrrheum2010106_CR81 publication-title: Ren. Fail. doi: 10.1081/JDI-48241 – volume: 93 start-page: 3088 year: 2008 ident: BFnrrheum2010106_CR39 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2007-2397 – volume: 22 start-page: 832 year: 2007 ident: BFnrrheum2010106_CR115 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.070317 – volume: 278 start-page: 24113 year: 2003 ident: BFnrrheum2010106_CR53 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M301716200 – volume: 45 start-page: 387 year: 2009 ident: BFnrrheum2010106_CR114 publication-title: Bone doi: 10.1016/j.bone.2009.04.254 – volume: 19 start-page: 914 year: 2004 ident: BFnrrheum2010106_CR62 publication-title: J. Bone Miner. Res. doi: 10.1359/JBMR.040132 – volume: 33 start-page: 177 year: 2003 ident: BFnrrheum2010106_CR63 publication-title: Nat. Genet. doi: 10.1038/ng1071 – volume: 9 start-page: 55 year: 2008 ident: BFnrrheum2010106_CR98 publication-title: BMC Med. Genet. doi: 10.1186/1471-2350-9-55 – volume: 358 start-page: 910 year: 2008 ident: BFnrrheum2010106_CR71 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa075819 – volume: 36 start-page: 700 year: 2005 ident: BFnrrheum2010106_CR40 publication-title: Bone doi: 10.1016/j.bone.2005.01.014 – volume: 24 start-page: 314 year: 2009 ident: BFnrrheum2010106_CR107 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.080912 – volume: 46 start-page: 1244 year: 2010 ident: BFnrrheum2010106_CR109 publication-title: Bone doi: 10.1016/j.bone.2009.11.018 – volume: 17 start-page: 693 year: 2006 ident: BFnrrheum2010106_CR95 publication-title: Osteoporos. Int. doi: 10.1007/s00198-005-0035-4 – volume: 73 start-page: 1162 year: 2003 ident: BFnrrheum2010106_CR125 publication-title: Am. J. Hum. Genet. doi: 10.1086/379378 – volume: 86 start-page: 3162 year: 2001 ident: BFnrrheum2010106_CR90 publication-title: J. Clin. Endocrinol. Metab. – volume: 35 start-page: 1029 year: 2004 ident: BFnrrheum2010106_CR8 publication-title: Bone doi: 10.1016/j.bone.2004.06.017 – volume: 39 start-page: 470 year: 2006 ident: BFnrrheum2010106_CR16 publication-title: Bone doi: 10.1016/j.bone.2006.02.069 – volume: 17 start-page: 2048 year: 2002 ident: BFnrrheum2010106_CR43 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.2002.17.11.2048 – volume: 22 start-page: 730 year: 2007 ident: BFnrrheum2010106_CR116 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.070201 – volume: 22 start-page: 173 year: 2007 ident: BFnrrheum2010106_CR20 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.060806 – ident: BFnrrheum2010106_CR28 – volume: 86 start-page: 631 year: 2001 ident: BFnrrheum2010106_CR88 publication-title: J. Clin. Endocrinol. Metab. – volume: 68 start-page: 577 year: 2001 ident: BFnrrheum2010106_CR52 publication-title: Am. J. Hum. Genet. doi: 10.1086/318811 – volume: 18 start-page: 1073 year: 2007 ident: BFnrrheum2010106_CR87 publication-title: Osteoporos. Int. doi: 