Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentia...

Full description

Saved in:
Bibliographic Details
Published inCell reports (Cambridge) Vol. 42; no. 9; p. 113038
Main Authors Zhao, Mengya, Toma, Kenichi, Kinde, Benyam, Li, Liang, Patel, Amit K., Wu, Kong-Yan, Lum, Matthew R., Tan, Chengxi, Hooper, Jody E., Kriegstein, Arnold R., La Torre, Anna, Liao, Yaping Joyce, Welsbie, Derek S., Hu, Yang, Han, Ying, Duan, Xin
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 26.09.2023
Elsevier
Subjects
CP: Neuroscience
Glaucoma
human retina
Humans
neuronal types
neuroprotection
Optic Nerve - metabolism
optic nerve crush
Optic Nerve Diseases - metabolism
Osteopontin
retinal ganglion cell
Retinal Ganglion Cells - metabolism
human retina
CP: Neuroscience
neuroprotection
glaucoma
neuronal types
Osteopontin
optic nerve crush
retinal ganglion cell
Online AccessGet full text
ISSN2211-1247
2211-1247
DOI10.1016/j.celrep.2023.113038

Cover

Abstract Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGC intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1’s role in mediating neuronal resiliency in glaucoma. [Display omitted] •αRGCs and ipRGCs are resilient retinal neuron types in glaucomatous and axotomy conditions•Elevated and ectopic Spp1 expression among RGCs occurs in the glaucoma model, not axotomy•Neuronal Spp1 drives RGC neuroprotection in glaucomatous conditions but not in axotomy•SPP1 protein levels in aqueous humor correlate with glaucoma progression in patients Zhao et al. reported that retinal neuron subpopulations are resilient with ectopic Spp1 expression, subject to an experimental glaucomatous model with ocular hypertension. Spp1 overexpression renders other susceptible retinal neurons with neuroprotection subject to glaucomatous conditions. Elevated SPP1 levels in aqueous humor may be biomarkers for human glaucoma progression.
AbstractList Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGC intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1's role in mediating neuronal resiliency in glaucoma.
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGC intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1’s role in mediating neuronal resiliency in glaucoma. [Display omitted] •αRGCs and ipRGCs are resilient retinal neuron types in glaucomatous and axotomy conditions•Elevated and ectopic Spp1 expression among RGCs occurs in the glaucoma model, not axotomy•Neuronal Spp1 drives RGC neuroprotection in glaucomatous conditions but not in axotomy•SPP1 protein levels in aqueous humor correlate with glaucoma progression in patients Zhao et al. reported that retinal neuron subpopulations are resilient with ectopic Spp1 expression, subject to an experimental glaucomatous model with ocular hypertension. Spp1 overexpression renders other susceptible retinal neurons with neuroprotection subject to glaucomatous conditions. Elevated SPP1 levels in aqueous humor may be biomarkers for human glaucoma progression.
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGCs intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1’s role in mediating neuronal resiliency in glaucoma. Zhao et al. reported that retinal neuron subpopulations are resilient with ectopic Spp1 expression, subject to an experimental glaucomatous model with ocular hypertension. Spp1 overexpression renders other susceptible retinal neurons with neuroprotection subject to glaucomatous conditions. Elevated SPP1 levels in aqueous humor may be biomarkers for human glaucoma progression.
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGC intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1's role in mediating neuronal resiliency in glaucoma.Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. Focusing on an αRGC intrinsic factor, Osteopontin (secreted phosphoprotein 1 [Spp1]), we found an ectopic neuronal expression of Osteopontin (Spp1) in other RGCs subject to glaucomatous conditions. This contrasted with the Spp1 downregulation subject to axotomy. αRGC-specific Spp1 elimination led to significant αRGC loss, diminishing their resiliency. Spp1 overexpression led to robust neuroprotection of susceptible RGC subclasses under glaucomatous conditions. In contrast, Spp1 overexpression did not significantly protect RGCs subject to axotomy. Additionally, SPP1 marked adult human RGC subsets with large somata and SPP1 expression in the aqueous humor correlated with glaucoma severity. Our study reveals Spp1's role in mediating neuronal resiliency in glaucoma.
ArticleNumber 113038
Author Toma, Kenichi
Lum, Matthew R.
Hooper, Jody E.
Patel, Amit K.
Liao, Yaping Joyce
Kinde, Benyam
Hu, Yang
Duan, Xin
Tan, Chengxi
Han, Ying
Kriegstein, Arnold R.
La Torre, Anna
Li, Liang
Welsbie, Derek S.
Zhao, Mengya
Wu, Kong-Yan
AuthorAffiliation 5 Department of Neurology and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
7 These authors contributed equally
2 Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
1 Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
4 Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
8 Lead contact
6 Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA 95616, USA
3 Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA 92037, USA
AuthorAffiliation_xml – name: 5 Department of Neurology and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
– name: 2 Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– name: 6 Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA 95616, USA
– name: 3 Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA 92037, USA
– name: 7 These authors contributed equally
– name: 4 Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– name: 8 Lead contact
– name: 1 Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
Author_xml – sequence: 1
  givenname: Mengya
  surname: Zhao
  fullname: Zhao, Mengya
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 2
  givenname: Kenichi
  surname: Toma
  fullname: Toma, Kenichi
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 3
  givenname: Benyam
  surname: Kinde
  fullname: Kinde, Benyam
  email: bkinde@gmail.com
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 4
  givenname: Liang
  surname: Li
  fullname: Li, Liang
  organization: Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– sequence: 5
  givenname: Amit K.
  surname: Patel
  fullname: Patel, Amit K.
  organization: Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA 92037, USA
– sequence: 6
  givenname: Kong-Yan
  surname: Wu
  fullname: Wu, Kong-Yan
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 7
  givenname: Matthew R.
  surname: Lum
  fullname: Lum, Matthew R.
