Lactobacilli and Bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model - Kandasamy, Sukumar; Chattha, Kuldeep S; Vlasova, Anastasia N; Rajashekara, Gireesh; Saif, Linda J (Gut microbes, 2014)
Keywords: Administration, Oral; Animals; Antibodies, Viral - analysis; Antibodies, Viral - blood; B cell responses; B-Lymphocytes - immunology; Bifidobacterium - growth & development; Cytokines - secretion; Disease Models, Animal; Feces - virology; Gastrointestinal Tract - immunology; Germ-Free Life; human rotavirus; Humans; Immunity, Mucosal; Immunoglobulin A - analysis; Immunoglobulin G - blood; Lactobacillus rhamnosus - growth & development; neonatal diarrhea; probiotics; Research Papers; Rotavirus Infections - pathology; Rotavirus Infections - prevention & control; Rotavirus Vaccines - administration & dosage; Rotavirus Vaccines - immunology; Swine; vaccine; Virus Shedding; MNCs, mononuclear cells; Vac+Pro, vaccinated probiotic colonized group; FFU, fluorescent foci forming unit; neonatal diarrhea; AUC, area under the curve; RAM, rat anti-mouse; AttHRV, attenuated human rotavirus; PCD, postchallenge day; VirHRV, virulent human rotavirus; APRIL, a proliferation-inducing ligand; human rotavirus; vaccine; B cell responses; HRV, human rotavirus; LGG, Lactobacillus rhamnosus strain GG; PID, postinoculation day; Vac, 3XAttHRV Wa vaccinated only group; Bb12, Bifidobacterium lactis Bb12; Gn, gnotobiotic; RV, rotavirus; PBCD, post bacterial colonization day; ASC, antibody secreting cell; probiotics