Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk
An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. Th...
Saved in:
| Published in | Neurobiology of aging Vol. 30; no. 2; pp. 322 - 324 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Elsevier Inc
01.02.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0197-4580 1558-1497 1558-1497 |
| DOI | 10.1016/j.neurobiolaging.2007.07.003 |
Cover
| Abstract | An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD. |
|---|---|
| AbstractList | Abstract An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p = 0.03) for very-late-onset (after the age of 86 years) AD. An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD. An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD. |
| Author | Infante, Jon Mateo, Ignacio Rodríguez-Rodríguez, Eloy Combarros, Onofre Berciano, José Sánchez-Quintana, Coro Sánchez-Juan, Pascual Llorca, Javier García-Gorostiaga, Inés |
| Author_xml | – sequence: 1 givenname: Eloy surname: Rodríguez-Rodríguez fullname: Rodríguez-Rodríguez, Eloy organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 2 givenname: Jon surname: Infante fullname: Infante, Jon organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 3 givenname: Javier surname: Llorca fullname: Llorca, Javier organization: Division of Epidemiology and Computational Biology, University of Cantabria School of Medicine, Santander, Spain – sequence: 4 givenname: Ignacio surname: Mateo fullname: Mateo, Ignacio organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 5 givenname: Coro surname: Sánchez-Quintana fullname: Sánchez-Quintana, Coro organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 6 givenname: Inés surname: García-Gorostiaga fullname: García-Gorostiaga, Inés organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 7 givenname: Pascual surname: Sánchez-Juan fullname: Sánchez-Juan, Pascual organization: Fundación “Marqués de Valdecilla”, IFIMAV, Santander, Spain – sequence: 8 givenname: José surname: Berciano fullname: Berciano, José organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain – sequence: 9 givenname: Onofre surname: Combarros fullname: Combarros, Onofre email: combarro@unican.es organization: Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23922934$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17707552$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNku1rFDEQxoNU7LX6L8h-8OXTnpPsZrMLIlyr1WJBfPsccsnsmetecmZ2C_Wvd9c7FQvCwUAg-c3D5HnmhB2FGJCxJxzmHHj1Yj0POKS49LEzKx9WcwGg5lNBcY_NuJR1zstGHbEZ8EblpazhmJ0QrWEES1U9YMdcKVBSihn7uFhh7nCLwWHoM0MUrTe9jyGLbfb-8uzTIlthwN7b7Mak_ZMJLlt0P76h32B6TpnzhIYwS56uH7L7rekIH-3PU_b14s2X83f51Ye3l-eLq9zKAvpcQtuiqfnS2lappiwQRW0KMV5WS3Att6VpVAtNXXKzBGyMdU6BlNYVlbJ1ccqe7XS3KX4fkHq98WSx60zAOJCuKqUk52IEH-_BYblBp7fJb0y61b9NGIGne8CQNV2bTLCe_nCiaIRoinLkXu44myJRwvavFOgpG73W_2ajp2z0VFCM7Wd32q3vf_nZJ-O7Q0UudiI4WnvjMWmyHoNF5xPaXrvoDxV6dUfIdj748f_XeIu0jkMKY3yaaxIa9Odpl6ZVAgUgdq69_r_A4XP8BAIF460 |
| CODEN | NEAGDO |
| CitedBy_id | crossref_primary_10_1016_j_ajhg_2008_12_008 crossref_primary_10_1038_s41467_019_09720_x crossref_primary_10_18632_oncotarget_23348 crossref_primary_10_1007_s12017_015_8348_8 crossref_primary_10_1038_s41419_023_06020_7 crossref_primary_10_1016_j_neurobiolaging_2018_08_001 crossref_primary_10_1016_j_neuroimage_2012_12_022 crossref_primary_10_1002_ajmg_b_32101 crossref_primary_10_1002_hipo_22148 crossref_primary_10_1002_gps_5068 crossref_primary_10_1016_j_neuropsychologia_2014_07_020 crossref_primary_10_1007_s11033_013_2830_x crossref_primary_10_3233_JAD_200871 crossref_primary_10_1007_s12038_018_9817_7 crossref_primary_10_1038_nrd2519 crossref_primary_10_1002_bies_201600224 