Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis - Xiang, Yan; Stine, Zachary E.; Xia, Jinsong; Lu, Yunqi; O’Connor, Roddy S.; Altman, Brian J.; Hsieh, Annie L.; Gouw, Arvin M.; Thomas, Ajit G.; Gao, Ping; Sun, Linchong; Song, Libing; et al. (The Journal of clinical investigation, 2015)
Keywords: Amino Acid Substitution; Animals; Biomedical research; Cancer; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell growth; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Colleges & universities; Crystal structure; Enzymes; Fatty acids; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase - antagonists & inhibitors; Glutaminase - biosynthesis; Glutaminase - genetics; Grants; Heterografts; Humans; Infrared imaging systems; Laboratory animals; Liver Neoplasms, Experimental - drug therapy; Liver Neoplasms, Experimental - enzymology; Liver Neoplasms, Experimental - genetics; Liver Neoplasms, Experimental - pathology; Lymphoma; Medical research; Metabolism; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mutation, Missense; Neoplasm Transplantation; Proteins; Software; Sulfides - pharmacology; Survival analysis; Thiadiazoles - pharmacology; Tumorigenesis; Tumors; Singapore