Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls
To explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs). We presented findings from...
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| Published in | Frontiers in psychiatry Vol. 12; p. 747386 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
25.01.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-0640 1664-0640 |
| DOI | 10.3389/fpsyt.2021.747386 |
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| Abstract | To explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).
We presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).
Larger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.
The different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders. |
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| AbstractList | To explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).
We presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).
Larger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.
The different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders. To explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).OBJECTIVETo explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).We presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).METHODSWe presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).Larger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.RESULTSLarger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.The different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders.CONCLUSIONThe different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders. ObjectiveTo explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).MethodsWe presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).ResultsLarger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.ConclusionThe different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders. |
| Author | An, Huimei Tan, Yunlong Shi, Jing Tan, Shuping Yang, Fude Liu, Sijia Li, Hui Fan, Hongzhen Xue, Wei Fan, Fengmei Guo, Hua Wang, Zhiren |
| AuthorAffiliation | 3 Department of Clinical Pharmacology, Beijing Hospital of the Ministry of Health , Beijing , China 2 The Psychiatric Hospital of Zhumadian , Zhumadian , China 1 Beijing Huilongguan Hospital, Peking University HuiLongGuan Clinical Medical School , Beijing , China |
| AuthorAffiliation_xml | – name: 1 Beijing Huilongguan Hospital, Peking University HuiLongGuan Clinical Medical School , Beijing , China – name: 2 The Psychiatric Hospital of Zhumadian , Zhumadian , China – name: 3 Department of Clinical Pharmacology, Beijing Hospital of the Ministry of Health , Beijing , China |
| Author_xml | – sequence: 1 givenname: Jing surname: Shi fullname: Shi, Jing – sequence: 2 givenname: Hua surname: Guo fullname: Guo, Hua – sequence: 3 givenname: Sijia surname: Liu fullname: Liu, Sijia – sequence: 4 givenname: Wei surname: Xue fullname: Xue, Wei – sequence: 5 givenname: Fengmei surname: Fan fullname: Fan, Fengmei – sequence: 6 givenname: Hui surname: Li fullname: Li, Hui – sequence: 7 givenname: Hongzhen surname: Fan fullname: Fan, Hongzhen – sequence: 8 givenname: Huimei surname: An fullname: An, Huimei – sequence: 9 givenname: Zhiren surname: Wang fullname: Wang, Zhiren – sequence: 10 givenname: Shuping surname: Tan fullname: Tan, Shuping – sequence: 11 givenname: Fude surname: Yang fullname: Yang, Fude – sequence: 12 givenname: Yunlong surname: Tan fullname: Tan, Yunlong |
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| Copyright | Copyright © 2022 Shi, Guo, Liu, Xue, Fan, Li, Fan, An, Wang, Tan, Yang and Tan. Copyright © 2022 Shi, Guo, Liu, Xue, Fan, Li, Fan, An, Wang, Tan, Yang and Tan. 2022 Shi, Guo, Liu, Xue, Fan, Li, Fan, An, Wang, Tan, Yang and Tan |
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| Keywords | subcortical major depression disorder bipolar disorder first episode cognitive MRI |
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| Title | Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls |
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