crossref_primary_10_1016_j_neuropsychologia_2015_09_031 crossref_primary_10_1016_j_neuron_2016_03_005 crossref_primary_10_2217_fnl_09_13 crossref_primary_10_1080_13825585_2015_1020916 crossref_primary_10_1271_bbb_80564 crossref_primary_10_1007_s11065_009_9116_z crossref_primary_10_1016_j_cellsig_2013_11_012 crossref_primary_10_1093_gerona_glz004 crossref_primary_10_3109_15622971003797258 crossref_primary_10_3109_02699052_2012_700089 crossref_primary_10_1134_S2079059715060118 crossref_primary_10_1016_j_psychres_2014_07_024 crossref_primary_10_1002_hipo_22731 crossref_primary_10_1093_cercor_bhw276 crossref_primary_10_1002_gps_2117 crossref_primary_10_1074_jbc_M111_246850 crossref_primary_10_1016_j_cellsig_2014_02_023 crossref_primary_10_1186_s10020_018_0007_8 crossref_primary_10_1016_j_neurobiolaging_2010_11_004 crossref_primary_10_1186_1479_7364_4_3_170 crossref_primary_10_3390_cells10113024 crossref_primary_10_1016_j_celrep_2019_01_097 crossref_primary_10_1002_jnr_24551 crossref_primary_10_1016_j_biopsych_2013_09_036 crossref_primary_10_1002_sim_4236 crossref_primary_10_1016_j_jpsychires_2010_01_012 crossref_primary_10_3389_fncel_2019_00137 crossref_primary_10_1016_j_neulet_2017_08_057 crossref_primary_10_1007_s00109_013_1089_y crossref_primary_10_1016_j_nlm_2016_07_028 crossref_primary_10_1038_npp_2009_80 crossref_primary_10_1016_j_neuropsychologia_2009_09_031 crossref_primary_10_1007_s00702_011_0667_9 crossref_primary_10_1007_s10072_019_03866_8 crossref_primary_10_1186_1471_2350_11_32 crossref_primary_10_1111_febs_13718 crossref_primary_10_1523_JNEUROSCI_3292_11_2011 crossref_primary_10_1177_13872877241284313 crossref_primary_10_1172_JCI169064 |
| Cites_doi | 10.1016/S0006-291X(02)02945-5 10.1093/cercor/bhl103 10.1016/j.neurobiolaging.2007.02.001 10.1212/WNL.34.7.939 10.1126/science.1129837 |
| ContentType | Journal Article |
| Copyright | 2007 Elsevier Inc. Elsevier Inc. 2015 INIST-CNRS |
| Copyright_xml | – notice: 2007 Elsevier Inc. – notice: Elsevier Inc. – notice: 2015 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.neurobiolaging.2007.07.003 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1558-1497 |
| EndPage | 324 |
| ExternalDocumentID | 17707552 23922934 10_1016_j_neurobiolaging_2007_07_003 S0197458007002552 1_s2_0_S0197458007002552 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Spain |
| GeographicLocations_xml | – name: Spain |
| GroupedDBID | --- --K --M -~X .1- .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29N 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABFRF ABGSF ABIVO ABJNI ABLJU ABMAC ABMZM ABOYX ABUDA ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX AEBSH AEFWE AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRLJ AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDW HMK HMO HMQ HVGLF HZ~ IHE J1W KOM LX8 M29 M2V M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OD~ OKEIE OO0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SSB SSH SSN SSU SSY SSZ T5K WUQ Z5R ZGI ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AADPK AAIAV ABLVK ABYKQ AFYLN AJBFU DOVZS EFLBG LCYCR AAYXX AGRNS CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c530t-50ffea81bccf77943ee28a32fea6b0df1c4a97f09841ab0e9acdd7055cd367c83 |
| IEDL.DBID | AIKHN |
| ISSN | 0197-4580 1558-1497 |
| IngestDate | Fri Sep 05 02:27:08 EDT 2025 Mon Jul 21 06:03:29 EDT 2025 Mon Jul 21 09:15:41 EDT 2025 Tue Jul 01 03:40:29 EDT 2025 Thu Apr 24 23:09:59 EDT 2025 Fri Feb 23 02:27:32 EST 2024 Sun Feb 23 10:19:38 EST 2025 Tue Aug 26 16:32:28 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | KIBRA Alzheimer's disease Episodic memory Polymorphism Nervous system diseases Senescence Alzheimer disease Memory Central nervous system disease Degenerative disease Age Cerebral disorder |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c530t-50ffea81bccf77943ee28a32fea6b0df1c4a97f09841ab0e9acdd7055cd367c83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 17707552 |
