microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer. We hypothesized that s...
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| Published in | Genome biology Vol. 8; no. 2; pp. R27 - 1509 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central
27.02.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1474-760X 1465-6906 1474-760X 1465-6914 |
| DOI | 10.1186/gb-2007-8-2-r27 |
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| Abstract | microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer.
We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR.
This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients. |
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| AbstractList | microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer.
We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR.
This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients. Transcriptional profiling reveals a possible association between schizophrenia and altered miRNA expression BACKGROUND: microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile × syndrome, and several types of cancer. RESULTS: We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR. CONCLUSION: This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients. microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer.BACKGROUNDmicroRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer.We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR.RESULTSWe hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR.This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients.CONCLUSIONThis study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients. |
| ArticleNumber | R27 |
| Author | Jeffries, Clark D Thomson, J Michael Newman, Martin A Hammond, Scott M Woods, Keith Parker, Joel S Jin, Jianping Perkins, Diana O Jarskog, L Fredrik |
| AuthorAffiliation | 4 Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, CB 7090, Chapel Hill, NC 27599, USA 2 School of Pharmacy, University of North Carolina at Chapel Hill, CB 7360, Chapel Hill, NC 27599, USA 6 Department of Molecular Biology, University of North Carolina at Chapel Hill, CB 7104, Chapel Hill, NC 27599, USA 1 Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA 3 Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 5 Constella Group, LLC, Meridian Parkway, Durham, NC 27713, USA |
| AuthorAffiliation_xml | – name: 4 Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, CB 7090, Chapel Hill, NC 27599, USA – name: 5 Constella Group, LLC, Meridian Parkway, Durham, NC 27713, USA – name: 3 Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA – name: 2 School of Pharmacy, University of North Carolina at Chapel Hill, CB 7360, Chapel Hill, NC 27599, USA – name: 1 Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA – name: 6 Department of Molecular Biology, University of North Carolina at Chapel Hill, CB 7104, Chapel Hill, NC 27599, USA |
| Author_xml | – sequence: 1 givenname: Diana O surname: Perkins fullname: Perkins, Diana O – sequence: 2 givenname: Clark D surname: Jeffries fullname: Jeffries, Clark D – sequence: 3 givenname: L Fredrik surname: Jarskog fullname: Jarskog, L Fredrik – sequence: 4 givenname: J Michael surname: Thomson fullname: Thomson, J Michael – sequence: 5 givenname: Keith surname: Woods fullname: Woods, Keith – sequence: 6 givenname: Martin A surname: Newman fullname: Newman, Martin A – sequence: 7 givenname: Joel S surname: Parker fullname: Parker, Joel S – sequence: 8 givenname: Jianping surname: Jin fullname: Jin, Jianping – sequence: 9 givenname: Scott M surname: Hammond fullname: Hammond, Scott M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17326821$$D View this record in MEDLINE/PubMed |
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| Snippet | microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology... BACKGROUND: microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in... Transcriptional profiling reveals a possible association between schizophrenia and altered miRNA expression |
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| SubjectTerms | Amino Acid Motifs - genetics DNA Primers etiology Female gene expression regulation Humans Male messenger RNA Microarray Analysis microarray technology microRNA MicroRNAs - genetics MicroRNAs - metabolism neoplasms non-coding RNA patients prefrontal cortex Prefrontal Cortex - metabolism Psychotic Disorders - genetics Psychotic Disorders - metabolism Reverse Transcriptase Polymerase Chain Reaction schizophrenia Schizophrenia - genetics Schizophrenia - metabolism |
| Title | microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder |
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