IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma
Summary Background We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle‐aged adults and in young subjects with asthma. Objective To in...
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| Published in | Clinical and experimental allergy Vol. 48; no. 9; pp. 1147 - 1154 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.09.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0954-7894 1365-2222 1365-2222 |
| DOI | 10.1111/cea.13165 |
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| Abstract | Summary
Background
We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle‐aged adults and in young subjects with asthma.
Objective
To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.
Methods
FeNO, urinary eosinophil‐derived neurotoxin (U‐EDN), serum eosinophil cationic protein (S‐ECP) and periostin were measured in 396 asthmatics, aged 17‐76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L).
Results
Asthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S‐ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non‐sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S‐ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S‐ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U‐EDN (0.16, P < .001). S‐ECP also correlated weakly with U‐EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.
Conclusions & Clinical Relevance
Sensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S‐ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. |
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| AbstractList | Summary
Background
We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle‐aged adults and in young subjects with asthma.
Objective
To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.
Methods
FeNO, urinary eosinophil‐derived neurotoxin (U‐EDN), serum eosinophil cationic protein (S‐ECP) and periostin were measured in 396 asthmatics, aged 17‐76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L).
Results
Asthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S‐ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non‐sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S‐ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S‐ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U‐EDN (0.16, P < .001). S‐ECP also correlated weakly with U‐EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.
Conclusions & Clinical Relevance
Sensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S‐ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma.BACKGROUNDWe have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma.To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.OBJECTIVETo investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L).METHODSFeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L).Asthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S-ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non-sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S-ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U-EDN (0.16, P < .001). S-ECP also correlated weakly with U-EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.RESULTSAsthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S-ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non-sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S-ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U-EDN (0.16, P < .001). S-ECP also correlated weakly with U-EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.Sensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management.CONCLUSIONS & CLINICAL RELEVANCESensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. BackgroundWe have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle‐aged adults and in young subjects with asthma.ObjectiveTo investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.MethodsFeNO, urinary eosinophil‐derived neurotoxin (U‐EDN), serum eosinophil cationic protein (S‐ECP) and periostin were measured in 396 asthmatics, aged 17‐76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L).ResultsAsthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S‐ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non‐sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S‐ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S‐ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U‐EDN (0.16, P < .001). S‐ECP also correlated weakly with U‐EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant.Conclusions & Clinical RelevanceSensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S‐ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. OBJECTIVE: To investigate the relation between IgE sensitisation and several type 2 inflammation biomarkers in adult asthmatics. METHODS: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Sensitisation to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitisation to food allergens with measurement of specific IgE (≥0.35kU/L). RESULTS: Asthmatics sensitised to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs. 16.1 ppb (14.2, 18.2) (p=0.005), S-ECP, 17.7 mg/L (14.8, 21.1) vs. 12.8 mg/L (10.9, 14.9) (p=0.01), and periostin, 73.7 (67.5, 80.3) ng/mL vs. 59.9 (55.8, 64.2) ng/mL (p=0.003), than non-sensitised subjects. Periostin levels in this group were also significantly higher than in the group sensitised only to airborne allergens (p=0.01). Sensitisation to food allergens related independently to FeNO (p=0.02), S-ECP (p=0.006) and periostin (p=0.004), whereas sensitisation only to airborne allergens related only to FeNO (p=0.02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r=0.17, p<0.001), periostin (r=0.19, p<0.001) and