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 8
  givenname: Chengxi
  surname: Tan
  fullname: Tan, Chengxi
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 9
  givenname: Jody E.
  surname: Hooper
  fullname: Hooper, Jody E.
  organization: Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– sequence: 10
  givenname: Arnold R.
  surname: Kriegstein
  fullname: Kriegstein, Arnold R.
  organization: Department of Neurology and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
– sequence: 11
  givenname: Anna
  surname: La Torre
  fullname: La Torre, Anna
  organization: Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA 95616, USA
– sequence: 12
  givenname: Yaping Joyce
  surname: Liao
  fullname: Liao, Yaping Joyce
  organization: Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– sequence: 13
  givenname: Derek S.
  surname: Welsbie
  fullname: Welsbie, Derek S.
  organization: Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA 92037, USA
– sequence: 14
  givenname: Yang
  surname: Hu
  fullname: Hu, Yang
  email: huyang@stanford.edu
  organization: Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
– sequence: 15
  givenname: Ying
  surname: Han
  fullname: Han, Ying
  email: ying.han@ucsf.edu
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
– sequence: 16
  givenname: Xin
  surname: Duan
  fullname: Duan, Xin
  email: xin.duan@ucsf.edu
  organization: Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37624696$$D View this record in MEDLINE/PubMed
BookMark eNqFUsFu3CAURFWqJtnmD6rKx152CwYD7qFVFLVppEi5pGeE4dlh5QUX8Er792XrpEp6aLkAjzcz6M2coxMfPCD0juANwYR_3G4MjBGmTY1ruiGEYipfobO6JmRNaiZOnp1P0UVKW1wWx4S07A06pYLXjLf8DN3fpQxhCj47X9no9pCqCOWix2rQfhhd8FXRGks1udGBN4eqtA6jnk3Y6RzmVIUpO1N5mGOYdH44vEWvez0muHjcV-jHt6_3V9_Xt3fXN1eXt2vTUJzXXc9ID5y2rZEAVLStpdCJjrO215xyDbKpBTUNWAAhoJEdIQwY73pte97RFbpZeG3QWzVFt9PxoIJ26nchxEHpWL42giKtFFRg08tGMi1sW1vQWDDorTU9lYXry8I1zd0OrAGfox5fkL588e5BDWGvCG5aIosFK_ThkSGGnzOkrHYuHUenPZQpqVo2QjaYM15a3z8X-6Py5Etp-LQ0mBhSitAr47LOxYyi7cYiqo45UFu15EAdc6CWHBQw-wv8xP8f2OcFBsWyvYOokjn6DdZFMLnM1P2b4Bep-dEW
CitedBy_id crossref_primary_10_1016_j_visres_2024_108533
crossref_primary_10_3389_fnana_2024_1335176
crossref_primary_10_1523_JNEUROSCI_0938_24_2024
crossref_primary_10_1002_cne_25663
crossref_primary_10_1523_JNEUROSCI_1310_23_2023
crossref_primary_10_3390_children11050586
crossref_primary_10_3390_ijms25136995
crossref_primary_10_1113_JP286414
crossref_primary_10_1038_s41467_024_46428_z
crossref_primary_10_1167_iovs_66_2_14
crossref_primary_10_1016_j_biopha_2025_117944
crossref_primary_10_1016_j_cell_2024_04_010
Cites_doi 10.1530/REP-17-0043
10.1016/j.neuron.2010.05.023
10.1359/jbmr.061103
10.1016/j.cell.2014.06.047
10.1016/j.cell.2013.06.044
10.1038/s41598-020-66092-9
10.1523/JNEUROSCI.0102-20.2020
10.1016/j.neuron.2016.04.022
10.1523/JNEUROSCI.0940-16.2016
10.1016/j.celrep.2022.111880
10.1080/02713683.2019.1608261
10.1038/nbt.3806
10.1016/j.neuron.2022.06.003
10.1016/j.neuron.2011.06.031
10.1016/j.neuron.2008.07.018
10.1186/1476-4598-9-101
10.1007/978-1-4939-7407-8_3
10.1038/s41593-020-00764-7
10.7554/eLife.45881
10.1016/j.devcel.2020.04.009
10.1073/pnas.2200914119
10.1146/annurev-vision-022720-094953
10.1523/JNEUROSCI.4779-09.2010
10.1016/j.celrep.2017.01.075
10.1098/rspb.1981.0032
10.1111/j.1749-6632.1995.tb44626.x
10.1016/j.neuron.2015.02.017
10.1016/0006-8993(92)90325-4
10.1146/annurev.pharmtox.41.1.723
10.1146/annurev-vision-111815-114417
10.1038/nrn.2017.85
10.1038/nature01844
10.1016/j.cell.2015.11.036
10.1038/s41598-020-71460-6
10.1167/iovs.09-3947
10.1126/science.1161566
10.1016/j.celrep.2016.04.069
10.1007/s12026-010-8179-5
10.1038/s41593-022-01068-8
10.1080/02713683.2018.1449222
10.1523/JNEUROSCI.1419-14.2015
10.3389/fncel.2020.00109
10.1016/S0945-053X(00)00108-6
10.1097/CRD.0b013e3181cfb646
10.1055/s-0030-1251504
10.1172/JCI2131
10.1016/S0896-6273(00)00084-2
10.1016/j.neuron.2018.08.019
10.1016/j.neuron.2017.07.037
10.1073/pnas.2206829119
10.1016/j.neuron.2019.11.006
10.1113/jphysiol.1966.sp008107
10.1016/j.neuron.2019.05.044
ContentType Journal Article
Copyright 2023 The Author(s)
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2023 The Author(s)
– notice: Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
DBID 6I.
AAFTH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOA
DOI 10.1016/j.celrep.2023.113038
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE



MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2211-1247
EndPage 113038
ExternalDocumentID oai_doaj_org_article_1987370cf8584a7d92dea074efddcf38
PMC10591811
37624696
10_1016_j_celrep_2023_113038
S2211124723010495
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NEI NIH HHS
  grantid: P30 EY026877
– fundername: NEI NIH HHS
  grantid: R01 EY030138
– fundername: NEI NIH HHS
  grantid: R01 EY029342
– fundername: NEI NIH HHS
  grantid: R01 EY024932
– fundername: NEI NIH HHS
  grantid: P30 EY002162
– fundername: NEI NIH HHS
  grantid: R01 EY034353
– fundername: NINDS NIH HHS
  grantid: R35 NS097305
– fundername: NEI NIH HHS
  grantid: R01 EY032518
– fundername: NEI NIH HHS
  grantid: R01 EY026942
– fundername: NEI NIH HHS
  grantid: R01 EY023295
GroupedDBID 0R~
0SF
4.4
457
53G
5VS
6I.
