Latent Structure Analysis in Pharmaceutical Formulations Using Kohonen's Self-Organizing Map and a Bayesian Network - Kikuchi, Shingo; Onuki, Yoshinori; Yasuda, Akihito; Hayashi, Yoshihiro; Takayama, Kozo (Journal of pharmaceutical sciences, 2011)
Keywords: Algorithms; Bayes Theorem; Biological and medical sciences; Calcium Channel Blockers - chemistry; Calcium Channel Blockers - pharmacokinetics; Cluster Analysis; controlled release; Dextran Sulfate - analogs & derivatives; Dextran Sulfate - chemistry; Diltiazem - chemistry; Diltiazem - pharmacokinetics; dissolution rate; Dosage Forms; Drug Compounding - methods; excipients; formulation; General pharmacology; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives; Medical sciences; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Models, Statistical; multivariate analysis; nonlinear regression; Pharmaceutical Preparations - chemistry; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymers - chemistry; preformulation; simulations; solid dosage form; Solubility; Tablets - chemistry; Viscosity; nonlinear regression; dissolution rate; controlled release; formulation; excipients; multivariate analysis; solid dosage form; preformulation; simulations; Pharmaceutical technology; Controlled release form; Control release polymer; Vehicle(excipient); Multivariate analysis; Dissolution; Simulation; Formulation; Dosage form; Solid form