U-EDN (0.16, p<0.001). S-ECP also correlated weakly with U-EDN (r=0.12, p=0.02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant. CONCLUSIONS & CLINICAL RELEVANCE: Sensitisation to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitisation, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. Background: We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. Objective: To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics. Methods: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (3mm wheal) and sensitization to food allergens with measurement of specific IgE (0.35kU/L). Results: Asthmatics sensitized to food allergens had higher FeNO, 22.3ppb (18.6, 26.7) vs 16.1ppb (14.2, 18.2) (P=.005), S-ECP, 17.7mg/L (14.8, 21.1) vs 12.8mg/L (10.9, 14.9) (P=.01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P=.003), than non-sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P=.01). Sensitization to food allergens related independently to FeNO (P=.02), S-ECP (P=.006) and periostin (P=.004), whereas sensitization only to airborne allergens related only to FeNO (P=.02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r=.17, P<.001), periostin (r=.19, P<.001) and U-EDN (0.16, P<.001). S-ECP also correlated weakly with U-EDN (r=.12, P=.02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant. Conclusions & Clinical Relevance: Sensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics. FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Sensitization to airborne allergens was examined with skin prick tests (≥3 mm wheal) and sensitization to food allergens with measurement of specific IgE (≥0.35 kU/L). Asthmatics sensitized to food allergens had higher FeNO, 22.3 ppb (18.6, 26.7) vs 16.1 ppb (14.2, 18.2) (P = .005), S-ECP, 17.7 mg/L (14.8, 21.1) vs 12.8 mg/L (10.9, 14.9) (P = .01), and periostin, 73.7 (67.5, 80.3) ng/mL vs 59.9 (55.8, 64.2) ng/mL (P = .003), than non-sensitized subjects. Periostin levels in this group were also significantly higher than in the group sensitized only to airborne allergens (P = .01). Sensitization to food allergens related independently to FeNO (P = .02), S-ECP (P = .006) and periostin (P = .004), whereas sensitization only to airborne allergens related only to FeNO (P = .02) after adjustments for age, sex, height, weight and smoking history. FeNO correlated weakly with S-ECP (r = .17, P < .001), periostin (r = .19, P < .001) and U-EDN (0.16, P < .001). S-ECP also correlated weakly with U-EDN (r = .12, P = .02). None of the correlations between the remaining pairs of markers of type 2 inflammation were significant. Sensitization to food allergens related to several local and systemic type 2 inflammation markers, such as FeNO, S-ECP and periostin. Assessing the profile of allergic sensitization, including to food allergens, might improve the understanding and interpretation of inflammatory markers and potentially improve asthma management. |
| Author | James, A. Ohta, S. Janson, C. Ono, J. Izuhara, K. Alving, K. Middelveld, R. Forsberg, B. Patelis, A. Malinovschi, A. Borres, M. P. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29746003$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147692$$DView record from Swedish Publication Index https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364202$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:139005450$$DView record from Swedish Publication Index |
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| Copyright | 2018 John Wiley & Sons Ltd 2018 John Wiley & Sons Ltd. Copyright © 2018 John Wiley & Sons Ltd |
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| Issue | 9 |
| Keywords | food allergens asthma type 2 inflammation airborne allergens IgE sensitization |
| Language | English |
| License | 2018 John Wiley & Sons Ltd. |
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| Notes | Funding information The study was funded by Västerbotten County Council (ALF), Uppsala University Hospital, Hesselman's Research Foundation, the EU FP6 project GA2LEN (EU contract number FOOD‐CT‐2004‐506378), The Centre for Allergy Research at the Karolinska Institute, The Swedish Heart‐Lung Foundation, The Swedish Heart and Lung Association, The Swedish Asthma and Allergy Association, The Centre for Allergy Research at Karolinska Institutet, the Medical Research Council, the Vårdal Foundation, Stockholm County Council (ALF), the Swedish Foundation for Strategic Research, Konsul Th C Berghs Foundation, the Karolinska Institutet SciLifeLab Collaborations on Translational Medicine (ChAMP) project and Karolinska Institutet. Thermo Fischer Scientific has kindly provided reagents for serum eosinophil cationic protein and IgE measurements in this study. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| PublicationDate | September 2018 |
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We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with... We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of... BackgroundWe have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased... BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased... Background: We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased... |
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| SubjectTerms | airborne allergens Allergens Asthma Biomarkers Eosinophil cationic protein Food food allergens Food allergies IgE sensitisation IgE sensitization Immunoglobulin E Inflammation Leukocytes (eosinophilic) Nitric oxide Skin tests Smoking type 2 inflammation |
| Title | IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma |
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