AACTN
AAEDT
AAEDW
AAFTH
AAIKJ
AAKRW
AALRI
AAXUO
ABMAC
ACGFO
ACGFS
ADBBV
ADEZE
ADVLN
AENEX
AEXQZ
AFTJW
AGHFR
AITUG
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
BAWUL
BCNDV
DIK
EBS
EJD
FCP
FDB
FRP
GROUPED_DOAJ
GX1
IXB
KQ8
M41
M48
NCXOZ
O-L
O9-
OK1
RCE
ROL
SSZ
AAMRU
AAYWO
AAYXX
ACVFH
ADCNI
AEUPX
AFPUW
AIGII
AKBMS
AKYEP
APXCP
CITATION
HZ~
IPNFZ
RIG
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c530t-bf41fe6399c8ee3799d3eb7b649fa636ae85273c5edee77e58b114e46bfadf6b3
IEDL.DBID M48
ISSN 2211-1247
IngestDate Wed Aug 27 01:24:59 EDT 2025
Thu Aug 21 18:35:58 EDT 2025
Fri Jul 11 15:12:01 EDT 2025
Mon Jul 21 05:53:48 EDT 2025
Thu Apr 24 23:07:44 EDT 2025
Tue Jul 01 02:59:37 EDT 2025
Sat Jul 13 15:32:40 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Keywords human retina
CP: Neuroscience
neuroprotection
glaucoma
neuronal types
Osteopontin
optic nerve crush
retinal ganglion cell
Language English
License This is an open access article under the CC BY license.
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c530t-bf41fe6399c8ee3799d3eb7b649fa636ae85273c5edee77e58b114e46bfadf6b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
AUTHOR CONTRIBUTIONS
Conceptualization, M.Z. and X.D.; methodology, M.Z., K.T., Y. Hu, and X.D.; investigation, M.Z., K.T., B.K., K.-Y.W, A.K.P., M.R.L., and C.T.; writing – original draft, M.Z., B.K., and X.D.; writing – review & editing, M.Z., X.D., K.T., B.K., Y. Hu, D.S.W., Y. Han, and A.L.T.; resources, Y. Han., J.E.H., Y.J.L., A.R.K.,L.L., and Y. Hu; funding acquisition, X.D., Y. Hu, Y. Han., B.K., A.R.K., Y.J.L., D.S.W., and A.L.T.; supervision, X.D., Y. Hu, and Y. Han.
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.celrep.2023.113038
PMID 37624696
PQID 2857850646
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_1987370cf8584a7d92dea074efddcf38
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10591811
proquest_miscellaneous_2857850646
pubmed_primary_37624696
crossref_citationtrail_10_1016_j_celrep_2023_113038
crossref_primary_10_1016_j_celrep_2023_113038
elsevier_sciencedirect_doi_10_1016_j_celrep_2023_113038
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-09-26
PublicationDateYYYYMMDD 2023-09-26
PublicationDate_xml – month: 09
  year: 2023
  text: 2023-09-26
  day: 26
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Cell reports (Cambridge)
PublicationTitleAlternate Cell Rep
PublicationYear 2023
Publisher Elsevier Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier
References Nikhalashree, George, Shantha, Lingam, Vidya, Panday, Sulochana, Coral (bib43) 2019; 44
Tian, Cheng, Zhou, Wang, Monavarfeshani, Gao, Jiang, Kawaguchi, Wang, Tang (bib41) 2022; 110
Straznicky, Vickers, Gábriel, Costa (bib30) 1992; 582
Zhang, Li, Huang, Fang, Webber, Zhuang, Liu, Dalal, Tang, Mahajan (bib18) 2019; 8
Park, Liu, Hu, Smith, Wang, Cai, Xu, Connolly, Kramvis, Sahin, He (bib26) 2008; 322
Tsai, Wang, Toma, Yin, Takatoh, Pai, Wu, Matcham, Yin, Dang (bib22) 2022; 25
Rousso, Qiao, Kagan, Yamagata, Palmiter, Sanes (bib21) 2016; 15
Klingel, Kandolf (bib33) 2010; 36
Giachelli, Steitz (bib32) 2000; 19
Williams, Benowitz, Goldberg, He (bib8) 2020; 6
Huberman, Manu, Koch, Susman, Lutz, Ullian, Baccus, Barres (bib17) 2008; 59
Ou, Jo, Ullian, Wong, Della Santina (bib14) 2016; 36
Enroth-Cugell, Robson (bib39) 1966; 187
Tran, Shekhar, Whitney, Jacobi, Benhar, Hong, Yan, Adiconis, Arnold, Lee (bib6) 2019; 104
Li, Jakobs (bib27) 2022; 41
van Zyl, Yan, McAdams, Monavarfeshani, Hageman, Sanes (bib45) 2022; 119
Denhardt, Giachelli, Rittling (bib35) 2001; 41
Yan, Peng, van Zyl, Regev, Shekhar, Juric, Sanes (bib28) 2020; 10
Duan, Qiao, Bei, Kim, He, Sanes (bib7) 2015; 85
Liu, Wang, Li, Zhang, Li, Zhang, Zhu, Chen, Williams, Zhang (bib12) 2017; 95
Liaw, Birk, Ballas, Whitsitt, Davidson, Hogan (bib50) 1998; 101
Li, Huang, Fang, Liu, Sun, Hu (bib24) 2020; 14
Ahmed, Kundu (bib37) 2010; 9
Zeng, Sanes (bib3) 2017; 18
Martersteck, Hirokawa, Evarts, Bernard, Duan, Li, Ng, Oh, Ouellette, Royall (bib19) 2017; 18
Kim, Zhang, Meister, Sanes (bib16) 2010; 30
Waller, Sanchez-Ross, Kaluski, Klapholz (bib34) 2010; 18
Bei, Lee, Liu, Gunner, Jin, Ma, Wang, Hou, Hensch, Frank (bib11) 2016; 164
Duvall, Taylor, Weiss, Wojtowicz, Guldberg (bib31) 2007; 22
Hartsock, Cho, Wu, Chen, Gong, Duh (bib51) 2016
Duan, Krishnaswamy, De la Huerta, Sanes (bib46) 2014; 158
Wässle, Peichl, Boycott (bib40) 1981; 212
Cantor (bib36) 1995; 760
Calkins, Lambert, Formichella, McLaughlin, Sappington (bib13) 2018; 1695
Wang, Zhuang, Huang, Li, Liu, Webber, Dalal, Siew, Fligor, Chang (bib54) 2020; 40
Wang, Fu, Liu, Wang, Zhang, Zhou, Xu (bib42) 2018; 43
Ecker, Dumitrescu, Wong, Alam, Chen, LeGates, Renna, Prusky, Berson, Hattar (bib47) 2010; 67