10.1007/s00198-007-0363-7 – volume: 70 start-page: 428 year: 2006 ident: BFnrrheum2010106_CR5 publication-title: Ann. Hum. Genet. doi: 10.1111/j.1469-1809.2005.00242.x – volume: 21 start-page: 141 year: 2006 ident: BFnrrheum2010106_CR48 publication-title: J. Bone Miner. Res. doi: 10.1359/JBMR.050904 – volume: 13 start-page: R1 issue: Spec. No. 1 year: 2004 ident: BFnrrheum2010106_CR61 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddh084 – volume: 3 start-page: 470 issue: Suppl. 3 year: 2006 ident: BFnrrheum2010106_CR79 publication-title: Pediatr. Endocrinol. Rev. – volume: 331 start-page: 1056 year: 1994 ident: BFnrrheum2010106_CR38 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199410203311604 – volume: 79 start-page: 289 year: 2006 ident: BFnrrheum2010106_CR100 publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-006-0143-y – volume: 120 start-page: 354 year: 2006 ident: BFnrrheum2010106_CR27 publication-title: Hum. Genet. doi: 10.1007/s00439-006-0220-3 – volume: 24 start-page: 1709 year: 2009 ident: BFnrrheum2010106_CR108 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.090404 – volume: 32 start-page: 681 year: 2003 ident: BFnrrheum2010106_CR93 publication-title: Bone doi: 10.1016/S8756-3282(03)00090-5 – volume: 24 start-page: 437 year: 2009 ident: BFnrrheum2010106_CR127 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.081106 – volume: 22 start-page: 19 year: 2007 ident: BFnrrheum2010106_CR56 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.061002 – volume: 74 start-page: 866 year: 2004 ident: BFnrrheum2010106_CR49 publication-title: Am. J. Hum. Genet. doi: 10.1086/420771 – volume: 360 start-page: 753 year: 2009 ident: BFnrrheum2010106_CR76 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0809329 – volume: 18 start-page: 295 year: 2007 ident: BFnrrheum2010106_CR44 publication-title: Osteoporos. Int. doi: 10.1007/s00198-006-0239-2 – ident: BFnrrheum2010106_CR1 doi: 10.1016/0002-9343(93)90218-E – volume: 19 start-page: 791 year: 2007 ident: BFnrrheum2010106_CR103 publication-title: Int. J. Mol. Med. – volume: 107 start-page: 513 year: 2001 ident: BFnrrheum2010106_CR17 publication-title: Cell doi: 10.1016/S0092-8674(01)00571-2 – volume: 119 start-page: S79 year: 2006 ident: BFnrrheum2010106_CR41 publication-title: Am. J. Med. doi: 10.1016/j.amjmed.2006.07.011 – volume: 77 start-page: 152 year: 2005 ident: BFnrrheum2010106_CR126 publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-004-0264-0 – volume: 41 start-page: 527 year: 2009 ident: BFnrrheum2010106_CR119 publication-title: Nat. Genet. doi: 10.1038/ng.357 – volume: 83 start-page: 273 year: 2008 ident: BFnrrheum2010106_CR83 publication-title: Clin. Pharmacol. Ther. doi: 10.1038/sj.clpt.6100275 – volume: 84 start-page: 388 year: 2009 ident: BFnrrheum2010106_CR120 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.01.025 – volume: 25 start-page: 1042 year: 2010 ident: