The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitu...
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| Published in | Current research in food science Vol. 5; pp. 1140 - 1147 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.01.2022
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2665-9271 2665-9271 |
| DOI | 10.1016/j.crfs.2022.06.010 |
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| Abstract | In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.
[Display omitted]
•Optimization of optimal extraction conditions by response surface methodology.•Total flavonoids of Sedum aizoon L. have good antioxidant activity in vitro.•Total flavonoids of Sedum aizoon L. have hypoglycemic effect.•Total flavonoids of Sedum aizoon L. can improve the oxidative stress in T1DM mice. |
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| AbstractList | In this study, the optimal extraction conditions for the total flavonoids of
Sedum aizoon
L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of
Sedum aizoon
L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.
Image 1
•
Optimization of optimal extraction conditions by response surface methodology.
•
Total flavonoids of
Sedum aizoon
L. have good antioxidant activity in vitro.
•
Total flavonoids of
Sedum aizoon
L. have hypoglycemic effect.
•
Total flavonoids of
Sedum aizoon
L. can improve the oxidative stress in T1DM mice. In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. [Display omitted] •Optimization of optimal extraction conditions by response surface methodology.•Total flavonoids of Sedum aizoon L. have good antioxidant activity in vitro.•Total flavonoids of Sedum aizoon L. have hypoglycemic effect.•Total flavonoids of Sedum aizoon L. can improve the oxidative stress in T1DM mice. |
| Author | Qi, Xin Lin, Chang-qing Sun, Xi-han Lu, Xin-tong Cui, Cheng-bi |
| Author_xml | – sequence: 1 givenname: Xin orcidid: 0000-0002-2974-0374 surname: Qi fullname: Qi, Xin organization: Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China – sequence: 2 givenname: Xin-tong surname: Lu fullname: Lu, Xin-tong organization: Department of Food Processing and Safety, College of Agricultural, Yanbian University, Yanji, 133002, China – sequence: 3 givenname: Xi-han surname: Sun fullname: Sun, Xi-han organization: Food Science and Engineering, Convergence College, Yanbian University, Yanji, 133002, China – sequence: 4 givenname: Chang-qing surname: Lin fullname: Lin, Chang-qing email: cqlin@ybu.edu.cn organization: Medical College, Yanbian University, Yanji, 133002, China – sequence: 5 givenname: Cheng-bi orcidid: 0000-0002-5207-3506 surname: Cui fullname: Cui, Cheng-bi email: cuichengbi@ybu.edu.cn organization: Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China |
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| Keywords | Sedum aizoon L Hypoglycemic Total flavonoids Mechanism |
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| Snippet | In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation... In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation... |
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| SubjectTerms | antioxidant activity antioxidants flavonoids food science from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu Hypoglycemic insulin-dependent diabetes mellitus liver Mechanism metabolism oxidative stress response surface methodology Sedum Sedum aizoon L Total flavonoids |
| Title | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
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