VanderWall, Lu, Alfaro, Allsop, Carr, Wang, Meyer (bib9) 2020; 10
Leng, Li, Eser, Piergies, Sit, Tan, Neff, Li, Rodriguez, Suemoto (bib1) 2021; 24
Lu, Shiau, Yi, Lu, Wu, Pearson, Kallman, Zhong, Hoang, Zuo (bib29) 2020; 53
Gilbert, Larson, Morsut, Liu, Brar, Torres, Stern-Ginossar, Brandman, Whitehead, Doudna (bib53) 2013; 154
El-Danaf, Huberman (bib15) 2015; 35
He, Jin (bib4) 2016; 90
Feng, Mellor, Bernstein, Keller-Peck, Nguyen, Wallace, Nerbonne, Lichtman, Sanes (bib49) 2000; 28
Duan, Krishnaswamy, Laboulaye, Liu, Peng, Yamagata, Toma, Sanes (bib20) 2018; 99
Staahl, Benekareddy, Coulon-Bainier, Banfal, Floor, Sabo, Urnes, Munares, Ghosh, Doudna (bib52) 2017; 35
Frank, Seo, Burghardt, Bayless, Johnson (bib38) 2017; 153
Saxena, Caroni (bib2) 2011; 71
Sappington, Carlson, Crish, Calkins (bib23) 2010; 51
Buffelli, Burgess, Feng, Lobe, Lichtman, Sanes (bib48) 2003; 424
Quigley (bib5) 2016; 2
Bray, Yungher, Levay, Ribeiro, Dvoryanchikov, Ayupe, Thakor, Marks, Randolph, Danzi (bib10) 2019; 103
Li, Feng, Fang, Miller, Zhang, Zhuang, Huang, Liu, Liu, Sredar (bib25) 2022; 119
Inoue, Shinohara (bib44) 2011; 49
Wässle (10.1016/j.celrep.2023.113038_bib40) 1981; 212
Enroth-Cugell (10.1016/j.celrep.2023.113038_bib39) 1966; 187
Staahl (10.1016/j.celrep.2023.113038_bib52) 2017; 35
Cantor (10.1016/j.celrep.2023.113038_bib36) 1995; 760
Martersteck (10.1016/j.celrep.2023.113038_bib19) 2017; 18
Ahmed (10.1016/j.celrep.2023.113038_bib37) 2010; 9
Li (10.1016/j.celrep.2023.113038_bib24) 2020; 14
Hartsock (10.1016/j.celrep.2023.113038_bib51) 2016
Duan (10.1016/j.celrep.2023.113038_bib20) 2018; 99
Inoue (10.1016/j.celrep.2023.113038_bib44) 2011; 49
Zhang (10.1016/j.celrep.2023.113038_bib18) 2019; 8
Giachelli (10.1016/j.celrep.2023.113038_bib32) 2000; 19
Tsai (10.1016/j.celrep.2023.113038_bib22) 2022; 25
Frank (10.1016/j.celrep.2023.113038_bib38) 2017; 153
Duvall (10.1016/j.celrep.2023.113038_bib31) 2007; 22
Huberman (10.1016/j.celrep.2023.113038_bib17) 2008; 59
Rousso (10.1016/j.celrep.2023.113038_bib21) 2016; 15
Ou (10.1016/j.celrep.2023.113038_bib14) 2016; 36
El-Danaf (10.1016/j.celrep.2023.113038_bib15) 2015; 35
Park (10.1016/j.celrep.2023.113038_bib26) 2008; 322
Tian (10.1016/j.celrep.2023.113038_bib41) 2022; 110
Lu (10.1016/j.celrep.2023.113038_bib29) 2020; 53
Leng (10.1016/j.celrep.2023.113038_bib1) 2021; 24
Duan (10.1016/j.celrep.2023.113038_bib46) 2014; 158
Wang (10.1016/j.celrep.2023.113038_bib42) 2018; 43
Bray (10.1016/j.celrep.2023.113038_bib10) 2019; 103
Sappington (10.1016/j.celrep.2023.113038_bib23) 2010; 51
Ecker (10.1016/j.celrep.2023.113038_bib47) 2010; 67
Liaw (10.1016/j.celrep.2023.113038_bib50) 1998; 101
Denhardt (10.1016/j.celrep.2023.113038_bib35) 2001; 41
He (10.1016/j.celrep.2023.113038_bib4) 2016; 90
Quigley (10.1016/j.celrep.2023.113038_bib5) 2016; 2
Zeng (10.1016/j.celrep.2023.113038_bib3) 2017; 18
Kim (10.1016/j.celrep.2023.113038_bib16) 2010; 30
Waller (10.1016/j.celrep.2023.113038_bib34) 2010; 18
Klingel (10.1016/j.celrep.2023.113038_bib33) 2010; 36
Li (10.1016/j.celrep.2023.113038_bib27) 2022; 41
Straznicky (10.1016/j.celrep.2023.113038_bib30) 1992; 582
Nikhalashree (10.1016/j.celrep.2023.113038_bib43) 2019; 44
Feng (10.1016/j.celrep.2023.113038_bib49) 2000; 28
Bei (10.1016/j.celrep.2023.113038_bib11) 2016; 164
Tran (10.1016/j.celrep.2023.113038_bib6) 2019; 104
Li (10.1016/j.celrep.2023.113038_bib25) 2022; 119
van Zyl (10.1016/j.celrep.2023.113038_bib45) 2022; 119
Buffelli (10.1016/j.celrep.2023.113038_bib48) 2003; 424
Calkins (10.1016/j.celrep.2023.113038_bib13) 2018; 1695
Saxena (10.1016/j.celrep.2023.113038_bib2) 2011; 71
Duan (10.1016/j.celrep.2023.113038_bib7) 2015; 85
Williams (10.1016/j.celrep.2023.113038_bib8) 2020; 6
VanderWall (10.1016/j.celrep.2023.113038_bib9) 2020; 10
Yan (10.1016/j.celrep.2023.113038_bib28) 2020; 10
Gilbert (10.1016/j.celrep.2023.113038_bib53) 2013; 154
Liu (10.1016/j.celrep.2023.113038_bib12) 2017; 95
Wang (10.1016/j.celrep.2023.113038_bib54) 2020; 40
References_xml – volume: 103
  start-page: 642
  year: 2019
  end-page: 657.e7
  ident: bib10
  article-title: Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
  publication-title: Neuron
– volume: 322
  start-page: 963
  year: 2008
  end-page: 966
  ident: bib26
  article-title: Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
  publication-title: Science
– volume: 59
  start-page: 425
  year: 2008
  end-page: 438
  ident: bib17
  article-title: Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells
  publication-title: Neuron
– volume: 18
  start-page: 2058
  year: 2017
  end-page: 2072
  ident: bib19
  article-title: Diverse Central Projection Patterns of Retinal Ganglion Cells
  publication-title: Cell Rep.