BFnrrheum2010106_CR121 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.091040 – volume: 156 start-page: 555 year: 2007 ident: BFnrrheum2010106_CR92 publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-06-0753 – volume: 41 start-page: 82 year: 2009 ident: BFnrrheum2010106_CR65 publication-title: Nat. Genet. doi: 10.1038/ng.288 – volume: 165 start-page: 1825 year: 2005 ident: BFnrrheum2010106_CR7 publication-title: Arch. Intern. Med. doi: 10.1001/archinte.165.16.1825 – volume: 22 start-page: 12 year: 2002 ident: BFnrrheum2010106_CR6 publication-title: Genet. Epidemiol. doi: 10.1002/gepi.1040 – volume: 83 start-page: 663 year: 2008 ident: BFnrrheum2010106_CR117 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.10.006 – volume: 85 start-page: 104 year: 2009 ident: BFnrrheum2010106_CR32 publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-009-9255-5 – volume: 70 start-page: 11 year: 2002 ident: BFnrrheum2010106_CR18 publication-title: Am. J. Hum. Genet. doi: 10.1086/338450 – volume: 90 start-page: 6323 year: 2005 ident: BFnrrheum2010106_CR89 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2005-0794 – volume: 16 start-page: 1368 year: 2005 ident: BFnrrheum2010106_CR91 publication-title: Osteoporos. Int. doi: 10.1007/s00198-005-1844-1 – volume: 41 start-page: 1199 year: 2009 ident: BFnrrheum2010106_CR34 publication-title: Nat. Genet. doi: 10.1038/ng.446 – volume: 19 start-page: 385 year: 2008 ident: BFnrrheum2010106_CR75 publication-title: Osteoporos. Int. doi: 10.1007/s00198-007-0543-5 – volume: 23 start-page: 1892 year: 2008 ident: BFnrrheum2010106_CR2 publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.080802 – volume: 82 start-page: 1262 year: 2008 ident: BFnrrheum2010106_CR102 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.04.016 – volume: 33 start-page: 308 year: 2003 ident: BFnrrheum2010106_CR22 publication-title: Bone doi: 10.1016/S8756-3282(03)00173-X – volume: 86 start-page: 229 year: 2010 ident: BFnrrheum2010106_CR123 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.12.014 – reference: 14633986 - EMBO J. 2003 Dec 1;22(23):6267-76 – reference: 18678289 - Bone. 2008 Nov;43(5):910-4 – reference: 16105967 - J Clin Endocrinol Metab. 2005 Nov;90(11):6323-31 – reference: 17137849 - Bone. 2007 Mar;40(3):587-96 – reference: 12702725 - J Biol Chem. 2003 Jun 27;278(26):24113-7 – reference: 19419293 - J Bone Miner Res. 2009 Oct;24(10):1709-18 – reference: 17554300 - Nature. 2007 Jun 7;447(7145):661-78 – reference: 16435076 - Osteoporos Int. 2006;17 (5):693-703 – reference: 17216495 - Hum Genet. 2007 May;121(3-4):491-500 – reference: 18505767 - J Clin Endocrinol Metab. 2008 Aug;93(8):3088-96 – reference: 18199855 - N Engl J Med. 2008 Feb 28;358(9):910-9 – reference: 19060908 - Nat Genet. 2009 Jan;41(1):82-8 – reference: 15523071 - JAMA. 2004 Nov 3;292(17):2105-14 – reference: 8090165 - N Engl J Med. 1994 Oct 20;331(16):1056-61 – reference: 17504906 - J Clin Endocrinol Metab. 