Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery

Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of p...

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Published in	Journal of international medical research Vol. 49; no. 5; p. 3000605211012569
Main Authors	Melchor-López, Alberto, Suárez-Cuenca, Juan Antonio, Banderas-Lares, Diana Zaineff, Peña-Sosa, Gustavo De la, Salamanca-García, Moisés, Vera-Gómez, Eduardo, Hernández-Patricio, Alejandro, Gutiérrez-Buendía, Juan Ariel, Zamora-Alemán, Carlos Ramiro, Alcaráz-Estrada, Sofía Lizeth, Ortiz-Fernández, Moisés, Montoya-Ramírez, Jesús, Gaytán-Fuentes, Omar Felipe, Pérez-Cabeza de Vaca, Rebeca, Escamilla-Tilch, Mónica, Pineda-Juárez, Juan Antonio, Téllez-González, Mario Antonio, Mondragón-Terán, Paul, Rodríguez-Arellano, Martha Eunice, Contreras-Ramos, Alejandra, García, Silvia, Hernández-Muñoz, Rolando Efraín
Format	Journal Article
Language	English
Published	London, England SAGE Publications 01.05.2021 Sage Publications Ltd SAGE Publishing
Subjects	Adipocytes Adipose Tissue - diagnostic imaging Adult Bariatric Surgery Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Case-Control Studies Female Gastrointestinal surgery Heart Disease Risk Factors Humans Male Metabolism Obesity Retrospective Clinical Research Report Risk Factors Vascular Endothelial Growth Factor A morbid obesity Metabolic surgery adipocyte density adipose tissue cardiovascular risk malondialdehyde vascular endothelial growth factor A
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ISSN	0300-0605 1473-2300 1473-2300
DOI	10.1177/03000605211012569

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Abstract	Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m2) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number: NCT0356198 (https://clinicaltrials.gov)
AbstractList	Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m2) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number: NCT0356198 (https://clinicaltrials.gov) Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m2) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number: NCT0356198 (https://clinicaltrials.gov) Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). Methods We performed a case–control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. Results We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m 2 ) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL). Conclusion The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. Clinical trial registration number : NCT0356198 ( https://clinicaltrials.gov ) We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS).OBJECTIVESWe aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS).We performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD.METHODSWe performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD.We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m2) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL).RESULTSWe studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m2) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 vs. 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 vs. 80 cells/field), low infiltration with CD68+ cells (18 vs. 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 vs. 405.7 ng/mL).The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS.Clinical trial registration number: NCT0356198 (https://clinicaltrials.gov).CONCLUSIONThe characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS.Clinical trial registration number: NCT0356198 (https://clinicaltrials.gov). We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS). We performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD. We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m ) and high prevalences of the metabolically unhealthy obesity phenotype, hypertension, and diabetes mellitus. A significant reduction in CVR was associated with lower vascular endothelial growth factor-A concentration (6.20 1.59 pg/mL, respectively), low adipocyte density in visceral adipose tissue (100 80 cells/field), low infiltration with CD68+ cells (18 8 cells/field) and higher concentrations of lipid peroxidation markers and malondialdehyde (313.7 405.7 ng/mL). The characteristics of adipose tissue and the circulating concentrations of markers of adipose pathology might represent useful predictors of the reduction in CVR following MS. : NCT0356198 (https://clinicaltrials.gov).
Author	Peña-Sosa, Gustavo De la Téllez-González, Mario Antonio Rodríguez-Arellano, Martha Eunice Zamora-Alemán, Carlos Ramiro Escamilla-Tilch, Mónica Salamanca-García, Moisés Montoya-Ramírez, Jesús Gaytán-Fuentes, Omar Felipe Mondragón-Terán, Paul Contreras-Ramos, Alejandra Melchor-López, Alberto Ortiz-Fernández, Moisés Pineda-Juárez, Juan Antonio Gutiérrez-Buendía, Juan Ariel Hernández-Muñoz, Rolando Efraín García, Silvia Suárez-Cuenca, Juan Antonio Alcaráz-Estrada, Sofía Lizeth Vera-Gómez, Eduardo Banderas-Lares, Diana Zaineff Hernández-Patricio, Alejandro Pérez-Cabeza de Vaca, Rebeca
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Zamora-Alemán fullname: Zamora-Alemán, Carlos Ramiro organization: Laboratory of Experimental Metabolism and Clinical Research, Division of Research, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 10 givenname: Sofía Lizeth surname: Alcaráz-Estrada fullname: Alcaráz-Estrada, Sofía Lizeth organization: División de Medicina Genómica, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 11 givenname: Moisés surname: Ortiz-Fernández fullname: Ortiz-Fernández, Moisés organization: Bariatric Surgery Department, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 12 givenname: Jesús surname: Montoya-Ramírez fullname: Montoya-Ramírez, Jesús organization: Bariatric Surgery Department, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 13 givenname: Omar Felipe surname: Gaytán-Fuentes fullname: Gaytán-Fuentes, Omar Felipe organization: Bariatric Surgery Department, Centro 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Tissue Engineering & Regenerative Medicine Research Group, Coordinación de Investigación, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 18 givenname: Paul surname: Mondragón-Terán fullname: Mondragón-Terán, Paul organization: Tissue Engineering & Regenerative Medicine Research Group, Coordinación de Investigación, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 19 givenname: Martha Eunice surname: Rodríguez-Arellano fullname: Rodríguez-Arellano, Martha Eunice organization: Laboratorio de Medicina Genómica, Hospital Regional “Lic, Adolfo López Mateos”, ISSSTE, Mexico City, Mexico – sequence: 20 givenname: Alejandra surname: Contreras-Ramos fullname: Contreras-Ramos, Alejandra organization: Laboratorio de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez, Mexico City, Mexico – sequence: 21 givenname: Silvia surname: García fullname: García, Silvia organization: Department of Clinical Research, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City, Mexico – sequence: 22 givenname: Rolando Efraín surname: Hernández-Muñoz fullname: Hernández-Muñoz, Rolando Efraín organization: Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular; Universidad Nacional Autónoma de México (UNAM), Coyoacán, Mexico City, Mexico
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Keywords	morbid obesity Metabolic surgery adipocyte density adipose tissue cardiovascular risk malondialdehyde vascular endothelial growth factor A
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Snippet	Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose... We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue... Objectives We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose...
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SubjectTerms	Adipocytes Adipose Tissue - diagnostic imaging Adult Bariatric Surgery Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Case-Control Studies Female Gastrointestinal surgery Heart Disease Risk Factors Humans Male Metabolism Obesity Retrospective Clinical Research Report Risk Factors Vascular Endothelial Growth Factor A
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Title	Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery
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