– volume: 104
  start-page: 1039
  year: 2019
  end-page: 1055.e12
  ident: bib6
  article-title: Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes
  publication-title: Neuron
– volume: 36
  start-page: 195
  year: 2010
  end-page: 202
  ident: bib33
  article-title: Osteopontin: a biomarker to predict the outcome of inflammatory heart disease
  publication-title: Semin. Thromb. Hemost.
– volume: 1695
  start-page: 23
  year: 2018
  end-page: 39
  ident: bib13
  article-title: The Microbead Occlusion Model of Ocular Hypertension in Mice
  publication-title: Methods Mol. Biol.
– volume: 18
  start-page: 530
  year: 2017
  end-page: 546
  ident: bib3
  article-title: Neuronal cell-type classification: challenges, opportunities and the path forward
  publication-title: Nat. Rev. Neurosci.
– volume: 35
  start-page: 431
  year: 2017
  end-page: 434
  ident: bib52
  article-title: Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
  publication-title: Nat. Biotechnol.
– volume: 36
  start-page: 9240
  year: 2016
  end-page: 9252
  ident: bib14
  article-title: Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension
  publication-title: J. Neurosci.
– volume: 15
  start-page: 1930
  year: 2016
  end-page: 1944
  ident: bib21
  article-title: Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression
  publication-title: Cell Rep.
– volume: 187
  start-page: 517
  year: 1966
  end-page: 552
  ident: bib39
  article-title: The contrast sensitivity of retinal ganglion cells of the cat
  publication-title: J. Physiol.
– volume: 582
  start-page: 123
  year: 1992
  end-page: 128
  ident: bib30
  article-title: A neurofilament protein antibody selectively labels a large ganglion cell type in the human retina
  publication-title: Brain Res.
– volume: 154
  start-page: 442
  year: 2013
  end-page: 451
  ident: bib53
  article-title: CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
  publication-title: Cell
– start-page: 54065
  year: 2016
  ident: bib51
  article-title: A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure
  publication-title: J. Vis. Exp.
– volume: 51
  start-page: 207
  year: 2010
  end-page: 216
  ident: bib23
  article-title: The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 53
  start-page: 473
  year: 2020
  end-page: 491.e9
  ident: bib29
  article-title: Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development
  publication-title: Dev. Cell
– volume: 10
  start-page: 17359
  year: 2020
  ident: bib9
  article-title: Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease
  publication-title: Sci. Rep.
– volume: 43
  start-page: 771
  year: 2018
  end-page: 777
  ident: bib42
  article-title: Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure
  publication-title: Curr. Eye Res.
– volume: 35
  start-page: 2329
  year: 2015
  end-page: 2343
  ident: bib15
  article-title: Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
  publication-title: J. Neurosci.
– volume: 44
  start-page: 1018
  year: 2019
  end-page: 1025
  ident: bib43
  article-title: Detection of Proteins Associated with Extracellular Matrix Regulation in the Aqueous Humour of Patients with Primary Glaucoma
  publication-title: Curr. Eye Res.
– volume: 8
  year: 2019
  ident: bib18
  article-title: Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse
  publication-title: Elife
– volume: 158
  start-page: 793
  year: 2014
  end-page: 807
  ident: bib46
  article-title: Type II cadherins guide assembly of a direction-selective retinal circuit
  publication-title: Cell
– volume: 164
  start-page: 219
  year: 2016
  end-page: 232
  ident: bib11
  article-title: Restoration of Visual Function by Enhancing Conduction in Regenerated Axons
  publication-title: Cell
– volume: 40
  start-page: 3896
  year: 2020
  end-page: 3914
  ident: bib54
  article-title: Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells
  publication-title: J. Neurosci.
– volume: 101
  start-page: 1468
  year: 1998
  end-page: 1478
  ident: bib50
  article-title: Altered wound healing in mice lacking a functional osteopontin gene (spp1)
  publication-title: J. Clin. Invest.
– volume: 18
  start-page: 125
  year: 2010
  end-page: 131
  ident: bib34
  article-title: Osteopontin in cardiovascular disease: a potential therapeutic target
  publication-title: Cardiol. Rev.
– volume: 2
  start-page: 235
  year: 2016
  end-page: 254
  ident: bib5
  article-title: Understanding Glaucomatous Optic Neuropathy: The Synergy Between Clinical Observation and Investigation
  publication-title: Annu. Rev. Vis. Sci.
– volume: 119
  year: 2022
  ident: bib25
  article-title: Longitudinal in vivo Ca(2+) imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 424
  start-page: 430
  year: 2003
  end-page: 434
  ident: bib48
  article-title: Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
  publication-title: Nature
– volume: 110
  start-page: 2607
  year: 2022
  end-page: 2624.e8
  ident: bib41
  article-title: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
  publication-title: Neuron
– volume: 41
  start-page: 723
  year: 2001
  end-page: 749
  ident: bib35
  article-title: Role of osteopontin in cellular signaling and toxicant injury
  publication-title: Annu. Rev. Pharmacol. Toxicol.
– volume: 22
  start-page: 286
  year: 2007
  end-page: 297
  ident: bib31
  article-title: Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice
  publication-title: J. Bone Miner. Res.
– volume: 24
  start-page: 276
  year: 2021
  end-page: 287
  ident: bib1
  article-title: Molecular characterization of selectively vulnerable neurons in Alzheimer's disease
  publication-title: Nat. Neurosci.
– volume: 153
  start-page: 695
  year: 2017
  end-page: 706
  ident: bib38
  article-title: ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion
  publication-title: Reproduction
– volume: 6
  start-page: 195
  year: 2020
  end-page: 213
  ident: bib8
  article-title: Axon Regeneration in the Mammalian Optic Nerve
  publication-title: Annu. Rev. Vis. Sci.
– volume: 10
  start-page: 9802
  year: 2020
  ident: bib28
  article-title: Cell Atlas of The Human Fovea and Peripheral Retina
  publication-title: Sci. Rep.
– volume: 119
  year: 2022
  ident: bib45
  article-title: Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 25
  start-page: 659
  year: 2022
  end-page: 674
  ident: bib22
  article-title: Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
  publication-title: Nat. Neurosci.
– volume: 14
  start-page: 109
  year: 2020
  ident: bib24
  article-title: Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse
  publication-title: Front. Cell. Neurosci.
– volume: 95
  start-page: 817
  year: 2017
  end-page: 833.e4
  ident: bib12
  article-title: A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions
  publication-title: Neuron
– volume: 85
  start-page: 1244
  year: 2015
  end-page: 1256
  ident: bib7
  article-title: Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling
  publication-title: Neuron
– volume: 41
  start-page: 111880
  year: 2022
  ident: bib27
  article-title: Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma
  publication-title: Cell Rep.