2007 Aug;92(8):3206-12 – reference: 15159268 - Arch Intern Med. 2004 May 24;164(10):1108-12 – reference: 16847694 - Hum Genet. 2006 Oct;120(3):354-9 – reference: 18461161 - PLoS One. 2008 May 07;3(5):e2031 – reference: 19376282 - Bone. 2009 Aug;45(2):295-300 – reference: 11741193 - Am J Hum Genet. 2002 Jan;70(1):11-9 – reference: 12810175 - Bone. 2003 Jun;32(6):681-6 – reference: 17371163 - J Bone Miner Res. 2007 Jun;22(6):832-40 – reference: 19427924 - Bone. 2009 Aug;45(2):387-91 – reference: 17609683 - Clin Pharmacol Ther. 2008 Feb;83(2):273-80 – reference: 18665788 - J Bone Miner Res. 2008 Dec;23(12):1935-45 – reference: 17451372 - J Bone Miner Res. 2007 Aug;22(8):1165-72 – reference: 17130180 - Clin Chem. 2007 Jan;53(1):8-16 – reference: 9520411 - Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602 – reference: 18451265 - Science. 2008 May 23;320(5879):1085-8 – reference: 20175129 - J Bone Miner Res. 2010 Feb;25(2):320-9 – reference: 15542027 - Bone. 2004 Nov;35(5):1029-37 – reference: 18597038 - Osteoporos Int. 2009 Feb;20(2):341-6 – reference: 17468191 - Eur J Endocrinol. 2007 May;156(5):555-62 – reference: 16059624 - J Bone Miner Res. 2005 Sep;20(9):1525-32 – reference: 19228618 - N Engl J Med. 2009 Feb 19;360(8):753-64 – reference: 17280526 - J Bone Miner Res. 2007 May;22(5):730-6 – reference: 15308610 - Endocrinology. 2004 Nov;145(11):5106-14 – reference: 12015390 - N Engl J Med. 2002 May 16;346(20):1513-21 – reference: 15711777 - Osteoporos Int. 2005 Nov;16(11):1368-74 – reference: 17708711 - J Bone Miner Res. 2007 Dec;22(12):1832-41 – reference: 19442614 - Bone. 2009 May;44(5):984-8 – reference: 18932002 - Rheumatol Int. 2009 Mar;29(5):539-44 – reference: 16151677 - Calcif Tissue Int. 2005 Sep;77(3):152-9 – reference: 11181578 - Hum Mol Genet. 2001 Mar 1;10(5):537-43 – reference: 15781005 - Bone. 2005 Apr;36(4):700-9 – reference: 18372903 - Nat Genet. 2008 May;40(5):638-45 – reference: 19453261 - J Bone Miner Res. 2009 Dec;24(12):2039-49 – reference: 16679074 - Bone. 2006 Sep;39(3):470-6 – reference: 15878318 - Bone. 2005 Jun;36(6):948-58 – reference: 18349089 - JAMA. 2008 Mar 19;299(11):1277-90 – reference: 16995806 - J Bone Miner Res. 2006 Oct;21(10):1511-35 – reference: 18445777 - N Engl J Med. 2008 May 29;358(22):2355-65 – reference: 12592605 - Am J Hum Genet. 2003 Mar;72(3):636-49 – reference: 15807179 - Ren Fail. 2005;27(2):155-61 – reference: 19727905 - Osteoporos Int. 2010 Jun;21(6):1009-20 – reference: 16475872 - PLoS Med. 2006 Apr;3(4):e90 – reference: 17384898 - Osteoporos Int. 2007 Aug;18(8):1073-82 – reference: 18292978 - Osteoporos Int. 2008 Apr;19(4):385-97 – reference: 11158021 - J Clin Endocrinol Metab. 2001 Feb;86(2):631-7 – reference: 16678095 - Cell. 2006 May 5;125(3):509-22 – reference: 11443182 - J Clin Endocrinol Metab. 2001 Jul;86(7):3162-5 – reference: 12524541 - Nat Genet. 