| PQID | 66775112 |
| PQPubID | 23479 |
| PageCount | 3 |
| ParticipantIDs | proquest_miscellaneous_66775112 pubmed_primary_17707552 pascalfrancis_primary_23922934 crossref_primary_10_1016_j_neurobiolaging_2007_07_003 crossref_citationtrail_10_1016_j_neurobiolaging_2007_07_003 elsevier_sciencedirect_doi_10_1016_j_neurobiolaging_2007_07_003 elsevier_clinicalkeyesjournals_1_s2_0_S0197458007002552 elsevier_clinicalkey_doi_10_1016_j_neurobiolaging_2007_07_003 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-02-01 |
| PublicationDateYYYYMMDD | 2009-02-01 |
| PublicationDate_xml | – month: 02 year: 2009 text: 2009-02-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: United States |
| PublicationTitle | Neurobiology of aging |
| PublicationTitleAlternate | Neurobiol Aging |
| PublicationYear | 2009 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Kremerskothen, Plaas, Büther, Finger, Veltel, Matanis, Liedtke, Barnekow (bib1) 2003; 300 Papassotiropoulos, Stephan, Huentelman, Hoerndli, Craig, Pearson, Huynh, Brunner, Corneveaux, Osborne, Wollmer, Aerni, Colucci, Hänggi, Mondadori, Buchmann, Reiman, Caselli, Henke, de Quervain (bib4) 2006; 314 Schaper, K., Holsch, H., Popp, J., Wagner, M., Jessen, F., 2007. KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiol. Aging (Epub ahead of print). McKhann, Drachman, Folstein, Katzman, Price, Stadlan (bib2) 1984; 24 Mondadori, C.R., de Quervain, D.J., Buchmann, A., Mustovic, H., Wollmer, M.A., Schmidt, C.F., Boesiger, P., Hock, C., Nitsch, R.M. Papassotiropoulos, A., Henke, K., 2006. Better memory and neural efficiency in young apolipoprotein E ɛ4 carriers. Cereb. Cortex (Epub ahead of print). Kremerskothen (10.1016/j.neurobiolaging.2007.07.003_bib1) 2003; 300 Papassotiropoulos (10.1016/j.neurobiolaging.2007.07.003_bib4) 2006; 314 10.1016/j.neurobiolaging.2007.07.003_bib5 10.1016/j.neurobiolaging.2007.07.003_bib3 McKhann (10.1016/j.neurobiolaging.2007.07.003_bib2) 1984; 24 |
| References_xml | – volume: 24 start-page: 939 year: 1984 end-page: 944 ident: bib2 article-title: Clinical diagnosis of Alzheimer disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer Disease publication-title: Neurology – volume: 314 start-page: 475 year: 2006 end-page: 478 ident: bib4 article-title: Common KIBRA alleles are associated with human memory performance publication-title: Science – volume: 300 start-page: 862 year: 2003 end-page: 867 ident: bib1 article-title: Characterization of KIBRA, a novel WW domain-containing protein publication-title: Biochem. Biophys. Res. Commun. – reference: Schaper, K., Holsch, H., Popp, J., Wagner, M., Jessen, F., 2007. KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiol. Aging (Epub ahead of print). – reference: Mondadori, C.R., de Quervain, D.J., Buchmann, A., Mustovic, H., Wollmer, M.A., Schmidt, C.F., Boesiger, P., Hock, C., Nitsch, R.M. Papassotiropoulos, A., Henke, K., 2006. Better memory and neural efficiency in young apolipoprotein E ɛ4 carriers. Cereb. Cortex (Epub ahead of print). – volume: 300 start-page: 862 year: 2003 ident: 10.1016/j.neurobiolaging.2007.07.003_bib1 article-title: Characterization of KIBRA, a novel WW domain-containing protein publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)02945-5 – ident: 10.1016/j.neurobiolaging.2007.07.003_bib3 doi: 10.1093/cercor/bhl103 – ident: 10.1016/j.neurobiolaging.2007.07.003_bib5 doi: 10.1016/j.neurobiolaging.2007.02.001 – volume: 24 start-page: 939 year: 1984 ident: 10.1016/j.neurobiolaging.2007.07.003_bib2 article-title: Clinical diagnosis of Alzheimer disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer Disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 314 start-page: 475 year: 2006 ident: 10.1016/j.neurobiolaging.2007.07.003_bib4 article-title: Common KIBRA alleles are associated with human memory performance publication-title: Science doi: 10.1126/science.1129837 |