– volume: 71
  start-page: 35
  year: 2011
  end-page: 48
  ident: bib2
  article-title: Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration
  publication-title: Neuron
– volume: 90
  start-page: 437
  year: 2016
  end-page: 451
  ident: bib4
  article-title: Intrinsic Control of Axon Regeneration
  publication-title: Neuron
– volume: 212
  start-page: 157
  year: 1981
  end-page: 175
  ident: bib40
  article-title: Morphology and topography of on- and off-alpha cells in the cat retina
  publication-title: Proc. R. Soc. Lond. B Biol. Sci.
– volume: 49
  start-page: 160
  year: 2011
  end-page: 172
  ident: bib44
  article-title: Intracellular osteopontin (iOPN) and immunity
  publication-title: Immunol. Res.
– volume: 9
  start-page: 101
  year: 2010
  ident: bib37
  article-title: Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
  publication-title: Mol. Cancer
– volume: 30
  start-page: 1452
  year: 2010
  end-page: 1462
  ident: bib16
  article-title: Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers
  publication-title: J. Neurosci.
– volume: 99
  start-page: 1145
  year: 2018
  end-page: 1154.e6
  ident: bib20
  article-title: Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold
  publication-title: Neuron
– volume: 67
  start-page: 49
  year: 2010
  end-page: 60
  ident: bib47
  article-title: Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision
  publication-title: Neuron
– volume: 19
  start-page: 615
  year: 2000
  end-page: 622
  ident: bib32
  article-title: Osteopontin: a versatile regulator of inflammation and biomineralization
  publication-title: Matrix Biol.
– volume: 760
  start-page: 143
  year: 1995
  end-page: 150
  ident: bib36
  article-title: The role of Eta-1/osteopontin in the pathogenesis of immunological disorders
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 28
  start-page: 41
  year: 2000
  end-page: 51
  ident: bib49
  article-title: Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
  publication-title: Neuron
– volume: 153
  start-page: 695
  year: 2017
  ident: 10.1016/j.celrep.2023.113038_bib38
  article-title: ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion
  publication-title: Reproduction
  doi: 10.1530/REP-17-0043
– volume: 67
  start-page: 49
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib47
  article-title: Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.05.023
– volume: 22
  start-page: 286
  year: 2007
  ident: 10.1016/j.celrep.2023.113038_bib31
  article-title: Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.061103
– start-page: 54065
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib51
  article-title: A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure
  publication-title: J. Vis. Exp.
– volume: 158
  start-page: 793
  year: 2014
  ident: 10.1016/j.celrep.2023.113038_bib46
  article-title: Type II cadherins guide assembly of a direction-selective retinal circuit
  publication-title: Cell
  doi: 10.1016/j.cell.2014.06.047
– volume: 154
  start-page: 442
  year: 2013
  ident: 10.1016/j.celrep.2023.113038_bib53
  article-title: CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.044
– volume: 10
  start-page: 9802
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib28
  article-title: Cell Atlas of The Human Fovea and Peripheral Retina
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-66092-9
– volume: 40
  start-page: 3896
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib54
  article-title: Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0102-20.2020
– volume: 90
  start-page: 437
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib4
  article-title: Intrinsic Control of Axon Regeneration
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.022
– volume: 36
  start-page: 9240
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib14
  article-title: Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0940-16.2016
– volume: 41
  start-page: 111880
  year: 2022
  ident: 10.1016/j.celrep.2023.113038_bib27
  article-title: Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2022.111880
– volume: 44
  start-page: 1018
  year: 2019
  ident: 10.1016/j.celrep.2023.113038_bib43
  article-title: Detection of Proteins Associated with Extracellular Matrix Regulation in the Aqueous Humour of Patients with Primary Glaucoma
  publication-title: Curr. Eye Res.
  doi: 10.1080/02713683.2019.1608261
– volume: 35
  start-page: 431
  year: 2017
  ident: 10.1016/j.celrep.2023.113038_bib52
  article-title: Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3806
– volume: 110
  start-page: 2607
  year: 2022
  ident: 10.1016/j.celrep.2023.113038_bib41
  article-title: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
  publication-title: Neuron
  doi: 10.1016/j.neuron.2022.06.003
– volume: 71
  start-page: 35
  year: 2011
  ident: 10.1016/j.celrep.2023.113038_bib2
  article-title: Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.06.031
– volume: 59
  start-page: 425
  year: 2008
  ident: 10.1016/j.celrep.2023.113038_bib17
  article-title: Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.07.018
– volume: 9
  start-page: 101
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib37
  article-title: Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-101
– volume: 1695
  start-page: 23
  year: 2018
  ident: 10.1016/j.celrep.2023.113038_bib13
  article-title: The Microbead Occlusion Model of Ocular Hypertension in Mice
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-7407-8_3
– volume: 24
  start-page: 276
  year: 2021
  ident: 10.1016/j.celrep.2023.113038_bib1
  article-title: Molecular characterization of selectively vulnerable neurons in Alzheimer's disease
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-00764-7
– volume: 8
  year: 2019
  ident: 10.1016/j.celrep.2023.113038_bib18
  article-title: Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse
  publication-title: Elife
  doi: 10.7554/eLife.45881
– volume: 53
  start-page: 473
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib29
  article-title: Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2020.04.009
– volume: 119
  year: 2022
  ident: 10.1016/j.celrep.2023.113038_bib45
  article-title: Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2200914119
– volume: 6
  start-page: 195
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib8
  article-title: Axon Regeneration in the Mammalian Optic Nerve
  publication-title: Annu. Rev. Vis. Sci.
  doi: 10.1146/annurev-vision-022720-094953
– volume: 30
  start-page: 1452
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib16
  article-title: Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4779-09.2010
– volume: 18
  start-page: 2058
  year: 2017
  ident: 10.1016/j.celrep.2023.113038_bib19
  article-title: Diverse Central Projection Patterns of Retinal Ganglion Cells
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.075
– volume: 212
  start-page: 157
  year: 1981
  ident: 10.1016/j.celrep.2023.113038_bib40
  article-title: Morphology and topography of on- and off-alpha cells in the cat retina
  publication-title: Proc. R. Soc. Lond. B Biol. Sci.