2003 Feb;33(2):177-82 – reference: 19801982 - Nat Genet. 2009 Nov;41(11):1199-206 – reference: 10326061 - Osteoporos Int. 1998;8(6):557-62 – reference: 10225954 - J Cell Biol. 1999 May 3;145(3):527-38 – reference: 19488670 - Calcif Tissue Int. 2009 Aug;85(2):85-93 – reference: 17028288 - J Clin Endocrinol Metab. 2006 Oct;91(10):3754-6 – reference: 18381571 - J Clin Endocrinol Metab. 2008 Jun;93(6):2149-57 – reference: 18290711 - J Bone Miner Res. 2007 Dec;22 Suppl 2:V105-7 – reference: 19642016 - Mol Biol Rep. 2010 Jan;37(1):227-34 – reference: 16816528 - Hum Hered. 2006;61(3):157-65 – reference: 11564687 - Endocrinology. 2001 Oct;142(10):4295-304 – reference: 19458885 - Calcif Tissue Int. 2009 Aug;85(2):104-12 – reference: 18767927 - J Bone Miner Res. 2009 Feb;24(2):314-23 – reference: 14574645 - Am J Hum Genet. 2003 Nov;73(5):1162-9 – reference: 19453265 - J Bone Miner Res. 2009 Dec;24(12):1989-97 – reference: 16949392 - Am J Med. 2006 Sep;119(9 Suppl 1):S79-86 – reference: 16926538 - Hum Hered. 2006;61(4):237-43 – reference: 18455228 - Lancet. 2008 May 3;371(9623):1505-12 – reference: 11179006 - Am J Hum Genet. 2001 Mar;68(3):577-89 – reference: 19874204 - J Bone Miner Res. 2010 May;25(5):1042-8 – reference: 17032150 - J Bone Miner Res. 2007 Jan;22(1):19-28 – reference: 17903296 - BMC Med Genet. 2007 Sep 19;8 Suppl 1:S14 – reference: 19841454 - Ann Intern Med. 2009 Oct 20;151(8):528-37 – reference: 18398418 - Nat Rev Genet. 2008 May;9(5):356-69 – reference: 17551468 - Pediatr Endocrinol Rev. 2006 Aug;3 Suppl 3:470-5 – reference: 19931660 - Bone. 2010 May;46(5):1244-50 – reference: 16157825 - Arch Intern Med. 2005 Sep 12;165(16):1825-30 – reference: 16043441 - Int J Epidemiol. 2005 Oct;34(5):1129-37 – reference: 15746152 - Hum Mol Genet. 2005 Apr 1;14(7):943-51 – reference: 16355283 - J Bone Miner Res. 2006 Jan;21(1):141-50 – reference: 11719191 - Cell. 2001 Nov 16;107(4):513-23 – reference: 18021006 - J Bone Miner Res. 2008 Apr;23(4):499-506 – reference: 16939403 - J Bone Miner Res. 2006 Sep;21(9):1443-56 – reference: 19064610 - Hum Mol Genet. 2009 Feb 15;18(4):679-87 – reference: 14962979 - Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R1-7 – reference: 8506892 - Am J Med. 1993 Jun;94(6):646-50 – reference: 13678771 - Bone. 2003 Sep;33(3):308-16 – reference: 19888898 - J Bone Miner Res. 2010 Jul;25(7):1564-71 – reference: 19396169 - Nat Genet. 2009 May;41(5):527-34 – reference: 18684092 - J Bone Miner Res. 2008 Dec;23 (12 ):1892-904 – reference: 18250146 - Clin Chem. 2008 Mar;54(3):467-74 – reference: 18588671 - BMC Med Genet. 2008 Jun 27;9:55 – reference: 16759177 - Ann Hum Genet. 2006 Jul;70(Pt 4):428-38 – reference: 15125790 - J Bone Miner Res. 2004 Jun;19(6):914-23 – reference: 10581302 - Genetics. 1999 Dec;153(4):2001-12 – reference: 11754470 - Genet Epidemiol. 