Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans - van Eijk, Lucas T.; John, Aaron S.E.; Schwoebel, Frank; Summo, Luciana; Vauléon, Stéphanie; Zöllner, Stefan; Laarakkers, Coby M.; Kox, Matthijs; van der Hoeven, Johannes G.; Swinkels, Dorine W.; Riecke, Kai; Pickkers, Peter (Blood, 2014)
Keywords: Adolescent; Adult; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacokinetics; Anti-Inflammatory Agents - therapeutic use; Brief Report; C-Reactive Protein - metabolism; Clinical Trials and Observations; Double-Blind Method; Endotoxemia - blood; Endotoxemia - chemically induced; Endotoxemia - prevention & control; Hepcidins - antagonists & inhibitors; Hepcidins - blood; Humans; Inflammation - blood; Inflammation - chemically induced; Inflammation - prevention & control; Injections, Intravenous; Interleukin 1 Receptor Antagonist Protein - blood; Interleukin-10; Interleukin-6 - blood; Iron - blood; Leukocyte Count; Lipopolysaccharides; Male; Metabolic Clearance Rate; Oligoribonucleotides - administration & dosage; Oligoribonucleotides - pharmacokinetics; Oligoribonucleotides - therapeutic use; Treatment Outcome; Tumor Necrosis Factor-alpha - blood; Young Adult