  doi: 10.1098/rspb.1981.0032
– volume: 760
  start-page: 143
  year: 1995
  ident: 10.1016/j.celrep.2023.113038_bib36
  article-title: The role of Eta-1/osteopontin in the pathogenesis of immunological disorders
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1995.tb44626.x
– volume: 85
  start-page: 1244
  year: 2015
  ident: 10.1016/j.celrep.2023.113038_bib7
  article-title: Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.02.017
– volume: 582
  start-page: 123
  year: 1992
  ident: 10.1016/j.celrep.2023.113038_bib30
  article-title: A neurofilament protein antibody selectively labels a large ganglion cell type in the human retina
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(92)90325-4
– volume: 41
  start-page: 723
  year: 2001
  ident: 10.1016/j.celrep.2023.113038_bib35
  article-title: Role of osteopontin in cellular signaling and toxicant injury
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pharmtox.41.1.723
– volume: 2
  start-page: 235
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib5
  article-title: Understanding Glaucomatous Optic Neuropathy: The Synergy Between Clinical Observation and Investigation
  publication-title: Annu. Rev. Vis. Sci.
  doi: 10.1146/annurev-vision-111815-114417
– volume: 18
  start-page: 530
  year: 2017
  ident: 10.1016/j.celrep.2023.113038_bib3
  article-title: Neuronal cell-type classification: challenges, opportunities and the path forward
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2017.85
– volume: 424
  start-page: 430
  year: 2003
  ident: 10.1016/j.celrep.2023.113038_bib48
  article-title: Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
  publication-title: Nature
  doi: 10.1038/nature01844
– volume: 164
  start-page: 219
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib11
  article-title: Restoration of Visual Function by Enhancing Conduction in Regenerated Axons
  publication-title: Cell
  doi: 10.1016/j.cell.2015.11.036
– volume: 10
  start-page: 17359
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib9
  article-title: Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-71460-6
– volume: 51
  start-page: 207
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib23
  article-title: The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.09-3947
– volume: 322
  start-page: 963
  year: 2008
  ident: 10.1016/j.celrep.2023.113038_bib26
  article-title: Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
  publication-title: Science
  doi: 10.1126/science.1161566
– volume: 15
  start-page: 1930
  year: 2016
  ident: 10.1016/j.celrep.2023.113038_bib21
  article-title: Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.04.069
– volume: 49
  start-page: 160
  year: 2011
  ident: 10.1016/j.celrep.2023.113038_bib44
  article-title: Intracellular osteopontin (iOPN) and immunity
  publication-title: Immunol. Res.
  doi: 10.1007/s12026-010-8179-5
– volume: 25
  start-page: 659
  year: 2022
  ident: 10.1016/j.celrep.2023.113038_bib22
  article-title: Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-022-01068-8
– volume: 43
  start-page: 771
  year: 2018
  ident: 10.1016/j.celrep.2023.113038_bib42
  article-title: Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure
  publication-title: Curr. Eye Res.
  doi: 10.1080/02713683.2018.1449222
– volume: 35
  start-page: 2329
  year: 2015
  ident: 10.1016/j.celrep.2023.113038_bib15
  article-title: Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1419-14.2015
– volume: 14
  start-page: 109
  year: 2020
  ident: 10.1016/j.celrep.2023.113038_bib24
  article-title: Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2020.00109
– volume: 19
  start-page: 615
  year: 2000
  ident: 10.1016/j.celrep.2023.113038_bib32
  article-title: Osteopontin: a versatile regulator of inflammation and biomineralization
  publication-title: Matrix Biol.
  doi: 10.1016/S0945-053X(00)00108-6
– volume: 18
  start-page: 125
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib34
  article-title: Osteopontin in cardiovascular disease: a potential therapeutic target
  publication-title: Cardiol. Rev.
  doi: 10.1097/CRD.0b013e3181cfb646
– volume: 36
  start-page: 195
  year: 2010
  ident: 10.1016/j.celrep.2023.113038_bib33
  article-title: Osteopontin: a biomarker to predict the outcome of inflammatory heart disease
  publication-title: Semin. Thromb. Hemost.
  doi: 10.1055/s-0030-1251504
– volume: 101
  start-page: 1468
  year: 1998
  ident: 10.1016/j.celrep.2023.113038_bib50
  article-title: Altered wound healing in mice lacking a functional osteopontin gene (spp1)
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI2131
– volume: 28
  start-page: 41
  year: 2000
  ident: 10.1016/j.celrep.2023.113038_bib49
  article-title: Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)00084-2
– volume: 99
  start-page: 1145
  year: 2018
  ident: 10.1016/j.celrep.2023.113038_bib20
  article-title: Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.08.019
– volume: 95
  start-page: 817
  year: 2017
  ident: 10.1016/j.celrep.2023.113038_bib12
  article-title: A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.07.037
– volume: 119