2002 Jan;22(1):12-25 – reference: 20181970 - N Engl J Med. 2010 Feb 25;362(8):686-96 – reference: 17089081 - Osteoporos Int. 2007 Mar;18(3):295-305 – reference: 17896124 - Osteoporos Int. 2008 Apr;19(4):571-9 – reference: 15778503 - J Biol Chem. 2005 May 20;280(20):19883-7 – reference: 17228994 - J Bone Miner Res. 2007 Feb;22(2):173-83 – reference: 18499081 - Am J Hum Genet. 2008 Jun;82(6):1262-9 – reference: 18073493 - Hum Hered. 2008;65(4):232-9 – reference: 18303076 - J Clin Endocrinol Metab. 2008 May;93(5):1789-95 – reference: 15077203 - Am J Hum Genet. 2004 May;74(5):866-75 – reference: 18992858 - Am J Hum Genet. 2008 Dec;83(6):663-74 – reference: 19249006 - Am J Hum Genet. 2009 Mar;84(3):388-98 – reference: 17898028 - Int J Epidemiol. 2008 Feb;37(1):120-32 – reference: 19371317 - Br J Clin Pharmacol. 2009 Apr;67(4):437-44 – reference: 12412813 - J Bone Miner Res. 2002 Nov;17(11):2048-60 – reference: 19016593 - J Bone Miner Res. 2009 Mar;24(3):437-47 – reference: 19079262 - Nat Genet. 2009 Jan;41(1):15-7 – reference: 20096396 - Am J Hum Genet. 2010 Feb 12;86(2):229-39 – reference: 17390085 - Int J Mol Med. 2007 May;19(5):791-801 – reference: 19371798 - Bone. 2009 Aug;45(2):289-94 – reference: 17115239 - Calcif Tissue Int. 2006 Nov;79(5):289-93 |
| SSID | ssj0064689 |
| Score | 2.19773 |
| SecondaryResourceType | review_article |
| Snippet | Technological innovations have contributed greatly to advancing our knowledge of the genetic basis of osteoporosis. This article reviews the current... Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment... |
| SourceID | proquest gale pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 507 |
| SubjectTerms | 631/208/205/2138 692/699/1670/316/801 692/700/478/174 Bone density Collaboration Complications and side effects Development and progression Disease Epidemiology Fractures Gene loci Genetic aspects Genetic Linkage Genetic markers Genetic Predisposition to Disease Genomes Genomics Geometry High-Throughput Nucleotide Sequencing Hip joint Humans Medicine Medicine & Public Health Meta-Analysis as Topic Molecular Epidemiology Osteoporosis Osteoporosis - epidemiology Osteoporosis - genetics Osteoporosis - therapy Physiological aspects Polymorphism, Single Nucleotide review-article Rheumatology Risk factors Ultrasonic imaging |
| Title | Genetic epidemiology of age-related osteoporosis and its clinical applications |
| URI | https://link.springer.com/article/10.1038/nrrheum.2010.106 https://www.ncbi.nlm.nih.gov/pubmed/20683440 https://www.proquest.com/docview/1790189757 https://www.proquest.com/docview/754001180 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1759-4804 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0064689 issn: 1759-4790 databaseCode: 7X7 dateStart: 20090401 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1759-4804 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0064689 issn: 1759-4790 databaseCode: BENPR dateStart: 20090401 