Target of rapamycin in the oriental fruit fly Bactrocera dorsalis (hendel): its cloning and effect on yolk protein expression
Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the orient...
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| Published in | Archives of insect biochemistry and physiology Vol. 75; no. 1; pp. 45 - 56 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Hoboken
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01.09.2010
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| ISSN | 0739-4462 1520-6327 1520-6327 |
| DOI | 10.1002/arch.20383 |
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| Abstract | Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT‐PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. © 2010 Wiley Periodicals, Inc. |
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| AbstractList | Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT-PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT‐PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. © 2010 Wiley Periodicals, Inc. Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT-PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis.Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT-PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT-PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. [copy 2010 Wiley Periodicals, Inc. Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT‐PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis . © 2010 Wiley Periodicals, Inc. Target of rapamycin (TOR), a serine/threonine protein kinase, is involved in regulating a number of growth and developmental processes of an organism, including yolk protein synthesis in insects. In this study, TOR gene was isolated, designated BdTOR (GenBank accession no. FJ167395), from the oriental fruit fly Bactrocera dorsalis (Hendel). Quantitative RT-PCR showed a higher expression of BdTOR in the pupa than in other developmental stages, as well as in ovary than in the fat body. Downregulation of BdTOR activity by rapamycin treatment and RNA interference (RNAi) in vivo resulted in a significant reduction in yolk protein transcripts in both fat body and ovary, with a substantial reduction in ovary size. However, an unexpected increase in the expression of yolk protein gene was observed in adult ovary 9 days after rapamycin treatment. Taken together, the results suggest the involvement of BdTOR in the regulation of yolk protein synthesis in B. dorsalis. ? 2010 Wiley Periodicals, Inc. |
| Author | Chen, Shiu-Ling Lu, Kuang-Hui Suganya, R. |
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| Cites_doi | 10.1016/j.ibmb.2007.10.003 10.1016/j.cub.2006.03.084 10.1074/jbc.M601517200 10.1152/ajpcell.1998.274.1.C206 10.1091/mbc.10.4.987 10.1016/0092-8674(94)90570-3 10.1016/j.ibmb.2008.07.003 10.1371/journal.pone.0000509 10.1074/jbc.M500712200 10.1074/jbc.M807042200 10.1016/S0962-8924(02)00042-9 10.1016/j.ceb.2005.02.008 10.1016/0965-1748(94)90018-3 10.1016/S0022-2836(05)80360-2 10.1146/annurev.en.37.010192.001245 10.1016/S0092-8674(03)00713-X 10.1093/jmedent/34.1.68 10.1101/gad.835000 10.1073/pnas.0403460101 10.1007/BF00868681 10.1128/MCB.23.24.9117-9126.2003 10.4049/jimmunol.155.7.3418 10.1093/molbev/msm092 |
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| References | Chen SL, Dai SM, Lu KH, Chang C. 2008. Female-specific doublesex dsRNA interrupts yolk protein gene expression and reproductive ability in oriental fruit fly, Bactrocera dorsalis (Hendel). Insect Biochem Mol Biol 38:155-165. Oldham S, Hafen E. 2003. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13:79-85. He M, Haymer DS. 1994. The actin gene family in the oriental fruit fly Bactrocera dorsalis. Muscle specific actins. Insect Biochem Mol Biol 24:891-906. Maestro JL, Cobo J, Bellés X. 2009. Target of rapamycin (TOR) mediates the transduction of nutritional signals into juvenile hormone production. J Biol Chem 284:5506-5513. Raikhel AS, Dhadialla TS. 1992. Accumulation of yolk proteins in insect oocytes. Annu Rev Entomol 37:217-251. Hansen IA, Attardo GM, Roy SG, Raikhel AS. 2005. Target of rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito. J Biol Chem 280:20565-20572. Su T, Mulla MS. 1997. Nutritional reserves, body weight, and starvation tolerance of autogenous and anautogenous strains of Culex tarsalis (Diptera: Culicidae). J Med Entomol 34:68-73. Park J, Attardo G, Hansen I, Raikhel AS. 2006. GATA factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito Aedes aegypti. J Biol Chem 281:11167-11176. Colombani J, Raisin S, Pantalacci S, Radimerski T, Montagne J, Leopold P. 2003. A nutrient sensor mechanism controls Drosophila growth. Cell 114:739-749. Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. 2000. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14:2712-2724. Lu HL, Lu KH. 2003. 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| References_xml | – reference: Chiu HT. 1978. Studies on the improvement of mass rearing for oriental fruit flies. Plant Protection Bull 20:87-92. – reference: Fox HL, Kimball SR, Jefferson LS, Lynch CJ. 1998. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol 274:C206-C213. – reference: Patel A, Fondrk MK, Kaftanoglu O, Emore C, Hunt G, Frederick K, Amdam GV. 2007. The making of a queen: TOR pathway is a key player in diphenic caste development. PLoS One 2:e509. – reference: Terada N, Takase K, Papst P, Nairn AC, Gelfand EW. 1995. Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes. J Immunol 155:3418-3426. – reference: Oldham S, Hafen E. 2003. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13:79-85. – reference: Burland TG. 1999. DNASTAR's lasergene sequence analysis software. Methods Mol Biol 132:71-91. – reference: Colombani J, Raisin S, Pantalacci S, Radimerski T, Montagne J, Leopold P. 2003. A nutrient sensor mechanism controls Drosophila growth. Cell 114:739-749. – reference: Gutzeit HO. 1980. Yolk synthesis in ovarian follicles of Drosophila. Roux Arch Dev Biol 189:221-224. – reference: Su T, Mulla MS. 1997. Nutritional reserves, body weight, and starvation tolerance of autogenous and anautogenous strains of Culex tarsalis (Diptera: Culicidae). J Med Entomol 34:68-73. – reference: Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. 2006. Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol 16:958-970. – reference: He M, Haymer DS. 1994. The actin gene family in the oriental fruit fly Bactrocera dorsalis. Muscle specific actins. Insect Biochem Mol Biol 24:891-906. – reference: Lu HL, Lu KH. 2003. 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| Title | Target of rapamycin in the oriental fruit fly Bactrocera dorsalis (hendel): its cloning and effect on yolk protein expression |
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