  year: 2022
  ident: 10.1016/j.celrep.2023.113038_bib25
  article-title: Longitudinal in vivo Ca(2+) imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2206829119
– volume: 104
  start-page: 1039
  year: 2019
  ident: 10.1016/j.celrep.2023.113038_bib6
  article-title: Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.11.006
– volume: 187
  start-page: 517
  year: 1966
  ident: 10.1016/j.celrep.2023.113038_bib39
  article-title: The contrast sensitivity of retinal ganglion cells of the cat
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1966.sp008107
– volume: 103
  start-page: 642
  year: 2019
  ident: 10.1016/j.celrep.2023.113038_bib10
  article-title: Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.05.044
SSID ssj0000601194
Score 2.453693
Snippet Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 113038
SubjectTerms CP: Neuroscience
Glaucoma
human retina
Humans
neuronal types
neuroprotection
Optic Nerve - metabolism
optic nerve crush
Optic Nerve Diseases - metabolism
Osteopontin
retinal ganglion cell
Retinal Ganglion Cells - metabolism
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT-MwELVWSEh7WQH7QVlAQdprtHHs2M4RVosQEssFJG6W7YyXoipBpRz673cmTqp2OfTCNXHSembseW5n3mPsR0S3elPoXEkOufTO5yZ4l3vMtXXkBlQv93bzR13dy-uH6mFN6otqwhI9cDLcTzoUC12EaDBVOt3UZQMO8x7EpglR9G2-RV2sHabSHkxcZvSXcllSzVYp9dg31xd3BZjNgegqS0GqJgW1p6zlpZ6-fyM9vYWf_1dRrqWlyz32acCT2Xmaxz77AO0B200Kk8vP7O4Wvdg9d6QHkTVz4pjNqG-RnvnrqIW3azP68R6vvkxntM6XGQ5FUP2KsUiC6S9Zh9tKyHrmSxIwXn5h95e_735d5YOQQh4qUSxyHyWPQFgkGACh67oR4LVXso5OCeXAEA9bqKAB0Boq4_GYBFL56JqovPjKdtquhUOWca6NczyA81LGgnshnOBQOUcv8GHCxGhGGwaWcRK7mNmxnOzJJuNbMr5Nxp-wfPXUc2LZ2DL-gjy0Gksc2f0FjBw7RI7dFjkTpkf_2gFuJBiBr5pu-fizMRwsrkbykmsBHWJLQ-RBCPPUhH1L4bH6kriVl1LVeMdsBM7GLDbvtNPHnvGbQDBCMX70HvP-zj7SXKjopVTHbGcxf4UTRFYLf9ovon959yOA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ScienceDirect Free & Delayed Access Titles
  dbid: IXB
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEBUhUOil9LubpsWFXs1alizJxyYkhELbQxPYm5DkUeqy2Mtmc9h_3xnZXuL2EOhxZUkrz4xHT2LmDWOfI6rVm0LnSnLIpXc-N8G73ONeW0duQKVyb9--q6sb-XVVrY7Y-ZQLQ2GVo-8ffHry1mPLcpTmctO2y58lnl1wd9IIovFMUVOiOWWVUhLf6uxwz0J8IzzVQ6T-OQ2YMuhSmFeA9RaIuLIUVN-koESVBztUIvKfbVT_AtG_4ykfbFCXz9mzEVlmX4bFv2BH0L1kT4Zak_tX7PoH6rPf9FQZImu2xDabUQYjjbl1lMzbdxld42PrXbsmSewz7Irw-h6FQ6XT77IeHUzIEgcmlTLev2Y3lxfX51f5WFIhD5UodrmPkkcgVBIMgNB13Qjw2itZR6eEcmCIkS1U0ABoDZXxeGACqXx0TVRevGHHXd_BO5Zxro1zPIDzUsaCeyGc4FA5RxP4sGBiEqMNI984lb1Y2ymw7LcdhG9J-HYQ_oLlh1GbgW_jkf5npKFDX2LLTg399taO5mLpYkXoIkSDcMvppi4bcIidIDZNiDSJnvRrZ8aHU7WP_P2nyRwsfpekJdcBKsSWhmiEEPCpBXs7mMdhkejUS6lqfGJmhjN7i_mTrv2VuL8JDiMo4yf_veT37Cn9opiXUp2y4932Hj4gsNr5j-nL-QODtyPa
  priority: 102
  providerName: Elsevier
Title Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy
URI https://dx.doi.org/10.1016/j.celrep.2023.113038
https://www.ncbi.nlm.nih.gov/pubmed/37624696
https://www.proquest.com/docview/2857850646
https://pubmed.ncbi.nlm.nih.gov/PMC10591811
https://doaj.org/article/1987370cf8584a7d92dea074efddcf38
Volume 42
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGEBIvaNwLYwoSr0Fx7NjOA0LbxDSQgJdV6ptlO8ejqEpG2kn033NOLoVw0SReKjVx3PRc7C_O8fcx9iqiW73JdKokh1R651MTvEs9zrVl5AZUJ_f28ZM6n8sPi2Kxx0bN1sGA678-2pGe1Lxdvf7-bfsWE_7Nz1qtAKsWiH0yFyRSkglzi93u3hhRMd8A-PuxmTjO6FVznlMtVy71uJ_uHx1N5quO1n8ybf0JS3-vrvxlujo7YPcGnJkc94Fxn-1B_YDd6ZUntw_ZxWf0bnPVkE5EUrXEPZvQfka65tLR1t6mTmhRH4-ulyvK_22CTRFsX2OMkpD6OmlwuAlJx4hJwsbbR2x-9u7i9DwdBBbSUIhsk_ooeQTCKMEACF2WlQCvvZJldEooB4b42UIBFYDWUBiPj08glY-uisqLx2y_bmp4yhLOtXGOB3BeyphxL4QTHArnqAMfZkyMZrRhYB8nEYyVHcvMvtre-JaMb3vjz1i6u-qqZ9-4of0JeWjXlrizuwNNe2mHVLS0zCJ0FqJB8OV0VeYVOERSEKsqROpEj_61Awzp4QV2tbzh51-O4WAxS8lLrgZ0iM0NkQoh_FMz9qQPj91N4hCfS1XiGTMJnMm_mJ6pl186JnACxwjR-LP_vuXn7C59owqYXB2y_U17DS8QZm38Ubc8gZ_vFydHXRb9AC_KKmM
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKEYILKu8FCkHiGm0cJ7ZzpBXVFtpyYCvtzbKdcQlaJavt9rD_npk8Vg09VOrVr_XOTMafrZlvGPsaUK1OJyqWGYc4c9bF2jsbOzxri8A1yLbc2_mFnF1mPxb5Yo8dD7kwFFbZ-_7Op7feum-Z9tKcrqpq-jvFuwueTgpBNN4pivwRe4xoICHTPl0c7R5aiHCEtwURaUJMM4YUujbOy8NyDcRcmQoqcJJQpsqtI6pl8h-dVHeR6P8BlbdOqJMD9ryHltG3bvcv2B7UL9mTrtjk9hWb_0KFNquGSkNE5ZroZiNKYaQ5V5ayeZs6ond8bL2uliSKbYRDEV_foHSodvp11KCH8VFLgkm1jLev2eXJ9_nxLO5rKsQ-F8kmdiHjAQiWeA0gVFGUApxyMiuClUJa0ETJ5nMoAZSCXDu8MUEmXbBlkE68Yft1U8M7FnGutLXcg3VZFhLuhLCCQ24tLeD8hIlBjMb3hONU92Jphsiyv6YTviHhm074ExbvZq06wo17xh-RhnZjiS67bWjWV6a3F0MvK0IlPmjEW1aVRVqCRfAEoSx9oEXUoF8zsj5cqrrn578M5mDwwyQt2RpQISbVxCOEiE9O2NvOPHabRK-eZrLAHj0ynNG_GPfU1Z-W_JvwMKIy_v7BW_7Mns7m52fm7PTi5wf2jHooACaVH9n-Zn0Dh4iyNu5T-xX9AzJUJv0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Osteopontin+drives+retinal+ganglion+cell+resiliency+in+glaucomatous+optic+neuropathy&rft.jtitle=Cell+reports+%28Cambridge%29&rft.au=Zhao%2C+Mengya&rft.au=Toma%2C+Kenichi&rft.au=Kinde%2C+Benyam&rft.au=Li%2C+Liang&rft.date=2023-09-26&rft.pub=Elsevier+Inc&rft.issn=2211-1247&rft.eissn=2211-1247&rft.volume=42&rft.issue=9&rft_id=info:doi/10.1016%2Fj.celrep.2023.113038&rft.externalDocID=S2211124723010495
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2211-1247&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2211-1247&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2211-1247&client=summon