| SSID | ssj0007476 |
| Score | 2.1659403 |
| Snippet | An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently... Abstract An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 322 |
| SubjectTerms | Aged Aged, 80 and over Aging - genetics Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development. Senescence. Regeneration. Transplantation Episodic memory Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Variation - genetics Humans Incidence Internal Medicine Intracellular Signaling Peptides and Proteins KIBRA Male Medical sciences Middle Aged Neurology Phosphoproteins Polymorphism Polymorphism, Single Nucleotide - genetics Proteins - genetics Risk Assessment - methods Risk Factors Spain - epidemiology Vertebrates: nervous system and sense organs |
| Title | Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0197458007002552 https://www.clinicalkey.es/playcontent/1-s2.0-S0197458007002552 https://dx.doi.org/10.1016/j.neurobiolaging.2007.07.003 https://www.ncbi.nlm.nih.gov/pubmed/17707552 https://www.proquest.com/docview/66775112 |
| Volume | 30 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB_qFUQQUetH_Dj3oehTvE2yHwkiEovlaqHgR6Fvy2azqydt7miugj74t7uTbO44tFAR8rRhyGZ2duaX7MxvAHadELVzRRVTa6oYjSTW3gvGnEvkGxMi1V2C7JGYHrP3J_xkC_aGWhhMqwy-v_fpnbcOI5OgzcliNpt88uBEMp4jYQ0CY--Ht1Mf7fMRbJcHh9OjlUP2iFn0VdNI8Z3T67C7TvPqaCOR8KhrChQ4DZHWMLssUt1c6Nbrz_WNLy5Hpl2E2r8NtwK0JGU_-zuwZZu7sFM2_rP67Ad5Trpkz-4v-g58KL_YeGiAuyR6vUhk7sjhwduPJfGmhRWO5Lv_nO5v6aYm5enPr3Z2Zs9ftCSc7hDMT78Hx_vvPu9N49BdITY8o8uYU-es9qjVGCeRJs7aNNdZ6gdFRWuXGKYL6WiRs0RX1Bba1DVy75g6E9Lk2X0YNfPGPgQiLWPOGMOEpSyrauSYo6IuKpdYrqWI4NWgSWUC9Th2wDhVQ47ZN7W5DtgdUyq8aBYBX0kvegqOK8q9HhZNDWWm3jEqHyuuKC__Jm_bsMtblag2VVT9YYkRvFlJbhjzPzx7vGFlqxdHC_cIjUXwbDA75R0CnvLoxs4vWiWElIiiI3jQW-NaaVJ6gMjTR_89vcdwoz9Vw7SeJzBanl_Ypx6cLasxXHv5KxmHLfgbdGM85A |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3_a9QwFH-MG6ggok5n_bLlh6E_lcu1adIyhtThuPPmgbrBfgtpmujJ1jvWmzD_-uW16R2HDiZCf0p5NH15-eTT5uXzAPYs56W1WRFSo4sQgyRUDgXDJBGoN8Z5pJoE2QkfnrJPZ8nZBhx2Z2EwrdJjf4vpDVr7lr73Zn8-nfa_OXIiWJKiYA0SY4fDmwyLWvdgMx-Nh5MlIDvGzNtT0yjxndJ7sLdK82pkI1HwqCkK5DUNUdYwvm2lejhXtfOfbQtf3M5MmxXq6DE88tSS5G3vn8CGqZ7CVl65z-qLa_KWNMmezV_0LfiSfzdhVwB3QdRqkMjMkvHow9ecuNDCE47kl_ucbm-pqiT5-e8fZnphLt_VxO_uEMxPfwanRx9PDoehr64Q6iSmizCh1hrlWKvWVqBMnDFRquLINfKClnagmcqEpVnKBqqgJlO6LFF7R5cxFzqNn0OvmlXmBRBhGLNaa8YNZXFRosYc5WVW2IFJlOAB7HeelNpLj2MFjHPZ5Zj9lOvjgNUxhcSLxgEkS-t5K8FxR7uDbtBkd8zUAaN0a8Ud7cXf7E3tZ3ktB7KOJJV_RGIA75eWa8H8D8_eWYuy5YtHjs86hsYC2O3CTjpAwF0eVZnZVS05FwJZdADbbTSunCaEI4hJ9PK_u7cL94cnn4_l8WgyfgUP2h02TPF5Db3F5ZV544jaotjxE_EG5Uw-yg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Age-dependent+association+of+KIBRA+genetic+variation+and+Alzheimer%27s+disease+risk&rft.jtitle=Neurobiology+of+aging&rft.au=Rodr%C3%ADguez-Rodr%C3%ADguez%2C+Eloy&rft.au=Infante%2C+Jon&rft.au=Llorca%2C+Javier&rft.au=Mateo%2C+Ignacio&rft.date=2009-02-01&rft.pub=Elsevier+Inc&rft.issn=0197-4580&rft.eissn=1558-1497&rft.volume=30&rft.issue=2&rft.spage=322&rft.epage=324&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2007.07.003&rft.externalDocID=S0197458007002552 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01974580%2FS0197458008X00132%2Fcov150h.gif |