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Ra9swED7aFMZeytaum7eu1cOgrGCiWLYlP4zRjZYyaChlhbwJSZZZYbPbOHnYv9-dLadJYX21JNuSTneS7u77AD5lUlZZZguib0_wgKJcXDjhYxRo57xw3OeUKHw1zS9v0x-zbLYF0yEXhsIqB53YKeqycXRHPiYkqYkqZCa_3j_ExBpF3tWBQsMEaoXySwcxtg07CSFjjWDn2_n0-mbQzXmad6R4aDMLulPiwXHJhRrX8_kvv_zTR3tNiAFpzVA9Vddr9uqJA7WzSxevYDdsKNlZLwGvYcvXe_DiKrjM92FKwNJYxvwjF-xf1lQMFUncZbL4klGmR4M78aa9a5mpS3a3aNmQNMnWndxv4Pbi_Of3yziQKMQuE8kiTpNSTQS5w8hhyA0eEIRThHsnLLdSSMsrJV3icSvQsSNkheFCSiWM86YQ4gBGdVP7d8Cs8zatCmtSU6YTVVlnM-5MVXKLdlCmEYyHEdMuIIwT0cVv3Xm6hdJhjDWNMT7JI_i8anHfo2s8U_eYJkH3-aGrhanPEpEricciHsFJV4OWJn7XmZBhgH9PIFcbNQ83auKScpvFw0TrsKRb_SiAEbBVMbWkMLXaN8tW46j2oHoRvO3lY9WthOdEaYIlp4PArL37P31-__yPfICXfTADhbwdwmgxX_qPuEda2CPYljN5FMT_H1xXD7A |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqVgIuiPJqoKU-gBBI0XpjJ3YOFSrQaku7K4RaqTdjO46oBEnZ7Ar1z_HbmEmc7W4leus1dl7j8Xy25_ER8jqVskxTmyN9ewIbFOXi3HEfg0I757ljPsNE4fEkG52JL-fp-Rr52-fCYFhlbxNbQ13UDs_IB1hJaqhymcoPl79jZI1C72pPoWECtUKx15YYC4kdx_7qD2zhmr2jzzDeb5Lk8OD00ygOLAOxS3kyi0VSqCFHfxF61JiBFTR3CgvDccus5NKyUkmXeMDKlj4gzQ3jUipunDc5HogCBGwILnLY_G18PJh8_dZjQSayloQPMDrHMywWHKWMq0E1nf7w819ddNkQGZeWgPEmPCzh4w2HbYuDh4_Iw7CApfudxm2SNV89JvfGwUX_hEywkDW0UX_NPXtF65KC4YrbzBlfUMwsqWHlXzcXDTVVQS9mDe2TNOmyU_0pObsTcT4j61Vd-S1CrfNWlLk1whRiqErrbMqcKQtmAXeliMigl5h2oaI5Emv81K1nnSsdZKxRxnAli8i7xR2XXTWPW_ru4iDoLh91YQj0fsIzJWEbxiLytu2BpgDe60zIaICvx6JaKz23V3rCFHarzf1A62BCGn2t8BGhi2a8E8PiKl_PGw1S7Yr4ReR5px-L30pYhhQq0PK-V5ilZ__nn1_c_iG75P7odHyiT44mxy_Jgy6QAsPttsn6bDr3O7A-m9lXYRJQ8v2u590_NopIDw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB5VRaq4ICivQGl9ACGQovXGSewcKlRRVi2lKw5U2puxHUetBEnZ7Ar1r_HrOpNXdyvRW6-xncTj8YzH8_gA3iZSFkliM4Jvj9BAUS7MnPAhMrRzXjjuU0oUPp2mR2fx11ky24B_fS4MhVX2MrER1Hnl6I58RJWkxiqTaMAXXVjE98PJp8s_ISFIkae1h9NoWeTEX_1F863ePz7EtX4XRZMvPz4fhR3CQOgSES3COMrVWJCviLxp3ODpWThFReGE5VYKaXmhpIs86skGOiDJDBdSKmGcNxldhqL4fyCFyCicUM4GYy-N0wZ-D7VzRrdXvHORcqFG5Xx-7pe_27iyMWEtrajE24phRTPectU2GnDyGB51R1d20PLaE9jw5TZsnXbO-acwpRLW2Mb8DersFasKhiIrbHJmfM4op6TCM39VX9TMlDm7WNSsT89kq-70Z3B2L8R8DptlVfqXwKzzNi4ya2KTx2NVWGcT7kyRc4saV8YBjHqKadfVMidIjV-68akLpTsaa6IxPkkD-DCMuGzreNzRd48WQbeZqIMI0AeRSJVEA4wH8L7pQUIAv-tMl8uAf0_ltNZ67qz1xM3r1pv7hdad8Kj1DasHwIZmGkkBcaWvlrVGqrbl-wJ40fLHMK2IpwSegi0fe4ZZefd_5vzq7h_Zgy3cbfrb8fTkNTxsIygozm4HNhfzpX-DB7OF3W12AIOf973lrgEkskWp |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+epidemiology+of+age-related+osteoporosis+and+its+clinical+applications&rft.jtitle=Nature+reviews.+Rheumatology&rft.au=Cheung%2C+Ching-Lung&rft.au=Xiao%2C+Su-Mei&rft.au=Kung%2C+Annie+W.+C.&rft.date=2010-09-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=1759-4790&rft.eissn=1759-4804&rft.volume=6&rft.issue=9&rft.spage=507&rft.epage=517&rft_id=info:doi/10.1038%2Fnrrheum.2010.106&rft.externalDocID=10_1038_nrrheum_2010_106 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-4790&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-4790&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-4790&client=summon |